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Research paper thumbnail of A Molecular Electrostatic Potential Analysis of Hydrogen, Halogen, and Dihydrogen Bonds

Hydrogen, halogen, and dihydrogen bonds in weak, medium and strong regimes (<1 to ∼60 kcal/mol) h... more Hydrogen, halogen, and dihydrogen bonds in weak, medium and strong regimes (<1 to ∼60 kcal/mol) have been investigated for several intermolecular donor−acceptor (D-A) complexes at ab initio MP4//MP2 method coupled with atoms-in-molecules and molecular electrostatic potential (MESP) approaches. Electron density ρ at bond critical point correlates well with interaction energy (E nb ) for each homogeneous sample of complexes, but its applicability to the entire set of complexes is not satisfactory. Analysis of MESP minimum (V min ) and MESP at the nuclei (V n ) shows that in all D-A complexes, MESP of A becomes more negative and that of D becomes less negative suggesting donation of electrons from D to A leading to electron donor−acceptor (eDA) interaction between A and D. MESP based parameter ΔΔV n measures donor−acceptor strength of the eDA interactions as it shows a good linear correlation with E nb for all D-A complexes (R 2 = 0.976) except the strongly bound bridged structures. The bridged structures are classified as donor−acceptor−donor complexes. MESP provides a clear evidence for hydrogen, halogen, and dihydrogen bond formation and defines them as eDA interactions in which hydrogen acts as electron acceptor in hydrogen and dihydrogen bonds while halogen acts as electron acceptor in halogen bonds. − (electron donors) with different electron acceptors. Throughout this paper, E nb represents the interaction energy calculated at MP4//MP2 method and the standard notations ρ and ∇ 2 ρ are used to indicate the electron density at the bond critical point (bcp) of the electron donor−acceptor bond and the Laplacian of the electron density at the bcp. Figure 7. Change in V min upon bond formation in electron donor−acceptor−donor complexes (a) F − ...IF and (b) F − ...IBr. The black dots represent the location of the most negative MESP-valued point and the corresponding V min values in kcal/mol are also depicted.

Research paper thumbnail of A Molecular Electrostatic Potential Analysis of Hydrogen, Halogen, and Dihydrogen Bonds

Hydrogen, halogen, and dihydrogen bonds in weak, medium and strong regimes (<1 to ∼60 kcal/mol) h... more Hydrogen, halogen, and dihydrogen bonds in weak, medium and strong regimes (<1 to ∼60 kcal/mol) have been investigated for several intermolecular donor−acceptor (D-A) complexes at ab initio MP4//MP2 method coupled with atoms-in-molecules and molecular electrostatic potential (MESP) approaches. Electron density ρ at bond critical point correlates well with interaction energy (E nb ) for each homogeneous sample of complexes, but its applicability to the entire set of complexes is not satisfactory. Analysis of MESP minimum (V min ) and MESP at the nuclei (V n ) shows that in all D-A complexes, MESP of A becomes more negative and that of D becomes less negative suggesting donation of electrons from D to A leading to electron donor−acceptor (eDA) interaction between A and D. MESP based parameter ΔΔV n measures donor−acceptor strength of the eDA interactions as it shows a good linear correlation with E nb for all D-A complexes (R 2 = 0.976) except the strongly bound bridged structures. The bridged structures are classified as donor−acceptor−donor complexes. MESP provides a clear evidence for hydrogen, halogen, and dihydrogen bond formation and defines them as eDA interactions in which hydrogen acts as electron acceptor in hydrogen and dihydrogen bonds while halogen acts as electron acceptor in halogen bonds. − (electron donors) with different electron acceptors. Throughout this paper, E nb represents the interaction energy calculated at MP4//MP2 method and the standard notations ρ and ∇ 2 ρ are used to indicate the electron density at the bond critical point (bcp) of the electron donor−acceptor bond and the Laplacian of the electron density at the bcp. Figure 7. Change in V min upon bond formation in electron donor−acceptor−donor complexes (a) F − ...IF and (b) F − ...IBr. The black dots represent the location of the most negative MESP-valued point and the corresponding V min values in kcal/mol are also depicted.

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