Tahir Jameel - Academia.edu (original) (raw)

Papers by Tahir Jameel

Background: Cigarette smoking is one of the leading causes of death in the world. Tobacco consump... more Background: Cigarette smoking is one of the leading causes of death in the world. Tobacco consumption has grave negative consequences for health so that it is important to understand the reasons and motivations towards cigarette smoking and barriers against quitting smoking among the young generation for developing effective policies to control this widespread problem. Materials and Methods: This cross-sectional survey was carried out at the Faculty of Medicine, Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia. A total of 438 young smokers participated from the University and the general population. Data were collected through anonymous, self-administered questionnaires in the Arabic language that contained questions about the reasons and motivations towards cigarette smoking and barriers against quitting smoking. The questionnaire also contained several questions regarding knowledge and attitude of the participants towards cigarette smoking. The data was analyzed on SPSS-16. Results: The mean age of the respondents was 22.9±3.48, out of 438 subjects 87 (19.9%) were married, and 351 (80.1%) were unmarried, and 331 (75.6%) belonged to urban areas while 107 (24.5%) were from the rural areas. Responding to a question about a number of cigarettes smoked per day, 31% answered 11-20, 29% answered 21-30, and 25% answered 1-10. Questioned about smokers in the family, 34.5% responded more than one, with 19% for brother and 13% for father. About the reasons for not quitting smoking, 26% described lack of willpower, 25% had no reason, 22% said that people around me smoke, and 15.3% responded stress at home/work. The major motivation for smokers was smoker friends (42%), for 33.8% others, for 12% father/brother and 7.8% media. Conclusions: There are several avoidable and preventable reasons and barriers against quitting smoking. However, knowledge and attitude about smoking were good, and the majority of the smokers were well aware of the associated hazards. Therefore, there is a need to search out ways and means to help them to quit this addiction.

Clinical Reviews in Allergy & Immunology, 2009

Chronic granulomatous disease was first described in 1954 (1) and 1957 (2) as recurrent infection... more Chronic granulomatous disease was first described in 1954 (1) and 1957 (2) as recurrent infections occurring in the setting of hypergammaglobulinemia, as opposed to the disease then recently recognized by Bruton, in which infections were associated with hypogammaglobulinemia (3). The disease was not well characterized until 1959 (4), when it was initially termed fatal granulomatous disease of childhood, but it is now simply referred to as chronic granulomatous disease (CGD). Originally thought to be only an X-linked disease, its recognition in girls in 1968 led to the determination of autosomal recessive forms, as well (5). Over almost 60 years CGD has evolved from a disease of early fatality to one of effective management with high survival (6). CGD is a paradigm for non-lymphoid primary immune defects, and has guided elucidation of oxygen metabolism in the phagocyte, the vasculature, and the brain (7). It has been in the forefront of the development of antimicrobial prophylaxis before the advent of advanced HIV and before its routine use in neutropenia (8). It has ben an attractive target for gene therapy and bone marrow transplantation for non-malignant diseases. Therefore, CGD is worthy of our interest both for its historical interest as well as for the fact that this is a disease for which expert management is imperative.

Dengue virus infection is the most common mosquito born viral disease and is a major public healt... more Dengue virus infection is the most common mosquito born viral disease and is a major public health problem (globally). More than 2.5 billion people in over 112 countries of the world are at risk from dengue virus. According to WHO, more than 100 million new cases of dengue fever occur world wide including dengue haemorrhagic fever (500,000) cases and Dengue Shock Syndrome (DSS) along with 2.5% mortality rate. In Pakistan incidence of dengue is increasing since 1994 and is becoming an important public health problem. Among the 341 acute cases, 166 (48.7%) were confirmed by IgM dengue specific kit, 27 (7.9%) in gray zone and 148 (43.4%) were negative. IgG was used on 200 suspected re-infected patients. Among them 79 (39.5%) were positive, 3 (1.5%) in gray zone and 118 (59%) were negative. Male to female ration was 1.25:1. Most patients presented typical sign and symptoms of fever, headache, myalgia, anorexia, malaise, skin rash and retroorbital pain in 98, 81, 75, 63, 47 and 41% respe...

International Journal of Research in Medical Sciences, 2019

Background: Vesiculobullous diseases have been the focus of intensive investigation in recent yea... more Background: Vesiculobullous diseases have been the focus of intensive investigation in recent years. However, these disorders are still associated with substantial morbidity, considerable mortality and impaired quality of life. Accurate diagnosis of vesiculobullous lesions of skin entails evaluation of clinical, histopathologic and immunofluorescence findings.Methods: Hospital based prospective study for a period of 24 months from August 2014 to July 2016 in the Department of Pathology at Andhra Medical College, Visakhapatnam, India. Total of 50 patients aged 3-70 years with vesiculobullous lesions of both sexes attending the Department of Dermatology were selected and analysed clinically, histopathological examination and direct immunofluorescence (DIF).Results: In the present study, majority of patients presented between 51-60 yrs of age (32%) with male to female ratio of 1.08:1 and mean age of 46.02 years. Pemphigus vulgaris constituted the most common vesiculobullous disorder (3...

Thrombosis and Haemostasis, 2002

SummaryThe F11 receptor (F11R) was first identified on the surface of human platelets as a target... more SummaryThe F11 receptor (F11R) was first identified on the surface of human platelets as a target for a stimulatory monoclonal antibody (M.Ab.F11) that induces secretion, followed by exposure of fibrinogen receptors and aggregation. Cloning of the gene of F11R has revealed that this protein is a cell adhesion molecule (CAM), a member of the Ig superfamily and an ortholog of the murine protein called junctional adhesion molecule (JAM). The present study has identified two domains through which M.Ab.F11 triggers a platelet response culminating with aggregation. M.Ab.F11-mediated platelet adhesion, and the potentiation of collagen and ADP-induced platelet aggregation by M.Ab.F11, were found to involve the same two domains. A F11R recombinant protein (sF11R) completely inhibited platelet aggregation, adhesion and potentiation induced by M.Ab.F11, indicative that the active conformation of the external domain of F11R is present in the soluble, secreted recombinant protein. Furthermore, a...

In almost all modern buildings today, HVAC equipment is used to provide a conditioned indoor envi... more In almost all modern buildings today, HVAC equipment is used to provide a conditioned indoor environment while using large amounts of energy to cool, filter, and dehumidify the air in these structures. This is especially true for buildings located in hot and humid climates around the world. International engineering organizations, such as ASHRAE, have developed indoor air quality standards which stipulate substantial requirements for fresh outside air to be introduced into a building's air conditioning system. Internal loads and additional outside ventilation air all generate considerable latent loads on these systems and exacerbate the already difficult moisture control problem. A manifestation of this load is the liquid water condensate that is typically drained away from the air conditioning equipment and routed to the nearest sanitary drain. This project investigated sustainability issues associated with the collection and storage of this condensate water from selected air conditioning equipment for an institutional building located on the Education City Campus in Doha, Qatar. Simplified modeling of the condensation potential from the existing air conditioning systems, means for tapping into existing condensate drainage systems for rerouting to a storage facility, metering of collected condensate water, and potential impact for this water capture and re-use technique were studied. This project demonstrated the potential to capture over 6 million liters (1.6 million gallons) of condensate water each year from the air conditioning systems for this building.

Frontiers in neurology, 2015

Selective neuronal loss (SNL) in the reperfused penumbra may impact clinical recovery and is thus... more Selective neuronal loss (SNL) in the reperfused penumbra may impact clinical recovery and is thus important to investigate. Brief proximal middle cerebral artery occlusion (MCAo) results in predominantly striatal SNL, yet cortical damage is more relevant given its behavioral implications and that thrombolytic therapy mainly rescues the cortex. Distal temporary MCAo (tMCAo) does target the cortex, but the optimal occlusion duration that results in isolated SNL has not been determined. In the present study, we assessed different distal tMCAo durations looking for consistently pure SNL. Microclip distal tMCAo (md-tMCAo) was performed in ~6-month old male spontaneously hypertensive rats (SHRs). We previously reported that 45 min md-tMCAo in SHRs results in pan-necrosis in the majority of subjects. Accordingly, three shorter MCAo durations were investigated here in decremental succession, namely 30, 22, and 15 min (n = 3, 3, and 7 subjects, respectively). Recanalization was confirmed by ...

JPMA. The Journal of the Pakistan Medical Association, 1999

To determine the feasibility of a PCR based strategy for prenatal diagnosis of Haemophilia-A in P... more To determine the feasibility of a PCR based strategy for prenatal diagnosis of Haemophilia-A in Pakistani Families. Prospective. Department of Haematology, Armed Forces Institute of Pathology, Rawalpindi. Five families with at least one child affected with Haemophilia-A. Each family comprised of father, mother, affected child and fetus when present. Short Tandem Repeat (STR) analysis in the Intron 22 of factor VIII gene. PCR based analysis of the STR in intron 22 of factor VIII gene showed that the marker was informative in 4/5 study families and could be used in these families for the prenatal diagnosis of Haemophilia-A. In two families prenatal diagnosis was carried out by Chorionic Villus Sampling at 10-13 weeks gestation and the results in both the cases showed a carrier female fetus. Linkage based prenatal diagnosis of Haemophilia-A by an intragenic STR marker is feasible in most of the Pakistani families. The long term response of the Haemophiliac families to the availability ...

JPMA. The Journal of the Pakistan Medical Association, 1990

HLA frequencies on 1231 subjects from within the country, using methods employed by National Inst... more HLA frequencies on 1231 subjects from within the country, using methods employed by National Institute of Health, USA is reported. Pakistani population appears to be a mixture of an indigenous population with others particularly Orientals and Negroids. Relationship with Caucasians is not convincing.

Thrombosis and haemostasis, 2002

The F11 receptor (F11R) is a cell adhesion molecule (CAM), member of the immunoglobulin superfami... more The F11 receptor (F11R) is a cell adhesion molecule (CAM), member of the immunoglobulin superfamily found on the surface of human platelets, and determined to play a role in platelet aggregation, secretion, adhesion and spreading. The same molecule is present also at tight junctions of endothelial cells (EC) where it is known as JAM and acts as a CAM through homophilic interactions. The role of F11R/JAM in the interaction of platelets with endothelial cells was investigated in the current studies. We report here that washed human platelets adhere specifically to a matrix made of immobilized, recombinant sF11R. Furthermore, platelets adhere to cytokine- (TNF-alpha, INF-gamma) stimulated human umbilical vein endothelial cells (HUVEC), and approximately 40-60% of the adhesive force is exerted by homophilic interactions between the F11R of platelets and EC. This is evidenced by the inhibition of platelet adhesion to endothelial cells by recombinant soluble form of the F11R, and by two F...

Objective: To evaluate the presence of intrinsic factor antibody in vitamin B12 deficient patient... more Objective: To evaluate the presence of intrinsic factor antibody in vitamin B12 deficient patients. Study Design: Cross-sectional, observational study. Place and Duration of Study: Fauji Foundation Hospital, Foundation University Medical College and Armed Forces Institute of Pathology, Rawalpindi, from January 2011 to June 2012. Methodology: A total of 120 patients of megaloblastic anaemia were selected on the basis of low serum vitamin B12 level. The intrinsic factor antibody tests were performed by ELISA method. The patients were considered positive or negative on the basis of presence or absence of intrinsic factor antibody respectively. The data was analyzed by using SPSS version 14. Results: Pernicious anaemia with intrinsic factor deficiency was found in 13.3% in 120 vitamin B12 deficient patients. The mean age of patients of pernicious anaemia was 41.5 years, with a male to female ratio of 1:2.5. It was relatively more common in older age (17% in age more than 60 years) as co...

Defect and Diffusion Forum, 2011

Metal matrix-particulate composites fabricated by using powder metallurgy possess a higher disloc... more Metal matrix-particulate composites fabricated by using powder metallurgy possess a higher dislocation density, a small sub-grain size and limited segregation of particles, which, when combined, result in superior mechanical properties. The present study aims to develop iron based silica sand nanoparticles composites with improved mechanical properties. An iron based silica sand nanoparticles composite with 5, 10, 15 and 20 wt.% of nanoparticles silica sand were developed through powder metallurgy technique. It was observed that by addition of silica sand nanoparticles with 20 wt.% increased the hardness up to 95HRB and tensile strength up to 690MPa. Sintered densities and electrical conductivity of the composites were improved with an optimum value of 15 wt.% silica sand nanoparticles. Proposed mechanism is due to diffusion of silica sand nanoparticles into porous sites of the composites.

The Journal of Neuroscience, 2008

Germline mutations inSPRED1, a negative regulator of Ras, have been described in a neurofibromato... more Germline mutations inSPRED1, a negative regulator of Ras, have been described in a neurofibromatosis type 1 (NF1)-like syndrome (NFLS) that included learning difficulties in some affected individuals. NFLS belongs to the group of phenotypically overlapping neuro-cardio-facial-cutaneous syndromes that are all caused by germ line mutations in genes of the Ras/mitogen-activated protein kinase extracellular signal-regulated kinase (ERK) pathway and that present with some degree of learning difficulties or mental retardation. We investigated hippocampus-dependent learning and memory as well as synaptic plasticity inSpred1−/−mice, an animal model of this newly discovered human syndrome.Spred1−/−mice show decreased learning and memory performance in the Morris water maze and visual-discrimination T-maze, but normal basic neuromotor and sensory abilities. Electrophysiological recordings on brain slices from these animals identified defects in short- and long-term synaptic hippocampal plasti...

The Journal of Neuroscience, 2006

In a previous study, we reported that a brief exposure to swim stress transforms an electrically ... more In a previous study, we reported that a brief exposure to swim stress transforms an electrically induced, protein synthesis-independent early long-term potentiation (early LTP) into a protein synthesis-dependent late LTP [“reinforcement of LTP” in the hippocampal dentate gyrus (DG)] (Korz and Frey, 2003). This transformation depends on activation of mineralocorticoid receptors (MRs) by corticosterone, and on intact basolateral amygdala (BLA) function. Here, we demonstrate that a brief swim experience results in lasting changes in levels of hippocampal cellular signaling molecules that are known to be involved in the induction of late LTP. Within the DG, MRs were rapidly upregulated, whereas glucocorticoid receptor (GR) levels were elevated with a 3 h delay. Levels of phosphorylated mitogen-activated protein kinase 2 (pMAPK2) and p38 MAPK, as well as phosphorylated calcium/calmodulin-dependent protein kinase II (pCaMKII) were enhanced shortly after swim stress and remained elevated u...

The Journal of Comparative Neurology, 2009

Homeostatic synaptic plasticity (HSP) is important for maintaining neurons' excitability within t... more Homeostatic synaptic plasticity (HSP) is important for maintaining neurons' excitability within the dynamic range and for protecting neurons from unconstrained LTP that can cause breakdown of synapse specificity (Turrigiano, 2008). Knowledge of the molecular mechanism underlying this phenomenon remains incomplete, especially for the rapid form of HSP. In order to test whether HSP in adulthood depends on an F-actin binding protein-drebrin A, mice deleted of the adult isoform of drebrin (DAKO) but retaining the embryonic isoform (drebrin E) were generated. HSP was assayed by determining whether the NR2A subunit of NMDA receptors (NMDARs) can rise rapidly within spines following the application of an NMDAR antagonist, D-APV, onto the cortical surface. Electron microscopic immunocytochemistry revealed that, as expected, the D-APV treatment of WT mouse cortex increased the proportion of NR2A-immunolabeled spines within 30 min, relative to basal levels in hemispheres treated with an inactive enantiomer, L-APV. This difference was significant at the postsynaptic membrane and postsynaptic density (i.e., synaptic junction) as well as at non-synaptic sites within spines and was not accompanied by spine size changes. In contrast, the D-APV treatment of DAKO brains did not augment NR2A labeling within the spine cytoplasm or at the synaptic junction, even though basal levels of NR2A were not significantly different from those of WT cortices. These findings indicate that drebrin A is required for the rapid (<30 min) form of HSP at excitatory synapses of adult cortices while drebrin E is sufficient for maintaining basal NR2A levels within spines.

Gynecological Surgery, 2005

Microwave endometrial ablation (MEA) is regarded as an effective nonsurgical option for managing ... more Microwave endometrial ablation (MEA) is regarded as an effective nonsurgical option for managing dysfunctional uterine bleeding (DUB). It is believed to be safe, quick, and easy to perform. To our knowledge, there has been only one reported case of a serious complication of a bowel injury during MEA. We report another similar case of accidental uterine perforation and bowel injury.

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D:/Biomedica Vol.26, Jan. Jun. 2010/Bio-19.Doc P. 50 53 (WC) ... SWINE FLU EXPERIENCE IN LOCA... more D:/Biomedica Vol.26, Jan. Jun. 2010/Bio-19.Doc P. 50 53 (WC) ... SWINE FLU EXPERIENCE IN LOCAL POPULATION OF LAHORE ... KHALID MAHMOOD, TAHIR JAMEEL, MUHAMMAD TAHIR AND HUMA F. ASLAM Citilab and Research Center, University of Lahore King ...

Annals of the Rheumatic Diseases, 1992

Journal of the College …, 2008

1. J Coll Physicians Surg Pak. 2008 May;18(5):310-1. CD5-positive acute lymphoblastic leukemia. A... more 1. J Coll Physicians Surg Pak. 2008 May;18(5):310-1. CD5-positive acute lymphoblastic leukemia. Ahmed D, Ahmed TA, Ahmed S, Tipu HN, Wiqar MA. Department of Immunology, Armed Forces Institute of Pathology, Rawalpindi, Pakistan. ...

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2006

Growth hormone (GH) stimulates STAT5 phosphorylation by JAK2, which activates IGF-I and serine pr... more Growth hormone (GH) stimulates STAT5 phosphorylation by JAK2, which activates IGF-I and serine protease inhibitor 2.1 (Spi 2.1) transcription, whereas STAT5 dephosphorylation by protein tyrosine phosphatases (PTPs) terminates this signal. We hypothesized that the inhibitory effects of TNF on GH signaling and gene transcription were responsible for hepatic GH resistance. CWSV-1 hepatocytes were treated with TNF, pervanadate (a PTP inhibitor), or both, before GH stimulation. Total and tyrosine-phosphorylated JAK2, STAT5, ERK1/2, SHP-1 and SHP-2, IGF-I, and Spi 2.1 mRNA levels were measured. GH stimulated STAT5 and ERK1/2 phosphorylation, IGF-I, and Spi 2.1 mRNA expression. TNF attenuated JAK2/STAT5 and ERK1/2 phosphorylation and IGF-I and Spi 2.1 mRNA expression following GH stimulation. SHP-1 and SHP-2 protein levels were unaltered by TNF or GH, and the GH-induced increase in SHP-1 PTP activity was not further increased by TNF. In TNF-treated cells, pervanadate restored STAT5 and ERK...