T. Ediberidze - Academia.edu (original) (raw)

Papers by T. Ediberidze

Research paper thumbnail of Cultural adaptation and psychometric validation of the Caring Efficacy scale in a sample of Italian nurses

Research paper thumbnail of Genetic epilepsy and sleep – A questionnaire-based study in Georgian population

European Journal of Paediatric Neurology, 2017

Research paper thumbnail of Cognitive functions in children exposed to antiepileptic drugs in utero - Study in Georgia

Epilepsy & Behavior, 2017

The cognitive teratogenicity of antiepileptic drugs (AEDs) has gained increasing attention in the... more The cognitive teratogenicity of antiepileptic drugs (AEDs) has gained increasing attention in the last decade. The objective of the current study was to assess the effects of AED fetal exposure on the cognitive development of children of mothers with epilepsy from Georgia in a controlled study taking into consideration major confounding factors. Methods: A prospective cohort group was formed from children and mothers registered in the Georgian National AED-Pregnancy Registry. The study group's age-and gender-matched control children without fetal AED exposure were selected retrospectively. The Intelligence Quotient (IQ) using the Wechsler Adult Intelligence Scalerevised (WAIS-R) was assessed in mothers. The Wechsler Preschool and Primary Scale of Intelligence (WPPSI-4) were used to assess intellectual functioning for children of both study and control groups. Linear regression analysis was performed to detect association of AED exposure on the cognitive performance of children. Results: In total, 100 children aged 36 to 72 months were evaluated. The IQ of WWE was significantly lower compared to women without epilepsy in all modalities. Exposure to valproate (VPA) (n = 18) was associated with lowest cognitive performance regarding Full Scale IQ (FSIQ) (β, −12.04; p = 0.006) and verbal comprehension (VCI) (β, −8.89; p = 0.019). Maternal FSIQ, maternal performance IQ (PIQ), and child's age at first phrases were independent factors associated with the cognitive development of children. Conclusions: Multivariate analysis showed VPA to be an independent predictor for decreased cognitive performance. Maternal FSIQ, PIQ, and child developmental achievements were significant confounders for cognitive performance in children.

Research paper thumbnail of PO-0834 Long-term Developmental Outcome Of Children Prenatally Exposed To Antiepileptic Drugs

Archives of Disease in Childhood, 2014

ABSTRACT Background and aims The long-term effects of intra-uterine exposure antiepileptic drugs ... more ABSTRACT Background and aims The long-term effects of intra-uterine exposure antiepileptic drugs (AEDs) on cognitive functioning are limited and conflicting. The aim of the study was to assess the remote effects of fetal AEDs on cognitive outcomes in children. Methods Children, aged 2–4 years, with fetal exposure of carbamazepine (CBZ), lamotrigine (LTG) or valproate (VPA) monotherapy were recruited from the local registry of Epilepsy-Pregnancy. Neuropsychological assessment was performed in all cases with Learning Accomplishment Profile (LAP) for children of 1–6 years. All age groups were evaluated with Wide Range Assessment of Visual Motor Abilities (WRAVMA) tests. The results were compared to the results of the epidemiological study evaluating developmental achievements in general preschool children population. Results In total 39 children were assessed. Eleven (28%) were exposed to intra-uterine VPA, 22 (56%) to CBZ and six (15%) to LTG. From whole group poor performance in expressive speech was detected in nine persons (23%; 95% CI 12% - 44%) and there were no cases with fetal exposure to LTG. Out of children with fetal-VPA exposure (n = 11) the speech problems were observed in three cases (27%); from 22 children with CBZ intra-uterine exposure – in six (27%); no significant deficits were revealed in other developmental milestones. Conclusions The data of our study suggests that difficulties in verbal abilities are more often associated with fetal exposure to VPA and CBZ. For more conclusive results further profound neuropsychological evaluations are needed.

Research paper thumbnail of Gut health of children with autism spectrum disorder

World Academy of Sciences Journal

Research paper thumbnail of Sleep-related problems and restless legs syndrome in the children with learning and developmental disorders

Sleep Medicine, 2013

nocturnal sleep quality and daytime sleepiness, but PLMA ¡Ã5 may increase the occurrence of insom... more nocturnal sleep quality and daytime sleepiness, but PLMA ¡Ã5 may increase the occurrence of insomnia more than twice.

Research paper thumbnail of PO-0820 Sleep Complaints Among The Neurologically Impaired Children: Questionnaire-based Study

Archives of Disease in Childhood, 2014

Research paper thumbnail of Sleep-related problems and restless legs syndrome in the children with learning and developmental disorders

Sleep Medicine, 2013

nocturnal sleep quality and daytime sleepiness, but PLMA ¡Ã5 may increase the occurrence of insom... more nocturnal sleep quality and daytime sleepiness, but PLMA ¡Ã5 may increase the occurrence of insomnia more than twice.

Research paper thumbnail of PO-0834 Long-term Developmental Outcome Of Children Prenatally Exposed To Antiepileptic Drugs

Archives of Disease in Childhood, 2014

ABSTRACT Background and aims The long-term effects of intra-uterine exposure antiepileptic drugs ... more ABSTRACT Background and aims The long-term effects of intra-uterine exposure antiepileptic drugs (AEDs) on cognitive functioning are limited and conflicting. The aim of the study was to assess the remote effects of fetal AEDs on cognitive outcomes in children. Methods Children, aged 2–4 years, with fetal exposure of carbamazepine (CBZ), lamotrigine (LTG) or valproate (VPA) monotherapy were recruited from the local registry of Epilepsy-Pregnancy. Neuropsychological assessment was performed in all cases with Learning Accomplishment Profile (LAP) for children of 1–6 years. All age groups were evaluated with Wide Range Assessment of Visual Motor Abilities (WRAVMA) tests. The results were compared to the results of the epidemiological study evaluating developmental achievements in general preschool children population. Results In total 39 children were assessed. Eleven (28%) were exposed to intra-uterine VPA, 22 (56%) to CBZ and six (15%) to LTG. From whole group poor performance in expressive speech was detected in nine persons (23%; 95% CI 12% - 44%) and there were no cases with fetal exposure to LTG. Out of children with fetal-VPA exposure (n = 11) the speech problems were observed in three cases (27%); from 22 children with CBZ intra-uterine exposure – in six (27%); no significant deficits were revealed in other developmental milestones. Conclusions The data of our study suggests that difficulties in verbal abilities are more often associated with fetal exposure to VPA and CBZ. For more conclusive results further profound neuropsychological evaluations are needed.

Research paper thumbnail of Cultural adaptation and psychometric validation of the Caring Efficacy scale in a sample of Italian nurses

Research paper thumbnail of Genetic epilepsy and sleep – A questionnaire-based study in Georgian population

European Journal of Paediatric Neurology, 2017

Research paper thumbnail of Cognitive functions in children exposed to antiepileptic drugs in utero - Study in Georgia

Epilepsy & Behavior, 2017

The cognitive teratogenicity of antiepileptic drugs (AEDs) has gained increasing attention in the... more The cognitive teratogenicity of antiepileptic drugs (AEDs) has gained increasing attention in the last decade. The objective of the current study was to assess the effects of AED fetal exposure on the cognitive development of children of mothers with epilepsy from Georgia in a controlled study taking into consideration major confounding factors. Methods: A prospective cohort group was formed from children and mothers registered in the Georgian National AED-Pregnancy Registry. The study group's age-and gender-matched control children without fetal AED exposure were selected retrospectively. The Intelligence Quotient (IQ) using the Wechsler Adult Intelligence Scalerevised (WAIS-R) was assessed in mothers. The Wechsler Preschool and Primary Scale of Intelligence (WPPSI-4) were used to assess intellectual functioning for children of both study and control groups. Linear regression analysis was performed to detect association of AED exposure on the cognitive performance of children. Results: In total, 100 children aged 36 to 72 months were evaluated. The IQ of WWE was significantly lower compared to women without epilepsy in all modalities. Exposure to valproate (VPA) (n = 18) was associated with lowest cognitive performance regarding Full Scale IQ (FSIQ) (β, −12.04; p = 0.006) and verbal comprehension (VCI) (β, −8.89; p = 0.019). Maternal FSIQ, maternal performance IQ (PIQ), and child's age at first phrases were independent factors associated with the cognitive development of children. Conclusions: Multivariate analysis showed VPA to be an independent predictor for decreased cognitive performance. Maternal FSIQ, PIQ, and child developmental achievements were significant confounders for cognitive performance in children.

Research paper thumbnail of PO-0834 Long-term Developmental Outcome Of Children Prenatally Exposed To Antiepileptic Drugs

Archives of Disease in Childhood, 2014

ABSTRACT Background and aims The long-term effects of intra-uterine exposure antiepileptic drugs ... more ABSTRACT Background and aims The long-term effects of intra-uterine exposure antiepileptic drugs (AEDs) on cognitive functioning are limited and conflicting. The aim of the study was to assess the remote effects of fetal AEDs on cognitive outcomes in children. Methods Children, aged 2–4 years, with fetal exposure of carbamazepine (CBZ), lamotrigine (LTG) or valproate (VPA) monotherapy were recruited from the local registry of Epilepsy-Pregnancy. Neuropsychological assessment was performed in all cases with Learning Accomplishment Profile (LAP) for children of 1–6 years. All age groups were evaluated with Wide Range Assessment of Visual Motor Abilities (WRAVMA) tests. The results were compared to the results of the epidemiological study evaluating developmental achievements in general preschool children population. Results In total 39 children were assessed. Eleven (28%) were exposed to intra-uterine VPA, 22 (56%) to CBZ and six (15%) to LTG. From whole group poor performance in expressive speech was detected in nine persons (23%; 95% CI 12% - 44%) and there were no cases with fetal exposure to LTG. Out of children with fetal-VPA exposure (n = 11) the speech problems were observed in three cases (27%); from 22 children with CBZ intra-uterine exposure – in six (27%); no significant deficits were revealed in other developmental milestones. Conclusions The data of our study suggests that difficulties in verbal abilities are more often associated with fetal exposure to VPA and CBZ. For more conclusive results further profound neuropsychological evaluations are needed.

Research paper thumbnail of Gut health of children with autism spectrum disorder

World Academy of Sciences Journal

Research paper thumbnail of Sleep-related problems and restless legs syndrome in the children with learning and developmental disorders

Sleep Medicine, 2013

nocturnal sleep quality and daytime sleepiness, but PLMA ¡Ã5 may increase the occurrence of insom... more nocturnal sleep quality and daytime sleepiness, but PLMA ¡Ã5 may increase the occurrence of insomnia more than twice.

Research paper thumbnail of PO-0820 Sleep Complaints Among The Neurologically Impaired Children: Questionnaire-based Study

Archives of Disease in Childhood, 2014

Research paper thumbnail of Sleep-related problems and restless legs syndrome in the children with learning and developmental disorders

Sleep Medicine, 2013

nocturnal sleep quality and daytime sleepiness, but PLMA ¡Ã5 may increase the occurrence of insom... more nocturnal sleep quality and daytime sleepiness, but PLMA ¡Ã5 may increase the occurrence of insomnia more than twice.

Research paper thumbnail of PO-0834 Long-term Developmental Outcome Of Children Prenatally Exposed To Antiepileptic Drugs

Archives of Disease in Childhood, 2014

ABSTRACT Background and aims The long-term effects of intra-uterine exposure antiepileptic drugs ... more ABSTRACT Background and aims The long-term effects of intra-uterine exposure antiepileptic drugs (AEDs) on cognitive functioning are limited and conflicting. The aim of the study was to assess the remote effects of fetal AEDs on cognitive outcomes in children. Methods Children, aged 2–4 years, with fetal exposure of carbamazepine (CBZ), lamotrigine (LTG) or valproate (VPA) monotherapy were recruited from the local registry of Epilepsy-Pregnancy. Neuropsychological assessment was performed in all cases with Learning Accomplishment Profile (LAP) for children of 1–6 years. All age groups were evaluated with Wide Range Assessment of Visual Motor Abilities (WRAVMA) tests. The results were compared to the results of the epidemiological study evaluating developmental achievements in general preschool children population. Results In total 39 children were assessed. Eleven (28%) were exposed to intra-uterine VPA, 22 (56%) to CBZ and six (15%) to LTG. From whole group poor performance in expressive speech was detected in nine persons (23%; 95% CI 12% - 44%) and there were no cases with fetal exposure to LTG. Out of children with fetal-VPA exposure (n = 11) the speech problems were observed in three cases (27%); from 22 children with CBZ intra-uterine exposure – in six (27%); no significant deficits were revealed in other developmental milestones. Conclusions The data of our study suggests that difficulties in verbal abilities are more often associated with fetal exposure to VPA and CBZ. For more conclusive results further profound neuropsychological evaluations are needed.