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Papers by T. Kalir

Research paper thumbnail of Does the Type of Surgery for Early-Stage Endometrial Cancer Affect the Rate of Reported Lymph Vascular Invasion in Final Pathology Specimens?

Journal of Minimally Invasive Gynecology, 2012

OBJECTIVE: Laparoscopically assisted vaginal hysterectomy (LAVH), which usually involves the use ... more OBJECTIVE: Laparoscopically assisted vaginal hysterectomy (LAVH), which usually involves the use of an intrauterine manipulator for optimal surgical control, has been shown to be as effective and safe as conventional total abdominal hysterectomy (TAH) for the staging of endometrial carcinoma. The purpose of this study was to determine whether the use of an intrauterine manipulator was associated with an increase in the pathologic reporting of lymphovascular space invasion (LVSI), which is an important determinant in choosing adjuvant therapy. We hypothesized that intracavitary manipulation and an increase of the intrauterine pressure could cause pseudolymphovascular invasion.

Research paper thumbnail of KLF6-SV1 is a novel uterine leiomyosarcoma gene: From transgenic mouse model to human disease

Gynecologic Oncology, 2011

Objective: Ovarian clear cell carcinomas (CCCs) exhibit frequent ARID1A mutations and HNF1B overe... more Objective: Ovarian clear cell carcinomas (CCCs) exhibit frequent ARID1A mutations and HNF1B overexpression, but the epigenomic features that characterize CCCs are not known. We previously reported that several CCC-specific genes, including HNF1B, are regulated by promoter methylation. Our objectives were to: (1) use genomewide methylation data to develop a CCC-specific methylation signature, and (2) characterize the molecular features of these genes.

Research paper thumbnail of Comparative immunohistochemical studies of endometriosis lesions and endometriotic cysts

Fertility and Sterility, 2002

Of these 456 subjects, 17% were younger than 20 years of age, 65% were between 21 and 45 years, a... more Of these 456 subjects, 17% were younger than 20 years of age, 65% were between 21 and 45 years, and 18% were over 45 years. In all age groups, the majority of patients (54%) showed spontaneous regression. The progression rate was significantly higher in younger patients (Ͻ20 years) than in older patients (P Ͻ 0.025).

Research paper thumbnail of Does the Type of Surgery for Early-Stage Endometrial Cancer Affect the Rate of Reported Lymph Vascular Invasion in Final Pathology Specimens?

Journal of Minimally Invasive Gynecology, 2012

OBJECTIVE: Laparoscopically assisted vaginal hysterectomy (LAVH), which usually involves the use ... more OBJECTIVE: Laparoscopically assisted vaginal hysterectomy (LAVH), which usually involves the use of an intrauterine manipulator for optimal surgical control, has been shown to be as effective and safe as conventional total abdominal hysterectomy (TAH) for the staging of endometrial carcinoma. The purpose of this study was to determine whether the use of an intrauterine manipulator was associated with an increase in the pathologic reporting of lymphovascular space invasion (LVSI), which is an important determinant in choosing adjuvant therapy. We hypothesized that intracavitary manipulation and an increase of the intrauterine pressure could cause pseudolymphovascular invasion.

Research paper thumbnail of KLF6-SV1 is a novel uterine leiomyosarcoma gene: From transgenic mouse model to human disease

Gynecologic Oncology, 2011

Objective: Ovarian clear cell carcinomas (CCCs) exhibit frequent ARID1A mutations and HNF1B overe... more Objective: Ovarian clear cell carcinomas (CCCs) exhibit frequent ARID1A mutations and HNF1B overexpression, but the epigenomic features that characterize CCCs are not known. We previously reported that several CCC-specific genes, including HNF1B, are regulated by promoter methylation. Our objectives were to: (1) use genomewide methylation data to develop a CCC-specific methylation signature, and (2) characterize the molecular features of these genes.

Research paper thumbnail of Comparative immunohistochemical studies of endometriosis lesions and endometriotic cysts

Fertility and Sterility, 2002

Of these 456 subjects, 17% were younger than 20 years of age, 65% were between 21 and 45 years, a... more Of these 456 subjects, 17% were younger than 20 years of age, 65% were between 21 and 45 years, and 18% were over 45 years. In all age groups, the majority of patients (54%) showed spontaneous regression. The progression rate was significantly higher in younger patients (Ͻ20 years) than in older patients (P Ͻ 0.025).

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