Steven Hanks - Academia.edu (original) (raw)
Papers by Steven Hanks
P & T : a peer-reviewed journal for formulary management, 2008
In 2001, The Joint Commission released new pain guidelines and attempted to address the problem o... more In 2001, The Joint Commission released new pain guidelines and attempted to address the problem of undertreated pain; however, the resulting focus on the pain score number has inadvertently led to some serious adverse drug events. In addition, the recent dramatic increase in opioid use has resulted in greater abuse of these prescribed drugs, often by teenagers.
P & T : a peer-reviewed journal for formulary management, 2008
In 2001, The Joint Commission released new pain guidelines and attempted to address the problem o... more In 2001, The Joint Commission released new pain guidelines and attempted to address the problem of undertreated pain; however, the resulting focus on the pain score number has inadvertently led to some serious adverse drug events. In addition, the recent dramatic increase in opioid use has resulted in greater abuse of these prescribed drugs, often by teenagers.
Clinica Chimica Acta, 2009
The thiazolidinediones (TZDs) improve tissue sensitivity to insulin in patients with type II diab... more The thiazolidinediones (TZDs) improve tissue sensitivity to insulin in patients with type II diabetes, resulting in reduced levels of fasting blood glucose and glycated hemoglobin. However, TZDs unpredictably demonstrate adverse effects of increased body weight, fluid retention, and edema. The balance of efficacy and safety of TZD varies widely from patient to patient. Genetic variability may reveal pathophysiological pathways underlying weight gain associated with TZD therapy and due to adiposity and/or edema. We analyzed 384 single nucleotide polymorphisms (SNPs) from 222 cardiovascular and metabolic genes in 87 outpatients with type 2 diabetes receiving thiazolidinedione therapy. Physiogenomic analysis was used to discover associations with body mass index (BMI) and edema. The 5 most significant gene associations found between BMI and SNPs were ADORA1, adenosine A1 receptor (rs903361, p<0.0003), PKM2, pyruvate kinase-muscle (rs2856929, p<0.002); ADIPOR2, adiponectin receptor 2 (rs7975375, p<0.007); UCP2, uncoupling protein 2 (rs660339, p<0.008); and APOH, apolipoprotein H (rs8178847, p<0.010). For edema, the 5 most significant gene associations were NPY, neuropeptide Y (rs1468271, p<0.006); GYS1, glycogen synthase 1-muscle (rs2287754, p<0.013); CCL2, chemokine C-C motif ligand 2 (rs3760396, p<0.015); OLR1, oxidized LDL receptor 1 (rs2742115, p<0.015); and GHRH, growth hormone releasing hormone (rs6032470, p<0.023). After accounting for multiple comparisons, ADORA1 was significantly associated with BMI at a false discovery rate (FDR) of <10%. Physiogenomic associations were discovered suggesting mechanistic links between adenosine signaling and BMI, and between vascular permeability and drug-induced edema.
Annals of Internal Medicine, 2005
Journal of the American College of Cardiology, 2010
P & T : a peer-reviewed journal for formulary management, 2008
In 2001, The Joint Commission released new pain guidelines and attempted to address the problem o... more In 2001, The Joint Commission released new pain guidelines and attempted to address the problem of undertreated pain; however, the resulting focus on the pain score number has inadvertently led to some serious adverse drug events. In addition, the recent dramatic increase in opioid use has resulted in greater abuse of these prescribed drugs, often by teenagers.
P & T : a peer-reviewed journal for formulary management, 2008
In 2001, The Joint Commission released new pain guidelines and attempted to address the problem o... more In 2001, The Joint Commission released new pain guidelines and attempted to address the problem of undertreated pain; however, the resulting focus on the pain score number has inadvertently led to some serious adverse drug events. In addition, the recent dramatic increase in opioid use has resulted in greater abuse of these prescribed drugs, often by teenagers.
Clinica Chimica Acta, 2009
The thiazolidinediones (TZDs) improve tissue sensitivity to insulin in patients with type II diab... more The thiazolidinediones (TZDs) improve tissue sensitivity to insulin in patients with type II diabetes, resulting in reduced levels of fasting blood glucose and glycated hemoglobin. However, TZDs unpredictably demonstrate adverse effects of increased body weight, fluid retention, and edema. The balance of efficacy and safety of TZD varies widely from patient to patient. Genetic variability may reveal pathophysiological pathways underlying weight gain associated with TZD therapy and due to adiposity and/or edema. We analyzed 384 single nucleotide polymorphisms (SNPs) from 222 cardiovascular and metabolic genes in 87 outpatients with type 2 diabetes receiving thiazolidinedione therapy. Physiogenomic analysis was used to discover associations with body mass index (BMI) and edema. The 5 most significant gene associations found between BMI and SNPs were ADORA1, adenosine A1 receptor (rs903361, p<0.0003), PKM2, pyruvate kinase-muscle (rs2856929, p<0.002); ADIPOR2, adiponectin receptor 2 (rs7975375, p<0.007); UCP2, uncoupling protein 2 (rs660339, p<0.008); and APOH, apolipoprotein H (rs8178847, p<0.010). For edema, the 5 most significant gene associations were NPY, neuropeptide Y (rs1468271, p<0.006); GYS1, glycogen synthase 1-muscle (rs2287754, p<0.013); CCL2, chemokine C-C motif ligand 2 (rs3760396, p<0.015); OLR1, oxidized LDL receptor 1 (rs2742115, p<0.015); and GHRH, growth hormone releasing hormone (rs6032470, p<0.023). After accounting for multiple comparisons, ADORA1 was significantly associated with BMI at a false discovery rate (FDR) of <10%. Physiogenomic associations were discovered suggesting mechanistic links between adenosine signaling and BMI, and between vascular permeability and drug-induced edema.
Annals of Internal Medicine, 2005
Journal of the American College of Cardiology, 2010