Sujith V Nair - Academia.edu (original) (raw)
Papers by Sujith V Nair
Journal of the American College of Radiology : JACR, Jan 22, 2017
Decreasing unnecessary variation in radiology reporting and producing guideline-concordant report... more Decreasing unnecessary variation in radiology reporting and producing guideline-concordant reports is fundamental to radiology's success in value-based payment models and good for patient care. In this article, we present an open authoring system for point-of-care clinical decision support tools integrated into the radiologist reporting environment referred to as the computer-assisted reporting and decision support (CAR/DS) framework. The CAR/DS authoring system, described herein, includes: (1) a definition format for representing radiology clinical guidelines as structured, machine-readable Extensible Markup Language documents and (2) a user-friendly reference implementation to test the fidelity of the created definition files with the clinical guideline. The proposed definition format and reference implementation will enable content creators to develop CAR/DS tools that voice recognition software (VRS) vendors can use to extend the commercial tools currently in use. In making ...
RSC Advances, 2015
Phase selective and thermodynamically controlled dispersion of filler particles into the dynamica... more Phase selective and thermodynamically controlled dispersion of filler particles into the dynamically vulcanized rubber/plastic blends depicting higher abundance of carbon black in the thermoplastic phase with the progressive filler addition.
Journal of Applied Polymer Science, 2014
ABSTRACT Thermoplastic vulcanizates (TPVs), which are a special class of elastomer alloy, prepare... more ABSTRACT Thermoplastic vulcanizates (TPVs), which are a special class of elastomer alloy, prepared by dynamic vulcanization possess unique morphology of finely dispersed micron-size cross-linked elastomeric particles in a continuous thermoplastic matrix. The present study investigates the microstructure formation of elastomeric phase and its associated morphological changes during reprocessing of TPVs based on poly[styrene-b-(ethylene-co-butylene)-b-styrene] triblock co-polymer (S-EB-S) and solution polymerized styrene butadiene elastomer (S-SBR) by scanning electron microscopy and atomic force microscopy. Semi-efficient and efficient sulfur-based curing systems have been adopted to cure the elastomeric phase and a comparative study has been made to demonstrate and explain the effect of reprocessing on the melt rheology and dynamic viscoelasticity of the TPVs. The present work also provides a better insight and guidance to control the microstructure of the cross-linked elastomeric phase to prepare selectively co-continuous or dispersed phase morphology. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 41182.
2013 IEEE MTT-S International Microwave Workshop Series on RF and Wireless Technologies for Biomedical and Healthcare Applications (IMWS-BIO), 2013
Radio frequency (RF) wireless communication development has unique challenges for medical implant... more Radio frequency (RF) wireless communication development has unique challenges for medical implantable applications stemming from the electromagnetic (EM) interactions with the surrounding biological tissue. There are, however, numerous benefits of higher frequency RF communication, including improved speed, range, reliability, and ease of use, that have resulted in a rapid growth of RF in implantable devices. There has also been significant development of numerous network protocols and FCC allocations of bands targeted specifically for these applications. Thorough survey and analysis of patient and physician use cases is critical for steering the design and development phases to maximize a product's chance of success. Sufficient modeling, representative and comprehensive testing utilizing anechoic chambers and RF phantom recipes, iterative design methods, and in vivo studies are necessary for successful development of a high-frequency RF Class III medical device targeted for commercial release.
RSC Adv., 2014
Novel thermally cross-linked and sulphur-vulcanized TPVs based on S-EB-S and S-SBR blends have re... more Novel thermally cross-linked and sulphur-vulcanized TPVs based on S-EB-S and S-SBR blends have registered good mechanical and dynamic mechanical properties with reduced hardness suitable for automotive applications.
PROTEOMICS, 2009
A stable and robust trypsin-based biocatalytic system was developed and demonstrated for proteomi... more A stable and robust trypsin-based biocatalytic system was developed and demonstrated for proteomic applications. The system utilizes polymer nanofibers coated with trypsin aggregates for immobilized protease digestions. After covalently attaching an initial layer of trypsin to the polymer nanofibers, highly concentrated trypsin molecules are crosslinked to the layered trypsin by way of a glutaraldehyde treatment. This process produced a 300-fold increase in trypsin activity compared with a conventional method for covalent trypsin immobilization, and proved to be robust in that it still maintained a high level of activity after a year of repeated recycling. This highly stable form of immobilized trypsin was resistant to autolysis, enabling repeated digestions of bovine serum albumin over 40 days and successful peptide identification by LC-MS/MS. This active and stable form of immobilized trypsin was successfully employed in the digestion of yeast proteome extract with high reproducibility and within shorter time than conventional protein digestion using solution phase trypsin. Finally, the immobilized trypsin was resistant to proteolysis when exposed to other enzymes (i.e. chymotrypsin), which makes it suitable for use in "realworld" proteomic applications. Overall, the biocatalytic nanofibers with trypsin aggregate coatings proved to be an effective approach for repeated and automated protein digestion in proteomic analyses.
Journal of the American College of Radiology : JACR, Jan 22, 2017
Decreasing unnecessary variation in radiology reporting and producing guideline-concordant report... more Decreasing unnecessary variation in radiology reporting and producing guideline-concordant reports is fundamental to radiology's success in value-based payment models and good for patient care. In this article, we present an open authoring system for point-of-care clinical decision support tools integrated into the radiologist reporting environment referred to as the computer-assisted reporting and decision support (CAR/DS) framework. The CAR/DS authoring system, described herein, includes: (1) a definition format for representing radiology clinical guidelines as structured, machine-readable Extensible Markup Language documents and (2) a user-friendly reference implementation to test the fidelity of the created definition files with the clinical guideline. The proposed definition format and reference implementation will enable content creators to develop CAR/DS tools that voice recognition software (VRS) vendors can use to extend the commercial tools currently in use. In making ...
RSC Advances, 2015
Phase selective and thermodynamically controlled dispersion of filler particles into the dynamica... more Phase selective and thermodynamically controlled dispersion of filler particles into the dynamically vulcanized rubber/plastic blends depicting higher abundance of carbon black in the thermoplastic phase with the progressive filler addition.
Journal of Applied Polymer Science, 2014
ABSTRACT Thermoplastic vulcanizates (TPVs), which are a special class of elastomer alloy, prepare... more ABSTRACT Thermoplastic vulcanizates (TPVs), which are a special class of elastomer alloy, prepared by dynamic vulcanization possess unique morphology of finely dispersed micron-size cross-linked elastomeric particles in a continuous thermoplastic matrix. The present study investigates the microstructure formation of elastomeric phase and its associated morphological changes during reprocessing of TPVs based on poly[styrene-b-(ethylene-co-butylene)-b-styrene] triblock co-polymer (S-EB-S) and solution polymerized styrene butadiene elastomer (S-SBR) by scanning electron microscopy and atomic force microscopy. Semi-efficient and efficient sulfur-based curing systems have been adopted to cure the elastomeric phase and a comparative study has been made to demonstrate and explain the effect of reprocessing on the melt rheology and dynamic viscoelasticity of the TPVs. The present work also provides a better insight and guidance to control the microstructure of the cross-linked elastomeric phase to prepare selectively co-continuous or dispersed phase morphology. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 41182.
2013 IEEE MTT-S International Microwave Workshop Series on RF and Wireless Technologies for Biomedical and Healthcare Applications (IMWS-BIO), 2013
Radio frequency (RF) wireless communication development has unique challenges for medical implant... more Radio frequency (RF) wireless communication development has unique challenges for medical implantable applications stemming from the electromagnetic (EM) interactions with the surrounding biological tissue. There are, however, numerous benefits of higher frequency RF communication, including improved speed, range, reliability, and ease of use, that have resulted in a rapid growth of RF in implantable devices. There has also been significant development of numerous network protocols and FCC allocations of bands targeted specifically for these applications. Thorough survey and analysis of patient and physician use cases is critical for steering the design and development phases to maximize a product's chance of success. Sufficient modeling, representative and comprehensive testing utilizing anechoic chambers and RF phantom recipes, iterative design methods, and in vivo studies are necessary for successful development of a high-frequency RF Class III medical device targeted for commercial release.
RSC Adv., 2014
Novel thermally cross-linked and sulphur-vulcanized TPVs based on S-EB-S and S-SBR blends have re... more Novel thermally cross-linked and sulphur-vulcanized TPVs based on S-EB-S and S-SBR blends have registered good mechanical and dynamic mechanical properties with reduced hardness suitable for automotive applications.
PROTEOMICS, 2009
A stable and robust trypsin-based biocatalytic system was developed and demonstrated for proteomi... more A stable and robust trypsin-based biocatalytic system was developed and demonstrated for proteomic applications. The system utilizes polymer nanofibers coated with trypsin aggregates for immobilized protease digestions. After covalently attaching an initial layer of trypsin to the polymer nanofibers, highly concentrated trypsin molecules are crosslinked to the layered trypsin by way of a glutaraldehyde treatment. This process produced a 300-fold increase in trypsin activity compared with a conventional method for covalent trypsin immobilization, and proved to be robust in that it still maintained a high level of activity after a year of repeated recycling. This highly stable form of immobilized trypsin was resistant to autolysis, enabling repeated digestions of bovine serum albumin over 40 days and successful peptide identification by LC-MS/MS. This active and stable form of immobilized trypsin was successfully employed in the digestion of yeast proteome extract with high reproducibility and within shorter time than conventional protein digestion using solution phase trypsin. Finally, the immobilized trypsin was resistant to proteolysis when exposed to other enzymes (i.e. chymotrypsin), which makes it suitable for use in "realworld" proteomic applications. Overall, the biocatalytic nanofibers with trypsin aggregate coatings proved to be an effective approach for repeated and automated protein digestion in proteomic analyses.