Tadashi Tojo - Academia.edu (original) (raw)

Papers by Tadashi Tojo

Meeting Abstracts of the Physical Society of Japan (Nihon Butsuri Gakkai koen gaiyoshu), 2012

Journal of immunology (Baltimore, Md. : 1950), Jan 15, 1995

Signals sent through CD40 play crucial roles in B cell differentiation, including blocking apopto... more Signals sent through CD40 play crucial roles in B cell differentiation, including blocking apoptosis of germinal center B cells. In this study, using a murine B cell WEHI-231 line that undergoes apoptosis by the cross-linking of surface Ag receptors (sIgM), we have demonstrated that CD40 signalings are linked to induction of the Bcl-xL, Cdk4, and Cdk6 proteins whose expression was significantly suppressed by the apoptotic signal through sIgM. Mutational analyses of CD40 revealed that the domain of human CD40 required for blocking apoptosis of WEHI-231 cells coincides with that required for Bcl-xL induction. Signals through sIgM arrest cells in the G1 phase of the cell cycle, which is followed by apoptosis. However, while constitutive expression of Bcl-XL leads to the inhibition of apoptosis. Nevertheless, Bcl-xL fails to induce S phase entry. By CD40 signalings, both Cdk4 and Cdk6 resume their normal expression levels, which are sufficient for passing the restriction point in G1 eve...

Visualization of the molecular dynamics of LPS on the plasma membrane of murine macrophages by TI... more Visualization of the molecular dynamics of LPS on the plasma membrane of murine macrophages by TIRFM Samia Shawkat, Risuke Karima, Tadashi Tojo, Hisashi Tadakuma, Shin-ichiroh Saitoh, Sachiko Akashi-Takamura, Kensuke Miyake, Takashi Funatsu, Kouji Matsushima 5 Department of Molecular Preventive Medicine, Graduate School of Medicine, The University of Tokyo, Japan, 2 Environmental Science Center, The University of Tokyo, Japan, Department of Physics, School of Science and Engineering, Waseda University, Tokyo, Japan, Division of Infectious Genetics, The Institute of Medical Science, The University of Tokyo, Japan. Running Title: Molecular dynamics of LPS on the living cell 10 Address correspondence to Prof. Kouji Matsuhsima, Department of Molecular Preventive Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyu-ku, Tokyo 113-0033, Japan. Tel: +81-3-5841-3431 Fax: +81-3-5684-2297 E-mail: koujim@m.u-tokyo.ac.jp

Journal of Biological …

CD40 signalings play crucial roles in B-cell function. To identify molecules which transduce CD40... more CD40 signalings play crucial roles in B-cell function. To identify molecules which transduce CD40 signalings, we have utilized the yeast two-hybrid system to clone cDNAs encoding proteins that bind the cytoplasmic tail of CD40. A cDNA encoding a putative signal transducer, ...