T Mamatha - Academia.edu (original) (raw)

Papers by T Mamatha

The aim of this investigation was to develop and validate a dissolution method for combination of... more The aim of this investigation was to develop and validate a dissolution method for combination of ibuprofen and paracetamol tablets using UV spectrophotometric method. The analytical method was developed by UV spectrophotometry using absorbance ratio method which involves the measurement of absorbance at two wavelengths 243 nm as the λmax of ibuprofen and 213.8 as isoabsorbtive point. The method was validated according to ICH guidelines which include accuracy, precision, specificity, linearity and analytical range. In addition, stability and solubility of both the drugs in different media i.e., water and phosphate buffer of different pH were studied. Based on this, the established dissolution conditions were 900 ml of 0. 2 M phosphate buffer pH 7.2 as dissolution medium at 37±0.5 °C, using USP apparatus II at a stirring rate of 75 rpm for 1 hr. The corresponding dissolution profiles were constructed and all the selected brands showed more than 80% drug release within 45 minutes. Thu...

The aim of the present study is to investigate the physicochemical equivalence of five brands of ... more The aim of the present study is to investigate the physicochemical equivalence of five brands of tablets containing paracetamol purchased from different retail pharmacy outlets in Hyderabad, Andhrapradesh, India. The tablets were evaluated for uniformity of weight, friability, hardness, thickness, disintegration, dissolution and assay. All the five brands of the tablets passed the Indian Pharmacopoeia (IP) standards for all in vitro evaluation tests. There was no significant difference in the amount of paracetamol released from the different brands (P>0.05). These results indicate that the tablets of paracetamol purchased from retail outlets in Hyderabad are manufactured and marketed from WHO GMP certified Indian companies. Further work is recommended on bioequivalence of these tablets.

International Journal of PharmTech Research, 2020

The heed on natural medications and their usage have been expanding quickly as of late, even in r... more The heed on natural medications and their usage have been expanding quickly as of late, even in regions where present day medication is accessible. Plant derived substances and herbal drugs ,recently attracted great interest towards their unique & vast applications. As medicinal herbs, have bioactive compounds in abundance & can be utilized in conventional and current medication. There has been an increasing demand for plant based medicines, health products, pharmaceuticals, food supplements. The Objective of this Study is to enlighten the various immune enhancing properties of ginseng & to deliver these immune strengthening properties of ginseng it has been formulated into a syrup dosage form. Formulation of syrup was designed by utilizing extracts of Panax Ginseng, Sucrose, Benzoin & required quantity of Distilled water. The prepared herbal syrup was evaluated for different physicochemical parameters like pH, color, odour, taste, density, specific gravity, viscosity and stability....

Journal of Pharmaceutical Research, 2017

The aim of the research is to develop Nevirapine tablets by direct compression method by improvin... more The aim of the research is to develop Nevirapine tablets by direct compression method by improving solubility using solid dispersion technique. Nevirapine is anti-viral drug, which is used in the prevention and treatment of HIV infections. It belongs to class II drug in Bio-Pharmaceutical Classification System i.e. low solubility and high permeability. It has a biological half-life of 45 hours. One of the major problems with this drug is its low solubility in biological fluids, which results into poor bioavailability after oral administration. Here, solid dispersions of Nevirapine are prepared with different carriers such as Plasdone S-630 and Soluplus in order to increase its solubility and dissolution rate. By increasing the solubility of Nevirapine, its bioavailability can be increased. Pre-formulation studies regarding the drug-carrier interaction was carried out by fourier transform infrared spectroscopy and differential scanning calorimetry. Nevirapine solid dispersions were evaluated for solubility, drug content estimation and in vitro dissolution studies. Powder blend was evaluated for bulk density, tapped density, Carr's index, Hausner's ratio and angle of repose. The dissolution pattern of the Nevirapine from all the standard dispersions followed predominantly first order kinetics. The study reflects the vital role of polymers as a novel approach to improve the solubility of nevirapine, which could minimize the variable dissolution rate with increase in bioavailability. With the studies conducted, the percentage drug release of Nevirapine was increased by melting method with Nevirapine: Plasdone S630 in the ratio of 1:2 Nevirapine is a suitable drug to formulate into tablet by using the above mentioned carriers and may provide a better therapeutic profile than that of conventional dosage form.

Journal of Pharmaceutical Research, 2016

The aim of the study was to evaluate medication errors in the Acute Multi Care Unit in a tertiary... more The aim of the study was to evaluate medication errors in the Acute Multi Care Unit in a tertiary care hospital. The study aims to promote safety in medication use and ensure quality in the healthcare service. The study objective was to detect and categorize medication errors, to ensure rational drug use in the hospital, to make recommendations for doctors, nurses, and patients to promote safe use of medications. The study was conducted in 152 inpatients in the Acute Multi Care Unit in a tertiary care hospital located in Hyderabad. It is a prospective observational study carried over a period of 8 months. Data was collected using a data collection form which included patient details, drug details, and criteria for identifying errors, its categorization, and the details of drugs involved in errors. Complete details of patients and medications were recorded through a review of nursing charts, patient's admission chart, patient's history sheet and doctor's order sheet. Collected details were then evaluated to detect the prescribing, administration, omission error, dose error and poly pharmacy. The study was conducted in 152 patients, where total number of prescriptions with error is 28. The percentage distribution of prescriptions with error (18%) and without error (82%) was also calculated. Among which prescribing errors (50%) were the most frequently occurring types of errors, which was followed by omission errors (18%), administration error (18%) and dose error (14%). Error prescriptions belonging to male patients were (60.7%) while for females it was (39.3%). And a total of 26 Poly pharmacy prescriptions were also reported among which (69%) belongs to male and (31%) belongs to female. The professionals involved in the practice should be focused, alert and determined. The nursing staff also needs to be slightly more knowledgeable and focused. Since this is an observational study and there is no scope of any intervention which can modify outcome.

Journal of Applied …, 2011

Excipients are included in dosage forms to aid manufacture, administration or absorption. Althoug... more Excipients are included in dosage forms to aid manufacture, administration or absorption. Although considered pharmacologically inert, excipients can initiate, propagate or participate in chemical or physical interactions with drug compounds, which may compromise the effectiveness of a medication. Exicipients are not exquisitely pure. Even for the most commonly used excipients, it is necessary to understand the context of their manufacture in order to identify potential active pharmaceutical ingredients interactions with trace components. Chemical interactions can lead to degradation of the active ingredient, thereby reducing the amount available for therapeutic effect. Physical interactions can affect rate of dissolution, uniformity of dose or ease of administration.

British Journal of Pharmaceutical Research, 2015

Lowering of blood glucose level in patients can be achieved by insulin therapy as it plays a key ... more Lowering of blood glucose level in patients can be achieved by insulin therapy as it plays a key role in the control of hyperglycaemia for type 1 diabetes. Insulin delivery systems that are currently available include syringes, infusion pumps, jet injectors and pens. The tedious part for the type 1 diabetes patients is to tolerate needle after needle injections while undergoing treatment for both glucose measurement and to deliver insulin. A rigorous research effort has been undertaken worldwide to replace the authentic subcutaneous route by a more accurate and non-invasive route. The newer methods explored include the artificial pancreas with closed-loop system, transdermal insulin, and buccal, oral, pulmonary, nasal, ocular and rectal routes. The future trends include use of insulin inhalers, trandermal patches, pills, pumps etc. Some of the non-invasive delivery systems include polymeric hydrogels and insulin loaded bioadhesive poly(D,L-lactide-co-glycolide) nanoparticles for oral delivery, aerosolized liposomes with dipalmitoyl phosphatidylcholine for pulmonary delivery, β cyclodextrins for nasal delivery, microneedle arrays fabricated from hyaluronic acid and iontophoresis for trandermal delivery, chitosan-zinc-insulin complex for the controlled delivery of insulin.

The Indian pharmacist, 2008

Lansoprazole is used in the treatment of ulcer and reflux oesophagitis. It is practically insolub... more Lansoprazole is used in the treatment of ulcer and reflux oesophagitis. It is practically insoluble in water, shows poor dissolution characteristics and results into poor bioavailability after oral administration. Among the various approaches to improve the dissolution rate of poorly soluble drugs, the preparation of solid dispersion (SD) has often proved to be successful. The main objective of the present study was to improve the dissolution rate of Lansoprazole. Physical mixtures and SDs of Lansoprazole were prepared to enhance its water solubility using polyvinyl pyrrolidone (PVP) K-30, urea and polyethylene glycol (PEG) 6000 as water soluble carriers at various proportions (1:1, 1:3, 1:9, 3:1, 9:1 by weight) by employing solvent evaporation method (SEM). The drug release profile was studied using USP XXVII dissolution apparatus-I in phosphate buffer pH 6.8. Lansoprazole was released at a much higher rate from SDs and physical mixtures as compared to that of pure drug powder. The...

Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2010

Lercanidipine hydrochloride (LRDP) is used in the treatment of hypertension because of its select... more Lercanidipine hydrochloride (LRDP) is used in the treatment of hypertension because of its selectivity and specificity on the smooth vascular cells. The pharmacokinetic parameters make LRDP a suitable candidate for transdermal delivery. The purpose of the study was to select a suitable formulation for the development of transdermal drug-delivery system (TDDS) of LRDP and to determine the effect of penetration enhancer, limonene on drug permeation The matrix type TDDS of LRDP were prepared by solvent evaporation technique. Formulations A1, A2, A3, A4, A5 and A6 were composed of Eudragit RL100 (ERL) and hydroxypropyl methyl cellulose (HPMC) in 1.5:8.5, 3:7, 4:6, 6:4, 7:3 and 8.5:1.5 ratios respectively. All the six formulations carried 10 mg of LRDP/patch area, 8% v/w of d-limonene as a penetration enhancer, 20% v/w of propylene glycol as plasticizer in methanol and dichloromethane as solvent system. The prepared TDDS were evaluated for physicochemical characteristics, in-vitro releas...

Current Trends in …, 2009