Liselot THIJS - Academia.edu (original) (raw)

Papers by Liselot THIJS

Research paper thumbnail of Additional file 4 of Technology-supported sitting balance therapy versus usual care in the chronic stage after stroke: a pilot randomized controlled trial

Additional file 4. Between group analysis on outcome for trunk function, gait, balance and functi... more Additional file 4. Between group analysis on outcome for trunk function, gait, balance and functional independence.

Research paper thumbnail of Sensorimotor upper limb therapy does not improve somatosensory function and may negatively interfere with motor recovery: a randomized controlled trial in the early rehabilitation phase after stroke

Question: Is sensorimotor upper limb (UL) therapy of more benefit for motor and somatosensory out... more Question: Is sensorimotor upper limb (UL) therapy of more benefit for motor and somatosensory outcome than motor therapy? Design: Randomised assessor-blinded multi-centre controlled trial with block randomization stratified for neglect, severity of motor impairment, and type of stroke. Participants: 40 first-ever stroke patients with UL sensorimotor impairments admitted to the rehabilitation centre Intervention: Both groups received 16 hours of additional therapy over four weeks consisting of sensorimotor (N=22) or motor (N=18) UL therapy. Outcome measures: Action Research Arm test (ARAT) as primary outcome, and other motor and somatosensory measures were assessed at baseline, post-intervention and after four weeks follow-up. Results: No significant between-group differences were found for change scores in ARAT or any somatosensory measure between the three time points. For UL impairment (Fugl-Meyer assessment), a significant greater improvement was found for the motor group compared to the sensorimotor group from baseline to post-intervention (mean (SD) improvement 14.65 (2.19) versus 5.99 (2.06); p=0.01) and from baseline to follow-up (17.38 (2.37) versus 6.75 (2.29); p=0.003).

Research paper thumbnail of Does sensorimotor upper limb therapy post stroke alter behavior and brain connectivity differently compared to motor therapy? Protocol of a phase II randomized controlled trial

Trials, Apr 20, 2018

Background: The role of somatosensory feedback in motor performance has been warranted in the lit... more Background: The role of somatosensory feedback in motor performance has been warranted in the literature. Although sensorimotor deficits are common after stroke, current rehabilitation approaches primarily focus on restoring upper limb motor ability. Evidence for integrative sensorimotor rehabilitation approaches is scarce, as is knowledge about neural correlates of somatosensory impairments after stroke and the effect of rehabilitation on brain connectivity level. Therefore, we aim to investigate changes in sensorimotor function and brain connectivity following a sensorimotor therapy program compared to an attention-matched motor therapy program for the upper limb after stroke. Methods: An assessor-blinded randomized controlled trial will be conducted. Sixty inpatient rehabilitation patients up to eight weeks after stroke will be included. Patients will be randomized to either an experimental group receiving sensorimotor therapy or a control group receiving attention-matched motor therapy for the upper limb, with both groups receiving conventional therapy. Thus, all patients will receive extra therapy, a total of 16 1-h sessions over four weeks. Patients will be assessed at baseline, after four weeks of training, and after four weeks of follow-up. Primary outcome measure is the Action Research Arm Test. Secondary outcome measures will consist of somatosensory, motor and cognitive assessments, and a standardized resting-state functional magnetic resonance imaging protocol. Discussion: The integration of sensory and motor rehabilitation into one therapy model might provide the added value of this therapy to improve sensorimotor performance post stroke. Insight in the behavioral and brain connectivity changes post therapy will lead to a better understanding of working mechanisms of therapy and will provide new knowledge for patient-tailored therapy approaches.

Research paper thumbnail of Do trunk exercises improve trunk and upper extremity performance, post stroke? A systematic review and meta-analysis

NeuroRehabilitation, 2018

Background: Post-stroke trunk control is reported to be associated with trunk performance and rec... more Background: Post-stroke trunk control is reported to be associated with trunk performance and recovery of the upper limb, but the evidence for the influence of trunk exercise on both of these is unclear. Objective: To evaluate the effect of trunk exercises on trunk performance post-stroke, and to determine if these exercises result in improved upper limb function. Methods: A comprehensive search of the literature published between January 1990 and February 2017 was conducted using the following electronic databases; AMED, CINAHL, Cochrane Library, EMBASE, MEDLINE, PsychInfo and SPORTDiscus. Only randomized, controlled trials, published in English, evaluating the effect of trunk exercises on trunk performance and/or upper limb function post-stroke, were included. Results: A total of 17 studies involving 599 participants were analysed. Meta-analysis showed that trunk exercises had a large significant effect on trunk performance post-stroke. This effect varied from very large for acute stroke to medium for subacute and chronic stroke. None of the included studies had measured the effect of trunk exercise on upper limb impairment or functional activity. Conclusions: Trunk exercises improve trunk performance for people with acute, subacute and chronic strokes. As yet there is no evidence to support the effect of trunk exercise on upper limb function.

Research paper thumbnail of Neurorehabilitation in Belgien

neuroreha

Wie ist die Neurorehabilitation im europäischen Nachbarland Belgien organisiert? Welche Inhalte u... more Wie ist die Neurorehabilitation im europäischen Nachbarland Belgien organisiert? Welche Inhalte und Verfahren werden in Kliniken und Rehabilitationszentren angewendet, und in welchem Umfang? Wie sieht die weitere Betreuung aus? Diese und andere Fragen beantwortet der Artikel in übersichtlicher und präziser Form.

Research paper thumbnail of Technology-supported sitting balance therapy versus usual care in the chronic stage after stroke: a pilot randomized controlled trial

Journal of NeuroEngineering and Rehabilitation

Background Technology development for sitting balance therapy and trunk rehabilitation is scarce.... more Background Technology development for sitting balance therapy and trunk rehabilitation is scarce. Hence, intensive one-to-one therapist-patient training is still required. We have developed a novel rehabilitation prototype, specifically aimed at providing sitting balance therapy. We investigated whether technology-supported sitting balance training was feasible and safe in chronic stroke patients and we determined whether clinical outcomes improved after a four-week programme, compared with usual care. Methods In this parallel-group, assessor-blinded, randomized controlled pilot trial, we divided first-event chronic stroke participants into two groups. The experimental group received usual care plus additional therapy supported by rehabilitation technology, consisting of 12 sessions of 50 min of therapy over four weeks. The control group received usual care only. We assessed all participants twice pre-intervention and once post-intervention. Feasibility and safety were descriptively...

Research paper thumbnail of Additional file 5 of Technology-supported sitting balance therapy versus usual care in the chronic stage after stroke: a pilot randomized controlled trial

Additional file 5. Between group analysis on outcome on trunk and leg strength and tonus.

Research paper thumbnail of Additional file 2 of Technology-supported sitting balance therapy versus usual care in the chronic stage after stroke: a pilot randomized controlled trial

Additional file 2. Patient experience questionnaire.

Research paper thumbnail of Additional file 1 of Technology-supported sitting balance therapy versus usual care in the chronic stage after stroke: a pilot randomized controlled trial

Additional file 1. Description of the exercises and cooling down of the first session of each week.

Research paper thumbnail of Additional file 3 of Technology-supported sitting balance therapy versus usual care in the chronic stage after stroke: a pilot randomized controlled trial

Additional file 3. Between group analysis on outcome for trunk function, gait, balance and functi... more Additional file 3. Between group analysis on outcome for trunk function, gait, balance and functional independence at baseline and change scores.

Research paper thumbnail of Additional file 3: of Does sensorimotor upper limb therapy post stroke alter behavior and brain connectivity differently compared to motor therapy? Protocol of a phase II randomized controlled trial

Outcome measures. (DOCX 26Â kb)

Research paper thumbnail of Additional file 2: of Does sensorimotor upper limb therapy post stroke alter behavior and brain connectivity differently compared to motor therapy? Protocol of a phase II randomized controlled trial

Examples of sensorimotor training tasks, overview of examples of exercises performed by the patie... more Examples of sensorimotor training tasks, overview of examples of exercises performed by the patients allocated in the sensorimotor trainings group. (DOCX 13Â kb)

Research paper thumbnail of Additional file 1: of Does sensorimotor upper limb therapy post stroke alter behavior and brain connectivity differently compared to motor therapy? Protocol of a phase II randomized controlled trial

SPIRIT checklist; checklist based on the SPIRIT guidelines. (DOCX 19Â kb)

Research paper thumbnail of Additional file 2: of Is upper limb virtual reality training more intensive than conventional training for patients in the subacute phase after stroke? An analysis of treatment intensity and content

Research paper thumbnail of Additional file 1: of Is upper limb virtual reality training more intensive than conventional training for patients in the subacute phase after stroke? An analysis of treatment intensity and content

The scoring form. (PDF 145 kb)

Research paper thumbnail of sj-pdf-1-jcb-10.1177_0271678X211047759 - Supplemental material for Changes in synaptic density in the subacute phase after ischemic stroke: A <sup>11</sup>C-UCB-J PET/MR study

Supplemental material, sj-pdf-1-jcb-10.1177_0271678X211047759 for Changes in synaptic density in ... more Supplemental material, sj-pdf-1-jcb-10.1177_0271678X211047759 for Changes in synaptic density in the subacute phase after ischemic stroke: A <sup>11</sup>C-UCB-J PET/MR study by Laura Michiels, Nathalie Mertens, Liselot Thijs, Ahmed Radwan, Stefan Sunaert, Mathieu Vandenbulcke, Geert Verheyden, Michel Koole, Koen Van Laere and Robin Lemmens in Journal of Cerebral Blood Flow & Metabolism

Research paper thumbnail of The influence of neglect on somatosensory impairments in patients after stroke: a multi-centre cross-sectional study

Research paper thumbnail of Sensorimotor upper limb therapy improves upper limb function in subacute stroke patients a randomized controlled trial

Research paper thumbnail of Trunk exercise programme post-stroke using a virtual reality video game-based system: a mixed methods feasibility study

Background: Trunk control post-stroke can be affected by muscle weakness, reduced position sense ... more Background: Trunk control post-stroke can be affected by muscle weakness, reduced position sense and poor coordination leading to decreases in balance and functional ability. Virtual reality (VR) technology in stroke rehabilitation has been demonstrated to improve function and activity. However, the feasibility of using VR to deliver post-stroke trunk exercises is unknown. Objective: To investigate the feasibility of conducting trunk exercise using VR video game-based system (Valedo®) by measuring adherence, safety, acceptability and participation. In addition, changes in pre-post measures of trunk impairment, balance and upper and lower limb motor function were assessed. Methods: The intervention consisted of 18 sessions of VR video games trunk training program (3 days/week, 45 min./day) over 6 weeks. The exercises consisted of specific upper and lower trunk exercises including lateral flexion, rotation, flexion and extension. The feasibility of using the Valedo® system was measure...

Research paper thumbnail of Trunk exercise to improve trunk and upper limb performance post stroke: a systematic review and meta-analysis

BACKGROUND:Post-stroke trunk control is reported to be associated with trunk performance and reco... more BACKGROUND:Post-stroke trunk control is reported to be associated with trunk performance and recovery of the upper limb, but the evidence for the influence of trunk exercise on both of these is unclear. OBJECTIVE:To evaluate the effect of trunk exercises on trunk performance post-stroke, and to determine if these exercises result in improved upper limb function. METHODS:A comprehensive search of the literature published between January 1990 and February 2017 was conducted using the following electronic databases; AMED, CINAHL, Cochrane Library, EMBASE, MEDLINE, PsychInfo and SPORTDiscus. Only randomized, controlled trials, published in English, evaluating the effect of trunk exercises on trunk performance and/or upper limb function post-stroke, were included. RESULTS:A total of 17 studies involving 599 participants were analysed. Meta-analysis showed that trunk exercises had large significant effect on trunk performance post-stroke. This effect varied from very large for acute strok...

Research paper thumbnail of Additional file 4 of Technology-supported sitting balance therapy versus usual care in the chronic stage after stroke: a pilot randomized controlled trial

Additional file 4. Between group analysis on outcome for trunk function, gait, balance and functi... more Additional file 4. Between group analysis on outcome for trunk function, gait, balance and functional independence.

Research paper thumbnail of Sensorimotor upper limb therapy does not improve somatosensory function and may negatively interfere with motor recovery: a randomized controlled trial in the early rehabilitation phase after stroke

Question: Is sensorimotor upper limb (UL) therapy of more benefit for motor and somatosensory out... more Question: Is sensorimotor upper limb (UL) therapy of more benefit for motor and somatosensory outcome than motor therapy? Design: Randomised assessor-blinded multi-centre controlled trial with block randomization stratified for neglect, severity of motor impairment, and type of stroke. Participants: 40 first-ever stroke patients with UL sensorimotor impairments admitted to the rehabilitation centre Intervention: Both groups received 16 hours of additional therapy over four weeks consisting of sensorimotor (N=22) or motor (N=18) UL therapy. Outcome measures: Action Research Arm test (ARAT) as primary outcome, and other motor and somatosensory measures were assessed at baseline, post-intervention and after four weeks follow-up. Results: No significant between-group differences were found for change scores in ARAT or any somatosensory measure between the three time points. For UL impairment (Fugl-Meyer assessment), a significant greater improvement was found for the motor group compared to the sensorimotor group from baseline to post-intervention (mean (SD) improvement 14.65 (2.19) versus 5.99 (2.06); p=0.01) and from baseline to follow-up (17.38 (2.37) versus 6.75 (2.29); p=0.003).

Research paper thumbnail of Does sensorimotor upper limb therapy post stroke alter behavior and brain connectivity differently compared to motor therapy? Protocol of a phase II randomized controlled trial

Trials, Apr 20, 2018

Background: The role of somatosensory feedback in motor performance has been warranted in the lit... more Background: The role of somatosensory feedback in motor performance has been warranted in the literature. Although sensorimotor deficits are common after stroke, current rehabilitation approaches primarily focus on restoring upper limb motor ability. Evidence for integrative sensorimotor rehabilitation approaches is scarce, as is knowledge about neural correlates of somatosensory impairments after stroke and the effect of rehabilitation on brain connectivity level. Therefore, we aim to investigate changes in sensorimotor function and brain connectivity following a sensorimotor therapy program compared to an attention-matched motor therapy program for the upper limb after stroke. Methods: An assessor-blinded randomized controlled trial will be conducted. Sixty inpatient rehabilitation patients up to eight weeks after stroke will be included. Patients will be randomized to either an experimental group receiving sensorimotor therapy or a control group receiving attention-matched motor therapy for the upper limb, with both groups receiving conventional therapy. Thus, all patients will receive extra therapy, a total of 16 1-h sessions over four weeks. Patients will be assessed at baseline, after four weeks of training, and after four weeks of follow-up. Primary outcome measure is the Action Research Arm Test. Secondary outcome measures will consist of somatosensory, motor and cognitive assessments, and a standardized resting-state functional magnetic resonance imaging protocol. Discussion: The integration of sensory and motor rehabilitation into one therapy model might provide the added value of this therapy to improve sensorimotor performance post stroke. Insight in the behavioral and brain connectivity changes post therapy will lead to a better understanding of working mechanisms of therapy and will provide new knowledge for patient-tailored therapy approaches.

Research paper thumbnail of Do trunk exercises improve trunk and upper extremity performance, post stroke? A systematic review and meta-analysis

NeuroRehabilitation, 2018

Background: Post-stroke trunk control is reported to be associated with trunk performance and rec... more Background: Post-stroke trunk control is reported to be associated with trunk performance and recovery of the upper limb, but the evidence for the influence of trunk exercise on both of these is unclear. Objective: To evaluate the effect of trunk exercises on trunk performance post-stroke, and to determine if these exercises result in improved upper limb function. Methods: A comprehensive search of the literature published between January 1990 and February 2017 was conducted using the following electronic databases; AMED, CINAHL, Cochrane Library, EMBASE, MEDLINE, PsychInfo and SPORTDiscus. Only randomized, controlled trials, published in English, evaluating the effect of trunk exercises on trunk performance and/or upper limb function post-stroke, were included. Results: A total of 17 studies involving 599 participants were analysed. Meta-analysis showed that trunk exercises had a large significant effect on trunk performance post-stroke. This effect varied from very large for acute stroke to medium for subacute and chronic stroke. None of the included studies had measured the effect of trunk exercise on upper limb impairment or functional activity. Conclusions: Trunk exercises improve trunk performance for people with acute, subacute and chronic strokes. As yet there is no evidence to support the effect of trunk exercise on upper limb function.

Research paper thumbnail of Neurorehabilitation in Belgien

neuroreha

Wie ist die Neurorehabilitation im europäischen Nachbarland Belgien organisiert? Welche Inhalte u... more Wie ist die Neurorehabilitation im europäischen Nachbarland Belgien organisiert? Welche Inhalte und Verfahren werden in Kliniken und Rehabilitationszentren angewendet, und in welchem Umfang? Wie sieht die weitere Betreuung aus? Diese und andere Fragen beantwortet der Artikel in übersichtlicher und präziser Form.

Research paper thumbnail of Technology-supported sitting balance therapy versus usual care in the chronic stage after stroke: a pilot randomized controlled trial

Journal of NeuroEngineering and Rehabilitation

Background Technology development for sitting balance therapy and trunk rehabilitation is scarce.... more Background Technology development for sitting balance therapy and trunk rehabilitation is scarce. Hence, intensive one-to-one therapist-patient training is still required. We have developed a novel rehabilitation prototype, specifically aimed at providing sitting balance therapy. We investigated whether technology-supported sitting balance training was feasible and safe in chronic stroke patients and we determined whether clinical outcomes improved after a four-week programme, compared with usual care. Methods In this parallel-group, assessor-blinded, randomized controlled pilot trial, we divided first-event chronic stroke participants into two groups. The experimental group received usual care plus additional therapy supported by rehabilitation technology, consisting of 12 sessions of 50 min of therapy over four weeks. The control group received usual care only. We assessed all participants twice pre-intervention and once post-intervention. Feasibility and safety were descriptively...

Research paper thumbnail of Additional file 5 of Technology-supported sitting balance therapy versus usual care in the chronic stage after stroke: a pilot randomized controlled trial

Additional file 5. Between group analysis on outcome on trunk and leg strength and tonus.

Research paper thumbnail of Additional file 2 of Technology-supported sitting balance therapy versus usual care in the chronic stage after stroke: a pilot randomized controlled trial

Additional file 2. Patient experience questionnaire.

Research paper thumbnail of Additional file 1 of Technology-supported sitting balance therapy versus usual care in the chronic stage after stroke: a pilot randomized controlled trial

Additional file 1. Description of the exercises and cooling down of the first session of each week.

Research paper thumbnail of Additional file 3 of Technology-supported sitting balance therapy versus usual care in the chronic stage after stroke: a pilot randomized controlled trial

Additional file 3. Between group analysis on outcome for trunk function, gait, balance and functi... more Additional file 3. Between group analysis on outcome for trunk function, gait, balance and functional independence at baseline and change scores.

Research paper thumbnail of Additional file 3: of Does sensorimotor upper limb therapy post stroke alter behavior and brain connectivity differently compared to motor therapy? Protocol of a phase II randomized controlled trial

Outcome measures. (DOCX 26Â kb)

Research paper thumbnail of Additional file 2: of Does sensorimotor upper limb therapy post stroke alter behavior and brain connectivity differently compared to motor therapy? Protocol of a phase II randomized controlled trial

Examples of sensorimotor training tasks, overview of examples of exercises performed by the patie... more Examples of sensorimotor training tasks, overview of examples of exercises performed by the patients allocated in the sensorimotor trainings group. (DOCX 13Â kb)

Research paper thumbnail of Additional file 1: of Does sensorimotor upper limb therapy post stroke alter behavior and brain connectivity differently compared to motor therapy? Protocol of a phase II randomized controlled trial

SPIRIT checklist; checklist based on the SPIRIT guidelines. (DOCX 19Â kb)

Research paper thumbnail of Additional file 2: of Is upper limb virtual reality training more intensive than conventional training for patients in the subacute phase after stroke? An analysis of treatment intensity and content

Research paper thumbnail of Additional file 1: of Is upper limb virtual reality training more intensive than conventional training for patients in the subacute phase after stroke? An analysis of treatment intensity and content

The scoring form. (PDF 145 kb)

Research paper thumbnail of sj-pdf-1-jcb-10.1177_0271678X211047759 - Supplemental material for Changes in synaptic density in the subacute phase after ischemic stroke: A <sup>11</sup>C-UCB-J PET/MR study

Supplemental material, sj-pdf-1-jcb-10.1177_0271678X211047759 for Changes in synaptic density in ... more Supplemental material, sj-pdf-1-jcb-10.1177_0271678X211047759 for Changes in synaptic density in the subacute phase after ischemic stroke: A <sup>11</sup>C-UCB-J PET/MR study by Laura Michiels, Nathalie Mertens, Liselot Thijs, Ahmed Radwan, Stefan Sunaert, Mathieu Vandenbulcke, Geert Verheyden, Michel Koole, Koen Van Laere and Robin Lemmens in Journal of Cerebral Blood Flow & Metabolism

Research paper thumbnail of The influence of neglect on somatosensory impairments in patients after stroke: a multi-centre cross-sectional study

Research paper thumbnail of Sensorimotor upper limb therapy improves upper limb function in subacute stroke patients a randomized controlled trial

Research paper thumbnail of Trunk exercise programme post-stroke using a virtual reality video game-based system: a mixed methods feasibility study

Background: Trunk control post-stroke can be affected by muscle weakness, reduced position sense ... more Background: Trunk control post-stroke can be affected by muscle weakness, reduced position sense and poor coordination leading to decreases in balance and functional ability. Virtual reality (VR) technology in stroke rehabilitation has been demonstrated to improve function and activity. However, the feasibility of using VR to deliver post-stroke trunk exercises is unknown. Objective: To investigate the feasibility of conducting trunk exercise using VR video game-based system (Valedo®) by measuring adherence, safety, acceptability and participation. In addition, changes in pre-post measures of trunk impairment, balance and upper and lower limb motor function were assessed. Methods: The intervention consisted of 18 sessions of VR video games trunk training program (3 days/week, 45 min./day) over 6 weeks. The exercises consisted of specific upper and lower trunk exercises including lateral flexion, rotation, flexion and extension. The feasibility of using the Valedo® system was measure...

Research paper thumbnail of Trunk exercise to improve trunk and upper limb performance post stroke: a systematic review and meta-analysis

BACKGROUND:Post-stroke trunk control is reported to be associated with trunk performance and reco... more BACKGROUND:Post-stroke trunk control is reported to be associated with trunk performance and recovery of the upper limb, but the evidence for the influence of trunk exercise on both of these is unclear. OBJECTIVE:To evaluate the effect of trunk exercises on trunk performance post-stroke, and to determine if these exercises result in improved upper limb function. METHODS:A comprehensive search of the literature published between January 1990 and February 2017 was conducted using the following electronic databases; AMED, CINAHL, Cochrane Library, EMBASE, MEDLINE, PsychInfo and SPORTDiscus. Only randomized, controlled trials, published in English, evaluating the effect of trunk exercises on trunk performance and/or upper limb function post-stroke, were included. RESULTS:A total of 17 studies involving 599 participants were analysed. Meta-analysis showed that trunk exercises had large significant effect on trunk performance post-stroke. This effect varied from very large for acute strok...