Sri Suryanti - Academia.edu (original) (raw)

Papers by Sri Suryanti

Jurnal Kesehatan Andalas, Dec 26, 2022

Bayi Berat Lahir Rendah (BBLR) erat kaitannya dengan morbiditas bayi, terhambatnya pertumbuhan da... more Bayi Berat Lahir Rendah (BBLR) erat kaitannya dengan morbiditas bayi, terhambatnya pertumbuhan dan perkembangan kognitif, serta penyakit kronis. Spektrum Plasenta Akreta (SPA) merupakan suatu kondisi penyulit kehamilan yang berkaitan erat dengan BBLR. Tujuan: Mengetahui insidensi BBLR pada ibu denga SPA di Rumah Sakit (RS) Dr. Hasan Sadikin Bandung. Metode: Sebuah studi pengamatan deskriptif yang melibatkan 71 kasus SPA di RS Dr. Hasan Sadikin Bandung, periode 2016-2020, yang telah memenuhi kriteria inklusi dan eksklusi. Kasus SPA dibagi kedalam tiga kelompok, yaitu plasenta akreta, inkreta, perkreta. Pada setiap kelompok SPA dievaluasi insidensi BBLR. Hasil: Sebanyak 46,5% (33/71 kasus SPA) memiliki BBLR, sedangkan 53,5% (38/71 kasus SPA) memiliki bayi berat lahir normal. Kelompok plasenta akreta dan perkreta didominasi bayi berat lahir normal [(18/31 kasus), (5/9 kasus)], sedangkan kelompok plasenta inkreta didominasi BBLR (16/31 kasus). Kategori BBLR dibagi menjadi Bayi Berat Lahir Ekstrem Rendah (BBLER), Bayi berat lahir Sangat Rendah (BBLSR), dan BBLR. Pada plasenta akreta didapatkan BBLER dan BBLSR sebanyak 2 bayi dan 9 BBLR. Pada plasenta inkreta terdapat 3 BBLER maupun BBLSR, dan 10 BBLR. Pada plasenta perkreta terdapat 1 BBLER dan 3 BBLR, sedangkan BBLSR tidak ditemukan pada plasenta perkreta. Simpulan: Insidensi BBLR ditemukan pada hampir setengah populasi kasus SPA di RS Dr.

JAMBI MEDICAL JOURNAL "Jurnal Kedokteran dan Kesehatan", 2014

Background: Most of cervical carcinoma patients, including cervical adenocarcinoma comes at an ad... more Background: Most of cervical carcinoma patients, including cervical adenocarcinoma comes at an advanced stage and thus radiotherapy is one of the modality treatment. The success of radiotherapy depends on several prognostic factors such as the performance, staging, histopathology of tumor, presence of organ dysfunction and cellular biology marker such as VEGF. Activation singaling pathway Vascular Endothelial Growth Factor (VEGF) can induce radioresistance on cervical adenocarcinoma. Activation angiogenesis mediated by VEGF can be counted from microvessel density (MVD). Counting MVD use imunohistochemical CD34 on endothelial cells form capiller of blood vessel in peritumoral. The aim of this study was to determine correlation between immunohistochemistry VEGF dan MVD with neoadjuvant radiotherapy response cervical adenocarcinoma. Methods: This study was an observational study, cross-sectional and correlational analysis. Samples was collected by total sampling with amount 32 samples block parafin from Departement Anatomical Pathology General Hospital Dr. Hasan Sadikin Bandung and treated with complete neoadjuvant radiotherapy from Januari 2007 until December 2013. Immunohistochemical examination of VEGF and CD34 for counting MVD was done on all sample block parafin. Result: There was a strong correlation between microvessel density (MVD) with neoadjuvant radiotherapy response in cervical adenocarcinoma (p = 0.000). In this study MVD above 30 correlate with poor neoadjuvant radiotherapy response in cervical adenocarcinoma. Conclusion: Examination MVD recommended for cervical adenocarcinoma patient before radiation treatment.

Jurnal Kedokteran Universitas Lampung, Apr 1, 2017

Karsinoma urotelial adalah keganasan yang berasal dari epitel transisional vesika urinaria. Karsi... more Karsinoma urotelial adalah keganasan yang berasal dari epitel transisional vesika urinaria. Karsinoma ini merupakan jenis keganasan vesika urinaria paling sering sekitar 90% dari seluruh tumor primer pada organ ini. Pemberian terapi yang tepat merupakan hal penting dalam menungkatkan harapan hidup pasien. Pemilihan terapi yang optimal sangat dipengaruhi oleh gradasi histopatologi. Penentuan diagnostik dan prognostik menjadi lebih akurat jika didukung dengan melihat peranan penanda molekuler Extracelullar Matrix Metalloproteinase Inducer (EMMPRIN) dalam menentukan adanya invasi pada karsinoma urotelial. Penelitian ini merupakan penelitian studi observasional analitik dengan desain crossectional. Analisis katagorik tidak berpasangan terhadap 40 kasus karsinoma urotelial di Departemen Patologi Anatomi Fakultas Kedokteran Universitas Padjadjaran/RSUP Dr.Hasan Sadikin Bandung, yang terdiri dari 20 kasus karsinoma urotelial infiltrating dan 20 kasus karsinoma urotelial non infiltrating. Seluruh sampel yang terkumpul diperiksa imunohistokimia EMMPRIN di Laboratorium Patologi Anatomi RSHS Bandung. Penelitian ini menunjukan terdapat perbedaan distribusi proporsi skor EMMPRIN pada kelompok karsinoma infiltrating dan non infiltrating diperoleh informasi nilai P=0,000 (<0,005).Berdasarkan hasil penelitian ini didapatkan hasil kesimpulan nahwa imunoekspresi EMMPRIN pada karsinoma infiltrating lebih tinggi dibandingkan karsinoma non infiltrating yang berarti signifikan atau bermakna secara statistik.

Majalah Patologi Indonesia, May 1, 2020

International Journal Of Medical Science And Clinical Invention, Apr 15, 2019

More than 40% patient of Hodgkin lymphoma (HL) are chemoresistance and show early disease relapse... more More than 40% patient of Hodgkin lymphoma (HL) are chemoresistance and show early disease relapse that leads to poor prognostic. Epstein-Barr Virus (EBV) appears to have poor prognostic in HL. The CD30 expression at Hodgkin and Reed-Stenberg cells suggested has associated with advanced disease stage. The International Prognostic Score-7 (IPS) is a sevenparameter of risk stratification index for prognostic and as a consideration for treatment plan. The aim of this journal is to see correlation between EBV infection and CD30 expression with IPS-7 in Classic HL (CHL) patient. Case-control research design was done to 40 Fixed Formalin Paraffin-Embedded (FFPE) of CHL at the Dr Hasan Sadikin Hospital, Bandung. Cases were 20 patients CHL of high-risk score IPS-7 and controls were 20 patients with low-risk score. Detection of EBV-encoded small RNA-1 (EBER1) by Real-Time RT-PCR and Immunohistochemical staining of CD30 was performed to all samples. All data were analyzed using Chi-Square test with p-value <0.05 of significant level. EBV was present in 10 cases of CHL (25%). The result of this study shows a different statistically significant of EBV infection (p=0.028) and CD30 expression (p=0.004) between low risk and high-risk IPS-7 HL. CD30 expression (OR= 7.429) may provide stronger factor for risk assessment for the patient with HL, compare to EBER1 detection (OR=6.000). This study concluded that CD30 expression and EBV Infection correlate with risk assessment IPS-7 in CHL.

Majalah Patologi Indonesia, Sep 12, 2022

BackgroundTriple Negative Breast Cancer (TNBC) accounts for 9-17% of all breast cancer diagnoses.... more BackgroundTriple Negative Breast Cancer (TNBC) accounts for 9-17% of all breast cancer diagnoses. TNBC has a high proliferation index and a poor prognosis with a higher response rate to neoadjuvant chemotherapy, but does not correlate with Overall Survival (OS) due to chemoresistence in more than 50% of TNBC. Neoadjuvant chemotherapy with anthracycline (doxorubicin) based regimens in combination with fluorouracil and cyclophosphamide (FAC) is still an option for TNBC. The aim of this study was to determine association between clinicopathological profile and response to neoajuvan chemotherapy in TNBC at Dr. Hasan Sadikin Bandung which is a referral hospital in West Java.MethodsThis study used an analytic observational method with a cross-sectional design. The research sample consisted of 40 TNBC cases from January 2017 to December 2019 at Dr. Hasan Sadikin hospital. Data obtained from medical records and archives of the Anatomical Pathology Laboratory consist of clinical response to neoadjuvant chemotherapy, age, tumor size, lymph node metastases and distant metastases, clinical stage, type of histopathology and lymphovascular vessel invasion.ResultsIn 40 cases of TNBC, 20 cases responded and 20 cases did not respond to neoadjuvant chemotherapy. In the non-response group, there were 90% of cases with histopathologic type invasive carcinoma of no special type and 75% showed invasion of lymphovascular vessels. There were no significant differences in age, tumor size, lymphovascular vessel invasion, stage, or histopathological type in the response and non-response groups.ConclusionThere is no correlation between clinicopathological features and neoadjuvant chemotherapy response in the case of Triple Negative Breast Cancer (TNBC). This can be caused by other factors including high heterogeneous tumor microenvironment (TME).

Indonesian Journal of Cancer, Sep 29, 2022

Background: Infiltrating urothelial carcinoma of the bladder (IUCB) is an aggressive urinary trac... more Background: Infiltrating urothelial carcinoma of the bladder (IUCB) is an aggressive urinary tract cancer. Most of the patients were diagnosed with advanced stages, and many have metastasized. Metastasis is responsible for 90% of cancer deaths compared to the primary tumor itself. In previous research, the expression of CXCR4 and MMP-9 has been suggested to correlate with metastasis and prognosis in several cancers. This study aimed to analyze the association of CXCR4 and MMP-9 expression with metastasis in infiltrating urothelial carcinoma of the bladder. Methods: This cross-sectional study included 40 selected paraffin-embedded tissue blocks from histopathologically diagnosed IUCB patients, consisting of 20 cases of non-metastasizing and 20 cases of metastasizing IUCB. Immunohistochemical staining for CXCR4 and MMP-9 was performed in all cases. All data were analyzed using the Chi-Square test with p < 0.05 of a significant level and then processed using SPSS 24.0 for Windows. Results: High CXCR4 immunoexpression was found in 18 (45%) of all cases, and high MMP-9 immunoexpression was found in 19 (47.5%) cases. High immunoexpression of CXCR4 and MMP-9 in infiltrating urothelial carcinoma of the bladder showed significant association with metastasis (p < 0.05). The stepwise logistic regression analysis revealed that both CXCR-4 and MMP-9 immunoexpressions were independent prognostic factors for metastasis. Conclusions: CXCR4 and MMP-9 play a role in the metastatic process in infiltrating urothelial carcinoma of the bladder.

The Malaysian journal of pathology, Aug 1, 2022

Global Medical & Health Communication (GMHC)

The placenta accreta spectrum (PAS) is an abnormal placenta condition with a high level of morbid... more The placenta accreta spectrum (PAS) is an abnormal placenta condition with a high level of morbidity and mortality in both the mother and fetus. The PAS has a multifactorial etiology, one of which is a chronic inflammation of the basal plate (CIBP) and the decidual existences (DE). The study aims to analyze the association between CIBP and DE with PAS. It was an analytical observational with a cross-sectional study design on 50 placentae (25 PAS paraffin block, 25 standard placenta samples) from Dr. Hasan Sadikin General Hospital and other health centers that meet the inclusion and exclusion criteria. The data are taken from PAS patients from January 2015–December 2020. All samples will be stained with hematoxylin-eosin (HE), then undergo histopathological examination. The result of the studies analyzed statistically using Fisher's exact. CIBP in PAS was found in 21/25 cases, while in the normal placenta was found in 16/21 patients. The DE is positive in 15/25 cases of PAS, wher...

Clinical, Cosmetic and Investigational Dermatology

Background: Acral melanoma (AM) is a malignancy that originates from melanocytes, located in an a... more Background: Acral melanoma (AM) is a malignancy that originates from melanocytes, located in an anatomical area without sun exposure, aggressive, resistant to chemotherapy, and quickly metastasize. The invasion capability of tumor cells is the main factor for metastasis in malignancy. E-cadherin is a marker of tumor progressivity that has an important role in the process of invasion. The responsibility of E-cadherin in the invasion process of AM is not well known. CD103 is an immune component found in the tumor microenvironment that contributes to melanoma progression control, whereas E-cadherin is the ligand for CD103. Purpose: The objective of this research was to see if there was an association between E-cadherin and CD103 immunoexpression and the thickness of invasion in AM. Materials and Methods: This is observational cross-sectional research. Formalin-fixed paraffin-embedded (FFPE) acral melanoma tissue samples were collected during 2014-2020 at the Department of Anatomic Pathology, Dr. Hasan Sadikin Hospital, Bandung. A total of 40 samples were collected, including 20 cases of invasive melanoma less than 4 mm thickness and 20 cases of invasive melanoma greater than 4 mm thickness. All samples were immunostained with E-cadherin and CD103. Chi-Square test was used to examine the association concerning E-cadherin and CD103 with the thickness of invasion, respectively. The p-value of 0.05 was chosen as the significance level. Results: This study showed an insignificant association between E-cadherin immunoexpression and the thickness of invasion on AM (p = 0.4272). CD103 immunoexpression had a significant association with the thickness of invasion on AM (p = 0.0001). Conclusion: The findings revealed that CD103 in AM is associated with the thickness of invasion, and it may play important functions throughout the invasion process despite the uninvolvement of E-cadherin.

Althea Medical Journal

Background: The placenta accreta spectrum (PAS) incidence has inclined today. The PAS is divided ... more Background: The placenta accreta spectrum (PAS) incidence has inclined today. The PAS is divided into three histopathological classifications, including accreta, increta, and percreta, associated with maternal, fetal morbidity, and mortality. This study aimed to explore the maternal characteristics and histopathological features in PAS at Dr. Hasan Sadikin General Hospital Bandung. Methods: This descriptive observational study involved 135 cases from January 2015–December 2020 at Dr. Hasan Sadikin General Hospital that met the inclusion criteria. The PAS histopathological classification was evaluated based on maternal characteristics such as age, parity, cesarean section (CS), and miscarriage. Results: The incidence of placenta accreta from 2015 to 2020 was 37.0%, whereas increta was 43.4%, followed by percreta at 19.3%. The maternal age of placenta accreta and increta mainly occurred at the age of 30–34 years with the prevalence of 40% and 46%, respectively, whereas percreta was ag...

Research and Reports in Urology, 2021

Introduction: Clear cell renal cell carcinoma (ccRCC) is the most lethal type of malignancy of th... more Introduction: Clear cell renal cell carcinoma (ccRCC) is the most lethal type of malignancy of the urinary tract system as it is resistant to chemotherapy and radiation and has a survival rate of less than 5% in cases of metastasis. Inflammation plays an essential role in the metastasis of ccRCC. Cyclooxygenase-2 (COX-2) is an inflammatory protein that affects the processes of carcinogenesis, invasion, migration, metastasis, and angiogenesis. COX-2 can modulate programmed death ligand-1 (PD-L1) expression and play a role in immune evasion, meaning that tumor cells are able to escape the body's immune response and more easily metastasize. Purpose: This study aims to determine the role of COX-2 and PD-L1 in the occurrence of ccRCC metastases. Materials and Methods: This study is an observational analytical study, which employed a cross-sectional approach to examine the paraffin block samples of 40 ccRCC cases from Dr. Hasan Sadikin Hospital Bandung, Indonesia, between 2014 and 2021. Immunoexpression was measured using immunohistochemical staining for COX-2 in tumor cells and for PD-L1 in immune cells. PD-L1 calculation was measured using Qupath 0.2.3. digital software. Metastatic data were obtained using radiological imaging and pathological examinations. Meanwhile, the data were analyzed using the chi-square test for COX-2 and Fischer's exact test for PD-L1. Results: The research results revealed a significant association between COX-2 and the occurrence of metastases in ccRCC (p=0.001) with a prevalence odds ratio of 10.28. Positive PD-L1 immunoexpression of the immune cells (≥1%) was found in 14% (3/ 21) of the metastatic group and 5% (1/19) of the non-metastatic group (p=0.607). There was no association between COX-2 and PD-L1 immunoexpression (p=0.278). Conclusion: This study shows that metastases in ccRCC patients are ten times as likely to be associated with high COX-2 immunoexpression than low COX-2 immunoexpression. COX-2 plays a role in the process of ccRCC metastasis without PD-L1 involvement.

ABSTRAK Latar belakang Epidermal growth factor receptor (EGFR) berperan dalam patogenesis dan pro... more ABSTRAK Latar belakang Epidermal growth factor receptor (EGFR) berperan dalam patogenesis dan progresivitas karsinoma kolorektal. Stadium Dukes menunjukkan luas penyebaran tumor dan digunakan sebagai pedoman terapi. Pada stadium Dukes A tumor masih terbatas pada tunika submukosa, stadium Dukes B tumor sudah menembus tunika muskularis dan stadium Dukes C sudah bermetastasis ke kelenjar getah bening. Penggunaan kemoterapi adjuvan pada stadium Dukes B masih kontroversi sehingga hanya diberikan pada stadium Dukes B yang high risk. Diperlukan penanda molekuler yang dapat menunjukkan tumor yang agresif. Pada penelitian ini akan diteliti hubungan imunoekspresi EGFR dengan stadium Dukes pada karsinoma kolorektal. EGFR diharapkan dapat digunakan menjadi penanda karsinoma kolorektal yang agresif. Metode Pewarnaan imunohistokimia EGFR dilakukan terhadap 45 blok parafin karsinoma kolorektal yang dilakukan kolektomi (masing-masing stadium Dukes A, B, C 15 kasus). Hasilnya dihubungkan dengan stad...

International Journal Of Medical Science And Clinical Invention, 2020

International Journal of Medical Science and Clinical invention, 2019

Pathology, 2016

Results: DDC feeding led to increased serum markers of hepatic injury, ductular reaction, inducti... more Results: DDC feeding led to increased serum markers of hepatic injury, ductular reaction, induction of proinflammatory cytokines and biliary fibrosis. Interestingly, melittin treatment attenuated hepatic function marker (ALT, AP, total bilirubin), ductular reaction (Cytokeratin 19), reactive phenotype of cholangiocytes and cholangitis (VCAM and CDb11) and biliary fibrosis (type I collagen, TIMP-1, TGF-b). Conclusion: Our data suggest that melittin treatment can be protective for chronic cholestasis disease as well in DDC feeding mice. Further study for the anti-inflammatory capacity of melittin is given target therapy in cholangiopathy.

International Journal Of Medical Science And Clinical Invention, Dec 19, 2020

Background: Nowadays, pathology services are more developed for quantitative diagnostic evaluatio... more Background: Nowadays, pathology services are more developed for quantitative diagnostic evaluation. The quantitative diagnostic evaluation requires detailed accuracy and can be done using digital image analysis (DIA). Assessment of the CD103 in acral melanoma needs to be done quantitatively. A visual microscopy evaluation of CD103 has difficulties in counting CD103 positive lymphocytes. These difficulties are due to the expression of CD103, which is very little, whereas the field of view of the tumor mass is considered quite exhaustive when viewed under a microscope. The evaluation of CD103 could be done digitally with the DIA technique to overcome these difficulties. The DIA technique is carried out automatically by counting the lymphocytes that express CD103 with bioimage analysis software. QuPath is one of the bioimage analysis software, has characteristics of cross-platform, intended for bioimage analysis and digital pathology. This study aims to compare the CD103 count by visual microscopy evaluation and DIA in acral melanoma. Methods: This study was a cross-sectional study. CD103 immunostained slides of 40 cases of acral melanoma were eyeballing assessed by two pathologists and automated digital images analyzed by one pathologist using QuPath. Results: Wilcoxon signed ranks test showed no significant difference between the visual microscopy evaluation and DIA of CD103 count (p = 0,580). Conclusions: Digital image analysis using QuPath can be used to count the CD103 automatically.

International Journal of Medical Science and Clinical Invention, 2020

Background. Galectin-3 has been suggested to involve in invasion and aggressive behaviour of seve... more Background. Galectin-3 has been suggested to involve in invasion and aggressive behaviour of several cancer. The aim of this study is to evaluate the immunoreactivity of Galectin-3 in follicular thyroid carcinoma (FTC) in an attempt to investigate its association with clinicopathology of FTC. Method. This study included 46 selected paraffin embedded tissue blocks from surgically resected follicular thyroid carcinoma minimally invasive, consists of 23 cases of FTC capsular invasion only and 23 cases of FTC encapsulated angioinvasive. Immunohistochemistry staining for Galectin-3 were performed on all cases. Galectin-3 protein expression was observed in the cytoplasm and the nucleus of examined tissues. Result. Forty-three (93.5%) samples had strong or moderate staining and 3 (6.5%) tumours had negative or weak staining. Positive immunoreactivity of Galectin-3 was found in 18/23 (78.3%) cases of FTC capsular invasion only and 20/23 (86.9%) cases of FTC encapsulated angioinvasive. The g...

The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy, 2021

Chronic diarrhea is a diarrhea symptom which persists for ≥ 4 weeks as a symptom of a disease. Ch... more Chronic diarrhea is a diarrhea symptom which persists for ≥ 4 weeks as a symptom of a disease. Chronic diarrhea is a symptom which often becomes the patient’s cause to be referred to gastroenterology. In general, the prevalence of chronic diarrhea is approximated to be 5% in each populations, but there are obstacles in diagnosing the cause of chronic diarrhea, due to many differential diagnoses of the cause of chronic diarrhea. The cause of chronic diarrhea could be neoplasm and non-neoplasm. In several studies, through results of colonoscopy and histopathology, it was found that the most common cause of chronic diarrhea was non-neoplasm, including IBD, microscopic colitis as a risk factor, and infectious colitis as a differential diagnosis. Each of those diseases has similar symptoms, but different pathological description. Through descriptions of colonoscopy and histopathology of chronic diarrhea causes, it is possible to differentiate each non-neoplasm causes of chronic diarrhea....