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Open Access by Stefan Borgwardt

Despite a large number of neuroimaging studies in schizophrenia reporting subtle brain abnormalit... more Despite a large number of neuroimaging studies in schizophrenia reporting subtle brain abnormalities, we do not know to what extent such abnormalities reflect the effects of antipsychotic treatment on brain structure. We therefore systematically reviewed cross-sectional and follow-up structural brain imaging studies of patients with schizophrenia treated with antipsychotics. 30 magnetic resonance imaging (MRI) studies were identified, 24 of them being longitudinal and six cross-sectional structural imaging studies. In patients with schizophrenia treated with antipsychotics, reduced gray matter volume was described, particularly in the frontal and temporal lobes. Structural neuroimaging studies indicate that treatment with typical as well as atypical antipsychotics may affect regional gray matter (GM) volume. In particular, typical antipsychotics led to increased gray matter volume of the basal ganglia, while atypical antipsychotics reversed this effect after switching. Atypical antipsychotics, however, seem to have no effect on basal ganglia structure.

Papers by Stefan Borgwardt

Imaging Genomics – An integrative approach to understand the biological susceptibility for schizophrenia

Medical Hypotheses, 2007

Schizophrenia Research, 2009

Insular pathology in the at-risk mental state

European Archives of Psychiatry and Clinical Neuroscience, 2008

European Psychiatry, 2007

We read the article by De Souza Crippa et al. (European Psychiatry 2006; 21:291e299) with great i... more We read the article by De Souza Crippa et al. (European Psychiatry 2006; 21:291e299) with great interest. This group compared the prevalence, size and volume of cavum septum pellucidum (CSP) in patients with schizophrenia and healthy controls using magnetic resonance imaging (MRI). They could not find differences between groups in the frequency (presence) of small CSP (less than 6 mm); however, if they considered only large CSPs with a length of more than 6 mm, CSPs were more common among patients than controls. They conclude that the clinical significance of a CSP depends more on its magnitude than whether it is present or absent.

Structural brain abnormalities in individuals with an at-risk mental state who later develop psychosis

The British journal of psychiatry. Supplement, 2007

Neuroanatomical abnormalities are a well-established feature of schizophrenia. However, the timin... more Neuroanatomical abnormalities are a well-established feature of schizophrenia. However, the timing of their emergence and the extent to which they are related to vulnerability to the disorder as opposed to psychotic illness itself is unclear. To assess regional grey matter volume in the at-risk individuals who subsequently developed psychosis. Magnetic resonance imaging data from at-risk individuals who developed psychosis (n=12) within the following 25 months were compared with data from healthy volunteers (n=22) and people with first-episode psychosis (n=25). Compared with healthy volunteers, individuals who subsequently developed psychosis had smaller grey matter volume in the posterior cingulate gyrus, precuneus, and paracentral lobule bilaterally and in the left superior parietal lobule, and greater grey matter volume in a left parietal/posterior temporal region. Compared with first-episode patients, they had relatively greater grey matter volume in the temporal gyrus bilateral...

Duration of Untreated Illness/Psychosis and Cognitive Functioning

Antipsychotika-Wirkung auf die Hirnstruktur bei Schizophrenie–Neue Evidenz durch Meta-Analysen?

564–DELTA-9-TETRAHYDROCANNABINOL MODULATES MEDIAL TEMP AND STRIATAL FUNCTION IN HUMANS: A NEURAL BASIS FOR THE EFFECTS OF CANNABIS ON MEMORY AND PSYCHOSIS

Early recognition of psychosis-The Basel FEPSY study, sample description and transition rate to psychosis of at-risk individuals

Fine motor function deficits in individuals at risk for schizophrenia-confounding factors (FEPSY study)

Early detection of schizophrenia using a multilevel approach-The Basel FEPSY Study

Fine motor function deficits and confounding factors in individuals at risk for schizophrenia (Basel FEPSY Study)

Pathological MRI brain scan and EEG findings in individuals at risk for schizophrenia (Basel FEPSY Study)

Neuropsychological deficits in individuals at-risk for psychosis (the Basel FEPSY Study)

Annual Meeting of the Swiss Society of Clinical Neurophysiology, Basel, Switzerland, 22–24 April 2004 Schweizerische Gesellschaft fur klinische Neurophysiologie/Société Suisse de Neurophysiologie Clinique

Neurokognitive Defizite bei Schizophrenien