Subhasis Misra - Academia.edu (original) (raw)

Papers by Subhasis Misra

Research paper thumbnail of The Association between Pre-Treatment Serum 25-Hydroxyvitamin D and Survival in Newly Diagnosed Stage IV Prostate Cancer

PLOS ONE, 2015

Emerging evidence in the literature suggests a positive association between serum 25hydroxyvitami... more Emerging evidence in the literature suggests a positive association between serum 25hydroxyvitamin D [25(OH)D], a standard indicator of vitamin D status, and survival in certain types of cancer. We investigated this relationship in newly diagnosed stage IV prostate cancer patients.

Research paper thumbnail of What is causing this patient's acute abdomen?

JAAPA : official journal of the American Academy of Physician Assistants, 2015

Research paper thumbnail of Esophageal cancer: A Review of epidemiology, pathogenesis, staging workup and treatment modalities

World journal of gastrointestinal oncology, Jan 15, 2014

Esophageal cancer is a serious malignancy with regards to mortality and prognosis. It is a growin... more Esophageal cancer is a serious malignancy with regards to mortality and prognosis. It is a growing health concern that is expected to increase in incidence over the next 10 years. Squamous cell carcinoma is the most common histological type of esophageal cancer worldwide, with a higher incidence in developing nations. With the increased prevalence of gastroesophageal reflux disease and obesity in developed nations, the incidence of esophageal adenocarcinoma has dramatically increased in the past 40 years. Esophageal cancer is staged according to the widely accepted TNM system. Staging plays an integral part in guiding stage specific treatment protocols and has a great impact on overall survival. Common imaging modalities used in staging include computed tomography, endoscopic ultrasound and positron emission tomography scans. Current treatment options include multimodality therapy mainstays of current treatment include surgery, radiation and chemotherapy. Tumor markers of esophageal...

Research paper thumbnail of Brown recluse spider bite on the breast

JAAPA : official journal of the American Academy of Physician Assistants, 2014

Brown recluse spiders are one of two types of spiders in the United States that can cause signifi... more Brown recluse spiders are one of two types of spiders in the United States that can cause significant tissue damage and, in rare cases, death. Brown recluse spider bites are most often benign and self-limiting, but in a few cases can cause severe necrotic skin lesions.

Research paper thumbnail of PCV50 Gastric Bypass Surgery–An Overview

Research paper thumbnail of Developments in Screening Tests and Strategies for Colorectal Cancer

BioMed Research International, 2015

Worldwide, colorectal cancer (CRC) is the third most common cancer in men and second most common ... more Worldwide, colorectal cancer (CRC) is the third most common cancer in men and second most common in women. It is the fourth most common cause of cancer mortality. In the United States, CRC is the third most common cause of cancer and second most common cause of cancer mortality. Incidence and mortality rates have steadily fallen, primarily due to widespread screening. We conducted keyword searches on PubMed in four categories of CRC screening: stool, endoscopic, radiologic, and serum, as well as news searches in Medscape and Google News. Colonoscopy is the gold standard for CRC screening and the most common method in the United States. Technological improvements continue to be made, including the promising "third-eye retroscope." Fecal occult blood remains widely used, particularly outside the United States. The first at-home screen, a fecal DNA screen, has also recently been approved. Radiological methods are effective but seldom used due to cost and other factors. Serum tests are largely experimental, although at least one is moving closer to market. Colonoscopy is likely to remain the most popular screening modality for the immediate future, although its shortcomings will continue to spur innovation in a variety of modalities.

Research paper thumbnail of The role of politics in shaping surgical training

Bulletin of the American College of Surgeons, 2013

Research paper thumbnail of P03.02. Application of an Integrative Medicine Model in Pancreatic Cancer

Global Advances in Health and Medicine, 2013

Research paper thumbnail of Value of screening endoscopy in evaluation of esophageal, gastric and colon cancers

World journal of gastroenterology, Jan 7, 2015

Esophageal, gastric, and colorectal cancers are deadly diseases that continue to plague our world... more Esophageal, gastric, and colorectal cancers are deadly diseases that continue to plague our world today. The value of screening endoscopy in evaluating these types of cancers is a critical area of discussion due to a potential reduction in morbidity and mortality. This article describes how to identify a good screening test and explains what are important criteria in the field of screening endoscopy. Furthermore, the current status and progress of screening endoscopy for esophageal, gastric, and colorectal cancer will be evaluated and discussed. Mass screening programs have not been implemented for esophageal and gastric carcinomas in those with average or low risk populations. However, studies of high-risk populations have found value and a cost-benefit in conducting screening endoscopy. Colorectal cancer, on the other hand, has had mass screening programs in place for many years due to the clear evidence of improved outcomes. As the role of endoscopy as a screening tool has contin...

Research paper thumbnail of Is there value in intraoperative frozen section during thyroidectomy for thyroid nodules?

Journal of the American College of Surgeons, 2015

Research paper thumbnail of Surgical versus conservative management of adult intussusception: Case series and review

International journal of surgery case reports, Jan 22, 2016

Intussusception is the telescoping of a segment of bowel into its adjacent segment. It is a known... more Intussusception is the telescoping of a segment of bowel into its adjacent segment. It is a known cause of abdominal pain in the pediatric population, however, it is rare in the adult. Adults do not always present with the typical symptoms seen in young children, making the clinical diagnosis more difficult. The etiology of adult intussusception can be idiopathic, benign, or malignant. Diagnosis is most accurately made with computed tomography, which is sensitive in detecting intussusception as well as potential lead points. This study presents four adult patients with intussusception. The first three patients are adults with idiopathic intussusception and no evidence of a lead point. The fourth case involves intussusception secondary to a jejunal carcinoid tumor which was treated surgically. Each case has unique features in terms of length and number of intussusceptions, duration of symptoms, and recurrence. Surgical treatment was once argued to be universally appropriate for adult...

Research paper thumbnail of Do geriatric patients with cancer have a higher incidence of venous thrombo-embolism than non-geriatric patients with cancer?

Journal of the American College of Surgeons, 2015

Research paper thumbnail of Needs Assessment for Establishing a Geriatric Surgical Oncology Curriculum to Educate Medical Students, Residents and Surgeons

Research paper thumbnail of Evaluating compliance with National Comprehensive Cancer Network guidelines in management of colorectal, liver and thyroid cancer

Journal of the American College of Surgeons, 2014

Research paper thumbnail of A giant pancreatic pseudocyst treated by cystogastrostomy

BMJ case reports, 2015

We report a case of a giant pancreatic pseudocyst in a 65-year-old man presenting with abdominal ... more We report a case of a giant pancreatic pseudocyst in a 65-year-old man presenting with abdominal pain, loss of appetite and abdominal distension. CT scans demonstrated a giant pancreatic pseudocyst measuring 25.7 cm×15.3 cm×10.9 cm anteroposteriorly, with significant compression of surrounding organs. An open cystogastrostomy was performed through a midline incision, and 3 L of fluid was drained from the giant pseudocyst. Recovery has been uneventful.

Research paper thumbnail of Management of Extramammary Paget's Disease: A Case Report and Review of the Literature

Case reports in dermatological medicine, 2013

Extramammary Paget's Disease (EMPD) is a rare condition of the skin that often involves the v... more Extramammary Paget's Disease (EMPD) is a rare condition of the skin that often involves the vulva, perianal region, scrotum, penis, and axilla. Although prognosis is generally favorable, it can be associated with neoplasms of the bladder, urethra, prostate, and rectum. This report presents a case of scrotal EMPD that failed treatment with imiquimod 5% cream and discusses benefits and complications of available treatment options. The variation of treatment success emphasizes the importance of further research.

Research paper thumbnail of A Case of Carcinoid Likely Causing Jejunal Intussusception

Case Reports in Surgery, 2014

A 34-year-old female was admitted to Emergency Department with an abrupt onset of diffuse abdomin... more A 34-year-old female was admitted to Emergency Department with an abrupt onset of diffuse abdominal pain. A CT scan done prior to her transfer revealed significant dilated loops of bowel as well as multiple target signs with likely torsed bowel. The patient consented to an exploratory laparotomy. During surgery, the proximal jejunum was found to be intussuscepted, a rare finding in an adult. There was evidence of mesenteric foreshortening throughout the small bowel and multiple whitish lesions within the mesentery, both consistent with the desmoplastic response that is characteristic of carcinoid. The interest for this case report comes from the patient's surgical findings of jejunal intussusception as well as her extensive history, which includes a bowel resection with an ileocolic anastomosis for presumed ischemia and a carcinoid tumor in the stomach which had been removed endoscopically.

Research paper thumbnail of The impact of duty hour regulations on resident operative experience education

Journal of Surgical Research, 2006

Hypothesis: A focused surgical resident readiness curriculum for senior medical students can impr... more Hypothesis: A focused surgical resident readiness curriculum for senior medical students can improve confidence in surgical skills compared to current surgical interns. Methods: With the purpose of improving surgical skills and easing anxiety prior to internship, we developed a three-week surgical skills lab elective for senior medical students applying to general surgery residency programs. Students were surveyed before and after the elective regarding their confidence in performing 21 basic skills covered by the curriculum. These skills vary from central line placement and biopsying of a nodule, to naming of surgical instruments and initial assessment of a trauma patient. A similar confidence survey was administered to the incoming surgical intern class. Interns were also surveyed regarding prior skills lab instruction during medical school. Statistical analyses included student's paired t-test and two-way analysis of variance. Results: Six medical students and 23 interns were surveyed. All medical students significantly improved their confidence by the end of the surgical skills lab elective (Pϭ0.0004). Though students initially had lower confidence than surgical interns in performing surgical skills and in their knowledge of anatomy prior to the course, their confidence after the course was significantly higher than that of the incoming surgical interns (Pϭ0.035). Less than half of the surgical interns (43%) had a skills lab as part of their medical school curriculum. Surgical interns with prior skills lab experience in their medical school reported higher confidence in basic skills than those who did not have a skills lab experience (Pϭ0.019). Among all subgroups, medical students with skills lab experience had the highest confidence score, followed by incoming interns with previous skills lab experience, then by interns with no previous skills lab experience, and lastly by medical student with no skills lab experience (i.e., prior to the skills lab elective). Conclusion: Most medical schools lack a skills curriculum during the clinical training years. At the same time, surgical interns are often anxious to begin residency and feel unprepared to perform basic skills. A focused skills lab elective during medical school can bridge the gap between medical school and residency and improve confidence prior to internship.

Research paper thumbnail of The role of PET probe–guided open biopsy in managing patients with lymphoma

Research paper thumbnail of Effect of Magnetic Resonance Imaging on Breast Conservation Therapy versus Mastectomy: A Review of the Literature

International journal of surgical oncology, 2011

The utilization of MRI in the workup of breast cancer has played a controversial role in the surg... more The utilization of MRI in the workup of breast cancer has played a controversial role in the surgical treatment of this disease. With the higher resolution of breast tissue afforded, additional lesions are being identified that often warrant additional procedures, subsequently affecting the decision to proceed with breast conservation therapy versus mastectomy. In this paper, a literature review is presented to help illuminate some of the benefits and pitfalls of employing MRI as a diagnostic tool in the care of breast cancer, while additionally providing insight into the management alterations this imaging modality can engender. Though further research is required in a randomized prospective form to fully answer this question, evidence for and against its use continues to mount, especially for select patient groups.

Research paper thumbnail of The Association between Pre-Treatment Serum 25-Hydroxyvitamin D and Survival in Newly Diagnosed Stage IV Prostate Cancer

PLOS ONE, 2015

Emerging evidence in the literature suggests a positive association between serum 25hydroxyvitami... more Emerging evidence in the literature suggests a positive association between serum 25hydroxyvitamin D [25(OH)D], a standard indicator of vitamin D status, and survival in certain types of cancer. We investigated this relationship in newly diagnosed stage IV prostate cancer patients.

Research paper thumbnail of What is causing this patient's acute abdomen?

JAAPA : official journal of the American Academy of Physician Assistants, 2015

Research paper thumbnail of Esophageal cancer: A Review of epidemiology, pathogenesis, staging workup and treatment modalities

World journal of gastrointestinal oncology, Jan 15, 2014

Esophageal cancer is a serious malignancy with regards to mortality and prognosis. It is a growin... more Esophageal cancer is a serious malignancy with regards to mortality and prognosis. It is a growing health concern that is expected to increase in incidence over the next 10 years. Squamous cell carcinoma is the most common histological type of esophageal cancer worldwide, with a higher incidence in developing nations. With the increased prevalence of gastroesophageal reflux disease and obesity in developed nations, the incidence of esophageal adenocarcinoma has dramatically increased in the past 40 years. Esophageal cancer is staged according to the widely accepted TNM system. Staging plays an integral part in guiding stage specific treatment protocols and has a great impact on overall survival. Common imaging modalities used in staging include computed tomography, endoscopic ultrasound and positron emission tomography scans. Current treatment options include multimodality therapy mainstays of current treatment include surgery, radiation and chemotherapy. Tumor markers of esophageal...

Research paper thumbnail of Brown recluse spider bite on the breast

JAAPA : official journal of the American Academy of Physician Assistants, 2014

Brown recluse spiders are one of two types of spiders in the United States that can cause signifi... more Brown recluse spiders are one of two types of spiders in the United States that can cause significant tissue damage and, in rare cases, death. Brown recluse spider bites are most often benign and self-limiting, but in a few cases can cause severe necrotic skin lesions.

Research paper thumbnail of PCV50 Gastric Bypass Surgery–An Overview

Research paper thumbnail of Developments in Screening Tests and Strategies for Colorectal Cancer

BioMed Research International, 2015

Worldwide, colorectal cancer (CRC) is the third most common cancer in men and second most common ... more Worldwide, colorectal cancer (CRC) is the third most common cancer in men and second most common in women. It is the fourth most common cause of cancer mortality. In the United States, CRC is the third most common cause of cancer and second most common cause of cancer mortality. Incidence and mortality rates have steadily fallen, primarily due to widespread screening. We conducted keyword searches on PubMed in four categories of CRC screening: stool, endoscopic, radiologic, and serum, as well as news searches in Medscape and Google News. Colonoscopy is the gold standard for CRC screening and the most common method in the United States. Technological improvements continue to be made, including the promising "third-eye retroscope." Fecal occult blood remains widely used, particularly outside the United States. The first at-home screen, a fecal DNA screen, has also recently been approved. Radiological methods are effective but seldom used due to cost and other factors. Serum tests are largely experimental, although at least one is moving closer to market. Colonoscopy is likely to remain the most popular screening modality for the immediate future, although its shortcomings will continue to spur innovation in a variety of modalities.

Research paper thumbnail of The role of politics in shaping surgical training

Bulletin of the American College of Surgeons, 2013

Research paper thumbnail of P03.02. Application of an Integrative Medicine Model in Pancreatic Cancer

Global Advances in Health and Medicine, 2013

Research paper thumbnail of Value of screening endoscopy in evaluation of esophageal, gastric and colon cancers

World journal of gastroenterology, Jan 7, 2015

Esophageal, gastric, and colorectal cancers are deadly diseases that continue to plague our world... more Esophageal, gastric, and colorectal cancers are deadly diseases that continue to plague our world today. The value of screening endoscopy in evaluating these types of cancers is a critical area of discussion due to a potential reduction in morbidity and mortality. This article describes how to identify a good screening test and explains what are important criteria in the field of screening endoscopy. Furthermore, the current status and progress of screening endoscopy for esophageal, gastric, and colorectal cancer will be evaluated and discussed. Mass screening programs have not been implemented for esophageal and gastric carcinomas in those with average or low risk populations. However, studies of high-risk populations have found value and a cost-benefit in conducting screening endoscopy. Colorectal cancer, on the other hand, has had mass screening programs in place for many years due to the clear evidence of improved outcomes. As the role of endoscopy as a screening tool has contin...

Research paper thumbnail of Is there value in intraoperative frozen section during thyroidectomy for thyroid nodules?

Journal of the American College of Surgeons, 2015

Research paper thumbnail of Surgical versus conservative management of adult intussusception: Case series and review

International journal of surgery case reports, Jan 22, 2016

Intussusception is the telescoping of a segment of bowel into its adjacent segment. It is a known... more Intussusception is the telescoping of a segment of bowel into its adjacent segment. It is a known cause of abdominal pain in the pediatric population, however, it is rare in the adult. Adults do not always present with the typical symptoms seen in young children, making the clinical diagnosis more difficult. The etiology of adult intussusception can be idiopathic, benign, or malignant. Diagnosis is most accurately made with computed tomography, which is sensitive in detecting intussusception as well as potential lead points. This study presents four adult patients with intussusception. The first three patients are adults with idiopathic intussusception and no evidence of a lead point. The fourth case involves intussusception secondary to a jejunal carcinoid tumor which was treated surgically. Each case has unique features in terms of length and number of intussusceptions, duration of symptoms, and recurrence. Surgical treatment was once argued to be universally appropriate for adult...

Research paper thumbnail of Do geriatric patients with cancer have a higher incidence of venous thrombo-embolism than non-geriatric patients with cancer?

Journal of the American College of Surgeons, 2015

Research paper thumbnail of Needs Assessment for Establishing a Geriatric Surgical Oncology Curriculum to Educate Medical Students, Residents and Surgeons

Research paper thumbnail of Evaluating compliance with National Comprehensive Cancer Network guidelines in management of colorectal, liver and thyroid cancer

Journal of the American College of Surgeons, 2014

Research paper thumbnail of A giant pancreatic pseudocyst treated by cystogastrostomy

BMJ case reports, 2015

We report a case of a giant pancreatic pseudocyst in a 65-year-old man presenting with abdominal ... more We report a case of a giant pancreatic pseudocyst in a 65-year-old man presenting with abdominal pain, loss of appetite and abdominal distension. CT scans demonstrated a giant pancreatic pseudocyst measuring 25.7 cm×15.3 cm×10.9 cm anteroposteriorly, with significant compression of surrounding organs. An open cystogastrostomy was performed through a midline incision, and 3 L of fluid was drained from the giant pseudocyst. Recovery has been uneventful.

Research paper thumbnail of Management of Extramammary Paget's Disease: A Case Report and Review of the Literature

Case reports in dermatological medicine, 2013

Extramammary Paget's Disease (EMPD) is a rare condition of the skin that often involves the v... more Extramammary Paget's Disease (EMPD) is a rare condition of the skin that often involves the vulva, perianal region, scrotum, penis, and axilla. Although prognosis is generally favorable, it can be associated with neoplasms of the bladder, urethra, prostate, and rectum. This report presents a case of scrotal EMPD that failed treatment with imiquimod 5% cream and discusses benefits and complications of available treatment options. The variation of treatment success emphasizes the importance of further research.

Research paper thumbnail of A Case of Carcinoid Likely Causing Jejunal Intussusception

Case Reports in Surgery, 2014

A 34-year-old female was admitted to Emergency Department with an abrupt onset of diffuse abdomin... more A 34-year-old female was admitted to Emergency Department with an abrupt onset of diffuse abdominal pain. A CT scan done prior to her transfer revealed significant dilated loops of bowel as well as multiple target signs with likely torsed bowel. The patient consented to an exploratory laparotomy. During surgery, the proximal jejunum was found to be intussuscepted, a rare finding in an adult. There was evidence of mesenteric foreshortening throughout the small bowel and multiple whitish lesions within the mesentery, both consistent with the desmoplastic response that is characteristic of carcinoid. The interest for this case report comes from the patient's surgical findings of jejunal intussusception as well as her extensive history, which includes a bowel resection with an ileocolic anastomosis for presumed ischemia and a carcinoid tumor in the stomach which had been removed endoscopically.

Research paper thumbnail of The impact of duty hour regulations on resident operative experience education

Journal of Surgical Research, 2006

Hypothesis: A focused surgical resident readiness curriculum for senior medical students can impr... more Hypothesis: A focused surgical resident readiness curriculum for senior medical students can improve confidence in surgical skills compared to current surgical interns. Methods: With the purpose of improving surgical skills and easing anxiety prior to internship, we developed a three-week surgical skills lab elective for senior medical students applying to general surgery residency programs. Students were surveyed before and after the elective regarding their confidence in performing 21 basic skills covered by the curriculum. These skills vary from central line placement and biopsying of a nodule, to naming of surgical instruments and initial assessment of a trauma patient. A similar confidence survey was administered to the incoming surgical intern class. Interns were also surveyed regarding prior skills lab instruction during medical school. Statistical analyses included student's paired t-test and two-way analysis of variance. Results: Six medical students and 23 interns were surveyed. All medical students significantly improved their confidence by the end of the surgical skills lab elective (Pϭ0.0004). Though students initially had lower confidence than surgical interns in performing surgical skills and in their knowledge of anatomy prior to the course, their confidence after the course was significantly higher than that of the incoming surgical interns (Pϭ0.035). Less than half of the surgical interns (43%) had a skills lab as part of their medical school curriculum. Surgical interns with prior skills lab experience in their medical school reported higher confidence in basic skills than those who did not have a skills lab experience (Pϭ0.019). Among all subgroups, medical students with skills lab experience had the highest confidence score, followed by incoming interns with previous skills lab experience, then by interns with no previous skills lab experience, and lastly by medical student with no skills lab experience (i.e., prior to the skills lab elective). Conclusion: Most medical schools lack a skills curriculum during the clinical training years. At the same time, surgical interns are often anxious to begin residency and feel unprepared to perform basic skills. A focused skills lab elective during medical school can bridge the gap between medical school and residency and improve confidence prior to internship.

Research paper thumbnail of The role of PET probe–guided open biopsy in managing patients with lymphoma

Research paper thumbnail of Effect of Magnetic Resonance Imaging on Breast Conservation Therapy versus Mastectomy: A Review of the Literature

International journal of surgical oncology, 2011

The utilization of MRI in the workup of breast cancer has played a controversial role in the surg... more The utilization of MRI in the workup of breast cancer has played a controversial role in the surgical treatment of this disease. With the higher resolution of breast tissue afforded, additional lesions are being identified that often warrant additional procedures, subsequently affecting the decision to proceed with breast conservation therapy versus mastectomy. In this paper, a literature review is presented to help illuminate some of the benefits and pitfalls of employing MRI as a diagnostic tool in the care of breast cancer, while additionally providing insight into the management alterations this imaging modality can engender. Though further research is required in a randomized prospective form to fully answer this question, evidence for and against its use continues to mount, especially for select patient groups.