Sudhanshu Kumar - Academia.edu (original) (raw)

Papers by Sudhanshu Kumar

During pregnancy, maternal liver exhibits robust growth to meet the metabolic demands of the deve... more During pregnancy, maternal liver exhibits robust growth to meet the metabolic demands of the developing placenta and fetus. Although hepatocyte hypertrophy and hyperplasia are seen in the maternal liver, the molecular and cellular mechanisms mediating the maternal hepatic adaptations to pregnancy is poorly understood. Previous microarray analysis revealed a most upregulated gene named Ascl1, a transcription factor essential for neural development, in the maternal liver at mid-gestation. The aims of the study were to (1) validate the activation of Ascl1 gene; (2) identify Ascl1-expressing cells; and (3) determine the fate of Ascl1-expressing cells, in the maternal liver during the course of gestation. Timed pregnancy was setup in mice and the maternal livers were collected at various stages of gestation. Maternal hepatic Ascl1 mRNA expression was evaluated by qRT-PCR and northern blotting. The results demonstrated that the transcript level of maternal hepatic Ascl1 is exponentially i...

2019 Innovations in Power and Advanced Computing Technologies (i-PACT), 2019

With the increased share of renewables in power generation grid tied multilevel Inverters find a ... more With the increased share of renewables in power generation grid tied multilevel Inverters find a greater use. The vector control scheme has been implemented in the reference frame rotating at synchronous speed based on the independent control of real and apparent flow of power from the inverter to the grid. The currents injected in to the grid are controlled with two current control loops, one for the direct axis and other for the quadrature axis. Here, a lag compensator is taken as a controller technique for grid interface inverter to mitigate the power quality issues. The Insulating Gate Bipolar Transistor has forms as semiconductor switch for the parallel connected Voltage Source Inverter. The switching control employs SPWM technique in which a high frequency carrier is modulates with sinusoidal wave of grid frequency. The mathematical model of the inverter and its operation for power quality improvement has been validate and represents by the simulation.

Kumar, Sudhanshu. M.S., Purdue University, August 2013. Identification and lineage tracing of Asc... more Kumar, Sudhanshu. M.S., Purdue University, August 2013. Identification and lineage tracing of Ascl1-expressing cells in maternal liver during pregnancy. Major Professor: Guoli Dai. During pregnancy, maternal liver exhibits robust growth to meet the metabolic demands of the developing placenta and fetus. Although hepatocyte hypertrophy and hyperplasia are seen in the maternal liver, the molecular and cellular mechanisms mediating the maternal hepatic adaptations to pregnancy is poorly understood. Previous microarray analysis revealed a most upregulated gene named Ascl1, a transcription factor essential for neural development, in the maternal liver at mid-gestation. The aims of the study were to (1) validate the activation of Ascl1 gene; (2) identify Ascl1-expressing cells; and (3) determine the fate of Ascl1-expressing cells, in the maternal liver during the course of gestation. Timed pregnancy was setup in mice and the maternal livers were collected at various stages of gestation. M...

The journal of contemporary dental practice, 2020

AIM AND OBJECTIVE To compare the efficacy of 2% lignocaine and 4% articaine in the extraction of ... more AIM AND OBJECTIVE To compare the efficacy of 2% lignocaine and 4% articaine in the extraction of mandibular molars. MATERIALS AND METHODS This study was conducted on 120 patients requiring surgical removal of tooth. Patients were categorized into 2 groups with 60 samples each. Group I patients were administered 2% lignocaine with 1:50,000 epinephrine and group II patients were administered 4% articaine with 1:100,000 epinephrine for the extraction of mandibular molar. Inferior alveolar nerve, lingual, and buccal nerve block used in both groups to anesthetize the area. RESULTS The mean onset of action in group I was 85.2 seconds and in group II was 52.6 seconds, duration of anesthesia in group I was 170.2 minutes and in group II was 226.8 minutes, duration of procedure was 30.4 minutes in group I and 32.6 minutes in group II, pain during procedure in group I was 2.75 and in group II was 1.42, pain after procedure was 1.41 in group I and 0.82 in group II, pain during anesthesia insert...

A low voltage MEMS switch based on electrostatic actuation scheme is introduced and investigated ... more A low voltage MEMS switch based on electrostatic actuation scheme is introduced and investigated thoroughly. Design variables are length, width, thickness of cantilever, and location of pull down electrode, for micro actuator. The model obtained is simulated in FEM-based software COMSOL multiphysics. In our proposed design, the effect of presence of holes, mechanical stress, actuation voltage, and change in location of pull down electrode has been explained. With the help of structural modification and by varying actuation voltage, the optimized value of 8 V is obtained which is desirable for noble performance. The capacitance is varied with the variation of dimensions and gap between two plates of beam structure with applied force, which is the basic principle of electrostatic actuation scheme.

Geocarto International, 2021

The COVID-19 lock/slow down affected humanity and livelihood, while it showed some positive effec... more The COVID-19 lock/slow down affected humanity and livelihood, while it showed some positive effects on the environment with improvement in air quality indicators. Though many studies published after COVID-19 first phase lockdown observed reduction in pollutants over India, no studies yet compared the air quality indicators over the two lock/slow down windows during 2020–2021. This study reports results of rapid assessment of seven air quality indicators such as Nitrogen dioxide (NO2), Sulphur dioxide (SO2), Formaldehyde (HCHO), Methane (CH4), Carbon monoxide (CO), Aerosol (Ultraviolet Aerosol Index, UVAI), and Ozone (O3) for the past three years on monthly time scale using TROPOMI (Tropospheric Monitoring Instrument) data on GEE (Google Earth Engine) platform over India, with focus on the Gangetic plain, an air pollution hotspot. Significant reduction in NO2, SO2, HCHO and Absorbing Aerosol Index (AAI) was observed during March–May 2020 as compared to the same period in 2019, while the levels of NO2, SO2, HCHO and CO increased significantly in 2021 compared to March–May 2020. This suggests that COVID-19 lock/slow down in 2020 played a significant role in improving air quality indicators, while the relaxation in 2021 has led to detoriation, compared to 2020. The pyrogenic (forest fire and slash and burn agriculture) and agricultural (wet crop) sources were identified to contaminate the expression of slow/lock down effects on air quality indicators such as HCHO, CO and CH4 over India.

Materials Today: Proceedings, 2020

IP International Journal of Maxillofacial Imaging, 2020

International Journal of Materials, Mechanics and Manufacturing, 2017

Human Pathology, 1999

... Pathol Annu 28 (part 2):77I 11, 1993 3. TaxyJB, Bharani NK, Mills SE, et al: The spectrum of ... more ... Pathol Annu 28 (part 2):77I 11, 1993 3. TaxyJB, Bharani NK, Mills SE, et al: The spectrum of olfactory neural tumors: A light microscopic, immunohistochemical and ultra structural analysis ... VanDevanter DR, George D, McNutt MA, et al: Trisomy 8 in primary esthesioneuroblastoma ...

Journal of the Association of Engineers, India, 2015

Electro Discharge Machining (EDM) is the most extensively used unconventional machining process i... more Electro Discharge Machining (EDM) is the most extensively used unconventional machining process in dies and molds industries. However, its capabilities are limited by high tooling cost and low material removal rate. Researchers have explored a number of ways to improve the performance of EDM process performance, one of the ways being orbital tool movement. The experimental and theoretical studies show that process performance can be improved considerably by tool orbiting along with proper selection of operating parameters. The orbital movement of tool electrode reduces the debris concentration at the discharge gap and thus reduces unstable machining and arcs. Tool orbiting allows standard sized electrodes to be used for a wide range of hole sizes and eliminates the need for custom made electrodes altogether. This paper contains the review of the research works carried out so far in the area of orbital EDM of different materials and shapes. It critically reports the available experimental and theoretical studies of orbital EDM to improve the process performance. In the final part of the paper, an outline is provided for trends in future research possibilities.

American journal of physiology. Renal physiology, May 17, 2016

Serum albumin is the most abundant plasma protein and has a long half-life due to neonatal Fc rec... more Serum albumin is the most abundant plasma protein and has a long half-life due to neonatal Fc receptor (FcRn) mediated transcytosis by many cell types including proximal tubule cells of the kidney. Albumin also interacts with, and is modified by, many small and large molecules. Therefore, the focus of this study was to address the impact of specific known biologic albumin modifications on albumin-FcRn binding and cellular handling. Binding at pH 6.0 and 7.4 was performed since FcRn binds albumin strongly at acidic pH and releases it following transcytosis at physiological pH. Equilibrium dissociation constants (KDs) were measured using microscale thermophoresis. Since studies have shown that glycated albumin is excreted in the urine at a higher rate than unmodified albumin we studied glucose and methylgloxal modified albumins (21day). All had reduced affinity to FcRn at pH 6.0 suggesting these albumins would not be returned to the circulation via the transcytotic pathway. To address...

Advances in Materials and Processing Technologies, 2015

Abstract Electrical discharge machining (EDM) has become a widely used nonconventional machining ... more Abstract Electrical discharge machining (EDM) has become a widely used nonconventional machining process in aerospace and die-/mould-making industries. This machining process is capable of machining any electrically conductive material irrespective of its hardness. This machining process requires identical shape of tool electrode with the cavity to be generated, which increases the requirement of tool electrodes. The requirement of tool electrodes can be reduced by the actuating the tool electrode on X, Y and Z axes, this is also called orbiting of tool electrode. The path of tool actuation may follow helical, radial, cylindrical path, etc. In the present investigation, circular hole is generated using radial tool actuation in EDM. An attempt has been made to study the effect of orbital parameters such as orbital radius and orbital speed on material removal rate (MRR). Experiments have been designed using Taguchi L9 orthogonal array. Using signal-to-noise ratio, analysis of variance results have been analysed. The results indicate that MRR varies with both orbital radius and orbital speed.

Prediction models have wide range of application in the field of manufacturing as it can reduce t... more Prediction models have wide range of application in the field of manufacturing as it can reduce time and cost for experimentation to identify the influence of a parameter or a set of parameters on a response under consideration. This paper deals with the development of an Adaptive Neuro Fuzzy Inference System (ANFIS) model for predicting inaccuracy in micro holes generated by Micro Electro Discharge Machining (MEDM) Process. The model has been developed using Fuzzy Logic Toolbox available in MATLAB software package. The inaccuracy in the micro holes generated has been estimated in terms of radial overcut. The Fuzzy Inference System for the development of the model has been generated using the concept of subtractive clustering. Values of design parameters used for developing the FIS have been identified through detailed analysis and the model has been developed using the combination of parameter values resulted in least Root Mean Square Error (RMSE). Results obtained using the model ...

Organic Preparations and Procedures International, 2003

Journal of International Financial Markets, Institutions and Money, 2012

Journal of Cell Science, 2013

Pregnancy induces widespread adaptive responses in maternal organ systems including the liver. Th... more Pregnancy induces widespread adaptive responses in maternal organ systems including the liver. The maternal liver exhibits significant growth by increasing the number and size of hepatocytes, with largely unknown mechanisms. Nrf2 mediates cellular defense against oxidative stress and inflammation and also regulates liver regeneration. To determine whether Nrf2 is involved in the regulation of maternal hepatic adaptations to pregnancy, we assessed the proliferation and size of maternal hepatocytes and the associated molecular events in wild-type and Nrf2-null mice at various stages of gestation. We found that wild-type maternal hepatocytes underwent proliferation and size reduction during the first half, and size increase without overt replication during the second half, of pregnancy. Although pregnancy decreased Nrf2 activity in the maternal liver, Nrf2 deficiency caused a delay in maternal hepatocyte proliferation, concomitant with dysregulation of the activation of Cyclins D1, E1,...