Tomislav Strinic - Academia.edu (original) (raw)

Papers by Tomislav Strinic

Kao sveucilisni udžbenik ovo je djelo namijenjeno prije svega studentima, polaznicima preddiploms... more Kao sveucilisni udžbenik ovo je djelo namijenjeno prije svega studentima, polaznicima preddiplomskih, diplomskih, integriranih, specijalistickih i doktorskih studija, ali i svima onima koji se bave forenzicnom toksikologijom ili su zainteresirani za istraživanja u tom podrucju. Također je namijenjeno sudcima, odvjetnicima i svima ostalima kojima je potrebno znanje, poduka ili razumijevanje vjestacenja iz forenzicne toksikologije. S obzirom na multidisciplinarnost tekstovi u knjizi podijeljeni su u dvadeset poglavlja. Obrađeni su osnovni pojmovi u toksikologiji, prikazana je dobra laboratorijska praksa, sudbina otrova u ljudskom organizmu, vrste i zapljena droga, ostali otrovi, vrste uzoraka za analizu. Obrađen je utjecaj sredstava ovisnosti na ljudsko zdravlje s osvrtom na njihov utjecaj na novorođence. Posebno je dan prikaz testiranja i vjestacenja sudionika u prometu. Spomenuta su testiranja na radnome mjestu i zloporaba lijekova u sportu. Na kraju je dan prikaz zakonskih okvira. ...

Fertility and Sterility, 2003

Objective: To determine whether oral contraceptives affect lung mechanics. Design: Open-label stu... more Objective: To determine whether oral contraceptives affect lung mechanics. Design: Open-label study. Setting: Academic medical center. Patient(s): Thirty-six healthy nonsmoking women. Intervention(s): Administration of an oral contraceptive containing ethinyl estradiol, 35 g, and norgestimat, 250 g for 6 months. Main Outcome Measure(s): Forced vital capacity; forced expiratory volume in 1 second; peak expiratory flow; and flow at large, medium, and small lung volumes. Result(s): At 6 months, all forced expiratory flow and volume had increased significantly (from 6.5% to 15%). Flows at small lung volumes especially increased. Conclusion(s): Combination oral contraceptives have a measurable effect on lung mechanics.

PubMed, 2000

The small cell neuroendocrine carcinoma of the uterine cervix is a rare, but very aggressive neop... more The small cell neuroendocrine carcinoma of the uterine cervix is a rare, but very aggressive neoplasm. Previous reports suggested that it had dismall prognosis if treated with conventional surgery and radiotherapy, even in early stage disease. We present the case of neuroendocrine cervical carcinoma that was cured from the disease following conventional surgery only.

Respiration, 1999

Background: Abnormalities in connective tissue and spirometric disorders have previously been fou... more Background: Abnormalities in connective tissue and spirometric disorders have previously been found in women with genital descensus. Objective: To evaluate the association of descensus and respiratory function. Methods: The blood gases and sex hormones were measured in 130 women scheduled for surgical correction of descensus and 60 matched women without descensus. All subjects were nonsmokers and without past or present cardiorespiratory disease. Results: Women with descensus had a lower pH (7.39 ± 0.04 vs. 7.41 ± 0.04, p = 0.01), lower arterial tensions of oxygen (12.7 ± 12. vs. 14.1 ± 0.9 kPa, p = 0.003) and carbon dioxide (5.1 ± 0.4 vs. 5.3 ± 0.3 kPa) but a higher hemoglobin concentration (141 ± 11 vs. 132 ± 9 g/l) and a higher serum progesterone in the follicular phase of the cycle (3.1 ± 4 vs. 1.5 ± 1 ng/ml, p = 0.03). In 39 (30%) women with descensus, the arterial carbon dioxide tension was below 4.9 kPa. All subjects ventilated more in the luteal compared to the follicular phase of the cycle. In women with descensus, the hemoglobin concentration increased with decreasing arterial oxygen tension (p = 10–4) and with decreasing pH (p < 10–3). Conclusion: Women with descensus frequently hyperventilate and, compared with women without descensus, have a lower arterial oxygen tension, increased hemoglobin concentration and slightly lower pH.

American Journal of Obstetrics and Gynecology, 2001

Objective: Our objectives were to establish an outpatient program for uterine artery embolization... more Objective: Our objectives were to establish an outpatient program for uterine artery embolization of fibroids and to monitor the following: percentage of patients who required immediate hospitalization or admission within 2 weeks, outcomes in terms of the degree of ultrasound regression of the fibroids, patient satisfaction, reduction of pressure symptoms, and reduction of bleeding. Study Design: Patients were screened by

Acta Clinica Croatica, Jun 1, 2013

Clinical department of gynecology and obstetrics, school of medicine, university of split; 2 scho... more Clinical department of gynecology and obstetrics, school of medicine, university of split; 2 school of medicine, university of split, split, Croatia summAry-The aim of the study was to compare perinatal outcome of singleton and twin pregnancies conceived after assisted reproductive technologies (Art). This retrospective study included singleton and twin pregnancies conceived after Art in the period from January 1, 2007 until december 31, 2008. The study variables were maternal age (years), parity, body mass index (BmI; kg/m 2), week (≤36 6/7 and ≥37) and mode of delivery (vaginal and cesarean section), birth weight (grams) and APgAr score (≤7; 8-10). during the study period, there were 195 pregnancies after Art that fulfilled inclusion criteria. we found no between-group difference in parity (χ 2 =0.0133; P=0.9081), but such difference was found in mean age (t=2.0486; P=0.0419) and BmI (χ 2 =31.038; P=0.001). A statistically significant difference was recorded in preterm delivery rate (χ 2 =25.539; P=0.001), average duration of pregnancy (t=12.8591; P=0.001), average birth weight (t=10.5446; P=0.001) and mode of delivery (χ 2 =13,691; P=0.001). A statistically significant difference was found in low birth weight babies (χ 2 =102.02; P=0.001) and APgAr score (χ 2 =19.96; P=0.001), but there was no difference in the prevalence of small for gestational age babies (χ 2 =0.90629; P=0.635). In conclusion, this study indicated the perinatal outcome after Art to be considerably poorer in twins than in singletons.

Acta clinica Croatica, 2013

The aim of the study was to compare perinatal outcome of singleton and twin pregnancies conceived... more The aim of the study was to compare perinatal outcome of singleton and twin pregnancies conceived after assisted reproductive technologies (ART). This retrospective study included singleton and twin pregnancies conceived after ART in the period from January 1, 2007 until December 31, 2008. The study variables were maternal age (years), parity, body mass index (BMI; kg/m2), week (< or =36 (6/7) and > or = 37) and mode of delivery (vaginal and cesarean section), birth weight (grams) and APGAR score (< or = 7; 8-10). During the study period, there were 195 pregnancies after ART that fulfilled inclusion criteria. We found no between-group difference in parity (chi2 = 0.0133; P = 0.9081), but such difference was found in mean age (t = 2.0486; P = 0.0419) and BMI (chi2 = 31.038; P = 0.001). A statistically significant difference was recorded in preterm delivery rate (chi2 = 25.539; P = 0.001), average duration of pregnancy (t = 12.8591; P = 0.001), average birth weight (t = 10.54...

Hepato-gastroenterology

The aim of this study was to determine the feasibility and technical aspects of a new endoluminal... more The aim of this study was to determine the feasibility and technical aspects of a new endoluminal surgical procedure: transvaginal laparoscopically assisted endoscopic cholecystectomy. Three female patients underwent transvaginal laparoscopically assisted endoscopic cholecystectomy (aged 40, 61 and 33 years). Pneumoperitoneum was created through a 5mm supraumbilical incision. Through the posterior fornix of the vagina the second 10mm trocar, laparoscope and 5mm laparoscopic grasper were introduced. The gallbladder was dissected using standard 5mm laparoscopic grasper, hook, electrocoagulation and harmonic shears introduced supraumbilically. The dissected gallbladder was removed in a specimen retrieval bag. Transvaginal laparoscopically assisted endoscopic cholecystectomy was feasible in all patients. No intraoperative or postoperative complications were observed and there was no need for extra-umbilical skin incisions. Total operative time ranged between 60 and 75 minutes. Median le...

Collegium antropologicum, 2010

Our aim was to investigate the incidence of respiratory infections in children treated at the Ped... more Our aim was to investigate the incidence of respiratory infections in children treated at the Pediatric Department of the University Hospital Mostar during war (1993 and 1994) and after the war (2003 and 2004). In order to collect data we used medical histories of children with respiratory infections. Incidence of respiratory infections in children in war period was 230/1000, while in post-war period it was 190/1000. There was no significant difference in the incidence of respiratory infections in children during war and after the war (p = 0.051). We have not found increase in respiratory infections prevalence in children treated during war period at the Pediatric department of University Hospital Mostar, compared to the period after the war. However, we did report certain differences related to age, clinical parameters, seasonal pattern, diagnosis, therapy and mean hospitalization time.

Collegium antropologicum, 2007

The aim of this study was to investigate the prevalence of pelvic organ prolapse in urban and rur... more The aim of this study was to investigate the prevalence of pelvic organ prolapse in urban and rural women and to identify possible related factors. They were 1749 participants; one thousand four hundred seventeen (81%) urban women and 332 rural residents (19%). The urban and rural women were congruently regarding to age, parity, using oral contraceptives and postmenopausal status. The urban women were more often obese (p < 0.01), estrogen replacement users (p < 0.001), smokers (p < 0.001), with mild (p < 0.001) and high (p < 0.001) education, and they were often divorced (p < 0.05) than rural women. Rural women were more often alcohol consumers (p < 0.001), with low level of education (p < 0.001) and more often married (p < 0.05) than rural examinees. There were no association between the presence of prolapse and: weight, menopausal status, oral contraceptives and estrogen replacement using, smoking, alcohol consuming and marital status. There were not obs...

Collegium antropologicum, 2005

We tested two groups of singletons born at term: fifty-six eutrophic newborns and 56 hypotrophic ... more We tested two groups of singletons born at term: fifty-six eutrophic newborns and 56 hypotrophic subjects. They were selected randomly from all newborns delivered by vaginal route between 8 and 14 hours. Excluded were preeclampsia, diabetes, labours longer than 12 hours and newborns with malformations. Written informed consent was obtained from all women and data were collected before and after labour. Umbilical cord blood samples were obtained immediately following the delivery and plasma cortisol concentrations were measured by radioimmunoassay. The groups did not differ significantly regarding maternal age, parity, gestational age and Apgar score, but birth weight was significant differed (p < 0.001). In addition, eutrophic newborns had significantly elevated cortisol levels (457.7 nmol/L, 321.8-696.6 nmol/L) compared with hypotrophic newborns (320.5 nmol/L, 215.1-578.7 nmol/L, p < 0.001). The role of fetal cortisol in intrauterine growth restriction (IUGR) pregnancy and la...

Collegium antropologicum, 2005

The aim of this study was to describe anthropometric, clinical, socio-demographic characteristics... more The aim of this study was to describe anthropometric, clinical, socio-demographic characteristics and lifestyle habits of pregnant smokers in comparison to pregnant nonsmokers. During years 1999-2003, 1,435 pregnant smokers and 4,772 pregnant nonsmokers were interviewed after delivery with a questionnaire. They were recorded clinical, anthropometric and socio-demographic data, smoking status, labor outcome, maternal and fetal hemoglobin concentrations for each patient. The two groups were comparable in anthropometric and clinical characteristics, duration of pregnancy and mode of delivery, except for birth weights, which were significantly lower in newborns of smokers. Maternal hemoglobin concentrations were significantly lower in smokers, but fetal hemoglobin concentrations were significantly higher in babies of smokers. The proportion of pregnant women who smoked during pregnancy was higher among urban women, among women with lower educational level and among unemployed subjects i...

Collegium antropologicum, 2003

The aim of this study is to determine the differences in sexual life of women with cervical cance... more The aim of this study is to determine the differences in sexual life of women with cervical cancer after surgery and radiation therapy. A total of 210 patients treated for cervical cancer at the Department of Obstetrics and Gynecology, School of Medicine, University of Zagreb, Croatia between March 2001 and March 2003 were asked to fill in the questionnaire. Sexual life had worsened in 42.86% of the surgical patients, as had in 25.00% of irradiated patients (p < 0.01). The main reason of sex life impairment was fear of pain (55.55% and 42.86%, respectively (p > 0.05)). More than 80% of patients didn't notice any changes in their partner's behavior. Almost every third woman felt certain change in her "body image", similar in both groups (p > 0.05). Need for consultations regarding sex life after diagnosis were recognized by 71.43% of patients. In conclusion we can say that considerable amount of attention should be given to psychological and sexual aspects ...

Collegium antropologicum, 2003

The aim of the paper was to describe general health, socio-economic and demographic characteristi... more The aim of the paper was to describe general health, socio-economic and demographic characteristics of endometrial cancer patients in comparison to healthy women. During years 1996-2002, 100 women with endometrial carcinoma and 100 healthy women were interviewed about their health, socio-economic and demographic status and compared. The endometrial cancer patients were more often older, postmenopausal, with higher body weight, and frequent history of hypertension and diabetes than controls. The healthy women had greater number of deliveries, used oral contraceptive and hormone replacement therapy, were smokers and alcohol consumers and lived in urban centers more often than patients. The cancer patients had worse socio-economic status, less education, and were more frequent single and widowed than controls. These data may be relevant for public health services in the future to improvement quality of life of the cancer patients.

Collegium antropologicum, 2010

Collagen metabolism is altered in the pelvic organ tissues of women with genital prolapse. The ai... more Collagen metabolism is altered in the pelvic organ tissues of women with genital prolapse. The aim of this study was to compare collagen metabolism by measuring matrix metalloproteinase-1 (MMP-1) expression in uterosacral ligament tissues of postmenopausal women with and without genital prolapse. Uterosacral ligament tissues were obtained at the time of abdominal or vaginal surgery from twenty-four patients with pelvic organ prolapse (POP) and 21 women who underwent gynecologic surgery for benign indications. The tissue samples were analyzed by immunohistochemistry. There were no differences in age, BMI and parity between two groups. The patients with genital prolapse demonstrated significantly higher occurences of MMP-1 expression compared to controls. These findings indicate that increased MMP-1 expression in uterosacral ligaments is associated with genital prolapse. Our data are consistent with the theory that increased collagen breakdown may play an important role in the onset a...

Collegium antropologicum, 2003

The aim of this study was to examine the prevalence of dysmenorrhea in female adolescents and the... more The aim of this study was to examine the prevalence of dysmenorrhea in female adolescents and the influence of anthropological characteristics and lifestyle factors on menstrual pain. Two hundred and ninety seven girls from several elementary and secondary schools were interviewed about the presence of the menstrual pain, their age, height and weight, menarcheal age, menstrual cycles quality, smoking and sexual activity. There were 164 (55%) subjects with and one hundred and thirty three (45%) without dysmenorrhea. The adolescents with dysmenorrhea answered the questions about missing activities and taking pills for pain. No difference was observed between the girls with and the girls without dysmenorrhea in their chronological age, height, weight, menarcheal age, menstrual cycles quality, cigarette smoking and sexual activity. In the group of dysmenorrheic adolescents there was infrequent missing activities and bedrest, but missing school was observed in 22 percent and taking pills...

Acta Obstetricia Et Gynecologica Scandinavica

Kao sveucilisni udžbenik ovo je djelo namijenjeno prije svega studentima, polaznicima preddiploms... more Kao sveucilisni udžbenik ovo je djelo namijenjeno prije svega studentima, polaznicima preddiplomskih, diplomskih, integriranih, specijalistickih i doktorskih studija, ali i svima onima koji se bave forenzicnom toksikologijom ili su zainteresirani za istraživanja u tom podrucju. Također je namijenjeno sudcima, odvjetnicima i svima ostalima kojima je potrebno znanje, poduka ili razumijevanje vjestacenja iz forenzicne toksikologije. S obzirom na multidisciplinarnost tekstovi u knjizi podijeljeni su u dvadeset poglavlja. Obrađeni su osnovni pojmovi u toksikologiji, prikazana je dobra laboratorijska praksa, sudbina otrova u ljudskom organizmu, vrste i zapljena droga, ostali otrovi, vrste uzoraka za analizu. Obrađen je utjecaj sredstava ovisnosti na ljudsko zdravlje s osvrtom na njihov utjecaj na novorođence. Posebno je dan prikaz testiranja i vjestacenja sudionika u prometu. Spomenuta su testiranja na radnome mjestu i zloporaba lijekova u sportu. Na kraju je dan prikaz zakonskih okvira. ...

Fertility and Sterility, 2003

Objective: To determine whether oral contraceptives affect lung mechanics. Design: Open-label stu... more Objective: To determine whether oral contraceptives affect lung mechanics. Design: Open-label study. Setting: Academic medical center. Patient(s): Thirty-six healthy nonsmoking women. Intervention(s): Administration of an oral contraceptive containing ethinyl estradiol, 35 g, and norgestimat, 250 g for 6 months. Main Outcome Measure(s): Forced vital capacity; forced expiratory volume in 1 second; peak expiratory flow; and flow at large, medium, and small lung volumes. Result(s): At 6 months, all forced expiratory flow and volume had increased significantly (from 6.5% to 15%). Flows at small lung volumes especially increased. Conclusion(s): Combination oral contraceptives have a measurable effect on lung mechanics.

PubMed, 2000

The small cell neuroendocrine carcinoma of the uterine cervix is a rare, but very aggressive neop... more The small cell neuroendocrine carcinoma of the uterine cervix is a rare, but very aggressive neoplasm. Previous reports suggested that it had dismall prognosis if treated with conventional surgery and radiotherapy, even in early stage disease. We present the case of neuroendocrine cervical carcinoma that was cured from the disease following conventional surgery only.

Respiration, 1999

Background: Abnormalities in connective tissue and spirometric disorders have previously been fou... more Background: Abnormalities in connective tissue and spirometric disorders have previously been found in women with genital descensus. Objective: To evaluate the association of descensus and respiratory function. Methods: The blood gases and sex hormones were measured in 130 women scheduled for surgical correction of descensus and 60 matched women without descensus. All subjects were nonsmokers and without past or present cardiorespiratory disease. Results: Women with descensus had a lower pH (7.39 ± 0.04 vs. 7.41 ± 0.04, p = 0.01), lower arterial tensions of oxygen (12.7 ± 12. vs. 14.1 ± 0.9 kPa, p = 0.003) and carbon dioxide (5.1 ± 0.4 vs. 5.3 ± 0.3 kPa) but a higher hemoglobin concentration (141 ± 11 vs. 132 ± 9 g/l) and a higher serum progesterone in the follicular phase of the cycle (3.1 ± 4 vs. 1.5 ± 1 ng/ml, p = 0.03). In 39 (30%) women with descensus, the arterial carbon dioxide tension was below 4.9 kPa. All subjects ventilated more in the luteal compared to the follicular phase of the cycle. In women with descensus, the hemoglobin concentration increased with decreasing arterial oxygen tension (p = 10–4) and with decreasing pH (p &lt; 10–3). Conclusion: Women with descensus frequently hyperventilate and, compared with women without descensus, have a lower arterial oxygen tension, increased hemoglobin concentration and slightly lower pH.

American Journal of Obstetrics and Gynecology, 2001

Objective: Our objectives were to establish an outpatient program for uterine artery embolization... more Objective: Our objectives were to establish an outpatient program for uterine artery embolization of fibroids and to monitor the following: percentage of patients who required immediate hospitalization or admission within 2 weeks, outcomes in terms of the degree of ultrasound regression of the fibroids, patient satisfaction, reduction of pressure symptoms, and reduction of bleeding. Study Design: Patients were screened by

Acta Clinica Croatica, Jun 1, 2013

Clinical department of gynecology and obstetrics, school of medicine, university of split; 2 scho... more Clinical department of gynecology and obstetrics, school of medicine, university of split; 2 school of medicine, university of split, split, Croatia summAry-The aim of the study was to compare perinatal outcome of singleton and twin pregnancies conceived after assisted reproductive technologies (Art). This retrospective study included singleton and twin pregnancies conceived after Art in the period from January 1, 2007 until december 31, 2008. The study variables were maternal age (years), parity, body mass index (BmI; kg/m 2), week (≤36 6/7 and ≥37) and mode of delivery (vaginal and cesarean section), birth weight (grams) and APgAr score (≤7; 8-10). during the study period, there were 195 pregnancies after Art that fulfilled inclusion criteria. we found no between-group difference in parity (χ 2 =0.0133; P=0.9081), but such difference was found in mean age (t=2.0486; P=0.0419) and BmI (χ 2 =31.038; P=0.001). A statistically significant difference was recorded in preterm delivery rate (χ 2 =25.539; P=0.001), average duration of pregnancy (t=12.8591; P=0.001), average birth weight (t=10.5446; P=0.001) and mode of delivery (χ 2 =13,691; P=0.001). A statistically significant difference was found in low birth weight babies (χ 2 =102.02; P=0.001) and APgAr score (χ 2 =19.96; P=0.001), but there was no difference in the prevalence of small for gestational age babies (χ 2 =0.90629; P=0.635). In conclusion, this study indicated the perinatal outcome after Art to be considerably poorer in twins than in singletons.

Acta clinica Croatica, 2013

The aim of the study was to compare perinatal outcome of singleton and twin pregnancies conceived... more The aim of the study was to compare perinatal outcome of singleton and twin pregnancies conceived after assisted reproductive technologies (ART). This retrospective study included singleton and twin pregnancies conceived after ART in the period from January 1, 2007 until December 31, 2008. The study variables were maternal age (years), parity, body mass index (BMI; kg/m2), week (< or =36 (6/7) and > or = 37) and mode of delivery (vaginal and cesarean section), birth weight (grams) and APGAR score (< or = 7; 8-10). During the study period, there were 195 pregnancies after ART that fulfilled inclusion criteria. We found no between-group difference in parity (chi2 = 0.0133; P = 0.9081), but such difference was found in mean age (t = 2.0486; P = 0.0419) and BMI (chi2 = 31.038; P = 0.001). A statistically significant difference was recorded in preterm delivery rate (chi2 = 25.539; P = 0.001), average duration of pregnancy (t = 12.8591; P = 0.001), average birth weight (t = 10.54...

Hepato-gastroenterology

The aim of this study was to determine the feasibility and technical aspects of a new endoluminal... more The aim of this study was to determine the feasibility and technical aspects of a new endoluminal surgical procedure: transvaginal laparoscopically assisted endoscopic cholecystectomy. Three female patients underwent transvaginal laparoscopically assisted endoscopic cholecystectomy (aged 40, 61 and 33 years). Pneumoperitoneum was created through a 5mm supraumbilical incision. Through the posterior fornix of the vagina the second 10mm trocar, laparoscope and 5mm laparoscopic grasper were introduced. The gallbladder was dissected using standard 5mm laparoscopic grasper, hook, electrocoagulation and harmonic shears introduced supraumbilically. The dissected gallbladder was removed in a specimen retrieval bag. Transvaginal laparoscopically assisted endoscopic cholecystectomy was feasible in all patients. No intraoperative or postoperative complications were observed and there was no need for extra-umbilical skin incisions. Total operative time ranged between 60 and 75 minutes. Median le...

Collegium antropologicum, 2010

Our aim was to investigate the incidence of respiratory infections in children treated at the Ped... more Our aim was to investigate the incidence of respiratory infections in children treated at the Pediatric Department of the University Hospital Mostar during war (1993 and 1994) and after the war (2003 and 2004). In order to collect data we used medical histories of children with respiratory infections. Incidence of respiratory infections in children in war period was 230/1000, while in post-war period it was 190/1000. There was no significant difference in the incidence of respiratory infections in children during war and after the war (p = 0.051). We have not found increase in respiratory infections prevalence in children treated during war period at the Pediatric department of University Hospital Mostar, compared to the period after the war. However, we did report certain differences related to age, clinical parameters, seasonal pattern, diagnosis, therapy and mean hospitalization time.

Collegium antropologicum, 2007

The aim of this study was to investigate the prevalence of pelvic organ prolapse in urban and rur... more The aim of this study was to investigate the prevalence of pelvic organ prolapse in urban and rural women and to identify possible related factors. They were 1749 participants; one thousand four hundred seventeen (81%) urban women and 332 rural residents (19%). The urban and rural women were congruently regarding to age, parity, using oral contraceptives and postmenopausal status. The urban women were more often obese (p < 0.01), estrogen replacement users (p < 0.001), smokers (p < 0.001), with mild (p < 0.001) and high (p < 0.001) education, and they were often divorced (p < 0.05) than rural women. Rural women were more often alcohol consumers (p < 0.001), with low level of education (p < 0.001) and more often married (p < 0.05) than rural examinees. There were no association between the presence of prolapse and: weight, menopausal status, oral contraceptives and estrogen replacement using, smoking, alcohol consuming and marital status. There were not obs...

Collegium antropologicum, 2005

We tested two groups of singletons born at term: fifty-six eutrophic newborns and 56 hypotrophic ... more We tested two groups of singletons born at term: fifty-six eutrophic newborns and 56 hypotrophic subjects. They were selected randomly from all newborns delivered by vaginal route between 8 and 14 hours. Excluded were preeclampsia, diabetes, labours longer than 12 hours and newborns with malformations. Written informed consent was obtained from all women and data were collected before and after labour. Umbilical cord blood samples were obtained immediately following the delivery and plasma cortisol concentrations were measured by radioimmunoassay. The groups did not differ significantly regarding maternal age, parity, gestational age and Apgar score, but birth weight was significant differed (p < 0.001). In addition, eutrophic newborns had significantly elevated cortisol levels (457.7 nmol/L, 321.8-696.6 nmol/L) compared with hypotrophic newborns (320.5 nmol/L, 215.1-578.7 nmol/L, p < 0.001). The role of fetal cortisol in intrauterine growth restriction (IUGR) pregnancy and la...

Collegium antropologicum, 2005

The aim of this study was to describe anthropometric, clinical, socio-demographic characteristics... more The aim of this study was to describe anthropometric, clinical, socio-demographic characteristics and lifestyle habits of pregnant smokers in comparison to pregnant nonsmokers. During years 1999-2003, 1,435 pregnant smokers and 4,772 pregnant nonsmokers were interviewed after delivery with a questionnaire. They were recorded clinical, anthropometric and socio-demographic data, smoking status, labor outcome, maternal and fetal hemoglobin concentrations for each patient. The two groups were comparable in anthropometric and clinical characteristics, duration of pregnancy and mode of delivery, except for birth weights, which were significantly lower in newborns of smokers. Maternal hemoglobin concentrations were significantly lower in smokers, but fetal hemoglobin concentrations were significantly higher in babies of smokers. The proportion of pregnant women who smoked during pregnancy was higher among urban women, among women with lower educational level and among unemployed subjects i...

Collegium antropologicum, 2003

The aim of this study is to determine the differences in sexual life of women with cervical cance... more The aim of this study is to determine the differences in sexual life of women with cervical cancer after surgery and radiation therapy. A total of 210 patients treated for cervical cancer at the Department of Obstetrics and Gynecology, School of Medicine, University of Zagreb, Croatia between March 2001 and March 2003 were asked to fill in the questionnaire. Sexual life had worsened in 42.86% of the surgical patients, as had in 25.00% of irradiated patients (p < 0.01). The main reason of sex life impairment was fear of pain (55.55% and 42.86%, respectively (p > 0.05)). More than 80% of patients didn't notice any changes in their partner's behavior. Almost every third woman felt certain change in her "body image", similar in both groups (p > 0.05). Need for consultations regarding sex life after diagnosis were recognized by 71.43% of patients. In conclusion we can say that considerable amount of attention should be given to psychological and sexual aspects ...

Collegium antropologicum, 2003

The aim of the paper was to describe general health, socio-economic and demographic characteristi... more The aim of the paper was to describe general health, socio-economic and demographic characteristics of endometrial cancer patients in comparison to healthy women. During years 1996-2002, 100 women with endometrial carcinoma and 100 healthy women were interviewed about their health, socio-economic and demographic status and compared. The endometrial cancer patients were more often older, postmenopausal, with higher body weight, and frequent history of hypertension and diabetes than controls. The healthy women had greater number of deliveries, used oral contraceptive and hormone replacement therapy, were smokers and alcohol consumers and lived in urban centers more often than patients. The cancer patients had worse socio-economic status, less education, and were more frequent single and widowed than controls. These data may be relevant for public health services in the future to improvement quality of life of the cancer patients.

Collegium antropologicum, 2010

Collagen metabolism is altered in the pelvic organ tissues of women with genital prolapse. The ai... more Collagen metabolism is altered in the pelvic organ tissues of women with genital prolapse. The aim of this study was to compare collagen metabolism by measuring matrix metalloproteinase-1 (MMP-1) expression in uterosacral ligament tissues of postmenopausal women with and without genital prolapse. Uterosacral ligament tissues were obtained at the time of abdominal or vaginal surgery from twenty-four patients with pelvic organ prolapse (POP) and 21 women who underwent gynecologic surgery for benign indications. The tissue samples were analyzed by immunohistochemistry. There were no differences in age, BMI and parity between two groups. The patients with genital prolapse demonstrated significantly higher occurences of MMP-1 expression compared to controls. These findings indicate that increased MMP-1 expression in uterosacral ligaments is associated with genital prolapse. Our data are consistent with the theory that increased collagen breakdown may play an important role in the onset a...

Collegium antropologicum, 2003

The aim of this study was to examine the prevalence of dysmenorrhea in female adolescents and the... more The aim of this study was to examine the prevalence of dysmenorrhea in female adolescents and the influence of anthropological characteristics and lifestyle factors on menstrual pain. Two hundred and ninety seven girls from several elementary and secondary schools were interviewed about the presence of the menstrual pain, their age, height and weight, menarcheal age, menstrual cycles quality, smoking and sexual activity. There were 164 (55%) subjects with and one hundred and thirty three (45%) without dysmenorrhea. The adolescents with dysmenorrhea answered the questions about missing activities and taking pills for pain. No difference was observed between the girls with and the girls without dysmenorrhea in their chronological age, height, weight, menarcheal age, menstrual cycles quality, cigarette smoking and sexual activity. In the group of dysmenorrheic adolescents there was infrequent missing activities and bedrest, but missing school was observed in 22 percent and taking pills...

Acta Obstetricia Et Gynecologica Scandinavica