Stefan Albu - Academia.edu (original) (raw)

Papers by Stefan Albu

Research paper thumbnail of Clinical Aspects and Therapeutic Management of an Aggressive Manifestation of Stage III Grade C Periodontitis in a Female Teenager

Diagnostics, Mar 13, 2023

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Research paper thumbnail of The efficiency of using enamel matrix derivative in therapeutic approach of periodontal furcation defects of maxillary and mandibular molars

Romanian Journal of Morphology and Embryology, Jan 12, 2022

Periodontal disease is an inflammatory condition which affects the covering and support structure... more Periodontal disease is an inflammatory condition which affects the covering and support structures of the teeth and, if left untreated, leads to tooth loss. Resorption of the alveolar bone from bi- and trifurcation regions of a multirooted tooth due to the progression of a periodontal disease bears involvement furcation. The degree of furcation involvement is clinically assessed by changes in the vertical and horizontal plane at the root separation area. In the approach of the furcation treatment, the morphological and functional particularities of pluriradicular teeth must be considered and the current techniques look for solutions for the regeneration of the destroyed periodontal tissues. Enamel matrix derivative (EMD) has the role of stimulating healing processes through effects on various growth factors, cement formation, angiogenesis and are used single or in combination with bone graft substitute (BGS) or guided tissue regeneration (GTR) in the complex treatment of periodontal disease. The present study follows PubMed publications on the efficiency of EMD in the treatment of pluriradicular tooth furcations. The findings are that there are not many studies in the usage of EMD associated with the treatment of furcations, but it is an important choice in the complex treatment of destructive periodontal disease, and further studies are needed to be done in periodontal regeneration.

Research paper thumbnail of The Effectiveness of the Association of Chlorhexidine with Mechanical Treatment of Peri-Implant Mucositis

Healthcare

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Research paper thumbnail of Clinical Aspects and Therapeutic Management of an Aggressive Manifestation of Stage III Grade C Periodontitis in a Female Teenager

Diagnostics

The main objective of this study was to evaluate the improvement of periodontal health in patient... more The main objective of this study was to evaluate the improvement of periodontal health in patients with periodontitis treated with non-surgical periodontal therapy and subgingival-administrated local and systemic antimicrobial agents. A female teenager with periodontitis-associated health issues and a history of dental trauma was selected for this study. Clinical indices were obtained, and radiographic examination was performed at the beginning of the study. The patient was treated with periodontal therapy and administration of antibiotics. After this therapy, visits were scheduled at regular intervals to observe the clinical changes. Non-surgical periodontal therapy and administration of local and systemic antibiotics resulted in a reduction in the patient pocket depth probing, plaque index, and bleeding on probing. Gingival and periodontal health improved in terms of gingival overgrowth, plaque, tartar index, and tooth mobility. Suppuration was eliminated, and no gingival inflamma...

Research paper thumbnail of Moderate associated fetal ventriculomegaly: prenatal diagnosis

International Journal of Research in Medical Sciences, Dec 28, 2020

Ventriculomegaly (VM) is a descriptive term, indicating the enlargement of the ventricles of the ... more Ventriculomegaly (VM) is a descriptive term, indicating the enlargement of the ventricles of the brain. We present the case of a 32-year-old primiparous women, at 18 weeks of pregnancy, who was referred in our clinic for a routine prenatal ultrasound examination. The ultrasound scan highlighted a single malformed fetus with several major abnormalities of the fetal head: hypoplastic nasal bone, agenesis of corpus callosum, choroid plexus hyperplasia, solid hypoechoic mass on the external wall of the left ventricle, no visible cavum septum pellucidum, third ventricle visible, moderately enlarged and VM with evolution to bilateral hydrocephalus. The parents were informed about the major severity of anomalies and decide to terminate the pregnancy. Prenatal ultrasound examination was decisive in the early prenatal diagnosis and optimized management of the malformed fetus with VM.

Research paper thumbnail of Tongue Piercing: a Current Trend with High-risk Effects

Revista De Chimie, Sep 15, 2019

Oral and facial piercing as a form of body art are being observed more frequently in medical and ... more Oral and facial piercing as a form of body art are being observed more frequently in medical and dental practices [1]. The use of oral piercings and especially the piercing of the tongue is mainly related to a series of local complications and individuals who decide to use piercings should be aware of such complications [2]. This article presents the dental complications produced by an unusual association between a tongue piercing and tic behavior, along with the implications associated with such a practice.

Research paper thumbnail of Research algorithm for the detection of genetic patterns and phenotypic variety of non-syndromic dental agenesis

Romanian Journal of Morphology and Embryology, Oct 2, 2021

This is an open-access article distributed under the terms of a Creative Commons Attribution-NonC... more This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited. ORIGINAL PAPER Research algorithm for the detection of genetic patterns and phenotypic variety of non-syndromic dental agenesis CRISTINA-CRENGUŢA ALBU 1) , ROMINA-CHRISTIANA PAVLOVICI 2) , MARINA IMRE 3) , ANA MARIA CRISTINA ŢÂNCU 3) , IOANA ANDREEA STANCIU 4) , ADRIANA VASILACHE 5) , ŞTEFAN MILICESCU 6) , GEORGE ION 6) , ŞTEFAN-DIMITRIE ALBU 7) , MIHAELA TĂNASE 4)

Research paper thumbnail of Folic Acid and Its Role in Oral Health: A Narrative Review

Processes

Vitamins, exogenous organic compounds that play a vital role in metabolic reactions, and fundamen... more Vitamins, exogenous organic compounds that play a vital role in metabolic reactions, and fundamental powerful antioxidants with a crucial role in the genetic transcription process, are considered essential nutritional factors. Folic acid (FA), also known as folate, or Vitamin B9, plays an indispensable role in various intracellular reactions, being the main pawn, with a strong impact on medical and dental science. The aim of this paper mainly focuses on presenting the latest and most advanced aspects related to the following topics: (1) the resonance that FA, and more specifically FA deficiency, has at the level of the oral cavity; (2) the elements involved in the molecular landscape, which reflect the interaction and the possible mechanisms of action, through which FA influences oral health; and (3) the particular processes by which FA deficiency causes certain clinical conditions. Moreover, we aim to draw the attention and trigger the curiosity of health professionals on the need ...

Research paper thumbnail of The Potential of Prenatal Diagnosis in the Early Detection of Congenital Malformations

International Journal of Medical Research & Review, 2021

We present a unique association of fetal malformations very early diagnosed by ultrasoundexaminat... more We present a unique association of fetal malformations very early diagnosed by ultrasoundexamination, at 14 weeks of gestation. A 28-year-old pregnant female, was addressed in a privatemedical center from Bucharest, Romania, for a routine ultrasound screening. A detailed ultrasoundevaluation of the fetus showed numerous and significant cephalic and heart malformations. Theultrasound examination of the fetal head suggest the diagnosis of fetal lobar hydrocephalus, and theultrasound examination of the fetal heart suggest the transposition of the great vessels. The parentswere informed about the severity of the fetal malformations and decided to terminate the pregnancydue to medical reasons. Anatomopathological examination confirmed the prenatal diagnosis. Firsttrimester ultrasonography was crucial in the early prenatal diagnosis and management of themalformed fetus with a unique association of fetal malformations.

Research paper thumbnail of The Importance of Customized Biometric Correlations in the Prevention of Growth and Development Disorders – A Determining Factor in the Social Integration of Children and Adolescents with Mental Disabilities

Revista de Cercetare si Interventie Sociala, 2021

This research illustrates a complex, observational, longitudinal, comparative and nonintervention... more This research illustrates a complex, observational, longitudinal, comparative and noninterventional biometric study on the evaluation, in dynamics, of stature-weight development, in children with Down syndrome (DS), compared to children with varying degrees of mental retardation (MR), by repeatedly determining their height and weight, as well as by correlating these two parameters, in order to highlight the harmonious or disharmonious aspect of their stature-weight development. For this purpose, from patients’ medical files, we extracted the data regarding the periodic, annual, height and weight determinations of 50 preschoolers and schoolchildren, institutionalized in two Special Schools in Bucharest, which we compared with the standard tables used for Romanian population. The results showed that all children with DS show a disharmonious stature-weight development, with excess weight, as a consequence of both chromosomal trisomy and associated congenital malformations, especially h...

Research paper thumbnail of Current opportunities and new horizons into the genetic study of infertility

Romanian Journal of Morphology and Embryology, 2021

This is an open-access article distributed under the terms of a Creative Commons Attribution-NonC... more This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited. ORIGINAL PAPER Current opportunities and new horizons into the genetic study of infertility ELENA-SILVIA NADĂ 1) , DINU-FLORIN ALBU 2) , ANCA PĂTRAŞCU 3) , ŞTEFAN-DIMITRIE ALBU 4) , ALEXANDRU MARIAN GOGĂNĂU 5) , CRISTINA-CRENGUŢA ALBU 6)

Research paper thumbnail of Moderate associated fetal ventriculomegaly: prenatal diagnosis

International Journal of Research in Medical Sciences, 2020

Ventriculomegaly (VM) is a descriptive term, indicating the enlargement of the ventricles of the ... more Ventriculomegaly (VM) is a descriptive term, indicating the enlargement of the ventricles of the brain. We present the case of a 32-year-old primiparous women, at 18 weeks of pregnancy, who was referred in our clinic for a routine prenatal ultrasound examination. The ultrasound scan highlighted a single malformed fetus with several major abnormalities of the fetal head: hypoplastic nasal bone, agenesis of corpus callosum, choroid plexus hyperplasia, solid hypoechoic mass on the external wall of the left ventricle, no visible cavum septum pellucidum, third ventricle visible, moderately enlarged and VM with evolution to bilateral hydrocephalus. The parents were informed about the major severity of anomalies and decide to terminate the pregnancy. Prenatal ultrasound examination was decisive in the early prenatal diagnosis and optimized management of the malformed fetus with VM.

Research paper thumbnail of Importance of ultrasound investigation in the early prenatal diagnosis of an Oral-Facial-Digital Syndrome Type I: a new case report

International Journal of Medical Research and Review, 2016

We report a case of a 29 year old female. Ultrasound examination showed a fetus with: cleft lip a... more We report a case of a 29 year old female. Ultrasound examination showed a fetus with: cleft lip and cleft palate, ocular hypertelorism, polydactyly and polycystic kidney. Amniocentesis was performed and the fetal chromosomal analysis indicated a normal cytogenetic female, karyotype: 46XX. Further genetic investigations were done. After genetical counseling the parents decided to terminate the pregnancy. The autopsy confirmed the ultrasound findings.

Research paper thumbnail of Twin Pregnancy discordordant for Downs syndrome: Case Report

International Journal of Medical Research and Review, 2015

The work presented is a clinical and genetical trial of a couple with a reproductive failure and ... more The work presented is a clinical and genetical trial of a couple with a reproductive failure and a family history of chromosomal abnormalities. The most reliable and accurate methods used for antenatal diagnosis of Down syndrome fetuses are highlighted.

Research paper thumbnail of Impact of Material Serum Screening in Early Prenatal Diagnosis and Management of Congenital Anomalies

Revista de Chimie, 2019

It was performed a case-control study, that included totally 187 pregnant women hospitalized in O... more It was performed a case-control study, that included totally 187 pregnant women hospitalized in Obstetrical-Gynecology Department of Prof. Dr. Panait Sarbu Hospital, Bucharest, Romania. The selection criteria for case sample were: age over 30 years, history of malformative risk, clinical exam that emphasised malformations and ultrasound examination that suspicioned embrio-fetal morphological abnormalities. We determined the serum levels of alpha fetoprotein (AFP), human chorionic gonadotropin (hCG) and unconjugated estriol (uE3), by immunoenzymometry. As statistical analysis we determined the estimated median value. For each of the three parametres, the final curve was compared with the value obtained by spectrophotometry. The study revealed the predictive value of correlated use of these three parameters, together with ultrasound examination and cytogenetic investigations, in order to early prenatal diagnosis of congenital fetal anomalies.

Research paper thumbnail of New Various Histopathological Findings of the Placenta in Preeclampsia

Revista de Chimie, 2019

Preeclampsia represents a pregnancy-related disease which affects both the mother and the fetus. ... more Preeclampsia represents a pregnancy-related disease which affects both the mother and the fetus. It�s an important cause of materno-fetal morbidity and mortality. The placenta seems to be the main cause because after placental removal preeclampsia is no longer present. Placental examination is crucial and can reveal important information about this disease. After careful examination, besides the classic findings, new and uncommon histopathological aspects of the placenta in preeclampsia were described. A short observational study was performed which included placentas from preeclampsia complicated pregnancies. The various histopathological findings of the placenta in preeclampsia were evaluated according to gestational age.

Research paper thumbnail of Tongue Piercing: a Current Trend with High-risk Effects

Revista de Chimie, 2019

Oral and facial piercing as a form of body art are being observed more frequently in medical and ... more Oral and facial piercing as a form of body art are being observed more frequently in medical and dental practices [1]. The use of oral piercings and especially the piercing of the tongue is mainly related to a series of local complications and individuals who decide to use piercings should be aware of such complications [2]. This article presents the dental complications produced by an unusual association between a tongue piercing and tic behavior, along with the implications associated with such a practice.

Research paper thumbnail of Early Prenatal Diagnosis of an Extremely Rare Association of Down Syndrome and Transposition of the Great Vessels

Revista de Chimie, 2019

Every year, an estimated 7.9 million infants (6% of worldwide births) are born with serious�birth... more Every year, an estimated 7.9 million infants (6% of worldwide births) are born with serious�birth defects [1].�Congenital cardiovascular defects make up one of the largest groups of severe congenital malformations [2].The incidence of congenital heart defects in different studies varies from about 4/1,000 to 50/1,000 live births [3].� Congenital heart disease is frequently described in patients with Down syndrome and is the main cause of death in this population during the first two years of life [4].�Trisomy 21 with cardiovascular malformations have a maternal age-adjusted regional prevalence of 4.33/10,000 for the white population and 3.70/10,000 for the nonwhite population [5].�Prenatal diagnosis of�congenital�heart disease is important for proper perinatal and neonatal management, as congenital cardiac malformations occurs in approximately eight of 1000 live births [6]. We present an extremely rare case of early prenatal diagnosis and management of a fetus with trisomy 21 associ...

Research paper thumbnail of Phenotypic heterogeneity of impacted third molar tooth: family case study

International Journal of Medical Research and Review, 2019

Tooth impaction is a pathological condition where a tooth fails to attain its normal functional p... more Tooth impaction is a pathological condition where a tooth fails to attain its normal functional position. The present study aims to highlight the phenotypic heterogeneity of impacted third molars in a Caucasian family, to investigate the characteristics of the dental phenotype, to evidence the diversity of dental phenotype, and to identify the inheritance mode of the condition. Detailed anamnesis, clinical examination, complementary tests (panoramic radiographs), family study and pedigree analysis. Phenotypic characteristics of impacted third molar tooth in our family case report was: Severe horizontal impaction of the mandibular right third molar, Angular impaction of the maxillary right third molar and angular impaction of the maxillary left third molar, Angular impaction of the mandibular left third molar and partial eruption of the maxillary right third molar, Horizontal impaction of the mandibular left third molar and Angular impaction of the mandibular left third molar. The inheritance mode of the impacted third molar tooth in the family case report was: from mother to both daughters' transmission, from mother to both sons' transmission, and from mother to daughter transmission. Family study and pedigree analysis are very important for illustrate the genetic basis of impacted teeth.

Research paper thumbnail of Omphalocele and Intrauterine Growth Restriction, an Unusual Association of two Congenital Syndromic Malformations

International Journal of Medical Research and Review, 2015

We report a case of a 30 year old pregnant woman. Ultrasound examination showed severe intrauteri... more We report a case of a 30 year old pregnant woman. Ultrasound examination showed severe intrauterine growth restriction (IUGR) and an omphalocele. Amniocentesis was performed and the fetal chromosomal analysis showed mosaic trisomy 18. Further genetic investigations were done. The pregnancy was terminated one week later. Autopsy confirmed the ultrasound images findings. Our presentation is a very rare case report of mosaic trisomy 18, prenatal diagnosis, with important an anusual association of two congenital malformation, omphalocele and intrauterine severe growth restriction.

Research paper thumbnail of Clinical Aspects and Therapeutic Management of an Aggressive Manifestation of Stage III Grade C Periodontitis in a Female Teenager

Diagnostics, Mar 13, 2023

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Research paper thumbnail of The efficiency of using enamel matrix derivative in therapeutic approach of periodontal furcation defects of maxillary and mandibular molars

Romanian Journal of Morphology and Embryology, Jan 12, 2022

Periodontal disease is an inflammatory condition which affects the covering and support structure... more Periodontal disease is an inflammatory condition which affects the covering and support structures of the teeth and, if left untreated, leads to tooth loss. Resorption of the alveolar bone from bi- and trifurcation regions of a multirooted tooth due to the progression of a periodontal disease bears involvement furcation. The degree of furcation involvement is clinically assessed by changes in the vertical and horizontal plane at the root separation area. In the approach of the furcation treatment, the morphological and functional particularities of pluriradicular teeth must be considered and the current techniques look for solutions for the regeneration of the destroyed periodontal tissues. Enamel matrix derivative (EMD) has the role of stimulating healing processes through effects on various growth factors, cement formation, angiogenesis and are used single or in combination with bone graft substitute (BGS) or guided tissue regeneration (GTR) in the complex treatment of periodontal disease. The present study follows PubMed publications on the efficiency of EMD in the treatment of pluriradicular tooth furcations. The findings are that there are not many studies in the usage of EMD associated with the treatment of furcations, but it is an important choice in the complex treatment of destructive periodontal disease, and further studies are needed to be done in periodontal regeneration.

Research paper thumbnail of The Effectiveness of the Association of Chlorhexidine with Mechanical Treatment of Peri-Implant Mucositis

Healthcare

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Research paper thumbnail of Clinical Aspects and Therapeutic Management of an Aggressive Manifestation of Stage III Grade C Periodontitis in a Female Teenager

Diagnostics

The main objective of this study was to evaluate the improvement of periodontal health in patient... more The main objective of this study was to evaluate the improvement of periodontal health in patients with periodontitis treated with non-surgical periodontal therapy and subgingival-administrated local and systemic antimicrobial agents. A female teenager with periodontitis-associated health issues and a history of dental trauma was selected for this study. Clinical indices were obtained, and radiographic examination was performed at the beginning of the study. The patient was treated with periodontal therapy and administration of antibiotics. After this therapy, visits were scheduled at regular intervals to observe the clinical changes. Non-surgical periodontal therapy and administration of local and systemic antibiotics resulted in a reduction in the patient pocket depth probing, plaque index, and bleeding on probing. Gingival and periodontal health improved in terms of gingival overgrowth, plaque, tartar index, and tooth mobility. Suppuration was eliminated, and no gingival inflamma...

Research paper thumbnail of Moderate associated fetal ventriculomegaly: prenatal diagnosis

International Journal of Research in Medical Sciences, Dec 28, 2020

Ventriculomegaly (VM) is a descriptive term, indicating the enlargement of the ventricles of the ... more Ventriculomegaly (VM) is a descriptive term, indicating the enlargement of the ventricles of the brain. We present the case of a 32-year-old primiparous women, at 18 weeks of pregnancy, who was referred in our clinic for a routine prenatal ultrasound examination. The ultrasound scan highlighted a single malformed fetus with several major abnormalities of the fetal head: hypoplastic nasal bone, agenesis of corpus callosum, choroid plexus hyperplasia, solid hypoechoic mass on the external wall of the left ventricle, no visible cavum septum pellucidum, third ventricle visible, moderately enlarged and VM with evolution to bilateral hydrocephalus. The parents were informed about the major severity of anomalies and decide to terminate the pregnancy. Prenatal ultrasound examination was decisive in the early prenatal diagnosis and optimized management of the malformed fetus with VM.

Research paper thumbnail of Tongue Piercing: a Current Trend with High-risk Effects

Revista De Chimie, Sep 15, 2019

Oral and facial piercing as a form of body art are being observed more frequently in medical and ... more Oral and facial piercing as a form of body art are being observed more frequently in medical and dental practices [1]. The use of oral piercings and especially the piercing of the tongue is mainly related to a series of local complications and individuals who decide to use piercings should be aware of such complications [2]. This article presents the dental complications produced by an unusual association between a tongue piercing and tic behavior, along with the implications associated with such a practice.

Research paper thumbnail of Research algorithm for the detection of genetic patterns and phenotypic variety of non-syndromic dental agenesis

Romanian Journal of Morphology and Embryology, Oct 2, 2021

This is an open-access article distributed under the terms of a Creative Commons Attribution-NonC... more This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited. ORIGINAL PAPER Research algorithm for the detection of genetic patterns and phenotypic variety of non-syndromic dental agenesis CRISTINA-CRENGUŢA ALBU 1) , ROMINA-CHRISTIANA PAVLOVICI 2) , MARINA IMRE 3) , ANA MARIA CRISTINA ŢÂNCU 3) , IOANA ANDREEA STANCIU 4) , ADRIANA VASILACHE 5) , ŞTEFAN MILICESCU 6) , GEORGE ION 6) , ŞTEFAN-DIMITRIE ALBU 7) , MIHAELA TĂNASE 4)

Research paper thumbnail of Folic Acid and Its Role in Oral Health: A Narrative Review

Processes

Vitamins, exogenous organic compounds that play a vital role in metabolic reactions, and fundamen... more Vitamins, exogenous organic compounds that play a vital role in metabolic reactions, and fundamental powerful antioxidants with a crucial role in the genetic transcription process, are considered essential nutritional factors. Folic acid (FA), also known as folate, or Vitamin B9, plays an indispensable role in various intracellular reactions, being the main pawn, with a strong impact on medical and dental science. The aim of this paper mainly focuses on presenting the latest and most advanced aspects related to the following topics: (1) the resonance that FA, and more specifically FA deficiency, has at the level of the oral cavity; (2) the elements involved in the molecular landscape, which reflect the interaction and the possible mechanisms of action, through which FA influences oral health; and (3) the particular processes by which FA deficiency causes certain clinical conditions. Moreover, we aim to draw the attention and trigger the curiosity of health professionals on the need ...

Research paper thumbnail of The Potential of Prenatal Diagnosis in the Early Detection of Congenital Malformations

International Journal of Medical Research & Review, 2021

We present a unique association of fetal malformations very early diagnosed by ultrasoundexaminat... more We present a unique association of fetal malformations very early diagnosed by ultrasoundexamination, at 14 weeks of gestation. A 28-year-old pregnant female, was addressed in a privatemedical center from Bucharest, Romania, for a routine ultrasound screening. A detailed ultrasoundevaluation of the fetus showed numerous and significant cephalic and heart malformations. Theultrasound examination of the fetal head suggest the diagnosis of fetal lobar hydrocephalus, and theultrasound examination of the fetal heart suggest the transposition of the great vessels. The parentswere informed about the severity of the fetal malformations and decided to terminate the pregnancydue to medical reasons. Anatomopathological examination confirmed the prenatal diagnosis. Firsttrimester ultrasonography was crucial in the early prenatal diagnosis and management of themalformed fetus with a unique association of fetal malformations.

Research paper thumbnail of The Importance of Customized Biometric Correlations in the Prevention of Growth and Development Disorders – A Determining Factor in the Social Integration of Children and Adolescents with Mental Disabilities

Revista de Cercetare si Interventie Sociala, 2021

This research illustrates a complex, observational, longitudinal, comparative and nonintervention... more This research illustrates a complex, observational, longitudinal, comparative and noninterventional biometric study on the evaluation, in dynamics, of stature-weight development, in children with Down syndrome (DS), compared to children with varying degrees of mental retardation (MR), by repeatedly determining their height and weight, as well as by correlating these two parameters, in order to highlight the harmonious or disharmonious aspect of their stature-weight development. For this purpose, from patients’ medical files, we extracted the data regarding the periodic, annual, height and weight determinations of 50 preschoolers and schoolchildren, institutionalized in two Special Schools in Bucharest, which we compared with the standard tables used for Romanian population. The results showed that all children with DS show a disharmonious stature-weight development, with excess weight, as a consequence of both chromosomal trisomy and associated congenital malformations, especially h...

Research paper thumbnail of Current opportunities and new horizons into the genetic study of infertility

Romanian Journal of Morphology and Embryology, 2021

This is an open-access article distributed under the terms of a Creative Commons Attribution-NonC... more This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited. ORIGINAL PAPER Current opportunities and new horizons into the genetic study of infertility ELENA-SILVIA NADĂ 1) , DINU-FLORIN ALBU 2) , ANCA PĂTRAŞCU 3) , ŞTEFAN-DIMITRIE ALBU 4) , ALEXANDRU MARIAN GOGĂNĂU 5) , CRISTINA-CRENGUŢA ALBU 6)

Research paper thumbnail of Moderate associated fetal ventriculomegaly: prenatal diagnosis

International Journal of Research in Medical Sciences, 2020

Ventriculomegaly (VM) is a descriptive term, indicating the enlargement of the ventricles of the ... more Ventriculomegaly (VM) is a descriptive term, indicating the enlargement of the ventricles of the brain. We present the case of a 32-year-old primiparous women, at 18 weeks of pregnancy, who was referred in our clinic for a routine prenatal ultrasound examination. The ultrasound scan highlighted a single malformed fetus with several major abnormalities of the fetal head: hypoplastic nasal bone, agenesis of corpus callosum, choroid plexus hyperplasia, solid hypoechoic mass on the external wall of the left ventricle, no visible cavum septum pellucidum, third ventricle visible, moderately enlarged and VM with evolution to bilateral hydrocephalus. The parents were informed about the major severity of anomalies and decide to terminate the pregnancy. Prenatal ultrasound examination was decisive in the early prenatal diagnosis and optimized management of the malformed fetus with VM.

Research paper thumbnail of Importance of ultrasound investigation in the early prenatal diagnosis of an Oral-Facial-Digital Syndrome Type I: a new case report

International Journal of Medical Research and Review, 2016

We report a case of a 29 year old female. Ultrasound examination showed a fetus with: cleft lip a... more We report a case of a 29 year old female. Ultrasound examination showed a fetus with: cleft lip and cleft palate, ocular hypertelorism, polydactyly and polycystic kidney. Amniocentesis was performed and the fetal chromosomal analysis indicated a normal cytogenetic female, karyotype: 46XX. Further genetic investigations were done. After genetical counseling the parents decided to terminate the pregnancy. The autopsy confirmed the ultrasound findings.

Research paper thumbnail of Twin Pregnancy discordordant for Downs syndrome: Case Report

International Journal of Medical Research and Review, 2015

The work presented is a clinical and genetical trial of a couple with a reproductive failure and ... more The work presented is a clinical and genetical trial of a couple with a reproductive failure and a family history of chromosomal abnormalities. The most reliable and accurate methods used for antenatal diagnosis of Down syndrome fetuses are highlighted.

Research paper thumbnail of Impact of Material Serum Screening in Early Prenatal Diagnosis and Management of Congenital Anomalies

Revista de Chimie, 2019

It was performed a case-control study, that included totally 187 pregnant women hospitalized in O... more It was performed a case-control study, that included totally 187 pregnant women hospitalized in Obstetrical-Gynecology Department of Prof. Dr. Panait Sarbu Hospital, Bucharest, Romania. The selection criteria for case sample were: age over 30 years, history of malformative risk, clinical exam that emphasised malformations and ultrasound examination that suspicioned embrio-fetal morphological abnormalities. We determined the serum levels of alpha fetoprotein (AFP), human chorionic gonadotropin (hCG) and unconjugated estriol (uE3), by immunoenzymometry. As statistical analysis we determined the estimated median value. For each of the three parametres, the final curve was compared with the value obtained by spectrophotometry. The study revealed the predictive value of correlated use of these three parameters, together with ultrasound examination and cytogenetic investigations, in order to early prenatal diagnosis of congenital fetal anomalies.

Research paper thumbnail of New Various Histopathological Findings of the Placenta in Preeclampsia

Revista de Chimie, 2019

Preeclampsia represents a pregnancy-related disease which affects both the mother and the fetus. ... more Preeclampsia represents a pregnancy-related disease which affects both the mother and the fetus. It�s an important cause of materno-fetal morbidity and mortality. The placenta seems to be the main cause because after placental removal preeclampsia is no longer present. Placental examination is crucial and can reveal important information about this disease. After careful examination, besides the classic findings, new and uncommon histopathological aspects of the placenta in preeclampsia were described. A short observational study was performed which included placentas from preeclampsia complicated pregnancies. The various histopathological findings of the placenta in preeclampsia were evaluated according to gestational age.

Research paper thumbnail of Tongue Piercing: a Current Trend with High-risk Effects

Revista de Chimie, 2019

Oral and facial piercing as a form of body art are being observed more frequently in medical and ... more Oral and facial piercing as a form of body art are being observed more frequently in medical and dental practices [1]. The use of oral piercings and especially the piercing of the tongue is mainly related to a series of local complications and individuals who decide to use piercings should be aware of such complications [2]. This article presents the dental complications produced by an unusual association between a tongue piercing and tic behavior, along with the implications associated with such a practice.

Research paper thumbnail of Early Prenatal Diagnosis of an Extremely Rare Association of Down Syndrome and Transposition of the Great Vessels

Revista de Chimie, 2019

Every year, an estimated 7.9 million infants (6% of worldwide births) are born with serious�birth... more Every year, an estimated 7.9 million infants (6% of worldwide births) are born with serious�birth defects [1].�Congenital cardiovascular defects make up one of the largest groups of severe congenital malformations [2].The incidence of congenital heart defects in different studies varies from about 4/1,000 to 50/1,000 live births [3].� Congenital heart disease is frequently described in patients with Down syndrome and is the main cause of death in this population during the first two years of life [4].�Trisomy 21 with cardiovascular malformations have a maternal age-adjusted regional prevalence of 4.33/10,000 for the white population and 3.70/10,000 for the nonwhite population [5].�Prenatal diagnosis of�congenital�heart disease is important for proper perinatal and neonatal management, as congenital cardiac malformations occurs in approximately eight of 1000 live births [6]. We present an extremely rare case of early prenatal diagnosis and management of a fetus with trisomy 21 associ...

Research paper thumbnail of Phenotypic heterogeneity of impacted third molar tooth: family case study

International Journal of Medical Research and Review, 2019

Tooth impaction is a pathological condition where a tooth fails to attain its normal functional p... more Tooth impaction is a pathological condition where a tooth fails to attain its normal functional position. The present study aims to highlight the phenotypic heterogeneity of impacted third molars in a Caucasian family, to investigate the characteristics of the dental phenotype, to evidence the diversity of dental phenotype, and to identify the inheritance mode of the condition. Detailed anamnesis, clinical examination, complementary tests (panoramic radiographs), family study and pedigree analysis. Phenotypic characteristics of impacted third molar tooth in our family case report was: Severe horizontal impaction of the mandibular right third molar, Angular impaction of the maxillary right third molar and angular impaction of the maxillary left third molar, Angular impaction of the mandibular left third molar and partial eruption of the maxillary right third molar, Horizontal impaction of the mandibular left third molar and Angular impaction of the mandibular left third molar. The inheritance mode of the impacted third molar tooth in the family case report was: from mother to both daughters' transmission, from mother to both sons' transmission, and from mother to daughter transmission. Family study and pedigree analysis are very important for illustrate the genetic basis of impacted teeth.

Research paper thumbnail of Omphalocele and Intrauterine Growth Restriction, an Unusual Association of two Congenital Syndromic Malformations

International Journal of Medical Research and Review, 2015

We report a case of a 30 year old pregnant woman. Ultrasound examination showed severe intrauteri... more We report a case of a 30 year old pregnant woman. Ultrasound examination showed severe intrauterine growth restriction (IUGR) and an omphalocele. Amniocentesis was performed and the fetal chromosomal analysis showed mosaic trisomy 18. Further genetic investigations were done. The pregnancy was terminated one week later. Autopsy confirmed the ultrasound images findings. Our presentation is a very rare case report of mosaic trisomy 18, prenatal diagnosis, with important an anusual association of two congenital malformation, omphalocele and intrauterine severe growth restriction.