Sunil Kumar Prajapati - Academia.edu (original) (raw)

Papers by Sunil Kumar Prajapati

Der Pharmacia Lettre, 2012

Asian Journal of Dental and Health Sciences

Many plants of genus Cordia comprise of trees and shrubs are widely distributed in warmer regions... more Many plants of genus Cordia comprise of trees and shrubs are widely distributed in warmer regions and have been utilized in management of various diseases. Many phytochemicals like flavonoids, alkaloids, terpenes, tannins, and glyceridess having different activities were screened and isolated from different parts of C. dichotoma. Various important Pharmacological properties including Antiulcer, Contraceptives, anti-inflammatory, anthelmintic, analgesic, anticancer, Antioxidant, antimicrobial, hepatoprotective, antidiabetic and others have been well documented for this plant. C. dichotoma is a promising source of natural antioxidants which possess remarkable therapeutic action as inflammatory activity. In the present review, we have briefly reviewed the Antioxidant Potential of C. dichotoma that can be followed for future research on this plant for health benefits. Keywords: Cordia dichotoma, Antioxidant, anti-inflammatory, flavonoids

Asian Journal of Dental and Health Sciences

This review gives concise information about the application of dendrimers as drug delivery carrie... more This review gives concise information about the application of dendrimers as drug delivery carrier in the field of drug delivery. Due to their unique architecture these have improved physical and chemical properties. Due to their terminal groups these show high solubility, miscibility and reactivity. Dendrimers have well defined size, shape, molecular weight and monodispersity. These properties make the dendrimers a suitable carrier in drug delivery application. Dendrimers are unimolecular miceller in nature and due to this enhances the solubility of poorly soluble drugs. Their compatibility with DNA, heparin and polyanions make them more versatile. Dendrimers, also referred as modern day polymers, they offer much more good properties than the conventional polymers. Due to their multivalent and mono disperse character dendrimers have stimulated wide interest in the field of chemistry biology, drug delivery, gene therapy and chemotherapy. Self-assembly produces a faster means of gene...

International Journal of Pharma Research & Review, 2015

Nanotechnology represents one of the most capable technologies of the 21st century. Recently Nano... more Nanotechnology represents one of the most capable technologies of the 21st century. Recently Nanotechnology is emerging in the field of cosmetics and it offers a revolutionize treatment of several skin diseases. It is proved effective in attaining safe and targeted delivery of active medicaments as well cosmetic ingredients. Use of carrier system in nanotechnology has added advantage of improved skin penetration, depot effect with sustained release drug action. The trend toward therapeutic cosmetics will lead to a better understanding of modern ingredients and their assessment techniques. To obtain skin care formulations with real consumer-perceivable benefits and to optimize sensory attributes, formulators are resorting to technology that until recently was exclusively used in cosmetic products. Various formulations comes under special delivery systems like Vesicular, Particulate systems, emulsions type Particulate type and other delivery systems along with their applications are s...

Journal of Biomedical and Pharmaceutical Research, 2015

The treatment of schizophrenia has advanced because the therapeutic efficacy, tolerability, and s... more The treatment of schizophrenia has advanced because the therapeutic efficacy, tolerability, and safety profiles of atypical antipsychotics. Amisulpride is an atypical antipsychotic drug, effective for positive and negative symptoms of schizophrenia with unique receptor pharmacology. As could be predicted from the pharmacologic profile of a pure D2/D3 receptor blocker. Nanoemulsion formulation containing Amisulpride was developed by ultra sonication method. Formulations were prepared using oil (oleic acid and IPM), two surfactants ( Labrasol, and Tween 20 “Smix”) and co-surfactant (PEG 400). Optimized formulation, containing 10% oil, 2:1 as Smix, co-surfactant ratio 1 and 2 as ratio of Labrasol and Tween-20 in Smix was prepared. Amisulpride is practically insoluble in water and suffers from irregular and low bioavailability (48%). The current study is aimed at developing and optimizing a Nanoemulsion formulation of amisulpride in order to improve oral absorption of amisulpride throug...

International Journal of Research and Development in Pharmacy & Life Sciences, 2017

Asian Journal of Pharmaceutical and Clinical Research, 2016

ABSTRACTObjective: The purpose of this research was to formulate and evaluate floating microspher... more ABSTRACTObjective: The purpose of this research was to formulate and evaluate floating microsphere of glipizide.Methods: Glipizide microsphere containing ethyl cellulose (EC) and hydroxyl propyl methyl cellulose (HPMC) were prepared by solvent evaporationmethod. Polymer to drug ratio affected characteristics of microspheres. Microspheres were discrete, spherical, and perforated form. The microspheresexhibited good floating property and achieved good gastric retention.Result: In vitro performance was evaluated by the usual pharmacopoeial and other tests such as drug polymer compatibility (Fourier transforminfrared scan), yield (%), micrometric properties such as tapped density (%). Compressibility particle size analysis (by optical microscopy), drugentrapment efficiency, surface topography (scanning electron microscope), and in vitro release study. On the basis of results, increasing the polymerratio increased the particle size (195.6±20.24 to 200.89±16.61), increased tapped density ...

Asian Journal of Pharmaceutical and Clinical Research, 2016

Floating microspheres (FM) were developed as dosage form capable of floating in the gastric fluid... more Floating microspheres (FM) were developed as dosage form capable of floating in the gastric fluid to increase its residence time in the stomach without contact with the mucosa. Floating microspheres were prepared by the solvent evaporation technique using different ratios of acrylic ...

International Journal of Agriculture, Environment and Biotechnology

The present investigation was carried out during Rabi season of 2014–2015 and laid out in a Rando... more The present investigation was carried out during Rabi season of 2014–2015 and laid out in a Randomized Block Design with three replications at Vegetable Research Farm, Department of Horticulture, J.N. Krishi Vishwa Vidyalaya, Jabalpur (Madhya Pradesh). The experimental material for the study was comprised of 18 novel treatments combination of Salicylic acid (SA) and Azospirillum to estimate the best treatment combination in Rabi onion under particular region. The growth parameters under present investigation noted under T17 recorded maximum plant height (cm) at 30, 60, 90,120 DAT (33.28 cm), (37.58 cm), (45.22 cm) and (48.46 cm) respectively, length of leaves (cm) at 30 DAT (32.57 cm), 60 DAT (36.29 cm) under (T17) and T11 (41.75 cm) at 60 DAT and T12 (44.15 cm) at 120 DAT respectively, maximum number of leaf at 30 DAT (8.09) in T14, 60,90 DAT (12.99,17.92) in T17 and at 120 DAT (19.37) in T11respectively, neck thickness (mm) at 120 DAT (13.71 mm) under T11, dry weight of leaf (g) at 120 DAT (3.92 g). The yield parameters also reported best under T17 as average weight of bulb (88.07g), equatorial diameter (67.38mm), polar diameter (60.37mm), double bulb(2.38%)T11, bolting per cent lowest (1.18%), A, B and C grade bulb (on weight basis) (37.22%)T5, (65.09%) and (34.19%) respectively, bulb yield polt 1(14.77kg), marketable bulb yield (26.28t/ha.) T13, total bulb yield estimated in T16 (30.47 t/ha). T11 recorded highest gross monitory return ( 450705/ha), net return ( 385020/ha) and benefit cost ratio 5.86.

In this research work, modified microsponges have been developed that release drug in controlled ... more In this research work, modified microsponges have been developed that release drug in controlled manner and enhance the bioavailability of drug. This study presents a novel colon specific drug delivery system containing prednisolone. Colon targeting is naturally of value for the topical treatment of diseases of colon such as chron’s disease, ulcerative colitis, colorectal cancer, and amebiasis. It is also valuable for the oral delivery of drugs unstable or susceptible to enzymatic degradation in upper G.I.T. tract. The advantages of targeting drug to specifically to the diseased colon are reduced incidence of systemic side-effects, lower dose of drug, supply of the drug to the biophase only when it is required and maintenance of the drug in its intact form as close as possible to the target site. That’s why improved drug delivery system is required for drugs currently in use to treat localised disease of the colon. It has been concluded that obtained microsponges work as a best dosa...

International Journal of Pharmaceutical Research and Life Sciences, 2020

Cancer is assemblage diseases involving abnormal cell growth amid the potential of spread to othe... more Cancer is assemblage diseases involving abnormal cell growth amid the potential of spread to other parts of the body due to tobacco use are the cause of about of cancer deaths. Another 10% is due to obesity, poor diet & drinking alcohol. In 2012 about 14.1 million new cases of cancer occurred globally. In females, the most common type is breast cancer. Cisplatin also known as cytophosphane is a nitrogen mustard alkylating agent from the oxazophosphinans groups were used to treat cancers & autoimmune disorders. Based on the above reasons I will fix the aim Preparation characterization of Cisplatin- nano particles & its anticancer activity. Solid tumor volume examination report showed that the assessment of different day indication 15,20,25 & 30th variations of different groups of tumor volumes were decreased CPG Nanoparticles (100 mg/kg)+ DAL(15th day 4.97±0.24↓), (20th day 0.6±0.13↓), (25th day 1.35±0.30↓) & (30th day 1.89±0.13↓).

Journal of Drug Delivery and Therapeutics, 2017

The use of phytoconstituents single or combined with standard medicines has been utilized in cure... more The use of phytoconstituents single or combined with standard medicines has been utilized in cure of different diseases. Many plants of genus Cordia comprise of trees and shrubs are widely distributed in warmer regions and have been utilized in management of various diseases. Various phytoconstituents like flavonoids, alkaloids, terpenes, tannins, and glyceridess having different activities were screened and isolated from different parts of C. dichotoma. Various important Pharmacological properties including Antiulcer, Contraceptives, anti-inflammatory, anthelmintic, analgesic, anticancer, Antioxidant, antimicrobial, hepatoprotective, antidiabetic and others have been well documented for this plant. Therefore, we have briefly reviewed the various bioactivities of C. dichotoma to improve our knowledge on plant phytochemicals as therapeutic entities. The present review describes the various phytoconstituents and therapeutic potential of C. dichotoma that can be followed for future research on this plant for human health benefits.

Original Research Article The aim of the present study was to prepare a nanoemulsion of diclofena... more Original Research Article The aim of the present study was to prepare a nanoemulsion of diclofenac sodium for reduce side effects and improved oral bioavailability to treat arthritic conditions and investigate the potential of a nanoemulsion formulation for targeting and systemic delivery of diclofenac sodium. Various oil-in-water nanoemulsions were prepared by the titration emulsification method. The nanoemulsion area was identified by constructing pseudoternary phase diagrams. The prepared nanoemulsions were subjected to different thermodynamic stability tests. The nanoemulsion formulations that passed thermodynamic stability tests were characterized for viscosity, droplet size, transmission electron microscopy, size and zeta potential, and refractive index. The physical stability of nanoemulsion was studied using autoclaving, centrifugal, desorption (dilution effect) stresses and on storage. The selected formulations, F1, F2 and F3, were relatively stable during centrifugal stres...

International Journal of Pharmacometrics and Integrated Biosciences

Opportunistic bacterial infections are common in the various parts of human body. In recent years... more Opportunistic bacterial infections are common in the various parts of human body. In recent years bacterial species have shown resistance against a number of synthetic drugs. This study measured the antibacterial activity of bacterial strains against five common pathogenic bacteria related strains. Cup plate method and two fold serial dilution method were used to evaluated by antibacterial activity by the help of different bacterial related strains. The results revealed that Cisplatin (CIP) using natural as a polymer showed a minimum inhibitory concentration (MIC) at 250 mg/ml to 500 mg/ml of the broth against all bacterial strains. CIP using natural as a polymer was prepared different doses1000 μg/ml and 2000 μg/ ml and measured zone of inhibition dose dementedly reduced when compared to standard. The CIP using natural as a polymer exhibited strong anti-bacterial activity against five different species of bacteria and this may be attributed to various active components. Our researc...

Journal of Drug Delivery and Therapeutics

Aims: Apocynaceae family is the 5th largest medicinal plant family rich in potent secondary metab... more Aims: Apocynaceae family is the 5th largest medicinal plant family rich in potent secondary metabolites such as Alkaloids, Cardiac glycosides,Terpenoids, irridoid/secoirridoids, flavonoids and Phenolic contents. The present study was aimed to evaluate and compare in-vitroantiproliferative activity of three plants of this family.Methods: Aerial parts of Carissa carandas Linn. (C), Nerium indicum Mill. (N) and Wrightia tinctoria RBr. (W), were collected and dried. Thepowdered drugs were extracted in Ethanol (1), 60% Ethanol (2) and Water (3). Estimation of Phytoconstituents performed using standardmethods. In-vitro cytotoxic activity performed using Sulphorhodamine B (SRB) assay in HepG2, HT29 and SKOV3 human cancer cell lines takingAdriamycin (ADR) as standard. For extracts, GI50 value ≤ 20μg/ml was considered to demonstrate activity.Results: For HepG2 cell line graphs and photomicrographs showed GI50 value as ADR=39.79, C1=2.5, N2=66.3, N3<10 and C2=C3= N1=W1-3>80. Also TGI fo...

Advances In Pharmaceutical Research

Journal of Drug Delivery Science and Technology

Molecular pharmaceutics, Nov 7, 2016

Vesicular and colloidal delivery systems can be designed to control drug release spatially and te... more Vesicular and colloidal delivery systems can be designed to control drug release spatially and temporally to improve drug efficacy and side effect profiles. Niosomes (vesicles prepared from nonionic surfactants in aqueous media) are gaining interest as an alternative vesicular delivery system as they offer advantages such as biocompatibility, chemical stability, low cost, high purity, and versatility. However, the physical stability of niosomes, like other vesicular systems, is limited by vesicle fusion, aggregation, and leakage. Proniosomes (dehydrated powder or gel formulations that spontaneously form niosomes on hydration with aqueous media) can overcome these physical stability problems and are more convenient for sterilization, storage, transport, distribution, and dosing. Proniosomes have mostly been explored for their potential to enhance transdermal and oral absorption. In this study we assess, for the first time, the potential for hydrated proniosomes to sustain systemic ex...

Journal of Drug Delivery Science and Technology, 2016

Der Pharmacia Lettre, 2012

Asian Journal of Dental and Health Sciences

Many plants of genus Cordia comprise of trees and shrubs are widely distributed in warmer regions... more Many plants of genus Cordia comprise of trees and shrubs are widely distributed in warmer regions and have been utilized in management of various diseases. Many phytochemicals like flavonoids, alkaloids, terpenes, tannins, and glyceridess having different activities were screened and isolated from different parts of C. dichotoma. Various important Pharmacological properties including Antiulcer, Contraceptives, anti-inflammatory, anthelmintic, analgesic, anticancer, Antioxidant, antimicrobial, hepatoprotective, antidiabetic and others have been well documented for this plant. C. dichotoma is a promising source of natural antioxidants which possess remarkable therapeutic action as inflammatory activity. In the present review, we have briefly reviewed the Antioxidant Potential of C. dichotoma that can be followed for future research on this plant for health benefits. Keywords: Cordia dichotoma, Antioxidant, anti-inflammatory, flavonoids

Asian Journal of Dental and Health Sciences

This review gives concise information about the application of dendrimers as drug delivery carrie... more This review gives concise information about the application of dendrimers as drug delivery carrier in the field of drug delivery. Due to their unique architecture these have improved physical and chemical properties. Due to their terminal groups these show high solubility, miscibility and reactivity. Dendrimers have well defined size, shape, molecular weight and monodispersity. These properties make the dendrimers a suitable carrier in drug delivery application. Dendrimers are unimolecular miceller in nature and due to this enhances the solubility of poorly soluble drugs. Their compatibility with DNA, heparin and polyanions make them more versatile. Dendrimers, also referred as modern day polymers, they offer much more good properties than the conventional polymers. Due to their multivalent and mono disperse character dendrimers have stimulated wide interest in the field of chemistry biology, drug delivery, gene therapy and chemotherapy. Self-assembly produces a faster means of gene...

International Journal of Pharma Research & Review, 2015

Nanotechnology represents one of the most capable technologies of the 21st century. Recently Nano... more Nanotechnology represents one of the most capable technologies of the 21st century. Recently Nanotechnology is emerging in the field of cosmetics and it offers a revolutionize treatment of several skin diseases. It is proved effective in attaining safe and targeted delivery of active medicaments as well cosmetic ingredients. Use of carrier system in nanotechnology has added advantage of improved skin penetration, depot effect with sustained release drug action. The trend toward therapeutic cosmetics will lead to a better understanding of modern ingredients and their assessment techniques. To obtain skin care formulations with real consumer-perceivable benefits and to optimize sensory attributes, formulators are resorting to technology that until recently was exclusively used in cosmetic products. Various formulations comes under special delivery systems like Vesicular, Particulate systems, emulsions type Particulate type and other delivery systems along with their applications are s...

Journal of Biomedical and Pharmaceutical Research, 2015

The treatment of schizophrenia has advanced because the therapeutic efficacy, tolerability, and s... more The treatment of schizophrenia has advanced because the therapeutic efficacy, tolerability, and safety profiles of atypical antipsychotics. Amisulpride is an atypical antipsychotic drug, effective for positive and negative symptoms of schizophrenia with unique receptor pharmacology. As could be predicted from the pharmacologic profile of a pure D2/D3 receptor blocker. Nanoemulsion formulation containing Amisulpride was developed by ultra sonication method. Formulations were prepared using oil (oleic acid and IPM), two surfactants ( Labrasol, and Tween 20 “Smix”) and co-surfactant (PEG 400). Optimized formulation, containing 10% oil, 2:1 as Smix, co-surfactant ratio 1 and 2 as ratio of Labrasol and Tween-20 in Smix was prepared. Amisulpride is practically insoluble in water and suffers from irregular and low bioavailability (48%). The current study is aimed at developing and optimizing a Nanoemulsion formulation of amisulpride in order to improve oral absorption of amisulpride throug...

International Journal of Research and Development in Pharmacy & Life Sciences, 2017

Asian Journal of Pharmaceutical and Clinical Research, 2016

ABSTRACTObjective: The purpose of this research was to formulate and evaluate floating microspher... more ABSTRACTObjective: The purpose of this research was to formulate and evaluate floating microsphere of glipizide.Methods: Glipizide microsphere containing ethyl cellulose (EC) and hydroxyl propyl methyl cellulose (HPMC) were prepared by solvent evaporationmethod. Polymer to drug ratio affected characteristics of microspheres. Microspheres were discrete, spherical, and perforated form. The microspheresexhibited good floating property and achieved good gastric retention.Result: In vitro performance was evaluated by the usual pharmacopoeial and other tests such as drug polymer compatibility (Fourier transforminfrared scan), yield (%), micrometric properties such as tapped density (%). Compressibility particle size analysis (by optical microscopy), drugentrapment efficiency, surface topography (scanning electron microscope), and in vitro release study. On the basis of results, increasing the polymerratio increased the particle size (195.6±20.24 to 200.89±16.61), increased tapped density ...

Asian Journal of Pharmaceutical and Clinical Research, 2016

Floating microspheres (FM) were developed as dosage form capable of floating in the gastric fluid... more Floating microspheres (FM) were developed as dosage form capable of floating in the gastric fluid to increase its residence time in the stomach without contact with the mucosa. Floating microspheres were prepared by the solvent evaporation technique using different ratios of acrylic ...

International Journal of Agriculture, Environment and Biotechnology

The present investigation was carried out during Rabi season of 2014–2015 and laid out in a Rando... more The present investigation was carried out during Rabi season of 2014–2015 and laid out in a Randomized Block Design with three replications at Vegetable Research Farm, Department of Horticulture, J.N. Krishi Vishwa Vidyalaya, Jabalpur (Madhya Pradesh). The experimental material for the study was comprised of 18 novel treatments combination of Salicylic acid (SA) and Azospirillum to estimate the best treatment combination in Rabi onion under particular region. The growth parameters under present investigation noted under T17 recorded maximum plant height (cm) at 30, 60, 90,120 DAT (33.28 cm), (37.58 cm), (45.22 cm) and (48.46 cm) respectively, length of leaves (cm) at 30 DAT (32.57 cm), 60 DAT (36.29 cm) under (T17) and T11 (41.75 cm) at 60 DAT and T12 (44.15 cm) at 120 DAT respectively, maximum number of leaf at 30 DAT (8.09) in T14, 60,90 DAT (12.99,17.92) in T17 and at 120 DAT (19.37) in T11respectively, neck thickness (mm) at 120 DAT (13.71 mm) under T11, dry weight of leaf (g) at 120 DAT (3.92 g). The yield parameters also reported best under T17 as average weight of bulb (88.07g), equatorial diameter (67.38mm), polar diameter (60.37mm), double bulb(2.38%)T11, bolting per cent lowest (1.18%), A, B and C grade bulb (on weight basis) (37.22%)T5, (65.09%) and (34.19%) respectively, bulb yield polt 1(14.77kg), marketable bulb yield (26.28t/ha.) T13, total bulb yield estimated in T16 (30.47 t/ha). T11 recorded highest gross monitory return ( 450705/ha), net return ( 385020/ha) and benefit cost ratio 5.86.

In this research work, modified microsponges have been developed that release drug in controlled ... more In this research work, modified microsponges have been developed that release drug in controlled manner and enhance the bioavailability of drug. This study presents a novel colon specific drug delivery system containing prednisolone. Colon targeting is naturally of value for the topical treatment of diseases of colon such as chron’s disease, ulcerative colitis, colorectal cancer, and amebiasis. It is also valuable for the oral delivery of drugs unstable or susceptible to enzymatic degradation in upper G.I.T. tract. The advantages of targeting drug to specifically to the diseased colon are reduced incidence of systemic side-effects, lower dose of drug, supply of the drug to the biophase only when it is required and maintenance of the drug in its intact form as close as possible to the target site. That’s why improved drug delivery system is required for drugs currently in use to treat localised disease of the colon. It has been concluded that obtained microsponges work as a best dosa...

International Journal of Pharmaceutical Research and Life Sciences, 2020

Cancer is assemblage diseases involving abnormal cell growth amid the potential of spread to othe... more Cancer is assemblage diseases involving abnormal cell growth amid the potential of spread to other parts of the body due to tobacco use are the cause of about of cancer deaths. Another 10% is due to obesity, poor diet & drinking alcohol. In 2012 about 14.1 million new cases of cancer occurred globally. In females, the most common type is breast cancer. Cisplatin also known as cytophosphane is a nitrogen mustard alkylating agent from the oxazophosphinans groups were used to treat cancers & autoimmune disorders. Based on the above reasons I will fix the aim Preparation characterization of Cisplatin- nano particles & its anticancer activity. Solid tumor volume examination report showed that the assessment of different day indication 15,20,25 & 30th variations of different groups of tumor volumes were decreased CPG Nanoparticles (100 mg/kg)+ DAL(15th day 4.97±0.24↓), (20th day 0.6±0.13↓), (25th day 1.35±0.30↓) & (30th day 1.89±0.13↓).

Journal of Drug Delivery and Therapeutics, 2017

The use of phytoconstituents single or combined with standard medicines has been utilized in cure... more The use of phytoconstituents single or combined with standard medicines has been utilized in cure of different diseases. Many plants of genus Cordia comprise of trees and shrubs are widely distributed in warmer regions and have been utilized in management of various diseases. Various phytoconstituents like flavonoids, alkaloids, terpenes, tannins, and glyceridess having different activities were screened and isolated from different parts of C. dichotoma. Various important Pharmacological properties including Antiulcer, Contraceptives, anti-inflammatory, anthelmintic, analgesic, anticancer, Antioxidant, antimicrobial, hepatoprotective, antidiabetic and others have been well documented for this plant. Therefore, we have briefly reviewed the various bioactivities of C. dichotoma to improve our knowledge on plant phytochemicals as therapeutic entities. The present review describes the various phytoconstituents and therapeutic potential of C. dichotoma that can be followed for future research on this plant for human health benefits.

Original Research Article The aim of the present study was to prepare a nanoemulsion of diclofena... more Original Research Article The aim of the present study was to prepare a nanoemulsion of diclofenac sodium for reduce side effects and improved oral bioavailability to treat arthritic conditions and investigate the potential of a nanoemulsion formulation for targeting and systemic delivery of diclofenac sodium. Various oil-in-water nanoemulsions were prepared by the titration emulsification method. The nanoemulsion area was identified by constructing pseudoternary phase diagrams. The prepared nanoemulsions were subjected to different thermodynamic stability tests. The nanoemulsion formulations that passed thermodynamic stability tests were characterized for viscosity, droplet size, transmission electron microscopy, size and zeta potential, and refractive index. The physical stability of nanoemulsion was studied using autoclaving, centrifugal, desorption (dilution effect) stresses and on storage. The selected formulations, F1, F2 and F3, were relatively stable during centrifugal stres...

International Journal of Pharmacometrics and Integrated Biosciences

Opportunistic bacterial infections are common in the various parts of human body. In recent years... more Opportunistic bacterial infections are common in the various parts of human body. In recent years bacterial species have shown resistance against a number of synthetic drugs. This study measured the antibacterial activity of bacterial strains against five common pathogenic bacteria related strains. Cup plate method and two fold serial dilution method were used to evaluated by antibacterial activity by the help of different bacterial related strains. The results revealed that Cisplatin (CIP) using natural as a polymer showed a minimum inhibitory concentration (MIC) at 250 mg/ml to 500 mg/ml of the broth against all bacterial strains. CIP using natural as a polymer was prepared different doses1000 μg/ml and 2000 μg/ ml and measured zone of inhibition dose dementedly reduced when compared to standard. The CIP using natural as a polymer exhibited strong anti-bacterial activity against five different species of bacteria and this may be attributed to various active components. Our researc...

Journal of Drug Delivery and Therapeutics

Aims: Apocynaceae family is the 5th largest medicinal plant family rich in potent secondary metab... more Aims: Apocynaceae family is the 5th largest medicinal plant family rich in potent secondary metabolites such as Alkaloids, Cardiac glycosides,Terpenoids, irridoid/secoirridoids, flavonoids and Phenolic contents. The present study was aimed to evaluate and compare in-vitroantiproliferative activity of three plants of this family.Methods: Aerial parts of Carissa carandas Linn. (C), Nerium indicum Mill. (N) and Wrightia tinctoria RBr. (W), were collected and dried. Thepowdered drugs were extracted in Ethanol (1), 60% Ethanol (2) and Water (3). Estimation of Phytoconstituents performed using standardmethods. In-vitro cytotoxic activity performed using Sulphorhodamine B (SRB) assay in HepG2, HT29 and SKOV3 human cancer cell lines takingAdriamycin (ADR) as standard. For extracts, GI50 value ≤ 20μg/ml was considered to demonstrate activity.Results: For HepG2 cell line graphs and photomicrographs showed GI50 value as ADR=39.79, C1=2.5, N2=66.3, N3<10 and C2=C3= N1=W1-3>80. Also TGI fo...

Advances In Pharmaceutical Research

Journal of Drug Delivery Science and Technology

Molecular pharmaceutics, Nov 7, 2016

Vesicular and colloidal delivery systems can be designed to control drug release spatially and te... more Vesicular and colloidal delivery systems can be designed to control drug release spatially and temporally to improve drug efficacy and side effect profiles. Niosomes (vesicles prepared from nonionic surfactants in aqueous media) are gaining interest as an alternative vesicular delivery system as they offer advantages such as biocompatibility, chemical stability, low cost, high purity, and versatility. However, the physical stability of niosomes, like other vesicular systems, is limited by vesicle fusion, aggregation, and leakage. Proniosomes (dehydrated powder or gel formulations that spontaneously form niosomes on hydration with aqueous media) can overcome these physical stability problems and are more convenient for sterilization, storage, transport, distribution, and dosing. Proniosomes have mostly been explored for their potential to enhance transdermal and oral absorption. In this study we assess, for the first time, the potential for hydrated proniosomes to sustain systemic ex...

Journal of Drug Delivery Science and Technology, 2016