Stuart Ballantine - Academia.edu (original) (raw)

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Papers by Stuart Ballantine

Research paper thumbnail of Quinolines as a novel structural class of potent and selective PDE4 inhibitors: Optimisation for oral administration

Bioorganic & Medicinal Chemistry Letters, 2009

Crystallography-driven optimisation of a lead derived from similarity searching of the GSK compou... more Crystallography-driven optimisation of a lead derived from similarity searching of the GSK compound collection resulted in the discovery of a series of quinoline derivatives that were highly potent and selective inhibitors of PDE4 with a good pharmacokinetic profile in the rat. Quinolines 43 and 48 have potential as oral medicines for the treatment of COPD Ó 2009 Elsevier Ltd. All rights reserved.

Research paper thumbnail of Quinolines as a novel structural class of potent and selective PDE4 inhibitors: Optimisation for oral administration

Bioorganic & Medicinal Chemistry Letters, 2009

Crystallography-driven optimisation of a lead derived from similarity searching of the GSK compou... more Crystallography-driven optimisation of a lead derived from similarity searching of the GSK compound collection resulted in the discovery of a series of quinoline derivatives that were highly potent and selective inhibitors of PDE4 with a good pharmacokinetic profile in the rat. Quinolines 43 and 48 have potential as oral medicines for the treatment of COPD Ó 2009 Elsevier Ltd. All rights reserved.

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