Sujay Datta - Academia.edu (original) (raw)

Papers by Sujay Datta

Research paper thumbnail of Bayesian Modeling of MPSS Data: Gene Expression Analysis of Bovine Salmonella Infection

Journal of the American Statistical Association, 2010

Research paper thumbnail of Bayesian hierarchical modeling of people’s decision-making during an extreme weather event

Japanese Journal of Statistics and Data Science

Research paper thumbnail of Determination of the Radical Reactivity Ratios of 2-(N-Ethylperfluorooctanesulfonamido)ethyl Acrylate and Methacrylate in Copolymerizations with N,N-Dimethylacrylamide by in Situ 1H NMR Analysis As Established for Styrene–Methyl Methacrylate Copolymerizations

Macromolecules

A model system of styrene (St) and methyl methacrylate (MMA) was copolymerized in an NMR tube at ... more A model system of styrene (St) and methyl methacrylate (MMA) was copolymerized in an NMR tube at 60°C using 2,2′-azobis(isobutyronitrile) as the initiator and pyridazine as an internal standard to optimize an in situ 1 H NMR spectroscopic method for determining reactivity ratios by generating data at hundreds of instantaneous comonomer compositions (244 data points from 8 to 91 mol % St) starting with only nine initial comonomer compositions. The radical reactivity ratios of styrene (r St = 0.697 ± 0.010) and methyl methacrylate (r MMA = 0.491 ± 0.007) were determined by nonlinear least-squares fitting of a Mayo−Lewis plot of the instantaneous copolymer composition as a function of the comonomer feed composition using the terminal model and MINITAB statistical software, in which the copolymer composition was calculated by assuming that all comonomer consumed was converted to copolymer without side reactions; the results were similar to accepted literature values for the terminal and implicit penultimate models. After correcting for changes in the "lock" value at the initial stages of the copolymerization (because of solids formed in the sealed NMR tube), the same technique was used to determine the reactivity ratios of 2-(N-ethylperfluorooctanesulfonamido)ethyl acrylate (FOSA; r FOSA = 1.624 ± 0.048) and 2-(N-ethylperfluorooctanesulfonamido)ethyl methacrylate (FOSM; r FOSM = 2.876 ± 0.083) in their radical copolymerizations with N,Ndimethylacrylamide (DMA; r DMA = 1.126 ± 0.031 with FOSA; r DMA = 0.859 ± 0.026 with FOSM).

Research paper thumbnail of A New Scale-Invariant Nonparametric Test for Two-Sample Bivariate Location Problem with Application

Springer Proceedings in Mathematics & Statistics, 2016

Research paper thumbnail of Dietary intakes of nutritionally nonessential amino acids among homebound older adults

The Faseb Journal, Mar 1, 2008

Research paper thumbnail of Dietary supplementation with cholesterol (Chol) and docosahexaenoic acid (DHA) alters the profiles of amino acids in tissues of neonatal pigs

The Faseb Journal, Mar 1, 2008

Research paper thumbnail of An Overview of Sequential and Multistage Methods in Regression Models

Advances on Theoretical and Methodological Aspects of Probability and Statistics, 2003

... 432 SUJAY DATTA of the ASN of the multistage procedure to the corresponding'opti... more ... 432 SUJAY DATTA of the ASN of the multistage procedure to the corresponding'optimal' fixed sample-size approaches 1 asymptotically; • Asymptotic Second Order Efficiency in the sense of Ghosh and Mukhopadhyay (1981)—if the difference between the ASN of the mul ...

Research paper thumbnail of Advances in statistical medicine

Computational and mathematical methods in medicine, 2014

Research paper thumbnail of Functional relationships between genes associated with differentiation potential of aged myogenic progenitors

Frontiers in physiology, 2010

Aging is accompanied by considerable heterogeneity with possible co-expression of differentiation... more Aging is accompanied by considerable heterogeneity with possible co-expression of differentiation pathways. The present study investigates the interplay between crucial myogenic, adipogenic, and Wnt-related genes orchestrating aged myogenic progenitor differentiation (AMPD) using clonal gene expression profiling in conjunction with Bayesian structure learning (BSL) techniques. The expression of three myogenic regulatory factor genes (Myogenin, Myf-5, MyoD1), four genes involved in regulating adipogenic potential (C/EBPα, DDIT3, FoxC2, PPARγ), and two genes in the Wnt signaling pathway (Lrp5, Wnt5a) known to influence both differentiation programs were determined across 34 clones by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR). Three control genes were used for normalization of the clonal expression data (18S, GAPDH, and B2M). Constraint-based BSL techniques, namely (a) PC Algorithm, (b) Grow-shrink (GS) algorithm, and (c) Incremental Association Markov Blan...

Research paper thumbnail of Parenteral Administration of L-Arginine Enhances Fetal Survival and Growth in Sheep Carrying Multiple Fetuses

Journal of Nutrition, 2011

The frequency of multiple fetuses has increased in human pregnancies due to assisted reproductive... more The frequency of multiple fetuses has increased in human pregnancies due to assisted reproductive technologies. This translates into a greater proportion of premature and low-birth weight infants in the United States and worldwide. In addition, improvements in sheep breeding have resulted in new breeds with increased litter size but reduced fetal survival and birth weight. Currently, there are no treatments for preventing fetal growth restriction in humans or sheep (an established model for studying human fetal physiology) carrying multiple fetuses. In this work, Booroola Rambouillet ewes (FecB+/2) with 2-4 fetuses were fed a diet providing 100% of NRC-recommended nutrient requirements. Between d 100 and 121 of gestation, ewes received an i.v. bolus injection of either saline solution or 345 mmol arginine-HCl/kg body weight 3 times daily. The arginine treatment reduced (P , 0.05) the percentage of lambs born dead by 23% while increasing (P = 0.05) the percentage of lambs born alive by 59%. The i.v. administration of arginine enhanced (P , 0.05) the birth weights of quadruplets by 23% without affecting maternal body weight. The improved pregnancy outcome was associated with an increase in maternal plasma concentrations of arginine, ornithine, cysteine, and proline, as well as a decrease in circulating levels of ammonia and b-hydroxybutyrate. These novel results indicate that parenteral administration of arginine to prolific ewes ameliorated fetal mortality and growth retardation. Our findings provide support for experiments to assess the clinical use of arginine to enhance fetal growth and survival in women gestating multiple fetuses.

Research paper thumbnail of Asymmetric Penalized Prediction Using Adaptive Sampling Procedures

Sequential Analysis, 2005

Page 1. Sequential Analysis, 24: 23–43, 2005 Copyright © Taylor & Francis, Inc. ISSN: 0747-49... more Page 1. Sequential Analysis, 24: 23–43, 2005 Copyright © Taylor & Francis, Inc. ISSN: 0747-4946 print/1532-4176 online DOI: 10.1081/SQA-200046827 Asymmetric Penalized Prediction Using Adaptive Sampling Procedures ...

Research paper thumbnail of Discussion on “Likelihood Ratio Identities and Their Applications to Sequential Analysis” by Tze L. Lai

Sequential Analysis, 2004

... Discussion on “Likelihood Ratio Identities and their Applications to Sequential Analysis” by ... more ... Discussion on “Likelihood Ratio Identities and their Applications to Sequential Analysis” by Tze L. Lai. View full textDownload full text Full access. DOI: 10.1081/SQA-200039025 Sujay Datta a b * pages 537-539. ... Notes. Recommened by Nitis Mukhopadhyay. References. ...

Research paper thumbnail of Sequential Fixed-Precision Estimation in Stochastic Linear Regression Models

Sequential Analysis, 2002

... Sujay Datta a pages 161-190. ... Sequential Anal. , 9: 243–268. [Taylor & Francis... more ... Sujay Datta a pages 161-190. ... Sequential Anal. , 9: 243–268. [Taylor & Francis Online] View all references, Mukhopadhyay and Abid (1986)[16]16. Mukhopadhyay, N. and Abid, AD 1986. On Fixed-Size Confidence Regions for the Regression Parameters. Metron. , 44: 197–206. ...

Research paper thumbnail of On fine-tuned bounded risk sequential point estimation of the mean of an exponential distribution

South African Statistical …, 1995

Research paper thumbnail of Intrauterine growth retardation in livestock: implications, mechanisms and solutions

Arch Fur Tierzucht-Arch …, 2008

... Because heritability for the number of piglets born alive is low (0.06-0.09; Haley and Lee, 1... more ... Because heritability for the number of piglets born alive is low (0.06-0.09; Haley and Lee, 1992; Lund et al., 2002), improvement in litter size through animal breeding has been slow (Distl, 2007). ... J. Anat. 152, 107-119. Haley, CS, Lee, GJ 1992. ...

Research paper thumbnail of Statistical Advances in the Biomedical Sciences: Clinical Trials, Epidemiology, Survival Analysis, and Bioinformatics edited by BISWAS, A., DATTA, S., FINE, J. P., and SEGAL, M. R

Statistical Advances in the Biomedical Sciences: Clinical Trials, Epidemiology, Survival Analysis, and Bioinformatics edited by BISWAS, A., DATTA, S., FINE, J. P., and SEGAL, M. R

Biometrics, 2008

... Keles Uriel Kitron Charles Kooperberg Debasis Kundu Lynn Kuo Gordon Lan Hongzhe Li Geoff McLa... more ... Keles Uriel Kitron Charles Kooperberg Debasis Kundu Lynn Kuo Gordon Lan Hongzhe Li Geoff McLachlan Giovanni Parmigiani Limin Peng John Pinney Xing Qiu Glen Satten Rob Scharpf Douglas Schaubel Pranab Sen Saunak Sen Kerby ... in Ayanendranath Basu, Applied Stat ...

Research paper thumbnail of On sequential fixed-width confidence intervals for the mean and second-order expansions of the associated coverage probabilities

Annals of the Institute of Statistical Mathematics, 1996

In order to construct fixed-width (2d) confidence intervals for the mean of an unknown distributi... more In order to construct fixed-width (2d) confidence intervals for the mean of an unknown distribution function F, a new purely sequential sampling strategy is proposed first. The approach is quite different from the more traditional methodology of Chow and Robbins (1965, Ann. Math. Statist., 36, 457-462). However, for this new procedure, the coverage probability is shown (Theorem 2.1) to be at least (1-a) + Ad 2 + o(d 2) as d-* 0 where (1-(~) is the preassigned level of confidence and A is an appropriate functional of F, under some regularity conditions on F. The rates of convergence of the coverage probability to (1-a) obtained by Csenki (1980,

Research paper thumbnail of Statistical advances in the biomedical sciences: clinical trials, epidemiology, survival analysis, and bioinformatics

... Keles Uriel Kitron Charles Kooperberg Debasis Kundu Lynn Kuo Gordon Lan Hongzhe Li Geoff McLa... more ... Keles Uriel Kitron Charles Kooperberg Debasis Kundu Lynn Kuo Gordon Lan Hongzhe Li Geoff McLachlan Giovanni Parmigiani Limin Peng John Pinney Xing Qiu Glen Satten Rob Scharpf Douglas Schaubel Pranab Sen Saunak Sen Kerby ... in Ayanendranath Basu, Applied Stat ...

Research paper thumbnail of Dietary supplementation with cholesterol and docosahexaenoic acid affects concentrations of amino acids in tissues of young pigs

Amino Acids, 2009

Cholesterol and docosahexaenoic acid (DHA) are important nutrients for neural development of infa... more Cholesterol and docosahexaenoic acid (DHA) are important nutrients for neural development of infants. However, little is known about the effect of cholesterol or DHA on concentrations of amino acids (AA) in neonatal tissues. This study was conducted with the piglet (an established model for studying human infant nutrition) to test the hypothesis that dietary supplementation with the lipids may modulate AA availability in tissues. Sixteen newborn pigs were nursed by sows for 24 h and then assigned to one of four treatment groups, representing supplementation with 0.0% (control), 0.2% cholesterol, 0.2% DHA, or cholesterol plus DHA to the basal milk-formula. All piglets were euthanized at 49 days of age. In brain, cholesterol supplementation reduced (P < 0.05) concentrations of glutamate, serine, glutamine, threonine, beta-alanine, alanine, methionine, isoleucine, leucine, and gamma-aminobutyrate but increased (P < 0.05) concentrations of glycine and lysine, whereas DHA supplementation similarly affected (P < 0.05) concentrations of the same AA (except for isoleucine and lysine) and taurine. In addition, concentrations of most AA in liver, muscle and plasma were substantially altered by dietary supplementation of cholesterol and DHA in a tissue-dependent manner. Further, DHA reduced concentrations of carnosine in skeletal muscle, as well as ammonia in both plasma and brain. The results reveal that cholesterol and DHA can regulate AA metabolism and availability in various tissues of piglets. These novel findings have important implications for designing the next generation of infant formula to optimize neonatal growth and development.

Research paper thumbnail of Asymmetric Penalized Prediction Using Adaptive Sampling Procedures

Sequential Analysis, 2005

Page 1. Sequential Analysis, 24: 23–43, 2005 Copyright © Taylor & Francis, Inc. ISSN: 0747-49... more Page 1. Sequential Analysis, 24: 23–43, 2005 Copyright © Taylor & Francis, Inc. ISSN: 0747-4946 print/1532-4176 online DOI: 10.1081/SQA-200046827 Asymmetric Penalized Prediction Using Adaptive Sampling Procedures ...

Research paper thumbnail of Bayesian Modeling of MPSS Data: Gene Expression Analysis of Bovine Salmonella Infection

Journal of the American Statistical Association, 2010

Research paper thumbnail of Bayesian hierarchical modeling of people’s decision-making during an extreme weather event

Japanese Journal of Statistics and Data Science

Research paper thumbnail of Determination of the Radical Reactivity Ratios of 2-(N-Ethylperfluorooctanesulfonamido)ethyl Acrylate and Methacrylate in Copolymerizations with N,N-Dimethylacrylamide by in Situ 1H NMR Analysis As Established for Styrene–Methyl Methacrylate Copolymerizations

Macromolecules

A model system of styrene (St) and methyl methacrylate (MMA) was copolymerized in an NMR tube at ... more A model system of styrene (St) and methyl methacrylate (MMA) was copolymerized in an NMR tube at 60°C using 2,2′-azobis(isobutyronitrile) as the initiator and pyridazine as an internal standard to optimize an in situ 1 H NMR spectroscopic method for determining reactivity ratios by generating data at hundreds of instantaneous comonomer compositions (244 data points from 8 to 91 mol % St) starting with only nine initial comonomer compositions. The radical reactivity ratios of styrene (r St = 0.697 ± 0.010) and methyl methacrylate (r MMA = 0.491 ± 0.007) were determined by nonlinear least-squares fitting of a Mayo−Lewis plot of the instantaneous copolymer composition as a function of the comonomer feed composition using the terminal model and MINITAB statistical software, in which the copolymer composition was calculated by assuming that all comonomer consumed was converted to copolymer without side reactions; the results were similar to accepted literature values for the terminal and implicit penultimate models. After correcting for changes in the "lock" value at the initial stages of the copolymerization (because of solids formed in the sealed NMR tube), the same technique was used to determine the reactivity ratios of 2-(N-ethylperfluorooctanesulfonamido)ethyl acrylate (FOSA; r FOSA = 1.624 ± 0.048) and 2-(N-ethylperfluorooctanesulfonamido)ethyl methacrylate (FOSM; r FOSM = 2.876 ± 0.083) in their radical copolymerizations with N,Ndimethylacrylamide (DMA; r DMA = 1.126 ± 0.031 with FOSA; r DMA = 0.859 ± 0.026 with FOSM).

Research paper thumbnail of A New Scale-Invariant Nonparametric Test for Two-Sample Bivariate Location Problem with Application

Springer Proceedings in Mathematics & Statistics, 2016

Research paper thumbnail of Dietary intakes of nutritionally nonessential amino acids among homebound older adults

The Faseb Journal, Mar 1, 2008

Research paper thumbnail of Dietary supplementation with cholesterol (Chol) and docosahexaenoic acid (DHA) alters the profiles of amino acids in tissues of neonatal pigs

The Faseb Journal, Mar 1, 2008

Research paper thumbnail of An Overview of Sequential and Multistage Methods in Regression Models

Advances on Theoretical and Methodological Aspects of Probability and Statistics, 2003

... 432 SUJAY DATTA of the ASN of the multistage procedure to the corresponding'opti... more ... 432 SUJAY DATTA of the ASN of the multistage procedure to the corresponding'optimal' fixed sample-size approaches 1 asymptotically; • Asymptotic Second Order Efficiency in the sense of Ghosh and Mukhopadhyay (1981)—if the difference between the ASN of the mul ...

Research paper thumbnail of Advances in statistical medicine

Computational and mathematical methods in medicine, 2014

Research paper thumbnail of Functional relationships between genes associated with differentiation potential of aged myogenic progenitors

Frontiers in physiology, 2010

Aging is accompanied by considerable heterogeneity with possible co-expression of differentiation... more Aging is accompanied by considerable heterogeneity with possible co-expression of differentiation pathways. The present study investigates the interplay between crucial myogenic, adipogenic, and Wnt-related genes orchestrating aged myogenic progenitor differentiation (AMPD) using clonal gene expression profiling in conjunction with Bayesian structure learning (BSL) techniques. The expression of three myogenic regulatory factor genes (Myogenin, Myf-5, MyoD1), four genes involved in regulating adipogenic potential (C/EBPα, DDIT3, FoxC2, PPARγ), and two genes in the Wnt signaling pathway (Lrp5, Wnt5a) known to influence both differentiation programs were determined across 34 clones by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR). Three control genes were used for normalization of the clonal expression data (18S, GAPDH, and B2M). Constraint-based BSL techniques, namely (a) PC Algorithm, (b) Grow-shrink (GS) algorithm, and (c) Incremental Association Markov Blan...

Research paper thumbnail of Parenteral Administration of L-Arginine Enhances Fetal Survival and Growth in Sheep Carrying Multiple Fetuses

Journal of Nutrition, 2011

The frequency of multiple fetuses has increased in human pregnancies due to assisted reproductive... more The frequency of multiple fetuses has increased in human pregnancies due to assisted reproductive technologies. This translates into a greater proportion of premature and low-birth weight infants in the United States and worldwide. In addition, improvements in sheep breeding have resulted in new breeds with increased litter size but reduced fetal survival and birth weight. Currently, there are no treatments for preventing fetal growth restriction in humans or sheep (an established model for studying human fetal physiology) carrying multiple fetuses. In this work, Booroola Rambouillet ewes (FecB+/2) with 2-4 fetuses were fed a diet providing 100% of NRC-recommended nutrient requirements. Between d 100 and 121 of gestation, ewes received an i.v. bolus injection of either saline solution or 345 mmol arginine-HCl/kg body weight 3 times daily. The arginine treatment reduced (P , 0.05) the percentage of lambs born dead by 23% while increasing (P = 0.05) the percentage of lambs born alive by 59%. The i.v. administration of arginine enhanced (P , 0.05) the birth weights of quadruplets by 23% without affecting maternal body weight. The improved pregnancy outcome was associated with an increase in maternal plasma concentrations of arginine, ornithine, cysteine, and proline, as well as a decrease in circulating levels of ammonia and b-hydroxybutyrate. These novel results indicate that parenteral administration of arginine to prolific ewes ameliorated fetal mortality and growth retardation. Our findings provide support for experiments to assess the clinical use of arginine to enhance fetal growth and survival in women gestating multiple fetuses.

Research paper thumbnail of Asymmetric Penalized Prediction Using Adaptive Sampling Procedures

Sequential Analysis, 2005

Page 1. Sequential Analysis, 24: 23–43, 2005 Copyright © Taylor & Francis, Inc. ISSN: 0747-49... more Page 1. Sequential Analysis, 24: 23–43, 2005 Copyright © Taylor & Francis, Inc. ISSN: 0747-4946 print/1532-4176 online DOI: 10.1081/SQA-200046827 Asymmetric Penalized Prediction Using Adaptive Sampling Procedures ...

Research paper thumbnail of Discussion on “Likelihood Ratio Identities and Their Applications to Sequential Analysis” by Tze L. Lai

Sequential Analysis, 2004

... Discussion on “Likelihood Ratio Identities and their Applications to Sequential Analysis” by ... more ... Discussion on “Likelihood Ratio Identities and their Applications to Sequential Analysis” by Tze L. Lai. View full textDownload full text Full access. DOI: 10.1081/SQA-200039025 Sujay Datta a b * pages 537-539. ... Notes. Recommened by Nitis Mukhopadhyay. References. ...

Research paper thumbnail of Sequential Fixed-Precision Estimation in Stochastic Linear Regression Models

Sequential Analysis, 2002

... Sujay Datta a pages 161-190. ... Sequential Anal. , 9: 243–268. [Taylor & Francis... more ... Sujay Datta a pages 161-190. ... Sequential Anal. , 9: 243–268. [Taylor & Francis Online] View all references, Mukhopadhyay and Abid (1986)[16]16. Mukhopadhyay, N. and Abid, AD 1986. On Fixed-Size Confidence Regions for the Regression Parameters. Metron. , 44: 197–206. ...

Research paper thumbnail of On fine-tuned bounded risk sequential point estimation of the mean of an exponential distribution

South African Statistical …, 1995

Research paper thumbnail of Intrauterine growth retardation in livestock: implications, mechanisms and solutions

Arch Fur Tierzucht-Arch …, 2008

... Because heritability for the number of piglets born alive is low (0.06-0.09; Haley and Lee, 1... more ... Because heritability for the number of piglets born alive is low (0.06-0.09; Haley and Lee, 1992; Lund et al., 2002), improvement in litter size through animal breeding has been slow (Distl, 2007). ... J. Anat. 152, 107-119. Haley, CS, Lee, GJ 1992. ...

Research paper thumbnail of Statistical Advances in the Biomedical Sciences: Clinical Trials, Epidemiology, Survival Analysis, and Bioinformatics edited by BISWAS, A., DATTA, S., FINE, J. P., and SEGAL, M. R

Statistical Advances in the Biomedical Sciences: Clinical Trials, Epidemiology, Survival Analysis, and Bioinformatics edited by BISWAS, A., DATTA, S., FINE, J. P., and SEGAL, M. R

Biometrics, 2008

... Keles Uriel Kitron Charles Kooperberg Debasis Kundu Lynn Kuo Gordon Lan Hongzhe Li Geoff McLa... more ... Keles Uriel Kitron Charles Kooperberg Debasis Kundu Lynn Kuo Gordon Lan Hongzhe Li Geoff McLachlan Giovanni Parmigiani Limin Peng John Pinney Xing Qiu Glen Satten Rob Scharpf Douglas Schaubel Pranab Sen Saunak Sen Kerby ... in Ayanendranath Basu, Applied Stat ...

Research paper thumbnail of On sequential fixed-width confidence intervals for the mean and second-order expansions of the associated coverage probabilities

Annals of the Institute of Statistical Mathematics, 1996

In order to construct fixed-width (2d) confidence intervals for the mean of an unknown distributi... more In order to construct fixed-width (2d) confidence intervals for the mean of an unknown distribution function F, a new purely sequential sampling strategy is proposed first. The approach is quite different from the more traditional methodology of Chow and Robbins (1965, Ann. Math. Statist., 36, 457-462). However, for this new procedure, the coverage probability is shown (Theorem 2.1) to be at least (1-a) + Ad 2 + o(d 2) as d-* 0 where (1-(~) is the preassigned level of confidence and A is an appropriate functional of F, under some regularity conditions on F. The rates of convergence of the coverage probability to (1-a) obtained by Csenki (1980,

Research paper thumbnail of Statistical advances in the biomedical sciences: clinical trials, epidemiology, survival analysis, and bioinformatics

... Keles Uriel Kitron Charles Kooperberg Debasis Kundu Lynn Kuo Gordon Lan Hongzhe Li Geoff McLa... more ... Keles Uriel Kitron Charles Kooperberg Debasis Kundu Lynn Kuo Gordon Lan Hongzhe Li Geoff McLachlan Giovanni Parmigiani Limin Peng John Pinney Xing Qiu Glen Satten Rob Scharpf Douglas Schaubel Pranab Sen Saunak Sen Kerby ... in Ayanendranath Basu, Applied Stat ...

Research paper thumbnail of Dietary supplementation with cholesterol and docosahexaenoic acid affects concentrations of amino acids in tissues of young pigs

Amino Acids, 2009

Cholesterol and docosahexaenoic acid (DHA) are important nutrients for neural development of infa... more Cholesterol and docosahexaenoic acid (DHA) are important nutrients for neural development of infants. However, little is known about the effect of cholesterol or DHA on concentrations of amino acids (AA) in neonatal tissues. This study was conducted with the piglet (an established model for studying human infant nutrition) to test the hypothesis that dietary supplementation with the lipids may modulate AA availability in tissues. Sixteen newborn pigs were nursed by sows for 24 h and then assigned to one of four treatment groups, representing supplementation with 0.0% (control), 0.2% cholesterol, 0.2% DHA, or cholesterol plus DHA to the basal milk-formula. All piglets were euthanized at 49 days of age. In brain, cholesterol supplementation reduced (P < 0.05) concentrations of glutamate, serine, glutamine, threonine, beta-alanine, alanine, methionine, isoleucine, leucine, and gamma-aminobutyrate but increased (P < 0.05) concentrations of glycine and lysine, whereas DHA supplementation similarly affected (P < 0.05) concentrations of the same AA (except for isoleucine and lysine) and taurine. In addition, concentrations of most AA in liver, muscle and plasma were substantially altered by dietary supplementation of cholesterol and DHA in a tissue-dependent manner. Further, DHA reduced concentrations of carnosine in skeletal muscle, as well as ammonia in both plasma and brain. The results reveal that cholesterol and DHA can regulate AA metabolism and availability in various tissues of piglets. These novel findings have important implications for designing the next generation of infant formula to optimize neonatal growth and development.

Research paper thumbnail of Asymmetric Penalized Prediction Using Adaptive Sampling Procedures

Sequential Analysis, 2005

Page 1. Sequential Analysis, 24: 23–43, 2005 Copyright © Taylor & Francis, Inc. ISSN: 0747-49... more Page 1. Sequential Analysis, 24: 23–43, 2005 Copyright © Taylor & Francis, Inc. ISSN: 0747-4946 print/1532-4176 online DOI: 10.1081/SQA-200046827 Asymmetric Penalized Prediction Using Adaptive Sampling Procedures ...