Suljo Kunic - Academia.edu (original) (raw)

Papers by Suljo Kunic

Acta neurologica Belgica/Acta neurologica belgica, Feb 14, 2024

Medical Hypotheses, Dec 1, 2020

Archives of Psychiatry Research

Multiple sclerosis (MS) is a chronic, inflammatory, (auto) immune disease of the central nervous ... more Multiple sclerosis (MS) is a chronic, inflammatory, (auto) immune disease of the central nervous system (CNS). The aim of the study was to determine the distribution of cognitive disorders in MS in relation to demographic parameters, degree of clinical disability and depression. The prospective study included 135 subjects with MS in the Clinic of Neurology of the University Clinical Center in Tuzla. The first group consisted of women (101 respondents) and the second of men (34 respondents). Clinical assessment instruments were: Expanded Disability Status Scale Score, Mini Mental Status, Beck Depression Scale, Battery of Cognitive Function Assessment Tests: Wechsler Intelligence Scale, Revised Beta Test, Raven Coloured Progressive Matrix, Wechsler Memory Verification Scale, Audio Memory Test learning, Rey-Osterriecht complex character test, verbal fluency test. There were no significant differences between the mentioned groups in age, level of education, duration of the disease, seve...

Psychiatria Danubina, Mar 31, 2022

Oleh Hornykiewicz was born on November 17, 1926 in Lamberg, Ukraine. After completing his studies... more Oleh Hornykiewicz was born on November 17, 1926 in Lamberg, Ukraine. After completing his studies in July 1951, he moved to the "Pharmacological Institute of the University of Vienna". In 1958, he started his research on centrally acting drugs at the same institute and came up with the idea of linking laboratory observations with animals with the basal ganglia of the human brain. Soon, Hornykiewicz initiated a new question: L-DOPA as a therapy for Parkinson's disease? Fortunately, after administration of this new drug, patients were able to perform motor activities which could not be prompted to any comparable degree by any known drug. In the following decades, initial fiction became an unavoidable fact. Dopamine, adapted and combined with carbidopa or benzerazide, has evolved into a drug that no longer recognizes the borders of countries and continents. Distinguished emeritus prof. Oleh Hornykiewicz died on May 26, 2020 at the age of 93 in Vienna, Austria. Unfortunately, despite everything he has done and deserved, the Nobel Prize was not received.

Psychiatria Danubina, 2021

BACKGROUND Delirium is a syndrome that occurs in all age groups and in many clinical departments,... more BACKGROUND Delirium is a syndrome that occurs in all age groups and in many clinical departments, and is most common in intensive care units. It is an emergency, in the overlapping fields of somatic medicine, neurology and psychiatry. Delirium occurs suddenly, dramatically, and requires a quick reaction, recognition and treatment. There are only a small number of studies that have reported delirium after a stroke. In our study, the goal was to determine the cognitive functionality of patients with delirium after a stroke. SUBJECTS AND METHODS This is a prospective study in which a group of 100 delirium patients in the acute phase of a stroke were evaluated for cognitive function. The control group consisted of the same number of patients with acute stroke who were not diagnosed with delirium. Neurological, neuropsychiatric and neuropsychological tests were performed in all patients at five different time periods. In these time periods, all patients were evaluated: Glasgow Coma Scale...

Psychiatria Danubina, 2019

BACKGROUND In order to protect itself from the pain or discomfort that would result from the forb... more BACKGROUND In order to protect itself from the pain or discomfort that would result from the forbidden instinctual impulses, the ego developed defence mechanisms (DM). Mature DMs are associated with adaptive functioning. Immature and neurotic DMs are associated with maladaptive functioning. Our goal was to determine the intensity of the most frequently used immature, neurotic and mature ego DMs in patients with epilepsy. SUBJECTS AND METHODS We examined 50 patients with epilepsy, using a Defense Style Questionnaire (DSQ-40). We measured the intensity of individual DMs. Mature DMs: sublimation, humour, suppression and anticipation; neurotic DMs: undoing, pseudo-altruism, idealization and reactive formation; and immature DMs: projections, passive aggression, acting out, isolation, devaluation, autistic fantasies, denial, displacement, dissociation, splitting, rationalization and somatization. The control group consisted of 36 healthy subjects. Groups are equal in age and level of educ...

Neurological Sciences, 2018

European Psychiatry, 2015

Medical Hypotheses, 2020

Huntington's chorea and Sydenham's chorea: First ever report of CO-occurrence Sydenham's chorea (... more Huntington's chorea and Sydenham's chorea: First ever report of CO-occurrence Sydenham's chorea (SC) is a post-streptococcal disorder [1]. Huntington's chorea (HC) is a rare neurodegenerative disorder characterized by involuntary movements, behavioural/psychiatric disturbances and dementia [2]. We presented a history of 27-year-old Caucasian man. His parents were nonconsanguineous-his birth was at full-term. There was no delay in attaining the developmental milestones. When he was 5, his father (44 years old, who had expressed purposeless movements, episodes of emotional instability and personality changes), died. At the age of 7, our patient and his older sister were hospitalized due to rheumatic fever, with positive ASO-titer ("yo-yo" phenomenon). Diagnosis of SC was determined on clinical and laboratory grounds. He experienced continuation of difficulties with migratory arthralgia and started prophylactic therapy with benzathine-benzyl penicillin, periodically for next 8 years). At 21, he was in a good health condition, and he attended second year at university. There were no signs of HC in that time. After 24, he began to experience anxiety, lack of attention, inadequate academic performance and discrete purposeless movements in right toe. Three years later, he expressed learning/mnestic difficulties, generalized dystonia, and multiple tics. Routine laboratory evaluations, also including caeruloplasmin, CPK, iron, coper, ferritine, homocysteine, acanthocytes, ANA, RF, ASO-titer, and dopler-sonography of brain parenchyma were normal. MMS (23 points) and MOCA (20 points) tests showed cognitive decline. MRI revealed reduced volume of nuclei caudate and molecular analysis showing 70 CAG-repeats. There was no knowledge about other family members on father's side with possible HC. Juvenile Huntington's chorea (JHC), characterized by onset before the age of 21, is a very rare clinical entity, constituing only 10% of total HC. Transmission is paternal in 80-90% of cases, with more than 60 CAG repeats: the longer repeat-the earlier onset [3]. Maternal transmission and expansion of fewer than 60 CAG repeats are not expected in JHC [4]. Caudate atrophy may be diagnostic parametar two years before onset, with faster rate of brain atrophy [5,6]. We observe that our patient has had features for JHC, with onset after 24. To the best of the author's knowledge and PubMed survey, cooccurrence of HC and SC has not been published yet. Also, there was only one case report of SC in the HC family, but mother of 6-year-old patient refused to undergo the pre-symptomatic genetic diagnosis [7]. In our patient, there was an obvious discrepancy between large number of CAG repeats and late time of expected JHC. Is there any unknown factor that postponed JHC for at least 3 years? We can speculate on multifactorial aetiology, with high probability of genetic burden for movement disorders in the family. Furthermore, we hypothesize that there is a possibility of unrecognized influence of prolonged antibiotic prophylaxis (8-year penicillin therapy) on potential delay of onset of JHC. Further investigations should offer the possible answer and illuminate current dilemmas.

PubMed, May 4, 2022

Objective: To evaluate the defense mechanisms (DM) in patients with drug-resistant epilepsy and, ... more Objective: To evaluate the defense mechanisms (DM) in patients with drug-resistant epilepsy and, to determine whether displacement is associated with seizures. Subjects and methods: Following an examination, 50 patients were diagnosed in accordance with the 2005 proposal of the International League Against Epilepsy and the definition of drug-resistant epilepsy from 2010. The neuropsychological examination used the Defense Style Questionnaire (DSQ-40). We measured the intensity of individual DMs. Mature DMs: sublimation, humor, suppression and anticipation; neurotic DMs: undoing, pseudo-altruism, idealization and reactive formation; and immature DMs: projections, passive aggression, acting out, isolation, devaluation, autistic fantasies, denial, displacement, dissociation, splitting, rationalization and somatization. The values were compared with 50 subjects without epilepsy. Results: Patients with drug-resistant epilepsy use immature defensive styles significantly more (p=0.0010). Displacement have a positive correlation with frequency of seizure (p=0.0412). Conclusion: Blaming others is a characteristic of the behavior of patients with drug-resistant epilepsy, especially if they have seizures. As such, they may be less adaptable in a micro social environment.

Sanamed, 2013

This study measured the frequency of carpal tunnel syndrome (CTS) and the levels of anxiety and d... more This study measured the frequency of carpal tunnel syndrome (CTS) and the levels of anxiety and depression in the third trimester of healthy pregnant women having regular prenatal visits. The study was performed at the Department of Neurophysiology Health Centre Tuzla in the period of January through April 2006. The group consisted of 40 pregnant women in the third trimester of pregnancy, age range of 25.6 ± 4.9 years. The control group consisted of healthy women, ages 31.1 ± 4.4 years. The electrophysiological parameters n. medians, the Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) were measured. The diagnosis of CTS is neurophysiologically confirmed in 12 pregnant women (30%) and 75% showed clinical signs and symptoms of disease. Pain was measured by subjective pain scale ranked from 0 (absence of pain) to 10 (severe pain). The mean value of BAI in control group was 8.6 ± 6.5, while in the group of pregnant women was 12.9 ± 6.9, which was significantly higher (p = 0.011). The mean value of BDI in control group was 4.2 ± 4.4 and in the group of pregnant women was 8.7 ± 5.9. which was significantly higher (p = 0.0008), The mean value of BAI in the group of women with CTS was 12.25 ± 6.7 which was not significantly higher than the compared to the control group (p = 0.113). The mean value of BDI in the group of pregnant women with CTS was 7.9 ± 6.4,which was significantly higher when compared to the control group (p = 0.037). The subjective assessment of pain in the group of women with CTS was 2.4 ± 2.1. There was a slight correlation between pain intensity and degree of BAI (r = 0.289) and a negative correlation with the level of depression (r =-0.297). The conclusion is that pregnant women with normal risk should make an extra effort in the treatment of unpleasant conditions such as CTS, anxiety and depression, which may impair the quality of life and have physical and psychological side effects on the future mother.

World Journal of Clinical Cases, Aug 26, 2022

Zdravstveni glasnik

Uvod: Neurodegenerativne bolesti karakteriziraju se prije svega motoričkim znakovima, ali ih prat... more Uvod: Neurodegenerativne bolesti karakteriziraju se prije svega motoričkim znakovima, ali ih prate i emocionalni poremećaji. Cilj: utvrditi stepen emocionalnih poremećaja u oboljelih od Parkinsonskove bolesti i multiple skleroze i njihov uticaj na kvalitet života oboljelih. Metode: Prospektivnim istraživanjem obuhvaćeno je po 50 pacijenata oboljelih od relaps remitentne multiple skleroze i Parkinsonove bolesti. U studiju su uvršteni pacijenti bez kognitivnog oštećenja ili sa blagim kognitivnim ošećenjem. Kvalitet života oboljelih je mjeren SF-36 skalom za procjenu kvaliteta života. Depresija je mjerena Bekovom skalom depresivnosti a anksioznost Hamiltonovom skalom za procjenu anksioznosti. present in high percentages in both groups of patients. High rates of emotional disorders in Parkinson's disease and multiple sclerosis affect the quality of life of patients. In principle, comorbidity consists more of subjective suffering, reduced psychological coping, and negative interference with quality of life.

Osteoporosis International

Zdravstveni glasnik

Uvod:Istovremena prisutnost metaboličkih faktorarizika za dijabetes melitus tipa 2 i kardiovaskul... more Uvod:Istovremena prisutnost metaboličkih faktorarizika za dijabetes melitus tipa 2 i kardiovaskularnubolest (abdominalna pretilost, hiperglikemija, dislipidemijai hipertenzija) ukazuju na postojanje "metaboličkogsindroma" Cilj ovog istraživanja je bio izmjeriti elektroneurografske parametre nervusmedianusa i nervusulnarisa kod ispitanika sa metaboličkim sindromom te utvrditi da li kod pacijenata u predijabetesu dolazi do promjena ka neuropatskom šablonu. Metode: U istraživanje je bilo uključeno 100 ispitanika sa metaboličkim sindromom dijagnosticiranim prema kriterijima Nacionalnog programa obrazovanja o holesterolu-Panel liječenja odraslih III.Na osnovu stepena glukoregulacije razvrstani su u dvije jednake grupe. Grupa I (n=50), ispitanici sa normalnom kontrolom glikemije. Grupa II (n=50), ispitanici sa predijabetesom: poremećajem glukoze natašte (PGT) ili poremećajem tolerancije na glukozu (PTG). Mjerene su senzorne konduktivne brzine (SKB), amplituda senzornog nervnog akcionog potencijala (SNAP), motorne konduktivne brzine (MKB), terminalna motorna latenca (TML) i kompleksi mišićnih akcionih potencijala nakon distalne stimulacije (KMAP-I) i nakon proksimalne stimulacije (KMAP-II). Rezultati: Svi senzorni i gotovo svi motorni parametri u grupi II su bili izmjenjeni ka neuropatskom šablonu u odnosu na grupu I. Signifikantno su se razlikovale: amplituda SNAP-a za lijevi nervusmedianus, brzina senzornog provođenja i amplituda SNAP-a za lijevi nervusulnaris i brzina senzornog provođenja za desni nervusulnaris, te vrijednosti KMAP-I i KMAP-II površina za desni nervusmedianus i vrijednosti terminalne motorne latence i brzine motornog provođenja za lijevi nervusulnaris. Zaključak: Ispitanici sa metaboličkim sindromom i predijabetesmelitusom imaju značajne promjene u motornim i senzornim perifernim nervima. Neuropatske promjene su moguće i u ispitanika sa metaboličkim sindromom i normalnom glukoregulacijom.

Medical Hypotheses, 2020

Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on ... more Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre-including this research content-immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

Acta Clinica Belgica, 2020

Objective: To evaluate memory in patients with drug-resistant epilepsy. Methods: Following an exa... more Objective: To evaluate memory in patients with drug-resistant epilepsy. Methods: Following an examination, 50 patients were diagnosed in accordance with the 2005 proposal of the International League Against Epilepsy and the definition of drug-resistant epilepsy from 2010. The neuropsychological examination used the Wechsler Memory Scale. It assessed seven structural types of memory: general knowledge, orientation, mental control, logical memory, number memory, associative memory, and visual reproduction. The values were compared with 50 subjects without epilepsy. Results: Patients with epilepsy had statistically significantly lower values in five of seven structural units of memory. The average value of overall memory efficacy in subjects with epilepsy was 96.5 ± 19.6, while in subjects without epilepsy it was 118 ± 15.6 (p = 0.0002). Memory impairments are greater in those taking polytherapy (p = 0.0429). The overall memory efficiency correlated significantly negatively with seizure frequency (p = 0.0015) and insignificantly negative with the duration of epilepsy (p = 0.1935). Conclusion: Patients with drug-resistant epilepsy have lower memory efficiency. Memory impairments are greater in those taking polytherapy, as with those with more frequent seizures. The duration of epilepsy has no significant effect on overall memory performance.

International Orthopaedics, 2020

Acta Neurologica Belgica, 2019

Acta neurologica Belgica/Acta neurologica belgica, Feb 14, 2024

Medical Hypotheses, Dec 1, 2020

Archives of Psychiatry Research

Multiple sclerosis (MS) is a chronic, inflammatory, (auto) immune disease of the central nervous ... more Multiple sclerosis (MS) is a chronic, inflammatory, (auto) immune disease of the central nervous system (CNS). The aim of the study was to determine the distribution of cognitive disorders in MS in relation to demographic parameters, degree of clinical disability and depression. The prospective study included 135 subjects with MS in the Clinic of Neurology of the University Clinical Center in Tuzla. The first group consisted of women (101 respondents) and the second of men (34 respondents). Clinical assessment instruments were: Expanded Disability Status Scale Score, Mini Mental Status, Beck Depression Scale, Battery of Cognitive Function Assessment Tests: Wechsler Intelligence Scale, Revised Beta Test, Raven Coloured Progressive Matrix, Wechsler Memory Verification Scale, Audio Memory Test learning, Rey-Osterriecht complex character test, verbal fluency test. There were no significant differences between the mentioned groups in age, level of education, duration of the disease, seve...

Psychiatria Danubina, Mar 31, 2022

Oleh Hornykiewicz was born on November 17, 1926 in Lamberg, Ukraine. After completing his studies... more Oleh Hornykiewicz was born on November 17, 1926 in Lamberg, Ukraine. After completing his studies in July 1951, he moved to the "Pharmacological Institute of the University of Vienna". In 1958, he started his research on centrally acting drugs at the same institute and came up with the idea of linking laboratory observations with animals with the basal ganglia of the human brain. Soon, Hornykiewicz initiated a new question: L-DOPA as a therapy for Parkinson's disease? Fortunately, after administration of this new drug, patients were able to perform motor activities which could not be prompted to any comparable degree by any known drug. In the following decades, initial fiction became an unavoidable fact. Dopamine, adapted and combined with carbidopa or benzerazide, has evolved into a drug that no longer recognizes the borders of countries and continents. Distinguished emeritus prof. Oleh Hornykiewicz died on May 26, 2020 at the age of 93 in Vienna, Austria. Unfortunately, despite everything he has done and deserved, the Nobel Prize was not received.

Psychiatria Danubina, 2021

BACKGROUND Delirium is a syndrome that occurs in all age groups and in many clinical departments,... more BACKGROUND Delirium is a syndrome that occurs in all age groups and in many clinical departments, and is most common in intensive care units. It is an emergency, in the overlapping fields of somatic medicine, neurology and psychiatry. Delirium occurs suddenly, dramatically, and requires a quick reaction, recognition and treatment. There are only a small number of studies that have reported delirium after a stroke. In our study, the goal was to determine the cognitive functionality of patients with delirium after a stroke. SUBJECTS AND METHODS This is a prospective study in which a group of 100 delirium patients in the acute phase of a stroke were evaluated for cognitive function. The control group consisted of the same number of patients with acute stroke who were not diagnosed with delirium. Neurological, neuropsychiatric and neuropsychological tests were performed in all patients at five different time periods. In these time periods, all patients were evaluated: Glasgow Coma Scale...

Psychiatria Danubina, 2019

BACKGROUND In order to protect itself from the pain or discomfort that would result from the forb... more BACKGROUND In order to protect itself from the pain or discomfort that would result from the forbidden instinctual impulses, the ego developed defence mechanisms (DM). Mature DMs are associated with adaptive functioning. Immature and neurotic DMs are associated with maladaptive functioning. Our goal was to determine the intensity of the most frequently used immature, neurotic and mature ego DMs in patients with epilepsy. SUBJECTS AND METHODS We examined 50 patients with epilepsy, using a Defense Style Questionnaire (DSQ-40). We measured the intensity of individual DMs. Mature DMs: sublimation, humour, suppression and anticipation; neurotic DMs: undoing, pseudo-altruism, idealization and reactive formation; and immature DMs: projections, passive aggression, acting out, isolation, devaluation, autistic fantasies, denial, displacement, dissociation, splitting, rationalization and somatization. The control group consisted of 36 healthy subjects. Groups are equal in age and level of educ...

Neurological Sciences, 2018

European Psychiatry, 2015

Medical Hypotheses, 2020

Huntington's chorea and Sydenham's chorea: First ever report of CO-occurrence Sydenham's chorea (... more Huntington's chorea and Sydenham's chorea: First ever report of CO-occurrence Sydenham's chorea (SC) is a post-streptococcal disorder [1]. Huntington's chorea (HC) is a rare neurodegenerative disorder characterized by involuntary movements, behavioural/psychiatric disturbances and dementia [2]. We presented a history of 27-year-old Caucasian man. His parents were nonconsanguineous-his birth was at full-term. There was no delay in attaining the developmental milestones. When he was 5, his father (44 years old, who had expressed purposeless movements, episodes of emotional instability and personality changes), died. At the age of 7, our patient and his older sister were hospitalized due to rheumatic fever, with positive ASO-titer ("yo-yo" phenomenon). Diagnosis of SC was determined on clinical and laboratory grounds. He experienced continuation of difficulties with migratory arthralgia and started prophylactic therapy with benzathine-benzyl penicillin, periodically for next 8 years). At 21, he was in a good health condition, and he attended second year at university. There were no signs of HC in that time. After 24, he began to experience anxiety, lack of attention, inadequate academic performance and discrete purposeless movements in right toe. Three years later, he expressed learning/mnestic difficulties, generalized dystonia, and multiple tics. Routine laboratory evaluations, also including caeruloplasmin, CPK, iron, coper, ferritine, homocysteine, acanthocytes, ANA, RF, ASO-titer, and dopler-sonography of brain parenchyma were normal. MMS (23 points) and MOCA (20 points) tests showed cognitive decline. MRI revealed reduced volume of nuclei caudate and molecular analysis showing 70 CAG-repeats. There was no knowledge about other family members on father's side with possible HC. Juvenile Huntington's chorea (JHC), characterized by onset before the age of 21, is a very rare clinical entity, constituing only 10% of total HC. Transmission is paternal in 80-90% of cases, with more than 60 CAG repeats: the longer repeat-the earlier onset [3]. Maternal transmission and expansion of fewer than 60 CAG repeats are not expected in JHC [4]. Caudate atrophy may be diagnostic parametar two years before onset, with faster rate of brain atrophy [5,6]. We observe that our patient has had features for JHC, with onset after 24. To the best of the author's knowledge and PubMed survey, cooccurrence of HC and SC has not been published yet. Also, there was only one case report of SC in the HC family, but mother of 6-year-old patient refused to undergo the pre-symptomatic genetic diagnosis [7]. In our patient, there was an obvious discrepancy between large number of CAG repeats and late time of expected JHC. Is there any unknown factor that postponed JHC for at least 3 years? We can speculate on multifactorial aetiology, with high probability of genetic burden for movement disorders in the family. Furthermore, we hypothesize that there is a possibility of unrecognized influence of prolonged antibiotic prophylaxis (8-year penicillin therapy) on potential delay of onset of JHC. Further investigations should offer the possible answer and illuminate current dilemmas.

PubMed, May 4, 2022

Objective: To evaluate the defense mechanisms (DM) in patients with drug-resistant epilepsy and, ... more Objective: To evaluate the defense mechanisms (DM) in patients with drug-resistant epilepsy and, to determine whether displacement is associated with seizures. Subjects and methods: Following an examination, 50 patients were diagnosed in accordance with the 2005 proposal of the International League Against Epilepsy and the definition of drug-resistant epilepsy from 2010. The neuropsychological examination used the Defense Style Questionnaire (DSQ-40). We measured the intensity of individual DMs. Mature DMs: sublimation, humor, suppression and anticipation; neurotic DMs: undoing, pseudo-altruism, idealization and reactive formation; and immature DMs: projections, passive aggression, acting out, isolation, devaluation, autistic fantasies, denial, displacement, dissociation, splitting, rationalization and somatization. The values were compared with 50 subjects without epilepsy. Results: Patients with drug-resistant epilepsy use immature defensive styles significantly more (p=0.0010). Displacement have a positive correlation with frequency of seizure (p=0.0412). Conclusion: Blaming others is a characteristic of the behavior of patients with drug-resistant epilepsy, especially if they have seizures. As such, they may be less adaptable in a micro social environment.

Sanamed, 2013

This study measured the frequency of carpal tunnel syndrome (CTS) and the levels of anxiety and d... more This study measured the frequency of carpal tunnel syndrome (CTS) and the levels of anxiety and depression in the third trimester of healthy pregnant women having regular prenatal visits. The study was performed at the Department of Neurophysiology Health Centre Tuzla in the period of January through April 2006. The group consisted of 40 pregnant women in the third trimester of pregnancy, age range of 25.6 ± 4.9 years. The control group consisted of healthy women, ages 31.1 ± 4.4 years. The electrophysiological parameters n. medians, the Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) were measured. The diagnosis of CTS is neurophysiologically confirmed in 12 pregnant women (30%) and 75% showed clinical signs and symptoms of disease. Pain was measured by subjective pain scale ranked from 0 (absence of pain) to 10 (severe pain). The mean value of BAI in control group was 8.6 ± 6.5, while in the group of pregnant women was 12.9 ± 6.9, which was significantly higher (p = 0.011). The mean value of BDI in control group was 4.2 ± 4.4 and in the group of pregnant women was 8.7 ± 5.9. which was significantly higher (p = 0.0008), The mean value of BAI in the group of women with CTS was 12.25 ± 6.7 which was not significantly higher than the compared to the control group (p = 0.113). The mean value of BDI in the group of pregnant women with CTS was 7.9 ± 6.4,which was significantly higher when compared to the control group (p = 0.037). The subjective assessment of pain in the group of women with CTS was 2.4 ± 2.1. There was a slight correlation between pain intensity and degree of BAI (r = 0.289) and a negative correlation with the level of depression (r =-0.297). The conclusion is that pregnant women with normal risk should make an extra effort in the treatment of unpleasant conditions such as CTS, anxiety and depression, which may impair the quality of life and have physical and psychological side effects on the future mother.

World Journal of Clinical Cases, Aug 26, 2022

Zdravstveni glasnik

Uvod: Neurodegenerativne bolesti karakteriziraju se prije svega motoričkim znakovima, ali ih prat... more Uvod: Neurodegenerativne bolesti karakteriziraju se prije svega motoričkim znakovima, ali ih prate i emocionalni poremećaji. Cilj: utvrditi stepen emocionalnih poremećaja u oboljelih od Parkinsonskove bolesti i multiple skleroze i njihov uticaj na kvalitet života oboljelih. Metode: Prospektivnim istraživanjem obuhvaćeno je po 50 pacijenata oboljelih od relaps remitentne multiple skleroze i Parkinsonove bolesti. U studiju su uvršteni pacijenti bez kognitivnog oštećenja ili sa blagim kognitivnim ošećenjem. Kvalitet života oboljelih je mjeren SF-36 skalom za procjenu kvaliteta života. Depresija je mjerena Bekovom skalom depresivnosti a anksioznost Hamiltonovom skalom za procjenu anksioznosti. present in high percentages in both groups of patients. High rates of emotional disorders in Parkinson's disease and multiple sclerosis affect the quality of life of patients. In principle, comorbidity consists more of subjective suffering, reduced psychological coping, and negative interference with quality of life.

Osteoporosis International

Zdravstveni glasnik

Uvod:Istovremena prisutnost metaboličkih faktorarizika za dijabetes melitus tipa 2 i kardiovaskul... more Uvod:Istovremena prisutnost metaboličkih faktorarizika za dijabetes melitus tipa 2 i kardiovaskularnubolest (abdominalna pretilost, hiperglikemija, dislipidemijai hipertenzija) ukazuju na postojanje "metaboličkogsindroma" Cilj ovog istraživanja je bio izmjeriti elektroneurografske parametre nervusmedianusa i nervusulnarisa kod ispitanika sa metaboličkim sindromom te utvrditi da li kod pacijenata u predijabetesu dolazi do promjena ka neuropatskom šablonu. Metode: U istraživanje je bilo uključeno 100 ispitanika sa metaboličkim sindromom dijagnosticiranim prema kriterijima Nacionalnog programa obrazovanja o holesterolu-Panel liječenja odraslih III.Na osnovu stepena glukoregulacije razvrstani su u dvije jednake grupe. Grupa I (n=50), ispitanici sa normalnom kontrolom glikemije. Grupa II (n=50), ispitanici sa predijabetesom: poremećajem glukoze natašte (PGT) ili poremećajem tolerancije na glukozu (PTG). Mjerene su senzorne konduktivne brzine (SKB), amplituda senzornog nervnog akcionog potencijala (SNAP), motorne konduktivne brzine (MKB), terminalna motorna latenca (TML) i kompleksi mišićnih akcionih potencijala nakon distalne stimulacije (KMAP-I) i nakon proksimalne stimulacije (KMAP-II). Rezultati: Svi senzorni i gotovo svi motorni parametri u grupi II su bili izmjenjeni ka neuropatskom šablonu u odnosu na grupu I. Signifikantno su se razlikovale: amplituda SNAP-a za lijevi nervusmedianus, brzina senzornog provođenja i amplituda SNAP-a za lijevi nervusulnaris i brzina senzornog provođenja za desni nervusulnaris, te vrijednosti KMAP-I i KMAP-II površina za desni nervusmedianus i vrijednosti terminalne motorne latence i brzine motornog provođenja za lijevi nervusulnaris. Zaključak: Ispitanici sa metaboličkim sindromom i predijabetesmelitusom imaju značajne promjene u motornim i senzornim perifernim nervima. Neuropatske promjene su moguće i u ispitanika sa metaboličkim sindromom i normalnom glukoregulacijom.

Medical Hypotheses, 2020

Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on ... more Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre-including this research content-immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

Acta Clinica Belgica, 2020

Objective: To evaluate memory in patients with drug-resistant epilepsy. Methods: Following an exa... more Objective: To evaluate memory in patients with drug-resistant epilepsy. Methods: Following an examination, 50 patients were diagnosed in accordance with the 2005 proposal of the International League Against Epilepsy and the definition of drug-resistant epilepsy from 2010. The neuropsychological examination used the Wechsler Memory Scale. It assessed seven structural types of memory: general knowledge, orientation, mental control, logical memory, number memory, associative memory, and visual reproduction. The values were compared with 50 subjects without epilepsy. Results: Patients with epilepsy had statistically significantly lower values in five of seven structural units of memory. The average value of overall memory efficacy in subjects with epilepsy was 96.5 ± 19.6, while in subjects without epilepsy it was 118 ± 15.6 (p = 0.0002). Memory impairments are greater in those taking polytherapy (p = 0.0429). The overall memory efficiency correlated significantly negatively with seizure frequency (p = 0.0015) and insignificantly negative with the duration of epilepsy (p = 0.1935). Conclusion: Patients with drug-resistant epilepsy have lower memory efficiency. Memory impairments are greater in those taking polytherapy, as with those with more frequent seizures. The duration of epilepsy has no significant effect on overall memory performance.

International Orthopaedics, 2020

Acta Neurologica Belgica, 2019