Stefan Borgwardt - Academia.edu (original) (raw)
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Open Access by Stefan Borgwardt
Despite a large number of neuroimaging studies in schizophrenia reporting subtle brain abnormalit... more Despite a large number of neuroimaging studies in schizophrenia reporting subtle brain abnormalities, we do not know to what extent such abnormalities reflect the effects of antipsychotic treatment on brain structure. We therefore systematically reviewed cross-sectional and follow-up structural brain imaging studies of patients with schizophrenia treated with antipsychotics. 30 magnetic resonance imaging (MRI) studies were identified, 24 of them being longitudinal and six cross-sectional structural imaging studies. In patients with schizophrenia treated with antipsychotics, reduced gray matter volume was described, particularly in the frontal and temporal lobes. Structural neuroimaging studies indicate that treatment with typical as well as atypical antipsychotics may affect regional gray matter (GM) volume. In particular, typical antipsychotics led to increased gray matter volume of the basal ganglia, while atypical antipsychotics reversed this effect after switching. Atypical antipsychotics, however, seem to have no effect on basal ganglia structure.
Papers by Stefan Borgwardt
Schizophrenia Research, 2009
European Archives of Psychiatry and Clinical Neuroscience, 2008
European Psychiatry, 2007
We read the article by De Souza Crippa et al. (European Psychiatry 2006; 21:291e299) with great i... more We read the article by De Souza Crippa et al. (European Psychiatry 2006; 21:291e299) with great interest. This group compared the prevalence, size and volume of cavum septum pellucidum (CSP) in patients with schizophrenia and healthy controls using magnetic resonance imaging (MRI). They could not find differences between groups in the frequency (presence) of small CSP (less than 6 mm); however, if they considered only large CSPs with a length of more than 6 mm, CSPs were more common among patients than controls. They conclude that the clinical significance of a CSP depends more on its magnitude than whether it is present or absent.
The British journal of psychiatry. Supplement, 2007
Neuroanatomical abnormalities are a well-established feature of schizophrenia. However, the timin... more Neuroanatomical abnormalities are a well-established feature of schizophrenia. However, the timing of their emergence and the extent to which they are related to vulnerability to the disorder as opposed to psychotic illness itself is unclear. To assess regional grey matter volume in the at-risk individuals who subsequently developed psychosis. Magnetic resonance imaging data from at-risk individuals who developed psychosis (n=12) within the following 25 months were compared with data from healthy volunteers (n=22) and people with first-episode psychosis (n=25). Compared with healthy volunteers, individuals who subsequently developed psychosis had smaller grey matter volume in the posterior cingulate gyrus, precuneus, and paracentral lobule bilaterally and in the left superior parietal lobule, and greater grey matter volume in a left parietal/posterior temporal region. Compared with first-episode patients, they had relatively greater grey matter volume in the temporal gyrus bilateral...
Despite a large number of neuroimaging studies in schizophrenia reporting subtle brain abnormalit... more Despite a large number of neuroimaging studies in schizophrenia reporting subtle brain abnormalities, we do not know to what extent such abnormalities reflect the effects of antipsychotic treatment on brain structure. We therefore systematically reviewed cross-sectional and follow-up structural brain imaging studies of patients with schizophrenia treated with antipsychotics. 30 magnetic resonance imaging (MRI) studies were identified, 24 of them being longitudinal and six cross-sectional structural imaging studies. In patients with schizophrenia treated with antipsychotics, reduced gray matter volume was described, particularly in the frontal and temporal lobes. Structural neuroimaging studies indicate that treatment with typical as well as atypical antipsychotics may affect regional gray matter (GM) volume. In particular, typical antipsychotics led to increased gray matter volume of the basal ganglia, while atypical antipsychotics reversed this effect after switching. Atypical antipsychotics, however, seem to have no effect on basal ganglia structure.
Schizophrenia Research, 2009
European Archives of Psychiatry and Clinical Neuroscience, 2008
European Psychiatry, 2007
We read the article by De Souza Crippa et al. (European Psychiatry 2006; 21:291e299) with great i... more We read the article by De Souza Crippa et al. (European Psychiatry 2006; 21:291e299) with great interest. This group compared the prevalence, size and volume of cavum septum pellucidum (CSP) in patients with schizophrenia and healthy controls using magnetic resonance imaging (MRI). They could not find differences between groups in the frequency (presence) of small CSP (less than 6 mm); however, if they considered only large CSPs with a length of more than 6 mm, CSPs were more common among patients than controls. They conclude that the clinical significance of a CSP depends more on its magnitude than whether it is present or absent.
The British journal of psychiatry. Supplement, 2007
Neuroanatomical abnormalities are a well-established feature of schizophrenia. However, the timin... more Neuroanatomical abnormalities are a well-established feature of schizophrenia. However, the timing of their emergence and the extent to which they are related to vulnerability to the disorder as opposed to psychotic illness itself is unclear. To assess regional grey matter volume in the at-risk individuals who subsequently developed psychosis. Magnetic resonance imaging data from at-risk individuals who developed psychosis (n=12) within the following 25 months were compared with data from healthy volunteers (n=22) and people with first-episode psychosis (n=25). Compared with healthy volunteers, individuals who subsequently developed psychosis had smaller grey matter volume in the posterior cingulate gyrus, precuneus, and paracentral lobule bilaterally and in the left superior parietal lobule, and greater grey matter volume in a left parietal/posterior temporal region. Compared with first-episode patients, they had relatively greater grey matter volume in the temporal gyrus bilateral...