Steven J Mentzer - Academia.edu (original) (raw)
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Papers by Steven J Mentzer
The Anatomical Record, 2013
Respiratory Research, 2011
Although blood vessel growth occurs readily in the systemic bronchial circulation, angiogenesis i... more Although blood vessel growth occurs readily in the systemic bronchial circulation, angiogenesis in the pulmonary circulation is rare. Compensatory lung growth after pneumonectomy is an experimental model with presumed alveolar capillary angiogenesis. To investigate the genes participating in murine neoalveolarization, we studied the expression of angiogenesis genes in lung endothelial cells. After left pneumonectomy, the remaining right lung was examined on days 3, 6, 14 and 21days after surgery and compared to both no surgery and sham thoracotomy controls. The lungs were enzymatically digested and CD31+ endothelial cells were isolated using flow cytometry cell sorting. The transcriptional profile of the CD31+ endothelial cells was assessed using quantitative real-time polymerase chain reaction (PCR) arrays. Focusing on 84 angiogenesis-associated genes, we identified 22 genes with greater than 4-fold regulation and significantly enhanced transcription (p <.05) within 21 days of p...
Journal of Cellular Physiology, 2012
Experimental Lung Research, 2012
Developmental Dynamics, 2011
The Anatomical Record, 2010
Intussusceptive angiogenesis is a morphogenetic process that forms new blood vessels by the divis... more Intussusceptive angiogenesis is a morphogenetic process that forms new blood vessels by the division of a single blood vessel into two lumens. Here, we show that this process of intraluminal division participates in the inflammation‐induced neovascularization associated with chemically induced murine colitis. In studies of both acute (4–7 days) and chronic (28–31 days) colitis, intravital microscopy of intravascular tracers demonstrated a twofold reduction in blood flow velocity. In the acute colitis model, the decreased velocity was associated with marked dilatation of the mucosal plexus. In contrast, chronic inflammation was associated with normal caliber vessels and duplication (and triplication) of the quasi‐polygonal mucosal plexus. Scanning electron microscopy (SEM) of intravascular corrosion casts suggested that pillar formation and septation, previously linked to the morphogenetic process of intussusceptive angiogenesis, were present within days of the onset of inflammation....
Plastic and Reconstructive Surgery, 2011
Background-Mechanical stretch has been shown to induce vascular remodeling and increase vessel de... more Background-Mechanical stretch has been shown to induce vascular remodeling and increase vessel density, but the pathophysiological mechanisms as well as the morphological changes induced by tensile forces to dermal vessels are poorly understood.
The Anatomical Record, 2013
Respiratory Research, 2011
Although blood vessel growth occurs readily in the systemic bronchial circulation, angiogenesis i... more Although blood vessel growth occurs readily in the systemic bronchial circulation, angiogenesis in the pulmonary circulation is rare. Compensatory lung growth after pneumonectomy is an experimental model with presumed alveolar capillary angiogenesis. To investigate the genes participating in murine neoalveolarization, we studied the expression of angiogenesis genes in lung endothelial cells. After left pneumonectomy, the remaining right lung was examined on days 3, 6, 14 and 21days after surgery and compared to both no surgery and sham thoracotomy controls. The lungs were enzymatically digested and CD31+ endothelial cells were isolated using flow cytometry cell sorting. The transcriptional profile of the CD31+ endothelial cells was assessed using quantitative real-time polymerase chain reaction (PCR) arrays. Focusing on 84 angiogenesis-associated genes, we identified 22 genes with greater than 4-fold regulation and significantly enhanced transcription (p <.05) within 21 days of p...
Journal of Cellular Physiology, 2012
Experimental Lung Research, 2012
Developmental Dynamics, 2011
The Anatomical Record, 2010
Intussusceptive angiogenesis is a morphogenetic process that forms new blood vessels by the divis... more Intussusceptive angiogenesis is a morphogenetic process that forms new blood vessels by the division of a single blood vessel into two lumens. Here, we show that this process of intraluminal division participates in the inflammation‐induced neovascularization associated with chemically induced murine colitis. In studies of both acute (4–7 days) and chronic (28–31 days) colitis, intravital microscopy of intravascular tracers demonstrated a twofold reduction in blood flow velocity. In the acute colitis model, the decreased velocity was associated with marked dilatation of the mucosal plexus. In contrast, chronic inflammation was associated with normal caliber vessels and duplication (and triplication) of the quasi‐polygonal mucosal plexus. Scanning electron microscopy (SEM) of intravascular corrosion casts suggested that pillar formation and septation, previously linked to the morphogenetic process of intussusceptive angiogenesis, were present within days of the onset of inflammation....
Plastic and Reconstructive Surgery, 2011
Background-Mechanical stretch has been shown to induce vascular remodeling and increase vessel de... more Background-Mechanical stretch has been shown to induce vascular remodeling and increase vessel density, but the pathophysiological mechanisms as well as the morphological changes induced by tensile forces to dermal vessels are poorly understood.