T. Kurrikoff - Academia.edu (original) (raw)

Papers by T. Kurrikoff

Research paper thumbnail of P.1.a.019 Serotonin transporter gene promoter polymorphism, education, depression and relations with partner

European Neuropsychopharmacology - EUR NEUROPSYCHOPHARMACOL, 2009

Research paper thumbnail of The effect of 5-HTT gene promoter polymorphism on impulsivity depends on family relations in girls

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2008

The short (S) allele of the 5-HTT gene promoter region polymorphism (5-HTTLPR), in combination wi... more The short (S) allele of the 5-HTT gene promoter region polymorphism (5-HTTLPR), in combination with adverse environmental influence, leads to higher likelihood of depression. Impulsivity has been related to low serotonin turnover, poor regulation of affect, and problems in the family, including child maltreatment. The current study explored the effect of the 5-HTTLPR polymorphism in the serotonin transporter gene and adverse family environment on impulsivity in adolescents. Healthy adolescents participating in the Estonian Children Personality Behaviour and Health Study (n = 483) filled the Adaptive and Maladaptive Impulsivity Scale (AMIS), Barratt Impulsiveness Scale (BIS-11), a scale measuring family relations, and were genotyped. While genotype alone was not associated with thoughtlessness, BIS-11 impulsiveness, fast decision-making or excitement seeking, 5-HTTLPR S allele carriers, however, had higher scores of disinhibition. In girls carrying the S allele, scores of thoughtlessness and disinhibition depended on family relations, being higher with less warmth in the family. Adverse family relations had no effect on impulsivity in girls with LL genotype. In boys, the effects of family relations on maladaptive impulsivity did not depend on genotype. However, the S allele and high maltreatment in the family both independently increased disinhibition and the BIS-11 score in boys. Family environment and the 5-HTTLPR genotype had no interactive effect on excitement seeking or fast decision-making. In summary, carrying the S allele may lead to high maladaptive impulsivity due to higher sensitivity to environmental adversity, which is more significantly expressed in girls.

Research paper thumbnail of P.6.02 Substance use and serotonin transporter gene L/S polymorphism in children and adolescents

European Neuropsychopharmacology, 2009

Research paper thumbnail of P.2.09 Serotonin transporter gene promoter polymorphism and family relations: effect on symptoms of depression in adolescents

European Neuropsychopharmacology, 2009

Research paper thumbnail of S.2.02 The brain prepared to become anxious: predisposing neurobiology in animals and humans

European Neuropsychopharmacology, 2009

Research paper thumbnail of P.1.a.019 Serotonin transporter gene promoter polymorphism, education, depression and relations with partner

European Neuropsychopharmacology, 2009

Research paper thumbnail of Association of a functional variant of the nitric oxide synthase 1 gene with personality, anxiety, and depressiveness

Development and Psychopathology, 2012

A functional promoter polymorphism of the nitric oxide synthase 1 gene first exon 1f variable num... more A functional promoter polymorphism of the nitric oxide synthase 1 gene first exon 1f variable number tandem repeat (NOS1 ex1f-VNTR) is associated with impulsivity and related psychopathology. Facets of impulsivity are strongly associated with personality traits; maladaptive impulsivity with neuroticism; and adaptive impulsivity with extraversion. Both high neuroticism and low extraversion predict anxiety and depressive symptoms. The aim of the present study was to evaluate the effect of the NOS1 ex1f-VNTR genotype and possible interaction with environmental factors on personality, anxiety, and depressiveness in a population-representative sample. Short allele carriers had higher neuroticism and anxiety than individuals with the long/long (l/l) genotype. Male short/short homozygotes also had higher extraversion. In the face of environmental adversity, females with a short allele had higher scores of neuroticism, anxiety, and depressiveness compared to the l/l genotype. Males were more sensitive to environmental conditions when they had the l/l genotype and low extraversion. In conclusion, the NOS1 ex1f-VNTR influences personality and emotional regulation dependent on gender and environment. Together with previous findings on the effect of the NOS1 genotype on impulse control, these data suggest that NOS1 should be considered another plasticity gene, because its variants are associated with different coping strategies.

Research paper thumbnail of P.1.a.017 Effect of a functional NOS1 promoter polymorphism and life events on personality, anxiety and depressiveness

European Neuropsychopharmacology, 2010

Research paper thumbnail of P.1.a.019 Serotonin transporter gene promoter polymorphism, education, depression and relations with partner

European Neuropsychopharmacology - EUR NEUROPSYCHOPHARMACOL, 2009

Research paper thumbnail of The effect of 5-HTT gene promoter polymorphism on impulsivity depends on family relations in girls

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2008

The short (S) allele of the 5-HTT gene promoter region polymorphism (5-HTTLPR), in combination wi... more The short (S) allele of the 5-HTT gene promoter region polymorphism (5-HTTLPR), in combination with adverse environmental influence, leads to higher likelihood of depression. Impulsivity has been related to low serotonin turnover, poor regulation of affect, and problems in the family, including child maltreatment. The current study explored the effect of the 5-HTTLPR polymorphism in the serotonin transporter gene and adverse family environment on impulsivity in adolescents. Healthy adolescents participating in the Estonian Children Personality Behaviour and Health Study (n = 483) filled the Adaptive and Maladaptive Impulsivity Scale (AMIS), Barratt Impulsiveness Scale (BIS-11), a scale measuring family relations, and were genotyped. While genotype alone was not associated with thoughtlessness, BIS-11 impulsiveness, fast decision-making or excitement seeking, 5-HTTLPR S allele carriers, however, had higher scores of disinhibition. In girls carrying the S allele, scores of thoughtlessness and disinhibition depended on family relations, being higher with less warmth in the family. Adverse family relations had no effect on impulsivity in girls with LL genotype. In boys, the effects of family relations on maladaptive impulsivity did not depend on genotype. However, the S allele and high maltreatment in the family both independently increased disinhibition and the BIS-11 score in boys. Family environment and the 5-HTTLPR genotype had no interactive effect on excitement seeking or fast decision-making. In summary, carrying the S allele may lead to high maladaptive impulsivity due to higher sensitivity to environmental adversity, which is more significantly expressed in girls.

Research paper thumbnail of P.6.02 Substance use and serotonin transporter gene L/S polymorphism in children and adolescents

European Neuropsychopharmacology, 2009

Research paper thumbnail of P.2.09 Serotonin transporter gene promoter polymorphism and family relations: effect on symptoms of depression in adolescents

European Neuropsychopharmacology, 2009

Research paper thumbnail of S.2.02 The brain prepared to become anxious: predisposing neurobiology in animals and humans

European Neuropsychopharmacology, 2009

Research paper thumbnail of P.1.a.019 Serotonin transporter gene promoter polymorphism, education, depression and relations with partner

European Neuropsychopharmacology, 2009

Research paper thumbnail of Association of a functional variant of the nitric oxide synthase 1 gene with personality, anxiety, and depressiveness

Development and Psychopathology, 2012

A functional promoter polymorphism of the nitric oxide synthase 1 gene first exon 1f variable num... more A functional promoter polymorphism of the nitric oxide synthase 1 gene first exon 1f variable number tandem repeat (NOS1 ex1f-VNTR) is associated with impulsivity and related psychopathology. Facets of impulsivity are strongly associated with personality traits; maladaptive impulsivity with neuroticism; and adaptive impulsivity with extraversion. Both high neuroticism and low extraversion predict anxiety and depressive symptoms. The aim of the present study was to evaluate the effect of the NOS1 ex1f-VNTR genotype and possible interaction with environmental factors on personality, anxiety, and depressiveness in a population-representative sample. Short allele carriers had higher neuroticism and anxiety than individuals with the long/long (l/l) genotype. Male short/short homozygotes also had higher extraversion. In the face of environmental adversity, females with a short allele had higher scores of neuroticism, anxiety, and depressiveness compared to the l/l genotype. Males were more sensitive to environmental conditions when they had the l/l genotype and low extraversion. In conclusion, the NOS1 ex1f-VNTR influences personality and emotional regulation dependent on gender and environment. Together with previous findings on the effect of the NOS1 genotype on impulse control, these data suggest that NOS1 should be considered another plasticity gene, because its variants are associated with different coping strategies.

Research paper thumbnail of P.1.a.017 Effect of a functional NOS1 promoter polymorphism and life events on personality, anxiety and depressiveness

European Neuropsychopharmacology, 2010