Sumit Sheoran - Academia.edu (original) (raw)
Papers by Sumit Sheoran
Abstract 5343: Evaluating the screened polyphenolics molecules as potential chemosensitizers against the oncogenic signalling proteins in lung cancer
Cancer Research
Background: Lung cancer is the most commonly diagnosed cancer globally. There are numerous agonis... more Background: Lung cancer is the most commonly diagnosed cancer globally. There are numerous agonists and antagonistic treatment interventions available for therapy. However, all of them possess different detrimental consequences in addition to resistance and remission in sufferers. Medicinal plants have traditionally been employed to treat a wide range of ailments and problems. Methodology: A total of 550 flavonoids and small molecules retrieved from literature and databases (Chembl, and PubChem) were analysed for molecular docking, biological activities, ADME, and drug-like properties through SwissADME and PreADMET, Molecular Simulation, and cytotoxicity studies. Simultaneously, review literature is employed to identify the novel protein targets viz. ROS1 (3ZBF) & EGFR (6DUK). Additionally, the crystal structures of the proteins were obtained from PDB and their domains and active sites were predicted using ScanProsite, MOTIF Search, metaPOCKET2, and PrankWeb tools. Finally, the prot...
Characterisation, development and validation of UV Spectrophotometric technique for determining Diosmetin in bulk and nanoformulations
Results in Chemistry
Artificial intelligence and nanotechnology for cervical cancer treatment: Current status and future perspectives
Journal of Drug Delivery Science and Technology
Research Square (Research Square), Nov 16, 2022
As per WHO, the pneumococcus causes one million fatalities each year because of their underdevelo... more As per WHO, the pneumococcus causes one million fatalities each year because of their underdeveloped immune systems, children are the most vulnerable to pneumococcal infections. The rise of S. pneumoniae resistance to antibiotics is causing widespread alarm all across the globe. Since the last couple of years, a recently developed technique is being used to overcome resistant pathogens. One of these is the computational subtractive genomics technique, in which the bacterial pathogen full proteins are effectively decreased to a limited amount of probable therapeutic targets. The procedures employed in this strategy are to locate human non-homologs targets, proteins that are vital to the illness producing agent, and participation of the identi ed proteins in pathogen metabolic pathways that are required for bacterial survival. In this work, we applied computational subtractive genomics on the proteins of the S. pneumonia strain D39 and came up with three cytoplasmic proteins that can serve as a promising candidate for novel drug to control the pathogenicity caused by S. pneumoniae.
Abstract 5342: Assessment of polyphenolic secondary metabolites and small molecules against the xenobiotic metabolic and cell cycle regulatory proteins in prostate cancer
Cancer Research
Background: Prostate cancer (PCa) is the second most frequent kind of cancer in males globally af... more Background: Prostate cancer (PCa) is the second most frequent kind of cancer in males globally after Lung Cancer. In clinical practice, medicines that act as antagonists/partial agonists of hormone receptors against prostate tissue are employed in PCa treatment. Cyproterone acetate, Flutamide, and Bicalutamide are prominent medications that induce acute and long-term toxicity and create drug resistance in patients and remission. We concentrated on flavonoids since they are non-cytotoxic and have substantial showing inhibitory action. Methodology: We selected 560 flavonoids and small compounds along with 3 targets from the extensive literature review. Three-dimensional (3D) structures of selected proteins were obtained from Protein Data Bank, docked with 560 flavonoids and small molecules 3D structures, obtained from PubChem and CHEMBL database using Gold Docking Software. ADME characteristics were used to determine their bioactivities in the human body and drug-like investigations b...
Heliyon
Investigators were continuously creating novel nanotechnologies to address unmet requirements thr... more Investigators were continuously creating novel nanotechnologies to address unmet requirements throughout the administration of therapeutic medicines & imaging agents for cancer treatment & diagnostics, appropriately. LNPs(Lipid nanoparticles) are legitimate particulates (approx. 100 nm in size) gathered from various lipid as well as other biochemical compounds which overall functionality to resolve biological barriers (biobarriers), allowing LNPs to selectively collect somewhere outside of disease-target cells again for responsive therapeutics. Most pharmaceutically important compounds were insoluble throughout water solutions, were chemical & physiologically unstable, or have toxicities. Among the most potential drug carrier for bioactive organic compounds is LBNPs (Lipid based nanoparticles) technologies. Its present use in chemotherapy have transformed treatment for cancer by increasing the antitumor effect of a number of chemotherapeutics. Because they may be created using naturally occurring sources, LBNPs have great temporal and thermal stability, maximum load potential, simplicity of preparations, cheap manufacturing costs, & big manufacturing output. Furthermore, combining chemotherapeutic drugs with LNPs reduces active therapeutic dosage and toxicities, lowers treatment resistance, & raises drug concentration in tumour cells while reducing concentrations in normal tissue. LBNPs were widely studied in cancer treatment, both in vitro and in vivo, with encouraging outcomes in certain clinical trials. This study provides an overview of the many types of LBNPs which have been created in latest years and their applications and contributions in different types of cancers. ☆ This article is a part of the "Lipid-Based Nanoparticles in Diagnosis and Treatment" Special issue.
International Journal on Biological Sciences, 2021
The active rising stage of childhood is referred to as school age. Children's malnutrition is... more The active rising stage of childhood is referred to as school age. Children's malnutrition is one of India's most significant problems. This issue is still being addressed throughout the country. Malnutrition, which is caused by insufficient nutrition, weakens the immune system and causes significant developmental delays. The key metric for determining a child's nutritional and health condition, as well as an indirect indication of well-being for adults, is development assessment. We used a predesigned and pre-tested questionnaire, anthropometric assessments, and clinical analysis to conduct a cross-sectional study in urban slums of Baghpat, U.P. India, from August 2021 to October 2021 to investigate nutritional status in school-age slum children and examine factors associated with malnutrition. The mean height and weight of boys and girls in the sample population were lower below the CDC 2000 (Centers for Disease Control and Prevention) guidelines in all age groups. In ...
The emergence and spread of antibiotic resistance, as well as the evolution of new strains of dis... more The emergence and spread of antibiotic resistance, as well as the evolution of new strains of disease causing agents, are of great concern to the global health community. Frequently used medicinal plants could be an exceptional source of drugs to scrap off this dilemma. Medicinal plants are traditionally used for the treatment of human infections. The present study was undertaken to investigate Apples, Amla and clove for the potential activity against human bacterial pathogen including Escherichia coli, Pseudomonas aeruginosa and Bacillus subtilis using agar well diffusion method. The results indicated that most of the extracts exhibited antimicrobial properties. Among the three medicinal plants, the highest potential was observed in the extract of Syzygium aromaticum (clove) against Staphylococcus aureus (2.8 cm) followed by Escherichia coliand Bacillus subtilis (2.0 cm), Phyllanthus emblica (Amla) extract displayed maximum potential activity against Pseudomonas aeruginosa (3.8 cm)...
IJRAR, 2019
In past, India uses herbs and medicinal plants for cure disease and infection caused by many agen... more In past, India uses herbs and medicinal plants for cure disease and infection caused by many agents. According to WHO, plants having medicinal properties are useful or best sources to obtain or to form various variety of drugs or medicines (1). The spread of antibacterial resistance and the mutation in bacteria and new stains are evolved, are of most important concern to world health community. Medicinal plants are traditionally used for the treatment of human infections caused by bacteria. The present study was done to find Malus domestica, Phyllanthus embica and Syzygium aromaticum for the potential activity against human bacterial pathogen including Escherichia coli, Pseudomonas aeruginosa and Bacillus subtilis using agar well diffusion method. The results indicated that most of the extracts having antibacterial properties. Among the three medicinal plants, the highest potential was observed in the extract of Syzygium aromaticum (clove) against Staphylococcus aureus (25Mm) followed by Escherichia coli (24Mm) and Bacillus subtilis (25Mm), Phyllanthus emblica (Amla) extract displayed maximum potential activity against Pseudomonas aeruginosa (35Mm). In addition to these extracts, extract of Malus domestica (apple fruit) also exhibited antimicrobial activity against bacterial pathogens. The experiment confirmed the effectiveness of selected plant extracts as a natural antioxidant and antibacterial and suggested the likelihood of employing them in drugs for the treatment of infectious diseases.
Microencapsulation is employed to protect bioactive compounds in foods. Ferulic acid is a derivat... more Microencapsulation is employed to protect bioactive compounds in foods. Ferulic acid is a derivative of hydroxyl cinnamic acids present in plants in its free form and covalently conjugated to the plant cell wall, offers a unique range of health benefits. Ferulic acid shows low toxicity and a wide range of biomedical effects including antioxidant, anti-inflammatory, antidiabetic, antimicrobial, antiallergic, anticarcinogenic, antithrombotic, antiviral, hepatoprotective, and vasodilatory actions. Ferulic acid has been approved globally as food additive to prevent the peroxidation of lipids as it affectively scavenges the superoxide anion radical. Ferulic acid has drawbacks for direct addition to functional foods. Microencapsulation of selected variety of vegetable waste extract was performed in a pilot-scale co-current spray dryer with whey protein isolate as a wall material. In this study, two different wall-to-core ratios (1:1 and 1.5:1) and dryer outlet temperatures (90°C and 105°C) were used for assessing the encapsulation efficiency. The results in this study showed that the microencapsulation efficiency (based on HPLC analysis) and antioxidant properties (based on 2,2diphenyl-1-picrylhydrazyl assay) were higher at 90°C outlet temperature of the spray dryer using 1.5:1 wallto-core ratio feed. Further, the spray-dried powders of this study demonstrated that incorporation of powder spray-dried at 90°C outlet temperature with 1.5:1 wall-to-core pasta exhibited higher antioxidant activity as well as sensory characteristics.
2017 - Microbial Signal Instructs Early Hematopoiesis Upon Intestinal Tissue Damage
Experimental Hematology
IJCIRAS, 2019
In the human body, there are highly reactive species or uncharged molecules having unpaired valan... more In the human body, there are highly reactive species or uncharged molecules having unpaired valance electron formed by exothermic and endothermic chemical metabolic reactions that are having the capability to oxidize organic molecules. All organisms have inbuild systems consist of organic catalysts such as catalases, glutathione reductase, and glutathione peroxidase, etc which can compensate for the effects of free radicals and other oxygen reactive species. To Check the antioxidant activity I perform TPC, TFC, DPPH, CAT, GSH, GST. I take fruits of medicinal important plants i.e. Malus domestica (Apples), Phyllanthus emblica (Amlas), Vitis vinifera (graphs), Allium sativum (Garlic), Syzygium aromaticum (Cloves) and Solanum lycopersicum (Tomatoes).
Abstract 5343: Evaluating the screened polyphenolics molecules as potential chemosensitizers against the oncogenic signalling proteins in lung cancer
Cancer Research
Background: Lung cancer is the most commonly diagnosed cancer globally. There are numerous agonis... more Background: Lung cancer is the most commonly diagnosed cancer globally. There are numerous agonists and antagonistic treatment interventions available for therapy. However, all of them possess different detrimental consequences in addition to resistance and remission in sufferers. Medicinal plants have traditionally been employed to treat a wide range of ailments and problems. Methodology: A total of 550 flavonoids and small molecules retrieved from literature and databases (Chembl, and PubChem) were analysed for molecular docking, biological activities, ADME, and drug-like properties through SwissADME and PreADMET, Molecular Simulation, and cytotoxicity studies. Simultaneously, review literature is employed to identify the novel protein targets viz. ROS1 (3ZBF) & EGFR (6DUK). Additionally, the crystal structures of the proteins were obtained from PDB and their domains and active sites were predicted using ScanProsite, MOTIF Search, metaPOCKET2, and PrankWeb tools. Finally, the prot...
Characterisation, development and validation of UV Spectrophotometric technique for determining Diosmetin in bulk and nanoformulations
Results in Chemistry
Artificial intelligence and nanotechnology for cervical cancer treatment: Current status and future perspectives
Journal of Drug Delivery Science and Technology
Research Square (Research Square), Nov 16, 2022
As per WHO, the pneumococcus causes one million fatalities each year because of their underdevelo... more As per WHO, the pneumococcus causes one million fatalities each year because of their underdeveloped immune systems, children are the most vulnerable to pneumococcal infections. The rise of S. pneumoniae resistance to antibiotics is causing widespread alarm all across the globe. Since the last couple of years, a recently developed technique is being used to overcome resistant pathogens. One of these is the computational subtractive genomics technique, in which the bacterial pathogen full proteins are effectively decreased to a limited amount of probable therapeutic targets. The procedures employed in this strategy are to locate human non-homologs targets, proteins that are vital to the illness producing agent, and participation of the identi ed proteins in pathogen metabolic pathways that are required for bacterial survival. In this work, we applied computational subtractive genomics on the proteins of the S. pneumonia strain D39 and came up with three cytoplasmic proteins that can serve as a promising candidate for novel drug to control the pathogenicity caused by S. pneumoniae.
Abstract 5342: Assessment of polyphenolic secondary metabolites and small molecules against the xenobiotic metabolic and cell cycle regulatory proteins in prostate cancer
Cancer Research
Background: Prostate cancer (PCa) is the second most frequent kind of cancer in males globally af... more Background: Prostate cancer (PCa) is the second most frequent kind of cancer in males globally after Lung Cancer. In clinical practice, medicines that act as antagonists/partial agonists of hormone receptors against prostate tissue are employed in PCa treatment. Cyproterone acetate, Flutamide, and Bicalutamide are prominent medications that induce acute and long-term toxicity and create drug resistance in patients and remission. We concentrated on flavonoids since they are non-cytotoxic and have substantial showing inhibitory action. Methodology: We selected 560 flavonoids and small compounds along with 3 targets from the extensive literature review. Three-dimensional (3D) structures of selected proteins were obtained from Protein Data Bank, docked with 560 flavonoids and small molecules 3D structures, obtained from PubChem and CHEMBL database using Gold Docking Software. ADME characteristics were used to determine their bioactivities in the human body and drug-like investigations b...
Heliyon
Investigators were continuously creating novel nanotechnologies to address unmet requirements thr... more Investigators were continuously creating novel nanotechnologies to address unmet requirements throughout the administration of therapeutic medicines & imaging agents for cancer treatment & diagnostics, appropriately. LNPs(Lipid nanoparticles) are legitimate particulates (approx. 100 nm in size) gathered from various lipid as well as other biochemical compounds which overall functionality to resolve biological barriers (biobarriers), allowing LNPs to selectively collect somewhere outside of disease-target cells again for responsive therapeutics. Most pharmaceutically important compounds were insoluble throughout water solutions, were chemical & physiologically unstable, or have toxicities. Among the most potential drug carrier for bioactive organic compounds is LBNPs (Lipid based nanoparticles) technologies. Its present use in chemotherapy have transformed treatment for cancer by increasing the antitumor effect of a number of chemotherapeutics. Because they may be created using naturally occurring sources, LBNPs have great temporal and thermal stability, maximum load potential, simplicity of preparations, cheap manufacturing costs, & big manufacturing output. Furthermore, combining chemotherapeutic drugs with LNPs reduces active therapeutic dosage and toxicities, lowers treatment resistance, & raises drug concentration in tumour cells while reducing concentrations in normal tissue. LBNPs were widely studied in cancer treatment, both in vitro and in vivo, with encouraging outcomes in certain clinical trials. This study provides an overview of the many types of LBNPs which have been created in latest years and their applications and contributions in different types of cancers. ☆ This article is a part of the "Lipid-Based Nanoparticles in Diagnosis and Treatment" Special issue.
International Journal on Biological Sciences, 2021
The active rising stage of childhood is referred to as school age. Children's malnutrition is... more The active rising stage of childhood is referred to as school age. Children's malnutrition is one of India's most significant problems. This issue is still being addressed throughout the country. Malnutrition, which is caused by insufficient nutrition, weakens the immune system and causes significant developmental delays. The key metric for determining a child's nutritional and health condition, as well as an indirect indication of well-being for adults, is development assessment. We used a predesigned and pre-tested questionnaire, anthropometric assessments, and clinical analysis to conduct a cross-sectional study in urban slums of Baghpat, U.P. India, from August 2021 to October 2021 to investigate nutritional status in school-age slum children and examine factors associated with malnutrition. The mean height and weight of boys and girls in the sample population were lower below the CDC 2000 (Centers for Disease Control and Prevention) guidelines in all age groups. In ...
The emergence and spread of antibiotic resistance, as well as the evolution of new strains of dis... more The emergence and spread of antibiotic resistance, as well as the evolution of new strains of disease causing agents, are of great concern to the global health community. Frequently used medicinal plants could be an exceptional source of drugs to scrap off this dilemma. Medicinal plants are traditionally used for the treatment of human infections. The present study was undertaken to investigate Apples, Amla and clove for the potential activity against human bacterial pathogen including Escherichia coli, Pseudomonas aeruginosa and Bacillus subtilis using agar well diffusion method. The results indicated that most of the extracts exhibited antimicrobial properties. Among the three medicinal plants, the highest potential was observed in the extract of Syzygium aromaticum (clove) against Staphylococcus aureus (2.8 cm) followed by Escherichia coliand Bacillus subtilis (2.0 cm), Phyllanthus emblica (Amla) extract displayed maximum potential activity against Pseudomonas aeruginosa (3.8 cm)...
IJRAR, 2019
In past, India uses herbs and medicinal plants for cure disease and infection caused by many agen... more In past, India uses herbs and medicinal plants for cure disease and infection caused by many agents. According to WHO, plants having medicinal properties are useful or best sources to obtain or to form various variety of drugs or medicines (1). The spread of antibacterial resistance and the mutation in bacteria and new stains are evolved, are of most important concern to world health community. Medicinal plants are traditionally used for the treatment of human infections caused by bacteria. The present study was done to find Malus domestica, Phyllanthus embica and Syzygium aromaticum for the potential activity against human bacterial pathogen including Escherichia coli, Pseudomonas aeruginosa and Bacillus subtilis using agar well diffusion method. The results indicated that most of the extracts having antibacterial properties. Among the three medicinal plants, the highest potential was observed in the extract of Syzygium aromaticum (clove) against Staphylococcus aureus (25Mm) followed by Escherichia coli (24Mm) and Bacillus subtilis (25Mm), Phyllanthus emblica (Amla) extract displayed maximum potential activity against Pseudomonas aeruginosa (35Mm). In addition to these extracts, extract of Malus domestica (apple fruit) also exhibited antimicrobial activity against bacterial pathogens. The experiment confirmed the effectiveness of selected plant extracts as a natural antioxidant and antibacterial and suggested the likelihood of employing them in drugs for the treatment of infectious diseases.
Microencapsulation is employed to protect bioactive compounds in foods. Ferulic acid is a derivat... more Microencapsulation is employed to protect bioactive compounds in foods. Ferulic acid is a derivative of hydroxyl cinnamic acids present in plants in its free form and covalently conjugated to the plant cell wall, offers a unique range of health benefits. Ferulic acid shows low toxicity and a wide range of biomedical effects including antioxidant, anti-inflammatory, antidiabetic, antimicrobial, antiallergic, anticarcinogenic, antithrombotic, antiviral, hepatoprotective, and vasodilatory actions. Ferulic acid has been approved globally as food additive to prevent the peroxidation of lipids as it affectively scavenges the superoxide anion radical. Ferulic acid has drawbacks for direct addition to functional foods. Microencapsulation of selected variety of vegetable waste extract was performed in a pilot-scale co-current spray dryer with whey protein isolate as a wall material. In this study, two different wall-to-core ratios (1:1 and 1.5:1) and dryer outlet temperatures (90°C and 105°C) were used for assessing the encapsulation efficiency. The results in this study showed that the microencapsulation efficiency (based on HPLC analysis) and antioxidant properties (based on 2,2diphenyl-1-picrylhydrazyl assay) were higher at 90°C outlet temperature of the spray dryer using 1.5:1 wallto-core ratio feed. Further, the spray-dried powders of this study demonstrated that incorporation of powder spray-dried at 90°C outlet temperature with 1.5:1 wall-to-core pasta exhibited higher antioxidant activity as well as sensory characteristics.
2017 - Microbial Signal Instructs Early Hematopoiesis Upon Intestinal Tissue Damage
Experimental Hematology
IJCIRAS, 2019
In the human body, there are highly reactive species or uncharged molecules having unpaired valan... more In the human body, there are highly reactive species or uncharged molecules having unpaired valance electron formed by exothermic and endothermic chemical metabolic reactions that are having the capability to oxidize organic molecules. All organisms have inbuild systems consist of organic catalysts such as catalases, glutathione reductase, and glutathione peroxidase, etc which can compensate for the effects of free radicals and other oxygen reactive species. To Check the antioxidant activity I perform TPC, TFC, DPPH, CAT, GSH, GST. I take fruits of medicinal important plants i.e. Malus domestica (Apples), Phyllanthus emblica (Amlas), Vitis vinifera (graphs), Allium sativum (Garlic), Syzygium aromaticum (Cloves) and Solanum lycopersicum (Tomatoes).