T. Hadda - Academia.edu (original) (raw)
Papers by T. Hadda
New ruthenium(II) mononuclear complexes of the type [RuCl2(PPh3)2(η(2)-triamine)] (2) [RuCl(PPh3)... more New ruthenium(II) mononuclear complexes of the type [RuCl2(PPh3)2(η(2)-triamine)] (2) [RuCl(PPh3)2(η(3)-triamine)]Cl (5) (triemine=N(1)-(2-aminoethyl)-1,2-ethanediamine) have been synthesized by reacting [RuCl2(PPh3)3] (1) with one mole equivalent of N(1)-(2-aminoethyl)-1,2-ethanediamine in dichloromethane. Reaction of (2) with half-equivalent of (PhCN)2PdCl2 or Pd(OAc)2 in dichloromethane as a solvent afforded two novel heterotrimetallic Ru(II)-Pd(II)-Ru(II) complexes, [Ru(II)Cl2(PPh3)2(triamine)]2[Pd(II)X2](X=Cl, OAc) (3 and 4), bearing bioactive ligand. The progress of the undertaken reactions was monitored by (31)P{1H} NMR and FTIR. Crystal structure of complex 2 was confirmed by X-ray diffraction. The absorption spectrum of 2 in dichloromethane was modeled by time-dependent density functional theory (TD-DFT). The in vitro antimicrobial studies of complex 2-5 against an array of microorganisms (bacteria and fungi) were conducted. Complexes 3 and 4 exhibit high dual antibacterial and antifungal activity inhibiting microorganisms possibly via hydrolytic pathway which further evidenced by electrochemical analyses. The complexes 3 and 4 show a high inhibitory activity at 200 μg/ml concentration, suggesting that complexes 3 and 4 are two efficient catalytic inhibitor of microorganisms and further, they should be tested against cancer strains.
Acta Chimica Slovenica, 2015
Corrosion inhibition effect of Nigella Sativa L extract (SE NS) on corrosion of mild steel in 1 M... more Corrosion inhibition effect of Nigella Sativa L extract (SE NS) on corrosion of mild steel in 1 M HCl solution was investigated using weight loss measurements, electrochemical polarization and EIS methods. Results obtained reveal that Nigella Sativa L extract acts as a mixed inhibitor without modifying the hydrogen reduction mechanism. The inhibition efficiency increases with increased Nigella Sativa L extract concentration to attain a maximum value of 99% at 2 g/L. The adsorption of natural product on the steel surface was found obey to Langmuir's adsorption isotherm.
Medicinal Chemistry Research, 2014
Pakistan journal of pharmaceutical sciences, 2015
Nutritional quality and antioxidant capacity of three edible wild berries (Rubus ellipticus Smith... more Nutritional quality and antioxidant capacity of three edible wild berries (Rubus ellipticus Smith, Rubus niveus Thunb, Rubus ulmifolius L.) from Lesser Himalayan Range (LHR) were evaluated. Their edible portion was assayed for moisture, fats, ash, carbohydrates, proteins, fibers, essential minerals (Ca, P, Mg, K, Na, Cl, S, Mn, Zn, Fe, Cu, Se, Co, Ni) and DPPH free radical scavenging activity was applied to determine the antioxidant potential. The fruit of Rubus ulmifolius L. (blackberry) possessed the highest values of energy (403.29 Kcal), total protein (6.56g/100 g), Nitrogen (N) content (1500mg/100g), K (860.17mg/100g), Ca (620.56mg/100g), Zn (17.509mg/100g) and the strongest antioxidant activity (98.89% inhibition). While the raspberries (Rubus ellipticus Smith, Rubus niveus Thunb.) exhibited more significant contents of dietary fiber (5.90g/100g), carbohydrates (86.4 g/100 g) and Fe (4.249mg/100g). Significant variation was observed among the tested samples in all the investig...
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 2015
Cadmium is a non-essential toxic metal used in industrial process, causes severe risk to human he... more Cadmium is a non-essential toxic metal used in industrial process, causes severe risk to human health. Selenium (Se) is an essential trace mineral of fundamental importance for human health. Selenium has antioxidant enzymes roles and is needed for the proper function of the immune system. In this study, the protective effects of selenium against cadmium intoxication in rats have been investigated by monitoring some selective cytokines (IL-1β, TNF α, IL-6, IL-10 and IFN-γ), antioxidant enzymes reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and lipid peroxidation malondialdehyde (MDA) as well as some selective biochemical markers of liver and kidney functions. Thirty-two rats were divided into four equal groups; the first group was used as a control. Groups 2-4 were treated with selenium (Se; 0.1mg/kg BW), cadmium (Cd; 40mg/L drinking water) and selenium plus cadmium, respectively. Rats were orally administered their relevant doses ...
Natural Product Research, 2015
A new triterpenic compound named pistagremic acid (PA) was once again isolated from Pistaciainteg... more A new triterpenic compound named pistagremic acid (PA) was once again isolated from Pistaciaintegerrima. The β-secretase inhibition study was carried out. Compound PA was found significantly active against β-secretase enzyme (BACE1) with IC50 value of 350 ± 2 nM in comparison to the standard inhibitors [Asn670, Sta671, Val672]-amyloid-β/A4 precursor protein 770 fragment 662-675 (IC50 = 290.71 ± 1 nM). The selectivity of this compound was also evaluated against the acetylcholinesterase and butyrylcholinesterase enzymes. Interestingly compound PA was found to be inactive against them and showed selectivity towards β-secretase enzyme (BACE1).
J. Comput. Method. Mol. Design, 2011
Phosphorus, Sulfur, and Silicon and the Related Elements, 2014
ABSTRACT A series of four different armed heterocyclic candidates; 1-(2-methyl-2,3-dihydro-1,3-be... more ABSTRACT A series of four different armed heterocyclic candidates; 1-(2-methyl-2,3-dihydro-1,3-benzothiazol-2-yl)acetone (2), 1-(3-methyl-4H-1,4-benzothiazin-2-yl)ethanone (3), 2-[(2-aminophenyl)dithio]aniline (4) and 3-hydroxy-3-methyl-4-(3-methyl-2-quinoxalinyl)-2-butanone (5) have been prepared and their microbial activities were evaluated. A correlation of the structure and activities relationships of these compounds with respect to molecular modeling, Lipinski Rule of Five, drug likeness, toxicity profiles and other physico-chemical properties of drugs are described and verified experimentally.
Medicinal Chemistry Research, 2011
Abstract Herein, we report the design and calculated molecular properties of ten existing azo Sch... more Abstract Herein, we report the design and calculated molecular properties of ten existing azo Schiff bases 5ah and 7a, b. On the basis of a hypothetical antibacterial pharmacophore, the structures are designed to interact with Gram-positive and Gram-negative bacteria. The in ...
Journal of Ethnobiology and Ethnomedicine, 2014
Journal of Enzyme Inhibition and Medicinal Chemistry, 2008
A series of nine polypyridyl-ruthenium (II) complexes (N-ligands = 2,2&am... more A series of nine polypyridyl-ruthenium (II) complexes (N-ligands = 2,2'-bipyridines; 2,2'-6',2'-terpyridines, di-alkyloxy-2,2'-6,2-bipyridine-3,3'-di-carboxylates), were tested against Mycobacterium tuberculosis (MBT). The complex (11) showed remarkable activity against MBT as compared to other complexes, (1-10). The aquo ligand of complex (11), as opposed to other chloro and acetonitrile derivatives, appears to play a key role in the antitubercular potency of this new class of metal-based compounds.
![Research paper thumbnail of Structure of a β-Amino Dicarbonyl Compound: 2-[(4-Chloro-Phenyl)-Pyrrolidin-1-yl-Methyl]-Malonic Acid Diethyl Ester](https://attachments.academia-assets.com/119445124/thumbnails/1.jpg)
](Journal of Chemical Crystallography, 2011
![Research paper thumbnail of Crystal Structure of Antitubercular Complex: cis-(chloro)-[N,N′-bis-(diethyl-2,2′-bipyridine-3,3′-dicarboxylate)]ruthenium(II) Monohydrate](https://attachments.academia-assets.com/119445123/thumbnails/1.jpg)
](Journal of Chemical Crystallography, 2008
Journal of Chemical Crystallography, 2010
![Research paper thumbnail of Crystal Structure of 3′-(4-Methoxyphenyl)-2-Phenyl-4′-(4-Ethoxyphenyl)-1,2-Dihydro-4H,4′H-Spiro [Isoquinoline-3,5′-Isoxazol]-4-One](https://attachments.academia-assets.com/119445126/thumbnails/1.jpg)
](Journal of Chemical Crystallography, 2009
The title compound, 3 0-(4-methoxyphenyl)-2phenyl-4 0-(4-ethoxyphenyl)-1,2-dihydro-4H,4 0 H-spiro... more The title compound, 3 0-(4-methoxyphenyl)-2phenyl-4 0-(4-ethoxyphenyl)-1,2-dihydro-4H,4 0 H-spiro[isoquinoline-3,5 0-isoxazol]-4-one was synthesized from the reaction of dipolarophile with p-methoxybenzadoxime in the presence of sodium hypochlorite in chloroform solution. The structure of the synthesized compound was determined by IR, 1 H NMR, mass spectroscopic data, 13 C NMR spectroscopy, elemental analysis and X-ray crystallography. The structure was solved in monoclinic, space group C2/c with a = 21.941 (4), b = 17.233 (3), c = 15.404 (3) Å , b = 122.193 (2), V = 4928.9 (16) Å 3 , Z = 8 and with R int = 0.154. The geometry of the title compound showed that the piperidine ring adopts a half-chair conformation. In the crystal structure, molecules are linked by C-HÁÁÁO and C-HÁÁÁN contacts. Weak C-HÁÁÁp interactions plays an important role in stabilizing the supramolecular structure. Keywords Crystal structure Á 3 0-(4-methoxyphenyl)-2-phenyl-4 0-(4-ethoxyphenyl)-1,2dihydro-4H,4 0 H-spiro[isoquinoline-3,5 0-isoxazol]-4-one Á Dipolarophile Á P-methoxybenzadoxime
New ruthenium(II) mononuclear complexes of the type [RuCl2(PPh3)2(η(2)-triamine)] (2) [RuCl(PPh3)... more New ruthenium(II) mononuclear complexes of the type [RuCl2(PPh3)2(η(2)-triamine)] (2) [RuCl(PPh3)2(η(3)-triamine)]Cl (5) (triemine=N(1)-(2-aminoethyl)-1,2-ethanediamine) have been synthesized by reacting [RuCl2(PPh3)3] (1) with one mole equivalent of N(1)-(2-aminoethyl)-1,2-ethanediamine in dichloromethane. Reaction of (2) with half-equivalent of (PhCN)2PdCl2 or Pd(OAc)2 in dichloromethane as a solvent afforded two novel heterotrimetallic Ru(II)-Pd(II)-Ru(II) complexes, [Ru(II)Cl2(PPh3)2(triamine)]2[Pd(II)X2](X=Cl, OAc) (3 and 4), bearing bioactive ligand. The progress of the undertaken reactions was monitored by (31)P{1H} NMR and FTIR. Crystal structure of complex 2 was confirmed by X-ray diffraction. The absorption spectrum of 2 in dichloromethane was modeled by time-dependent density functional theory (TD-DFT). The in vitro antimicrobial studies of complex 2-5 against an array of microorganisms (bacteria and fungi) were conducted. Complexes 3 and 4 exhibit high dual antibacterial and antifungal activity inhibiting microorganisms possibly via hydrolytic pathway which further evidenced by electrochemical analyses. The complexes 3 and 4 show a high inhibitory activity at 200 μg/ml concentration, suggesting that complexes 3 and 4 are two efficient catalytic inhibitor of microorganisms and further, they should be tested against cancer strains.
Acta Chimica Slovenica, 2015
Corrosion inhibition effect of Nigella Sativa L extract (SE NS) on corrosion of mild steel in 1 M... more Corrosion inhibition effect of Nigella Sativa L extract (SE NS) on corrosion of mild steel in 1 M HCl solution was investigated using weight loss measurements, electrochemical polarization and EIS methods. Results obtained reveal that Nigella Sativa L extract acts as a mixed inhibitor without modifying the hydrogen reduction mechanism. The inhibition efficiency increases with increased Nigella Sativa L extract concentration to attain a maximum value of 99% at 2 g/L. The adsorption of natural product on the steel surface was found obey to Langmuir's adsorption isotherm.
Medicinal Chemistry Research, 2014
Pakistan journal of pharmaceutical sciences, 2015
Nutritional quality and antioxidant capacity of three edible wild berries (Rubus ellipticus Smith... more Nutritional quality and antioxidant capacity of three edible wild berries (Rubus ellipticus Smith, Rubus niveus Thunb, Rubus ulmifolius L.) from Lesser Himalayan Range (LHR) were evaluated. Their edible portion was assayed for moisture, fats, ash, carbohydrates, proteins, fibers, essential minerals (Ca, P, Mg, K, Na, Cl, S, Mn, Zn, Fe, Cu, Se, Co, Ni) and DPPH free radical scavenging activity was applied to determine the antioxidant potential. The fruit of Rubus ulmifolius L. (blackberry) possessed the highest values of energy (403.29 Kcal), total protein (6.56g/100 g), Nitrogen (N) content (1500mg/100g), K (860.17mg/100g), Ca (620.56mg/100g), Zn (17.509mg/100g) and the strongest antioxidant activity (98.89% inhibition). While the raspberries (Rubus ellipticus Smith, Rubus niveus Thunb.) exhibited more significant contents of dietary fiber (5.90g/100g), carbohydrates (86.4 g/100 g) and Fe (4.249mg/100g). Significant variation was observed among the tested samples in all the investig...
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 2015
Cadmium is a non-essential toxic metal used in industrial process, causes severe risk to human he... more Cadmium is a non-essential toxic metal used in industrial process, causes severe risk to human health. Selenium (Se) is an essential trace mineral of fundamental importance for human health. Selenium has antioxidant enzymes roles and is needed for the proper function of the immune system. In this study, the protective effects of selenium against cadmium intoxication in rats have been investigated by monitoring some selective cytokines (IL-1β, TNF α, IL-6, IL-10 and IFN-γ), antioxidant enzymes reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and lipid peroxidation malondialdehyde (MDA) as well as some selective biochemical markers of liver and kidney functions. Thirty-two rats were divided into four equal groups; the first group was used as a control. Groups 2-4 were treated with selenium (Se; 0.1mg/kg BW), cadmium (Cd; 40mg/L drinking water) and selenium plus cadmium, respectively. Rats were orally administered their relevant doses ...
Natural Product Research, 2015
A new triterpenic compound named pistagremic acid (PA) was once again isolated from Pistaciainteg... more A new triterpenic compound named pistagremic acid (PA) was once again isolated from Pistaciaintegerrima. The β-secretase inhibition study was carried out. Compound PA was found significantly active against β-secretase enzyme (BACE1) with IC50 value of 350 ± 2 nM in comparison to the standard inhibitors [Asn670, Sta671, Val672]-amyloid-β/A4 precursor protein 770 fragment 662-675 (IC50 = 290.71 ± 1 nM). The selectivity of this compound was also evaluated against the acetylcholinesterase and butyrylcholinesterase enzymes. Interestingly compound PA was found to be inactive against them and showed selectivity towards β-secretase enzyme (BACE1).
J. Comput. Method. Mol. Design, 2011
Phosphorus, Sulfur, and Silicon and the Related Elements, 2014
ABSTRACT A series of four different armed heterocyclic candidates; 1-(2-methyl-2,3-dihydro-1,3-be... more ABSTRACT A series of four different armed heterocyclic candidates; 1-(2-methyl-2,3-dihydro-1,3-benzothiazol-2-yl)acetone (2), 1-(3-methyl-4H-1,4-benzothiazin-2-yl)ethanone (3), 2-[(2-aminophenyl)dithio]aniline (4) and 3-hydroxy-3-methyl-4-(3-methyl-2-quinoxalinyl)-2-butanone (5) have been prepared and their microbial activities were evaluated. A correlation of the structure and activities relationships of these compounds with respect to molecular modeling, Lipinski Rule of Five, drug likeness, toxicity profiles and other physico-chemical properties of drugs are described and verified experimentally.
Medicinal Chemistry Research, 2011
Abstract Herein, we report the design and calculated molecular properties of ten existing azo Sch... more Abstract Herein, we report the design and calculated molecular properties of ten existing azo Schiff bases 5ah and 7a, b. On the basis of a hypothetical antibacterial pharmacophore, the structures are designed to interact with Gram-positive and Gram-negative bacteria. The in ...
Journal of Ethnobiology and Ethnomedicine, 2014
Journal of Enzyme Inhibition and Medicinal Chemistry, 2008
A series of nine polypyridyl-ruthenium (II) complexes (N-ligands = 2,2&am... more A series of nine polypyridyl-ruthenium (II) complexes (N-ligands = 2,2'-bipyridines; 2,2'-6',2'-terpyridines, di-alkyloxy-2,2'-6,2-bipyridine-3,3'-di-carboxylates), were tested against Mycobacterium tuberculosis (MBT). The complex (11) showed remarkable activity against MBT as compared to other complexes, (1-10). The aquo ligand of complex (11), as opposed to other chloro and acetonitrile derivatives, appears to play a key role in the antitubercular potency of this new class of metal-based compounds.
Journal of Chemical Crystallography, 2011
Journal of Chemical Crystallography, 2008
Journal of Chemical Crystallography, 2010
Journal of Chemical Crystallography, 2009
The title compound, 3 0-(4-methoxyphenyl)-2phenyl-4 0-(4-ethoxyphenyl)-1,2-dihydro-4H,4 0 H-spiro... more The title compound, 3 0-(4-methoxyphenyl)-2phenyl-4 0-(4-ethoxyphenyl)-1,2-dihydro-4H,4 0 H-spiro[isoquinoline-3,5 0-isoxazol]-4-one was synthesized from the reaction of dipolarophile with p-methoxybenzadoxime in the presence of sodium hypochlorite in chloroform solution. The structure of the synthesized compound was determined by IR, 1 H NMR, mass spectroscopic data, 13 C NMR spectroscopy, elemental analysis and X-ray crystallography. The structure was solved in monoclinic, space group C2/c with a = 21.941 (4), b = 17.233 (3), c = 15.404 (3) Å , b = 122.193 (2), V = 4928.9 (16) Å 3 , Z = 8 and with R int = 0.154. The geometry of the title compound showed that the piperidine ring adopts a half-chair conformation. In the crystal structure, molecules are linked by C-HÁÁÁO and C-HÁÁÁN contacts. Weak C-HÁÁÁp interactions plays an important role in stabilizing the supramolecular structure. Keywords Crystal structure Á 3 0-(4-methoxyphenyl)-2-phenyl-4 0-(4-ethoxyphenyl)-1,2dihydro-4H,4 0 H-spiro[isoquinoline-3,5 0-isoxazol]-4-one Á Dipolarophile Á P-methoxybenzadoxime