Subash Philip - Academia.edu (original) (raw)

Papers by Subash Philip

Cost-of-illness studies measure the economic burden of a disease and estimate the maximum amount ... more Cost-of-illness studies measure the economic burden of a disease and estimate the maximum amount that could potentially be saved or gained if a disease were to be eradicated. Direct medical costs and indirect costs are measured using top down and bottom up approaches Human Capital approach, Willingness-to-Pay (WTP) approach and Friction Costs approach respectively. The perspectives may measure costs to society, the health care system, third-party payers, businesses, the government, and participants and their families. Incidence-based studies, estimate lifetime costs, measure the costs of an illness from onset to conclusion for cases beginning within the period of the study, usually a year. Incidence costs include the discounted, lifetime medical, morbidity, and mortality costs for the incident cohort. Prevalence-based studies measure the costs of an illness in a year, regardless of the date of onset and include all medical care costs and morbidity costs for a disease. Indirect costs...

Plan: Five fastest moving brands of 54 generic drugs in eight therapeutic classes comprising a to... more Plan: Five fastest moving brands of 54 generic drugs in eight therapeutic classes comprising a total of 323 brands were ranked based on retail sales twelve major retailers of Kannur and Kasargod in Kerala using a pretested questionnaire to find the percentage variation ion in prices between brands. Prologue: Over the years the numbers of drugs whose prices are controlled have come down to ninety one. Rest of the drugs are priced with huge profit margins and even life saving and essential medicines have not been spared. Methodology: A preliminary survey was conducted to understand the therapeutic categories which had highest sales. The selected brands were ranked in the order of their sale volume. Outcome: Percentage price variation between different fast moving brands in the therapeutic classes of Analgesics, Antiasthma, Antibiotics, Cardiovascular, , Antidiabetics, Antiulcer, Hypolipidemics and Antipsychotics varies from 33 % – 1620%. A price corridor should be fixed for brands com...

The regulation of medical products has been expanding since early 20 th century. Regulatory agenc... more The regulation of medical products has been expanding since early 20 th century. Regulatory agencies are being established in an ever increasing number of countries across the globe. Those that have established are reorganizing their systems and attempting to harmonize with organizations of other countries 1. The pharmaceutical, biotechnology and medical devices are among the most highly regulated industries in the world. Regulatory affairs (RA) professionals are employed in pharmaceutical industry, government, academic research and clinical institutions. The Indian Pharmaceutical industry is one of the fastest growing industries in India, with a compounded annual growth rate (CAGR) of over 13 % in last 5 years and it is expected to grow at a higher rate in coming 10 years. It is valued at $ 8.0 billion approximately and ranks 4th in terms of volume and 13th in terms of value globally 2. All companies engaged in R&D worth its salt has an individual RA department to aid them in new p...

Plan: Five fastest moving brands of 54 generic drugs in eight therapeutic classes comprising a to... more Plan: Five fastest moving brands of 54 generic drugs in eight therapeutic classes comprising a total of 323 brands were ranked based on retail sales twelve major retailers of Kannur and Kasargod in Kerala using a pretested questionnaire to find the percentage variation ion in prices between brands. Prologue: Over the years the numbers of drugs whose prices are controlled have come down to ninety one. Rest of the drugs are priced with huge profit margins and even life saving and essential medicines have not been spared. Methodology: A preliminary survey was conducted to understand the therapeutic categories which had highest sales. The selected brands were ranked in the order of their sale volume. Outcome: Percentage price variation between different fast moving brands in the therapeutic classes of Analgesics, Antiasthma, Antibiotics, Cardiovascular, , Antidiabetics, Antiulcer, Hypolipidemics and Antipsychotics varies from 33 % – 1620%. A price corridor should be fixed for brands com...

as nearly 65 % Taking 8 glasses of water a day for females. Most often water in sufficient quanti... more as nearly 65 % Taking 8 glasses of water a day for females. Most often water in sufficient quantity. on drugs to restore our health. Water therapy 1 is the use of water simply providing The term hydropathy 2 relatively cheap and easy and Historical Background civilizations. 3,4,5,6 community in people such as JS Hahn (1696-1773) 1850) 9,10 and JH Rausse (1805-1848) website www.watercure.com 13,14 the elixir of life. An examination of the composition of the human 5 % of water. Even bones considered to be the driest organ have 22 % water. or less from kidney or from the internal water. The recommended water intake 75 is 3.7 L/day and for females is 2.7 L/day which is communicable diseases externally as sponges, baths, etc to cure ailments was derived from the ‘use of hot or cold water as eventually lent to its popularity. Water Other cultures noted for a long history of hydrotherapy include China and Japan 4 oblivion during the Middles Ages, hydrotherapy was rediscovered during the 18...

The regulation of medical products has been expanding since early 20 century. Regulatory agencies... more The regulation of medical products has been expanding since early 20 century. Regulatory agencies are being established in an ever increasing number of countries across the globe. Those that have established are reorganizing their systems and attempting to harmonize with organizations of other countries. The pharmaceutical, biotechnology and medical devices are among the most highly regulated industries in the world. Regulatory affairs (RA) professionals are employed in pharmaceutical industry, government, academic research and clinical institutions.

Diabetes mellitus is a spectrum of heterogeneous disorders which is one of the rapidly growing ch... more Diabetes mellitus is a spectrum of heterogeneous disorders which is one of the rapidly growing chronic diseases in the world. It occurs due to impaired response of insulin action, insulin deficiency, increased glucose production and abnormal fat or protein metabolism. The International Diabetes Federation (IDF) Diabetes Atlas, Seventh Edition, 2015, point outs that one in 11 adults have diabetes (416 million), among which nearly half (46.5%) of adults with diabetes are undiagnosed. Diabetic foot ulcers are the most devastating, chronic and costliest complication of diabetes. Diabetic foot ulcers can evoke a galore of complications with lower limb amputation being the dreadful one. It can bring months of hospitalization and enormous expenses. Even an acute wound, if untreated can lead to lower limb amputations. Wound healing is a complex purpose which involves a series of events. Phagocytosis, collagen synthesis and mitogenesis to name a few. Chronic foot ulcers with poor vasculariza...

International Journal of Research in Ayurveda and Pharmacy

Drug-induced liver injury (DILI) is an infrequent condition but can become potentially dangerous ... more Drug-induced liver injury (DILI) is an infrequent condition but can become potentially dangerous due to various factors. The triggering factors of liver disease are often associated with Over the Counter (OTC) medicines, prescription medications, and herbal and dietary supplements (HDS). DILI are of two types: intrinsic and idiosyncratic. Risk factors for idiosyncratic DILI (IDILI) are frequently associated with multiple hosts, environmental and compound factors. The formation of international syndicates for the registry made it advantageous for conducting the study of individual predispositions to DILI. Recent data highlight antibiotics, central nervous system agents, anti-tubercular drugs, herbal/dietary supplements and immunomodulatory agents as the most common causes of DILI. Female patients are often affected by this disorder. Treatment modalities range from the use of nanotechnology to provide hepatoprotective agents directly to the liver, up to polyherbal formulations. Future areas of research include the identification of predisposing factors in the patients at highest risk for DILI.

Plan : Five fastest moving brands of 54 generic drugs in eight therapeutic classes comprising a t... more Plan : Five fastest moving brands of 54 generic drugs in eight therapeutic classes comprising a total of 323 brands were ranked based on retail sales twelve major retailers of Kannur and Kasargod find the percentage variat ion in prices between brands Prologue : Over the years the numbers of drugs whose prices are drugs are priced with huge profit margins and even life saving and essential medicines have not been spared. Methodology: A preliminary survey was conducted to understand the therapeutic categories which had highest sales. selected brands were ranked in the order of their sale volume. Outcome: Percentage price variation between different fast moving brands in the therapeutic classes of Analgesics, Antiasthma, Antibiotics, Cardiovascular 1620%. A price corridor should be fixed for brands coming under these generics to prevent exploitation of patients. Branding and marketing strategies

Cost-of-illness studies measure the economic burden of a disease and estimate the maximum amount ... more Cost-of-illness studies measure the economic burden of a disease and estimate the maximum amount that could potentially be saved or gained if a disease were to be eradicated. Direct medical costs and indirect costs are measured using top down and bottom up approaches Human Capital approach, Willingness-to-Pay (WTP) approach and Friction Costs approach respectively. The perspectives may measure costs to society, the health care system, third-party payers, businesses, the government, and participants and their families. Incidence-based studies, estimate lifetime costs, measure the costs of an illness from onset to conclusion for cases beginning within the period of the study, usually a year. Incidence costs include the discounted, lifetime medical, morbidity, and mortality costs for the incident cohort. Prevalence-based studies measure the costs of an illness in a year, regardless of the date of onset and include all medical care costs and morbidity costs for a disease. Indirect costs...

Plan: Five fastest moving brands of 54 generic drugs in eight therapeutic classes comprising a to... more Plan: Five fastest moving brands of 54 generic drugs in eight therapeutic classes comprising a total of 323 brands were ranked based on retail sales twelve major retailers of Kannur and Kasargod in Kerala using a pretested questionnaire to find the percentage variation ion in prices between brands. Prologue: Over the years the numbers of drugs whose prices are controlled have come down to ninety one. Rest of the drugs are priced with huge profit margins and even life saving and essential medicines have not been spared. Methodology: A preliminary survey was conducted to understand the therapeutic categories which had highest sales. The selected brands were ranked in the order of their sale volume. Outcome: Percentage price variation between different fast moving brands in the therapeutic classes of Analgesics, Antiasthma, Antibiotics, Cardiovascular, , Antidiabetics, Antiulcer, Hypolipidemics and Antipsychotics varies from 33 % – 1620%. A price corridor should be fixed for brands com...

The regulation of medical products has been expanding since early 20 th century. Regulatory agenc... more The regulation of medical products has been expanding since early 20 th century. Regulatory agencies are being established in an ever increasing number of countries across the globe. Those that have established are reorganizing their systems and attempting to harmonize with organizations of other countries 1. The pharmaceutical, biotechnology and medical devices are among the most highly regulated industries in the world. Regulatory affairs (RA) professionals are employed in pharmaceutical industry, government, academic research and clinical institutions. The Indian Pharmaceutical industry is one of the fastest growing industries in India, with a compounded annual growth rate (CAGR) of over 13 % in last 5 years and it is expected to grow at a higher rate in coming 10 years. It is valued at $ 8.0 billion approximately and ranks 4th in terms of volume and 13th in terms of value globally 2. All companies engaged in R&D worth its salt has an individual RA department to aid them in new p...

Plan: Five fastest moving brands of 54 generic drugs in eight therapeutic classes comprising a to... more Plan: Five fastest moving brands of 54 generic drugs in eight therapeutic classes comprising a total of 323 brands were ranked based on retail sales twelve major retailers of Kannur and Kasargod in Kerala using a pretested questionnaire to find the percentage variation ion in prices between brands. Prologue: Over the years the numbers of drugs whose prices are controlled have come down to ninety one. Rest of the drugs are priced with huge profit margins and even life saving and essential medicines have not been spared. Methodology: A preliminary survey was conducted to understand the therapeutic categories which had highest sales. The selected brands were ranked in the order of their sale volume. Outcome: Percentage price variation between different fast moving brands in the therapeutic classes of Analgesics, Antiasthma, Antibiotics, Cardiovascular, , Antidiabetics, Antiulcer, Hypolipidemics and Antipsychotics varies from 33 % – 1620%. A price corridor should be fixed for brands com...

as nearly 65 % Taking 8 glasses of water a day for females. Most often water in sufficient quanti... more as nearly 65 % Taking 8 glasses of water a day for females. Most often water in sufficient quantity. on drugs to restore our health. Water therapy 1 is the use of water simply providing The term hydropathy 2 relatively cheap and easy and Historical Background civilizations. 3,4,5,6 community in people such as JS Hahn (1696-1773) 1850) 9,10 and JH Rausse (1805-1848) website www.watercure.com 13,14 the elixir of life. An examination of the composition of the human 5 % of water. Even bones considered to be the driest organ have 22 % water. or less from kidney or from the internal water. The recommended water intake 75 is 3.7 L/day and for females is 2.7 L/day which is communicable diseases externally as sponges, baths, etc to cure ailments was derived from the ‘use of hot or cold water as eventually lent to its popularity. Water Other cultures noted for a long history of hydrotherapy include China and Japan 4 oblivion during the Middles Ages, hydrotherapy was rediscovered during the 18...

The regulation of medical products has been expanding since early 20 century. Regulatory agencies... more The regulation of medical products has been expanding since early 20 century. Regulatory agencies are being established in an ever increasing number of countries across the globe. Those that have established are reorganizing their systems and attempting to harmonize with organizations of other countries. The pharmaceutical, biotechnology and medical devices are among the most highly regulated industries in the world. Regulatory affairs (RA) professionals are employed in pharmaceutical industry, government, academic research and clinical institutions.

Diabetes mellitus is a spectrum of heterogeneous disorders which is one of the rapidly growing ch... more Diabetes mellitus is a spectrum of heterogeneous disorders which is one of the rapidly growing chronic diseases in the world. It occurs due to impaired response of insulin action, insulin deficiency, increased glucose production and abnormal fat or protein metabolism. The International Diabetes Federation (IDF) Diabetes Atlas, Seventh Edition, 2015, point outs that one in 11 adults have diabetes (416 million), among which nearly half (46.5%) of adults with diabetes are undiagnosed. Diabetic foot ulcers are the most devastating, chronic and costliest complication of diabetes. Diabetic foot ulcers can evoke a galore of complications with lower limb amputation being the dreadful one. It can bring months of hospitalization and enormous expenses. Even an acute wound, if untreated can lead to lower limb amputations. Wound healing is a complex purpose which involves a series of events. Phagocytosis, collagen synthesis and mitogenesis to name a few. Chronic foot ulcers with poor vasculariza...

International Journal of Research in Ayurveda and Pharmacy

Drug-induced liver injury (DILI) is an infrequent condition but can become potentially dangerous ... more Drug-induced liver injury (DILI) is an infrequent condition but can become potentially dangerous due to various factors. The triggering factors of liver disease are often associated with Over the Counter (OTC) medicines, prescription medications, and herbal and dietary supplements (HDS). DILI are of two types: intrinsic and idiosyncratic. Risk factors for idiosyncratic DILI (IDILI) are frequently associated with multiple hosts, environmental and compound factors. The formation of international syndicates for the registry made it advantageous for conducting the study of individual predispositions to DILI. Recent data highlight antibiotics, central nervous system agents, anti-tubercular drugs, herbal/dietary supplements and immunomodulatory agents as the most common causes of DILI. Female patients are often affected by this disorder. Treatment modalities range from the use of nanotechnology to provide hepatoprotective agents directly to the liver, up to polyherbal formulations. Future areas of research include the identification of predisposing factors in the patients at highest risk for DILI.

Plan : Five fastest moving brands of 54 generic drugs in eight therapeutic classes comprising a t... more Plan : Five fastest moving brands of 54 generic drugs in eight therapeutic classes comprising a total of 323 brands were ranked based on retail sales twelve major retailers of Kannur and Kasargod find the percentage variat ion in prices between brands Prologue : Over the years the numbers of drugs whose prices are drugs are priced with huge profit margins and even life saving and essential medicines have not been spared. Methodology: A preliminary survey was conducted to understand the therapeutic categories which had highest sales. selected brands were ranked in the order of their sale volume. Outcome: Percentage price variation between different fast moving brands in the therapeutic classes of Analgesics, Antiasthma, Antibiotics, Cardiovascular 1620%. A price corridor should be fixed for brands coming under these generics to prevent exploitation of patients. Branding and marketing strategies