Suzan Attar - Academia.edu (original) (raw)

Papers by Suzan Attar

Research paper thumbnail of Tetracyclines: what a rheumatologist needs to know?

International Journal of Rheumatic Diseases, Jul 1, 2009

Tetracyclines are broad-spectrum antibiotics that act at the ribosomal level. They were first int... more Tetracyclines are broad-spectrum antibiotics that act at the ribosomal level. They were first introduced in 1948 and were widely prescribed by dermatologists in the early 1950s for treatment of acne. More recently, biologic actions of tetracyclines affecting inflammation, angiogenesis, and bone metabolism have been researched. The therapeutic effects of tetracycline and its analogues in rheumatic diseases have also been investigated. This article will review the rheumatological use of tetracycline and its analogues.

Research paper thumbnail of Extra-articular manifestations of rheumatoid arthritis: a hospital-based study

Annals of Saudi Medicine, May 1, 2009

Research paper thumbnail of Effectiveness of screening in patients with rheumatic disease on biological therapy and risk of active tuberculosis

Annals of Rheumatology and Autoimmunity

Research paper thumbnail of Preferred Mode of Therapy Among Patients in Rheumatoid Arthritis Saudi Database: A Cross-Sectional Study

Cureus

Aims and objectives: Current knowledge of patients' preferences for rheumatoid arthritis (RA) tre... more Aims and objectives: Current knowledge of patients' preferences for rheumatoid arthritis (RA) treatment is limited. Our goal was to determine the most favorable mode of therapy and the reasons behind choosing each route among RA patients in the Rheumatoid Arthritis Saudi Database (RASD). Materials and methods: In this cross-sectional, nationwide, qualitative study, we conducted interviews with 308 RA patients to assess their preferred mode of therapy (oral, subcutaneous (SC) injection, or intravenous (IV) infusion) and to determine the reasons behind their choice. The determining factors behind patients' preferred mode of therapy were evaluated using a 10-point allocation system (1 = least important, 10 = most important). Results: We interviewed 308 RA patients (83.4% females, mean age, 48 years). Among all administration modes, the oral route was identified as the most preferred mode among our patients, with a percentage of 73.3%, followed by SC injection and IV infusion at 19.5% and 7.3%, respectively. Ease of drug administration was the most reported reason for patients who chose the oral route over the injection route (63.2%). Difficulty remembering to take the drug and finding it hard to swallow the pills were the highest-scored reasons for avoiding the oral route (24.9%). Conclusion: Our study demonstrates and emphasizes the importance of shared decision-making between patients and their physicians. The oral route of therapy is, by far, the most preferred mode among our cohort of RA patients.

Research paper thumbnail of Comparison of the anti-cyclic citrullinated peptide and rheumatoid factor in rheumatoid arthritis at an arthritis center

Saudi Medical Journal, Mar 1, 2009

Research paper thumbnail of PS7:139 Efficacy and safety of rituximab in resistant sle

Research paper thumbnail of The value of single complement testing in SLE

Kuwait Medical Journal, 2010

Research paper thumbnail of Comparison of the anti-cyclic citrullinated peptide and rheumatoid factor in rheumatoid arthritis at an arthritis center

Saudi Medical Journal, Mar 1, 2009

Research paper thumbnail of Hyperlipidemia in rheumatoid arthritis patients in Saudi Arabia

Saudi Medical Journal, Jun 1, 2015

Objectives: To determine the prevalence of hyperlipidemia in patients from Saudi Arabia with rheu... more Objectives: To determine the prevalence of hyperlipidemia in patients from Saudi Arabia with rheumatoid arthritis)RA(, and to investigate its relationship with C-reactive protein level and disease activity.

Research paper thumbnail of Adverse effects of low dose methotrexate in rheumatoid arthritis patients. A hospital-based study

PubMed, Aug 1, 2010

Objective: To evaluate the side effects of methotrexate (MTX) in rheumatoid arthritis (RA) patien... more Objective: To evaluate the side effects of methotrexate (MTX) in rheumatoid arthritis (RA) patients and to evaluate the possible predisposing variables. Methods: A retrospective analysis conducted for all patients diagnosed with RA and treated with MTX over 3-years (January 2006 to December 2008) at King Abdul-Aziz University Hospital, Jeddah, Kingdom of Saudi Arabia. Frequency of MTX side effects and the predictive variables were recorded and analyzed statistically. Results: Out of 116 RA patients, 71 patients used MTX. The most frequent side effect was gastrointestinal (GIT) disturbance in 31%, followed by central nervous system symptoms in 18%, hepatotoxicity in 14%, stomatitis and alopecia in 10% each, macrocytosis 7%, fever, malar rash and pancytopenia in 4%, and MTX-induced lung injury with increase in the size of rheumatoid nodule in 1% of patients. By Logistic regression analysis, renal impairment was the most significant variable increasing the risk of the side effects (OR=7.14, p<0.05). Other associated variables were male-gender, non-Saudi nationality, smoking, steroids use, hypoalbuminemia, and the presence of extra-articular manifestations. Conclusion: Methotrexate is the most commonly drug used in the treatment of RA. Gastrointestinal disturbances were the most common side effect while lung involvement was the least. The impact of each clinical variable on MTX side effects requires paying more attention on the disease management as not all variables can be considered as risk factors.

Research paper thumbnail of Vitamin D deficiency in rheumatoid arthritis. Prevalence and association with disease activity in Western Saudi Arabia

PubMed, May 1, 2012

Objective: To estimate the prevalence of low serum vitamin D level (25[OH]D) in patients with rhe... more Objective: To estimate the prevalence of low serum vitamin D level (25[OH]D) in patients with rheumatoid arthritis (RA) compared with healthy controls, and to analyze the association between 25(OH)D and disease activity. Methods: This retrospective analysis included 100 RA patients (85% women) and 100 controls, not on vitamin D supplements from January 2010 to December 2011 at a tertiary care center at the Department of Internal Medicine, King Abdulaziz University Hospital (KAUH), Jeddah, Kingdom of Saudi Arabia. Disease activity was measured using the disease activity score index (DAS28). According to the DAS28 score, RA patients were divided into 3 groups as high, moderate, and low disease activity. Patients' serum 25(OH)D was measured in a centralized laboratory. Results: The mean 25(OH)D in patients with RA was similar to the control group (32.3+/-14.4 nmol/L) versus (31.4+/-16.4 nmol/L) (p=0.41). Patients with high disease activity had the lowest 25(OH)D levels (18.25+/-8.3 nmol/L) compared with patients with moderate (35.13+/-15.2 nmol/L) and low (38.05+/-7.3 nmol/L) disease activity (p<0.001). Serum 25(OH)D was negatively correlated with DAS28, which was statistically significant (r= -0.42, p<0.0001). Conclusion: Serum vitamin D levels in RA patients were similar to the healthy control group. However, significantly lower 25(OH)D values were found in patients who are poorly responding to treatment, and not in a state of disease remission.

Research paper thumbnail of Musculoskeletal manifestations in diabetic patients at a tertiary center

Libyan Journal of Medicine, 2012

Objectives: Diabetes mellitus is a major public health problem worldwide. Most diabetic patients ... more Objectives: Diabetes mellitus is a major public health problem worldwide. Most diabetic patients will develop functional disabilities due to multiple factors, including musculoskeletal (MSK) manifestations. The purpose of this study was to determine the frequency of MSK in diabetic patients and to examine the possible predictors for its development. Methods: We performed a cross-sectional study from June 1, 2010, to June 30, 2011, to evaluate MSK manifestations in adult diabetic patients at an outpatient clinic of

Research paper thumbnail of Burden and Disease Characteristics of Psoriatic Arthritis Among King Abdulaziz University Hospital Patients

Cureus, Jul 27, 2022

Background: Psoriatic arthritis (PsA) has a detrimental influence on the quality of life (QoL). T... more Background: Psoriatic arthritis (PsA) has a detrimental influence on the quality of life (QoL). The goal of this study was to evaluate the QoL of patients with PsA and its determinants at the King Abdulaziz University Hospital in Jeddah, Saudi Arabia. Methods: A cross-sectional study was conducted on 60 PsA patients. A questionnaire was used to collect data about their demographics. Assessment of health-related quality of life (HRQOL) was done by the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36). The Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue and the FACIT-General (FACIT-G) scales were used to assess fatigue. The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) was used to assess disease activity.

Research paper thumbnail of Vitamin D Deficiency in Patients with Systemic Lupus Erythematosus

Oman Medical Journal, Jan 16, 2013

Objectives: Hypovitaminosis D is common in the general population. Many studies that have been co... more Objectives: Hypovitaminosis D is common in the general population. Many studies that have been conducted to show the association between vitamin D deficiency and systemic lupus erythematosus (SLE) reveal that deficiencies in vitamin D are common in this group of patients. Our aim was to study the relationship between 25(OH)D and disease activity in patients with SLE. Methods: Retrospective cohort study of patients with SLE who were followed up at King Abdulaziz University Hospital, Jeddah, from January 2007 to November 2010. Demographic and clinical data were recorded and the 25(OH)D levels of the patients were measured. Chi square tests, Student' s t-test, ANOVA and Pearson tests were used for data analysis. ANOVA test was followed by Bonferroni correction. A p-value <0.05 was considered significant. Results: Ninety-five patients with SLE were enrolled in the study. The levels of 25(OH)D were significantly lower in patients with active SLE (n=41; 43%) than in those with inactive disease (n=54; 57%; p=0.04). The mean (SD) levels were 22.3 (14) nmol/L for patients with active disease against 25.0 (14) nmol/L for patients with inactive SLE. No correlation was detected between 25(OH) D levels and disease activity score evaluated by SLEDAI-2K. By Pearson correlation, a significant negative correlation existed between 25(OH) D and anti ds-DNA (r=-0.38; p<0.001); a positive correlation existed between 25(OH)D levels and C4 (r=0.25; p=0.25). By chi square testing, azathioprine treatment (OR=3.5), low C4 (OR= 2.23), low C3 (OR=1.92), and active disease (OR=1.6) were associated with 25(OH)D deficiency in SLE patients. Conclusion: Vitamin D deficiency is frequent in patients with SLE. Patients with SLE have a higher risk of developing 25(OH)D deficiency in the presence of low serum C3 and C4 levels, and high anti-dsDNA levels.

Research paper thumbnail of Prevalence of obstructive sleep apnea in patients with rheumatoid arthritis

Sleep Medicine, Dec 1, 2019

ABSTRACT Chronic non-healing wounds are a major human and economic burden. Obstructive sleep apne... more ABSTRACT Chronic non-healing wounds are a major human and economic burden. Obstructive sleep apnea (OSA) is prevalent in patients with obesity, diabetes, aging, and cardiovascular disease, all of which are risk factors for chronic wounds. We hypothesized that OSA would have more prevalence in patients of a wound center than the general middle-aged population. Consecutive patients of the Ohio State University Comprehensive Wound Center (CWC) were surveyed with the Berlin and Epworth questionnaires. In the second stage of the protocol, 50 consecutive unselected CWC patients with lower extremity wounds underwent home sleep studies. In 249 patients of the CWC who underwent the survey study, OSA had been previously diagnosed in only 22%. The prevalence of high-risk status based on questionnaires for OSA was 46% (95% CI 40%, 52%). In the 50 patients who underwent home sleep studies, and using an apnea hypopnea index of 15 events per hour, the prevalence of OSA was 57% (95% CI 42%, 71%). There was no difference between the Berlin questionnaire score and weight between patients with OSA and those without. The prevalence of OSA in patients with chronic wounds exceeds the estimated prevalence of OSA in the general middle aged population. This study identifies a previously unrecognized population with high risk for OSA. Commonly used questionnaires were not sufficiently sensitive for the detection of high risk status for OSA in this patient population.

Research paper thumbnail of Vitamin D and Autoimmune Disease

InTech eBooks, Jan 13, 2012

Research paper thumbnail of Plantar Fasciitis

Saudi Journal of Internal Medicine, Jun 30, 2012

Plantar fasciitis is a common cause of heel pain in adults. It is a clinical diagnosis, as patien... more Plantar fasciitis is a common cause of heel pain in adults. It is a clinical diagnosis, as patients classically presents with pain that is particularly severe with the first few steps in the morning. Although it is a self-limited condition; however, due to the severity of the pain, medical attention is sought. Symptoms will ease quicker if risk factors are adjusted and multiple treatment modalities are started as early as possible. This article reviews plantar fasciitis; presents the most effective treatment options currently available.

Research paper thumbnail of Anti-Mutated Citrullinated Vimentin Antibody and Rheumatoid Factor (Prevalence and Association) in Rheumatoid Arthritis Patients; Saudi and Non-Saudi

Clinical Laboratory, 2015

background: The aims of this study were to assess the prevalence of anti-mutated citrullinated vi... more background: The aims of this study were to assess the prevalence of anti-mutated citrullinated vimentin (MCV) antibodies and rheumatoid factor (RF) and to evaluate their association in rheumatoid arthritis patients, both Saudi and non-Saudi. Retrospectively, we studied 280 rheumatoid arthritis patients, at King Abdulaziz University Hospital. The antibodies were measured by enzyme linked immunosorbent assay and rheumatoid factor by nephelometry. The 280 patients included 196 Saudis and 84 non-Saudis, 88% females and 12% males, and the mean age was 45.3 years (SD = 14.3). Prevalence of rheumatoid factor was 141/280 (50%) divided as 93/196 (47.5%) Saudis and 48/84 (57%) non-Saudis, with no significant differences (p &gt; 0.05). Prevalence of mutated citrullinated vimentin antibodies was 165/280 (58.2%) divided as 121/196 (61.7%) Saudis and 44/84 (52.4%) non-Saudis, with no significant differences (p &gt; 0.05). Among RF -ve patients, considerable numbers were anti-MCV +ve, and vice versa. Also, among the anti-MCV -ve patients, considerable numbers were RF +ve, and vice versa. In all cohorts and in Saudi and non Saudi patients, anti-MCV positivity was significantly associated with RF positivity (odds ratio (OR) 3.15; 95% CI 1.9, 5.19/p = 0.000); ESR and CRP were high with significant correlation (p &lt; 0.005) with each other, with RF positivity but not with anti-MC positivity. Anti-MC positivity showed no significant correlation with age and gender. In this cohort of patients, anti-MCV antibodies are a useful diagnostic tool for RA, but its combination with RF is essential. Both markers are significantly associated. Larger scale studies are recommended. Correlation of anti-MCV with treatment and with disease activity still has to be published.

Research paper thumbnail of Radiological changes in rheumatoid arthritis patients at a teaching hospital in Saudi Arabia

Eastern Mediterranean Health Journal, Sep 1, 2010

The frequency of radiological changes of the hands and the feet were investigated in a well-defin... more The frequency of radiological changes of the hands and the feet were investigated in a well-defined hospital population of patients with rheumatoid arthritis in Jeddah, Saudi Arabia. A total of 57 patients who fulfilled the American College of Rheumatology 1987 criteria for the diagnosis of rheumatoid arthritis were randomly chosen from the rheumatology outpatient clinic at King AbdulAziz University Hospital. Erosions were seen in 60% of the patients and periarticular osteopenia in 34%; deformity and soft tissue swelling were present in 26% and 14% of patients respectively. The proportion with erosions is lower than data reported from Western European and North American populations but higher than previous data from the Central region of Saudi Arabia.

Research paper thumbnail of Frequency and risk factors of musculoskeletal pain in nurses at a tertiary centre in Jeddah, Saudi Arabia: a cross sectional study

BMC Research Notes, Jan 25, 2014

Background: Musculoskeletal complaints are an important occupational problem; nevertheless, few s... more Background: Musculoskeletal complaints are an important occupational problem; nevertheless, few studies have targeted nurses in Saudi Arabia. The aim of this study was to determine the frequency and risk factors of work-related musculoskeletal disorders (WMSDs) among nursing personnel at a tertiary centre in Jeddah. Methods: A comparative cross-sectional study was performed in which full-time registered nurses from four different departments (n = 200) were selected for analysis between September 1, 2011 and February 29, 2012. Musculoskeletal symptoms over the past year were assessed using the Nordic Standardised Musculoskeletal Questionnaire. In addition to demographic questions, the researcher evaluated employment history, physical risk factors at work, and general health status. Results: In this study, approximately 85% of the nurses reported experiencing at least one musculoskeletal symptom. Musculoskeletal symptoms occurred most commonly in the lower back (65.7%), ankles and feet (41.5%), and shoulders (29%). Prolonged working hours and being underweight were significantly associated with the development of these symptoms (OR 3.66, 95% CI 1.24-10.79, P = 0.018, and OR 2.66, 95% CI 1.37-5.93, P = 0.004, respectively). Working in the surgical department was a greater risk factor for low back pain compared with working in other departments. Conclusions: WMSDs are common among our nurses, and back pain is the most common symptom. As prolonged working hours and being underweight were factors that contributed most to WMSDs, decreasing shift durations or offering nutrition educational programmes may be suitable solutions. However, further studies are required to examine the best modality for decreasing the occurrence of WMSDs.

Research paper thumbnail of Tetracyclines: what a rheumatologist needs to know?

International Journal of Rheumatic Diseases, Jul 1, 2009

Tetracyclines are broad-spectrum antibiotics that act at the ribosomal level. They were first int... more Tetracyclines are broad-spectrum antibiotics that act at the ribosomal level. They were first introduced in 1948 and were widely prescribed by dermatologists in the early 1950s for treatment of acne. More recently, biologic actions of tetracyclines affecting inflammation, angiogenesis, and bone metabolism have been researched. The therapeutic effects of tetracycline and its analogues in rheumatic diseases have also been investigated. This article will review the rheumatological use of tetracycline and its analogues.

Research paper thumbnail of Extra-articular manifestations of rheumatoid arthritis: a hospital-based study

Annals of Saudi Medicine, May 1, 2009

Research paper thumbnail of Effectiveness of screening in patients with rheumatic disease on biological therapy and risk of active tuberculosis

Annals of Rheumatology and Autoimmunity

Research paper thumbnail of Preferred Mode of Therapy Among Patients in Rheumatoid Arthritis Saudi Database: A Cross-Sectional Study

Cureus

Aims and objectives: Current knowledge of patients' preferences for rheumatoid arthritis (RA) tre... more Aims and objectives: Current knowledge of patients' preferences for rheumatoid arthritis (RA) treatment is limited. Our goal was to determine the most favorable mode of therapy and the reasons behind choosing each route among RA patients in the Rheumatoid Arthritis Saudi Database (RASD). Materials and methods: In this cross-sectional, nationwide, qualitative study, we conducted interviews with 308 RA patients to assess their preferred mode of therapy (oral, subcutaneous (SC) injection, or intravenous (IV) infusion) and to determine the reasons behind their choice. The determining factors behind patients' preferred mode of therapy were evaluated using a 10-point allocation system (1 = least important, 10 = most important). Results: We interviewed 308 RA patients (83.4% females, mean age, 48 years). Among all administration modes, the oral route was identified as the most preferred mode among our patients, with a percentage of 73.3%, followed by SC injection and IV infusion at 19.5% and 7.3%, respectively. Ease of drug administration was the most reported reason for patients who chose the oral route over the injection route (63.2%). Difficulty remembering to take the drug and finding it hard to swallow the pills were the highest-scored reasons for avoiding the oral route (24.9%). Conclusion: Our study demonstrates and emphasizes the importance of shared decision-making between patients and their physicians. The oral route of therapy is, by far, the most preferred mode among our cohort of RA patients.

Research paper thumbnail of Comparison of the anti-cyclic citrullinated peptide and rheumatoid factor in rheumatoid arthritis at an arthritis center

Saudi Medical Journal, Mar 1, 2009

Research paper thumbnail of PS7:139 Efficacy and safety of rituximab in resistant sle

Research paper thumbnail of The value of single complement testing in SLE

Kuwait Medical Journal, 2010

Research paper thumbnail of Comparison of the anti-cyclic citrullinated peptide and rheumatoid factor in rheumatoid arthritis at an arthritis center

Saudi Medical Journal, Mar 1, 2009

Research paper thumbnail of Hyperlipidemia in rheumatoid arthritis patients in Saudi Arabia

Saudi Medical Journal, Jun 1, 2015

Objectives: To determine the prevalence of hyperlipidemia in patients from Saudi Arabia with rheu... more Objectives: To determine the prevalence of hyperlipidemia in patients from Saudi Arabia with rheumatoid arthritis)RA(, and to investigate its relationship with C-reactive protein level and disease activity.

Research paper thumbnail of Adverse effects of low dose methotrexate in rheumatoid arthritis patients. A hospital-based study

PubMed, Aug 1, 2010

Objective: To evaluate the side effects of methotrexate (MTX) in rheumatoid arthritis (RA) patien... more Objective: To evaluate the side effects of methotrexate (MTX) in rheumatoid arthritis (RA) patients and to evaluate the possible predisposing variables. Methods: A retrospective analysis conducted for all patients diagnosed with RA and treated with MTX over 3-years (January 2006 to December 2008) at King Abdul-Aziz University Hospital, Jeddah, Kingdom of Saudi Arabia. Frequency of MTX side effects and the predictive variables were recorded and analyzed statistically. Results: Out of 116 RA patients, 71 patients used MTX. The most frequent side effect was gastrointestinal (GIT) disturbance in 31%, followed by central nervous system symptoms in 18%, hepatotoxicity in 14%, stomatitis and alopecia in 10% each, macrocytosis 7%, fever, malar rash and pancytopenia in 4%, and MTX-induced lung injury with increase in the size of rheumatoid nodule in 1% of patients. By Logistic regression analysis, renal impairment was the most significant variable increasing the risk of the side effects (OR=7.14, p<0.05). Other associated variables were male-gender, non-Saudi nationality, smoking, steroids use, hypoalbuminemia, and the presence of extra-articular manifestations. Conclusion: Methotrexate is the most commonly drug used in the treatment of RA. Gastrointestinal disturbances were the most common side effect while lung involvement was the least. The impact of each clinical variable on MTX side effects requires paying more attention on the disease management as not all variables can be considered as risk factors.

Research paper thumbnail of Vitamin D deficiency in rheumatoid arthritis. Prevalence and association with disease activity in Western Saudi Arabia

PubMed, May 1, 2012

Objective: To estimate the prevalence of low serum vitamin D level (25[OH]D) in patients with rhe... more Objective: To estimate the prevalence of low serum vitamin D level (25[OH]D) in patients with rheumatoid arthritis (RA) compared with healthy controls, and to analyze the association between 25(OH)D and disease activity. Methods: This retrospective analysis included 100 RA patients (85% women) and 100 controls, not on vitamin D supplements from January 2010 to December 2011 at a tertiary care center at the Department of Internal Medicine, King Abdulaziz University Hospital (KAUH), Jeddah, Kingdom of Saudi Arabia. Disease activity was measured using the disease activity score index (DAS28). According to the DAS28 score, RA patients were divided into 3 groups as high, moderate, and low disease activity. Patients' serum 25(OH)D was measured in a centralized laboratory. Results: The mean 25(OH)D in patients with RA was similar to the control group (32.3+/-14.4 nmol/L) versus (31.4+/-16.4 nmol/L) (p=0.41). Patients with high disease activity had the lowest 25(OH)D levels (18.25+/-8.3 nmol/L) compared with patients with moderate (35.13+/-15.2 nmol/L) and low (38.05+/-7.3 nmol/L) disease activity (p<0.001). Serum 25(OH)D was negatively correlated with DAS28, which was statistically significant (r= -0.42, p<0.0001). Conclusion: Serum vitamin D levels in RA patients were similar to the healthy control group. However, significantly lower 25(OH)D values were found in patients who are poorly responding to treatment, and not in a state of disease remission.

Research paper thumbnail of Musculoskeletal manifestations in diabetic patients at a tertiary center

Libyan Journal of Medicine, 2012

Objectives: Diabetes mellitus is a major public health problem worldwide. Most diabetic patients ... more Objectives: Diabetes mellitus is a major public health problem worldwide. Most diabetic patients will develop functional disabilities due to multiple factors, including musculoskeletal (MSK) manifestations. The purpose of this study was to determine the frequency of MSK in diabetic patients and to examine the possible predictors for its development. Methods: We performed a cross-sectional study from June 1, 2010, to June 30, 2011, to evaluate MSK manifestations in adult diabetic patients at an outpatient clinic of

Research paper thumbnail of Burden and Disease Characteristics of Psoriatic Arthritis Among King Abdulaziz University Hospital Patients

Cureus, Jul 27, 2022

Background: Psoriatic arthritis (PsA) has a detrimental influence on the quality of life (QoL). T... more Background: Psoriatic arthritis (PsA) has a detrimental influence on the quality of life (QoL). The goal of this study was to evaluate the QoL of patients with PsA and its determinants at the King Abdulaziz University Hospital in Jeddah, Saudi Arabia. Methods: A cross-sectional study was conducted on 60 PsA patients. A questionnaire was used to collect data about their demographics. Assessment of health-related quality of life (HRQOL) was done by the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36). The Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue and the FACIT-General (FACIT-G) scales were used to assess fatigue. The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) was used to assess disease activity.

Research paper thumbnail of Vitamin D Deficiency in Patients with Systemic Lupus Erythematosus

Oman Medical Journal, Jan 16, 2013

Objectives: Hypovitaminosis D is common in the general population. Many studies that have been co... more Objectives: Hypovitaminosis D is common in the general population. Many studies that have been conducted to show the association between vitamin D deficiency and systemic lupus erythematosus (SLE) reveal that deficiencies in vitamin D are common in this group of patients. Our aim was to study the relationship between 25(OH)D and disease activity in patients with SLE. Methods: Retrospective cohort study of patients with SLE who were followed up at King Abdulaziz University Hospital, Jeddah, from January 2007 to November 2010. Demographic and clinical data were recorded and the 25(OH)D levels of the patients were measured. Chi square tests, Student' s t-test, ANOVA and Pearson tests were used for data analysis. ANOVA test was followed by Bonferroni correction. A p-value <0.05 was considered significant. Results: Ninety-five patients with SLE were enrolled in the study. The levels of 25(OH)D were significantly lower in patients with active SLE (n=41; 43%) than in those with inactive disease (n=54; 57%; p=0.04). The mean (SD) levels were 22.3 (14) nmol/L for patients with active disease against 25.0 (14) nmol/L for patients with inactive SLE. No correlation was detected between 25(OH) D levels and disease activity score evaluated by SLEDAI-2K. By Pearson correlation, a significant negative correlation existed between 25(OH) D and anti ds-DNA (r=-0.38; p<0.001); a positive correlation existed between 25(OH)D levels and C4 (r=0.25; p=0.25). By chi square testing, azathioprine treatment (OR=3.5), low C4 (OR= 2.23), low C3 (OR=1.92), and active disease (OR=1.6) were associated with 25(OH)D deficiency in SLE patients. Conclusion: Vitamin D deficiency is frequent in patients with SLE. Patients with SLE have a higher risk of developing 25(OH)D deficiency in the presence of low serum C3 and C4 levels, and high anti-dsDNA levels.

Research paper thumbnail of Prevalence of obstructive sleep apnea in patients with rheumatoid arthritis

Sleep Medicine, Dec 1, 2019

ABSTRACT Chronic non-healing wounds are a major human and economic burden. Obstructive sleep apne... more ABSTRACT Chronic non-healing wounds are a major human and economic burden. Obstructive sleep apnea (OSA) is prevalent in patients with obesity, diabetes, aging, and cardiovascular disease, all of which are risk factors for chronic wounds. We hypothesized that OSA would have more prevalence in patients of a wound center than the general middle-aged population. Consecutive patients of the Ohio State University Comprehensive Wound Center (CWC) were surveyed with the Berlin and Epworth questionnaires. In the second stage of the protocol, 50 consecutive unselected CWC patients with lower extremity wounds underwent home sleep studies. In 249 patients of the CWC who underwent the survey study, OSA had been previously diagnosed in only 22%. The prevalence of high-risk status based on questionnaires for OSA was 46% (95% CI 40%, 52%). In the 50 patients who underwent home sleep studies, and using an apnea hypopnea index of 15 events per hour, the prevalence of OSA was 57% (95% CI 42%, 71%). There was no difference between the Berlin questionnaire score and weight between patients with OSA and those without. The prevalence of OSA in patients with chronic wounds exceeds the estimated prevalence of OSA in the general middle aged population. This study identifies a previously unrecognized population with high risk for OSA. Commonly used questionnaires were not sufficiently sensitive for the detection of high risk status for OSA in this patient population.

Research paper thumbnail of Vitamin D and Autoimmune Disease

InTech eBooks, Jan 13, 2012

Research paper thumbnail of Plantar Fasciitis

Saudi Journal of Internal Medicine, Jun 30, 2012

Plantar fasciitis is a common cause of heel pain in adults. It is a clinical diagnosis, as patien... more Plantar fasciitis is a common cause of heel pain in adults. It is a clinical diagnosis, as patients classically presents with pain that is particularly severe with the first few steps in the morning. Although it is a self-limited condition; however, due to the severity of the pain, medical attention is sought. Symptoms will ease quicker if risk factors are adjusted and multiple treatment modalities are started as early as possible. This article reviews plantar fasciitis; presents the most effective treatment options currently available.

Research paper thumbnail of Anti-Mutated Citrullinated Vimentin Antibody and Rheumatoid Factor (Prevalence and Association) in Rheumatoid Arthritis Patients; Saudi and Non-Saudi

Clinical Laboratory, 2015

background: The aims of this study were to assess the prevalence of anti-mutated citrullinated vi... more background: The aims of this study were to assess the prevalence of anti-mutated citrullinated vimentin (MCV) antibodies and rheumatoid factor (RF) and to evaluate their association in rheumatoid arthritis patients, both Saudi and non-Saudi. Retrospectively, we studied 280 rheumatoid arthritis patients, at King Abdulaziz University Hospital. The antibodies were measured by enzyme linked immunosorbent assay and rheumatoid factor by nephelometry. The 280 patients included 196 Saudis and 84 non-Saudis, 88% females and 12% males, and the mean age was 45.3 years (SD = 14.3). Prevalence of rheumatoid factor was 141/280 (50%) divided as 93/196 (47.5%) Saudis and 48/84 (57%) non-Saudis, with no significant differences (p &gt; 0.05). Prevalence of mutated citrullinated vimentin antibodies was 165/280 (58.2%) divided as 121/196 (61.7%) Saudis and 44/84 (52.4%) non-Saudis, with no significant differences (p &gt; 0.05). Among RF -ve patients, considerable numbers were anti-MCV +ve, and vice versa. Also, among the anti-MCV -ve patients, considerable numbers were RF +ve, and vice versa. In all cohorts and in Saudi and non Saudi patients, anti-MCV positivity was significantly associated with RF positivity (odds ratio (OR) 3.15; 95% CI 1.9, 5.19/p = 0.000); ESR and CRP were high with significant correlation (p &lt; 0.005) with each other, with RF positivity but not with anti-MC positivity. Anti-MC positivity showed no significant correlation with age and gender. In this cohort of patients, anti-MCV antibodies are a useful diagnostic tool for RA, but its combination with RF is essential. Both markers are significantly associated. Larger scale studies are recommended. Correlation of anti-MCV with treatment and with disease activity still has to be published.

Research paper thumbnail of Radiological changes in rheumatoid arthritis patients at a teaching hospital in Saudi Arabia

Eastern Mediterranean Health Journal, Sep 1, 2010

The frequency of radiological changes of the hands and the feet were investigated in a well-defin... more The frequency of radiological changes of the hands and the feet were investigated in a well-defined hospital population of patients with rheumatoid arthritis in Jeddah, Saudi Arabia. A total of 57 patients who fulfilled the American College of Rheumatology 1987 criteria for the diagnosis of rheumatoid arthritis were randomly chosen from the rheumatology outpatient clinic at King AbdulAziz University Hospital. Erosions were seen in 60% of the patients and periarticular osteopenia in 34%; deformity and soft tissue swelling were present in 26% and 14% of patients respectively. The proportion with erosions is lower than data reported from Western European and North American populations but higher than previous data from the Central region of Saudi Arabia.

Research paper thumbnail of Frequency and risk factors of musculoskeletal pain in nurses at a tertiary centre in Jeddah, Saudi Arabia: a cross sectional study

BMC Research Notes, Jan 25, 2014

Background: Musculoskeletal complaints are an important occupational problem; nevertheless, few s... more Background: Musculoskeletal complaints are an important occupational problem; nevertheless, few studies have targeted nurses in Saudi Arabia. The aim of this study was to determine the frequency and risk factors of work-related musculoskeletal disorders (WMSDs) among nursing personnel at a tertiary centre in Jeddah. Methods: A comparative cross-sectional study was performed in which full-time registered nurses from four different departments (n = 200) were selected for analysis between September 1, 2011 and February 29, 2012. Musculoskeletal symptoms over the past year were assessed using the Nordic Standardised Musculoskeletal Questionnaire. In addition to demographic questions, the researcher evaluated employment history, physical risk factors at work, and general health status. Results: In this study, approximately 85% of the nurses reported experiencing at least one musculoskeletal symptom. Musculoskeletal symptoms occurred most commonly in the lower back (65.7%), ankles and feet (41.5%), and shoulders (29%). Prolonged working hours and being underweight were significantly associated with the development of these symptoms (OR 3.66, 95% CI 1.24-10.79, P = 0.018, and OR 2.66, 95% CI 1.37-5.93, P = 0.004, respectively). Working in the surgical department was a greater risk factor for low back pain compared with working in other departments. Conclusions: WMSDs are common among our nurses, and back pain is the most common symptom. As prolonged working hours and being underweight were factors that contributed most to WMSDs, decreasing shift durations or offering nutrition educational programmes may be suitable solutions. However, further studies are required to examine the best modality for decreasing the occurrence of WMSDs.