Talita Rocha - Academia.edu (original) (raw)
Papers by Talita Rocha
Eventos traumáticos e câncer
A obesidade sendo uma doenca de dificil aceitacao, apresenta baixa adesao ao tratamento, manutenc... more A obesidade sendo uma doenca de dificil aceitacao, apresenta baixa adesao ao tratamento, manutencao e acompanhamento nutricional, atualmente a maior parte dos tratamentos em saude encontrados no pais, principalmente na rede privada de saude dificilmente atendem a todos os publicos, devido a alta demanda de custo, frente a necessidade de novos reparos dos servicos, os usuarios sao obrigados a procurarem por outros locais que oferecem atendimento diferenciado, de boa qualidade e baixo custo. Por esta razao, o objetivo do trabalho foi verificar os principais motivos do abandono ao tratamento nutricional proposto em uma clinica-escola de nutricao. A pesquisa foi um estudo transversal e descritivo realizado atraves de prontuarios da clinica escola, e auxiliado com a aplicacao por telefone de um questionario respondido por, 150 individuos obesos de ambos os sexos, de 21 a 60 anos que participaram de no minimo duas consultas nutricionais que constituiram a amostra deste estudo. Indicaram m...
Journal of Herbal Medicine, 2020
This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Toxicology in Vitro, 2020
Soybean toxin (SBTX) is a protein isolated from soybean seeds and composed of two polypeptide sub... more Soybean toxin (SBTX) is a protein isolated from soybean seeds and composed of two polypeptide subunits (17 and 27 kDa). SBTX has in vitro activity against phytopathogenic fungi such as Cercospora sojina, Aspergillus niger, and Penicillium herguei, and yeasts like Candida albicans, C. parapsilosis, Kluyveromyces marxiannus, and Pichia membranifaciens. The present study aimed to analyze in vitro whether SBTX causes any side effects on non-target bacterial and mammalian cells that could impede its potential use as a novel antifungal agent. SBTX at 100 μg/ mL and 200 μg/mL did not hinder the growth of the bacteria Salmonella enterica (subspecies enterica serovar choleraesuis), Bacillus subtilis (subspecies spizizenii) and Staphylococcus aureus. Moreover, SBTX at concentrations up to 500 μg/mL did not significantly affect the viability of erythrocytes, neutrophils, and human intestinal Caco-2 cells. To study whether SBTX could induce relevant alterations in gene expression, in vitro DNA microarray experiments were conducted in which differentiated Caco-2 cells were exposed for 24 h to 100 μg/mL or 200 μg/mL SBTX. SBTX up-regulated genes involved in cell cycle and immune response pathways, but downregulated genes that play a role in cholesterol biosynthesis and platelet degranulation pathways. Thus, although SBTX did not affect bacteria, nor induced cytotoxity in mammalian cells, it affected some biological pathways in the human Caco-2 cell line that warrants further investigation.
Hematology, Transfusion and Cell Therapy, 2020
The novel Coronavirus (CoVid-19) outbreak is now consider a world pandemic, affecting more than 1... more The novel Coronavirus (CoVid-19) outbreak is now consider a world pandemic, affecting more than 1,300,000 people worldwide. Cancer patients are in risk for severe disease, including a higher risk of intensive care unit (ICU) admission, need for invasive ventilation or death. Management of patients with lymphoid malignancies can be challenging during the outbreak, due to need of multiple hospital visits and admissions, immunosuppression and need for chemotherapy, radiotherapy and stem cell transplantation. In this article, we will focus on the practical management of patients with lymphoid malignancies during the COVID-19 pandemic, focusing on minimizing the risk for patients.
Triplaris gardneriana seeds extract exhibits in vitro anti-inflammatory properties in human neutrophils after oxidative treatment
Journal of Ethnopharmacology, 2019
ETHNOPHARMACOLOGICAL RELEVANCE Triplaris gardneriana Wedd. (Polygonaceae family) is a plant speci... more ETHNOPHARMACOLOGICAL RELEVANCE Triplaris gardneriana Wedd. (Polygonaceae family) is a plant species from Brazilian semiarid region which is used in local traditional medicine for the treatment of inflammatory conditions such as hemorrhoids. AIM OF THE STUDY In this study, the in vitro anti-inflammatory activity of different concentrations of ethanolic extract from T. gardneriana seeds (EETg) was performed in order to contribute to the knowledge about etnomedicinal use of this plant species. MATERIALS AND METHODS The anti-inflammatory properties were evaluated through different approaches, such as in vitro protein anti-denaturation test, scavenging of reactive oxygen species (ROS) and myeloperoxidase (MPO) inhibition in human neutrophils activated by phorbol-12-myristate-13-acetate (PMA). Besides that, molecular docking was performed to provide new insights about the interaction between the major phenolic components in the plant extract and MPO. RESULTS EETg was characterized showing a total phenol content of 153.5 ± 6.3 μg gallic acid equivalent/mg extract, ability to remove hydrogen peroxide (H2O2) in a concentration-dependent manner and had a spectroscopic profile which suggests the presence of hydroxyl groups. EETg was able to prevent protein denaturation ranging from 40.17 to 75.09%. The extract at 10 and 20 μg/mL, was able to modulate neutrophils pro-inflammatory functions, such as degranulation and burst respiratory. In both assays, the EETg had anti-inflammatory effect comparable to nonsteroidal anti-inflammatory drugs. Among the main phenolic compounds of EETg, quercitrin, quercetin and catechin showed the highest binding affinity in silico to MPO. CONCLUSION This study demonstrated, for the first time, that the anti-inflammatory effect of T. gardneriana seeds occurs due to its modulatory effect on human neutrophil degranulation and free-radical scavenging activity.
DLBCL with CD30+ Has Not a Better Prognosis in a Brazilian Coorte Population
Blood, 2015
Background: CD30 is a well-known diagnostic marker in both anaplastic large cell lymphoma (ALCL) ... more Background: CD30 is a well-known diagnostic marker in both anaplastic large cell lymphoma (ALCL) and classical Hodgkin's lymphoma (CHL). The chimeric drug brentuximab vedotin that combines an anti-CD30 monoclonal antibody with the anti-tubulin agent monomethyl auristatin E demonstrated activity in patients with relapsed CHL, ALCL and other lymphomas that express CD30+. Previous observational studies have suggested that CD30 may be expressed in 10 to 20% of DLBCLs. It is possible that CD30+ DLBCLs may show different biologic behavior and be amenable to anti-CD30 therapy. The aim of this study was to determine the prevalence of CD30 expression in DLBCL by immunohistochemistry and explore possible relationships with important clinical and biologic variables of DLBCL. Methods: We retrospectively identified cases of DLBCL diagnosed between Jan 2007 and march 2014 at our institution. Eligible cases included patients with diagnosis of DLBCL irrespective of anatomic site or tumor stage....
Pathophysiology, 2019
This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Letras, 2019
Este estudo objetiva analisar as provas arregimentadas por Antônio Vieira para constituir seu eth... more Este estudo objetiva analisar as provas arregimentadas por Antônio Vieira para constituir seu ethos em diferentes discursos, em uma carta enviada ao rei de Portugal no dia 20 de maio de 1653 e no sermão da Epifania, de 1662. Para isso, foi necessário discutir questões pertinentes à retórica, arte que fundamentava a produção letrada do Seiscentos. As conclusões que serão apresentadas apontam para uma dúbia configuração do ethos do jesuíta, dada a adequação do discurso a cada situação.
Natural Product Communications, 2013
Bumelia sartorum (Sapotaceae) is used ethnomedicinally for treatment of several diseases, includi... more Bumelia sartorum (Sapotaceae) is used ethnomedicinally for treatment of several diseases, including diabetes mellitus. The aim of this work was to investigate the hypoglycemic effect of B. sartorum extracts, rich in polyphenolic compounds, and the possible mechanisms of action. Assessment of B. sartorum hypoglycemic activity was performed from the blood glucose level in normoglycemic mice after administration of the extract by oral gavage. The hypothesis that sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) inhibition could prolong the increase in cytoplasmic Ca2+ concentration, thus leading to an increase of insulin release was evaluated. The enzyme inhibition was measured by ATP hydrolysis using SERCA1 isolated from rabbit skeletal muscle. The total content of phenolic compounds was determined by the Folin-Ciocalteau method. The ethyl acetate (EtOAc) partition and F5 fraction obtained from B. sartorum, both of them rich in polyphenolics, were shown to have a hypoglycemic effect on ...
Oxidative Medicine and Cellular Longevity, 2018
Contact dermatitis produces an inflammatory reaction primarily via stimulation of keratinocytes a... more Contact dermatitis produces an inflammatory reaction primarily via stimulation of keratinocytes and cells of the immune system, which promote the release of cytokines, reactive oxygen species (ROS), and other chemical mediators. Eugenol (EUG, phenylpropanoid of essential oils) has attracted attention due to its anti-inflammatory properties, as well as antioxidant effect. On the other hand, it is volatile and insoluble and is a skin irritant. In this case, nanostructured systems have been successfully employed as a drug carrier for skin diseases since they improve both biological and pharmaceutical properties of active compounds. The cytotoxic, antioxidant, and anti-inflammatory effects of EUG were assessed in human neutrophils and keratinocytes. Additionally, polymeric nanocarries (NCEUG) were prepared to improve the chemical and irritant characteristics of EUG. EUG presented apparent safety and antioxidant and anti-inflammatory effects on human neutrophils, but presented cytotoxic ...
Extrato de cajá - Spondias mombin: padronização e avaliação do efeito anti-inflamatório em neutrófilo humano
Anais do Encontro do Programa de Pós-Graduação em Ciências Farmacêuticas, 2017
Avaliação da atividade anti-inflamatória, antioxidante e neuroprotetota da fração fenólica residual (FFAC) e do extrato seco de Amburana cearensis
Anais do Encontro do Programa de Pós-Graduação em Ciências Farmacêuticas, 2017
Anais do Encontro do Programa de Pós-Graduação em Ciências Farmacêuticas, 2017
Food Hydrocolloids, 2017
In this study, the potential therapeutic benefits of galactomannan from Caesalpinia ferrea (juca)... more In this study, the potential therapeutic benefits of galactomannan from Caesalpinia ferrea (juca) seeds on streptozotocin (STZ) induced diabetic Wistar rats were evaluated. After purification procedure, the purified juca seed galactomannan (JSG) was characterized by infrared spectroscopy (FTIR), surface tension, atomic force microscopy (AFM), zeta potential and particle
Caryocar coriaceum Wittm. (Pequi) fixed oil presents hypolipemic and anti-inflammatory effects in vivo and in vitro
Journal of Ethnopharmacology, 2016
Caryocar coriaceum Wittm. (Pequi) is found in southern Ceará, where the fruit is used as food and... more Caryocar coriaceum Wittm. (Pequi) is found in southern Ceará, where the fruit is used as food and in folk medicine as an anti-inflammatory, and to promote healing. However, little is known about the effects of repeated administration of its oil on the biochemical parameters of the blood. This work aimed to evaluate the effects Caryocar coriaceum fixed oil (OFCC); on the lipid profiles of healthy mice, on dyslipidemia induced by tyloxapol, and to study its anti-inflammatory effect both in vivo and in vitro. The results revealed significate reduction in total serum cholesterol and triglycerides, and an increase in HDL-C. The paw edema (induced by carrageenan) and myeloperoxidase (MPO), in polymorphonuclear culture cells, was reduced at all dose levels. Results demonstrated that Caryocar coriaceum's fix oil present anti-inflammatory activity and, for the first time describe the hypolipidemic effects, supporting its traditional use and suggest that present a potential cardioprotective effect.
Revista Brasileira de Hematologia e Hemoterapia, 2009
Marginal zone lymphoma is a low grade lymphoma with an indolent course and chance to relapse. We ... more Marginal zone lymphoma is a low grade lymphoma with an indolent course and chance to relapse. We present a case of a patient who suffered relapse after 25 years of apparently complete remission of a low-grade non-Hodgkin lymphoma. Rev. Bras. Hematol. Hemoter.
Ciência & Saúde Coletiva, 2015
Atualmente, no Brasil, configura-se um pensamento social em saúde, como campo científico, polític... more Atualmente, no Brasil, configura-se um pensamento social em saúde, como campo científico, político e atuante: Estudar os Congressos de Ciências Sociais em Saúde da Abrasco representa realizar uma genealogia parcial da área, apreendendo como se deu a constituição desse subcampo e seu desenvolvimento, além de mapear o atual ‘estado da arte’ dessa área de conhecimento. Este artigo analisa as falas de informantes-chave sobre as realizações dos Congressos. São 13 entrevistas com presidentes da Abrasco e coordenadores das Comissões de Ciências Sociais, em diferentes gestões – anos de realização dos Congressos Brasileiros de Ciências Sociais e Humanas em Saúde, entre 1995 e 2011. Os depoimentos permitiram identificar três momentos marcantes da realização dos Congressos: o primeiro, em 1995, quando da realização do I Congresso, que significou a maturação do conhecimento das ciências sociais em saúde, a demarcação do campo; o III Congresso, de 2005, referido como o de consolidação da área de...
Sensationalism in Pictures: An Analysis of the Portrayal of Suffering In Prize Winning News Images
Sensationalism in Pictures : An Analysis of the Portrayal of Suffering In Prize Winning News Images
Physis: Revista de Saúde Coletiva, 2014
Nos dias de hoje, é cada vez mais perceptível a importância das Ciências Sociais para a consolida... more Nos dias de hoje, é cada vez mais perceptível a importância das Ciências Sociais para a consolidação da Saúde Coletiva no Brasil. Compreender, portanto, a trajetória dos profissionais que de certa forma fundaram o campo e o mantiveram é, enfim, compreender a própria trajetória teórica e prática dessa área, evidenciada, também, nos congressos de Ciências Sociais em Saúde realizados pela Abrasco. No contexto dessa discussão, o presente artigo realiza um mapeamento do perfil dos presidentes da Abrasco e dos coordenadores das Comissões de Ciências Sociais que ocuparam esses cargos entre 1995 e 2011, anos em que aconteceram os Congressos Brasileiros de Ciências Sociais e Humanas em Saúde. Foram realizadas 13 entrevistas com presidentes da Abrasco e com os coordenadores das Comissões de Ciências Sociais, em suas diferentes gestões. Apesar de este artigo assumir caráter mais descritivo acerca da constituição e institucionalização das Ciências Sociais em Saúde na Abrasco, acredita-se que a ...
Eventos traumáticos e câncer
A obesidade sendo uma doenca de dificil aceitacao, apresenta baixa adesao ao tratamento, manutenc... more A obesidade sendo uma doenca de dificil aceitacao, apresenta baixa adesao ao tratamento, manutencao e acompanhamento nutricional, atualmente a maior parte dos tratamentos em saude encontrados no pais, principalmente na rede privada de saude dificilmente atendem a todos os publicos, devido a alta demanda de custo, frente a necessidade de novos reparos dos servicos, os usuarios sao obrigados a procurarem por outros locais que oferecem atendimento diferenciado, de boa qualidade e baixo custo. Por esta razao, o objetivo do trabalho foi verificar os principais motivos do abandono ao tratamento nutricional proposto em uma clinica-escola de nutricao. A pesquisa foi um estudo transversal e descritivo realizado atraves de prontuarios da clinica escola, e auxiliado com a aplicacao por telefone de um questionario respondido por, 150 individuos obesos de ambos os sexos, de 21 a 60 anos que participaram de no minimo duas consultas nutricionais que constituiram a amostra deste estudo. Indicaram m...
Journal of Herbal Medicine, 2020
This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Toxicology in Vitro, 2020
Soybean toxin (SBTX) is a protein isolated from soybean seeds and composed of two polypeptide sub... more Soybean toxin (SBTX) is a protein isolated from soybean seeds and composed of two polypeptide subunits (17 and 27 kDa). SBTX has in vitro activity against phytopathogenic fungi such as Cercospora sojina, Aspergillus niger, and Penicillium herguei, and yeasts like Candida albicans, C. parapsilosis, Kluyveromyces marxiannus, and Pichia membranifaciens. The present study aimed to analyze in vitro whether SBTX causes any side effects on non-target bacterial and mammalian cells that could impede its potential use as a novel antifungal agent. SBTX at 100 μg/ mL and 200 μg/mL did not hinder the growth of the bacteria Salmonella enterica (subspecies enterica serovar choleraesuis), Bacillus subtilis (subspecies spizizenii) and Staphylococcus aureus. Moreover, SBTX at concentrations up to 500 μg/mL did not significantly affect the viability of erythrocytes, neutrophils, and human intestinal Caco-2 cells. To study whether SBTX could induce relevant alterations in gene expression, in vitro DNA microarray experiments were conducted in which differentiated Caco-2 cells were exposed for 24 h to 100 μg/mL or 200 μg/mL SBTX. SBTX up-regulated genes involved in cell cycle and immune response pathways, but downregulated genes that play a role in cholesterol biosynthesis and platelet degranulation pathways. Thus, although SBTX did not affect bacteria, nor induced cytotoxity in mammalian cells, it affected some biological pathways in the human Caco-2 cell line that warrants further investigation.
Hematology, Transfusion and Cell Therapy, 2020
The novel Coronavirus (CoVid-19) outbreak is now consider a world pandemic, affecting more than 1... more The novel Coronavirus (CoVid-19) outbreak is now consider a world pandemic, affecting more than 1,300,000 people worldwide. Cancer patients are in risk for severe disease, including a higher risk of intensive care unit (ICU) admission, need for invasive ventilation or death. Management of patients with lymphoid malignancies can be challenging during the outbreak, due to need of multiple hospital visits and admissions, immunosuppression and need for chemotherapy, radiotherapy and stem cell transplantation. In this article, we will focus on the practical management of patients with lymphoid malignancies during the COVID-19 pandemic, focusing on minimizing the risk for patients.
Triplaris gardneriana seeds extract exhibits in vitro anti-inflammatory properties in human neutrophils after oxidative treatment
Journal of Ethnopharmacology, 2019
ETHNOPHARMACOLOGICAL RELEVANCE Triplaris gardneriana Wedd. (Polygonaceae family) is a plant speci... more ETHNOPHARMACOLOGICAL RELEVANCE Triplaris gardneriana Wedd. (Polygonaceae family) is a plant species from Brazilian semiarid region which is used in local traditional medicine for the treatment of inflammatory conditions such as hemorrhoids. AIM OF THE STUDY In this study, the in vitro anti-inflammatory activity of different concentrations of ethanolic extract from T. gardneriana seeds (EETg) was performed in order to contribute to the knowledge about etnomedicinal use of this plant species. MATERIALS AND METHODS The anti-inflammatory properties were evaluated through different approaches, such as in vitro protein anti-denaturation test, scavenging of reactive oxygen species (ROS) and myeloperoxidase (MPO) inhibition in human neutrophils activated by phorbol-12-myristate-13-acetate (PMA). Besides that, molecular docking was performed to provide new insights about the interaction between the major phenolic components in the plant extract and MPO. RESULTS EETg was characterized showing a total phenol content of 153.5 ± 6.3 μg gallic acid equivalent/mg extract, ability to remove hydrogen peroxide (H2O2) in a concentration-dependent manner and had a spectroscopic profile which suggests the presence of hydroxyl groups. EETg was able to prevent protein denaturation ranging from 40.17 to 75.09%. The extract at 10 and 20 μg/mL, was able to modulate neutrophils pro-inflammatory functions, such as degranulation and burst respiratory. In both assays, the EETg had anti-inflammatory effect comparable to nonsteroidal anti-inflammatory drugs. Among the main phenolic compounds of EETg, quercitrin, quercetin and catechin showed the highest binding affinity in silico to MPO. CONCLUSION This study demonstrated, for the first time, that the anti-inflammatory effect of T. gardneriana seeds occurs due to its modulatory effect on human neutrophil degranulation and free-radical scavenging activity.
DLBCL with CD30+ Has Not a Better Prognosis in a Brazilian Coorte Population
Blood, 2015
Background: CD30 is a well-known diagnostic marker in both anaplastic large cell lymphoma (ALCL) ... more Background: CD30 is a well-known diagnostic marker in both anaplastic large cell lymphoma (ALCL) and classical Hodgkin's lymphoma (CHL). The chimeric drug brentuximab vedotin that combines an anti-CD30 monoclonal antibody with the anti-tubulin agent monomethyl auristatin E demonstrated activity in patients with relapsed CHL, ALCL and other lymphomas that express CD30+. Previous observational studies have suggested that CD30 may be expressed in 10 to 20% of DLBCLs. It is possible that CD30+ DLBCLs may show different biologic behavior and be amenable to anti-CD30 therapy. The aim of this study was to determine the prevalence of CD30 expression in DLBCL by immunohistochemistry and explore possible relationships with important clinical and biologic variables of DLBCL. Methods: We retrospectively identified cases of DLBCL diagnosed between Jan 2007 and march 2014 at our institution. Eligible cases included patients with diagnosis of DLBCL irrespective of anatomic site or tumor stage....
Pathophysiology, 2019
This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Letras, 2019
Este estudo objetiva analisar as provas arregimentadas por Antônio Vieira para constituir seu eth... more Este estudo objetiva analisar as provas arregimentadas por Antônio Vieira para constituir seu ethos em diferentes discursos, em uma carta enviada ao rei de Portugal no dia 20 de maio de 1653 e no sermão da Epifania, de 1662. Para isso, foi necessário discutir questões pertinentes à retórica, arte que fundamentava a produção letrada do Seiscentos. As conclusões que serão apresentadas apontam para uma dúbia configuração do ethos do jesuíta, dada a adequação do discurso a cada situação.
Natural Product Communications, 2013
Bumelia sartorum (Sapotaceae) is used ethnomedicinally for treatment of several diseases, includi... more Bumelia sartorum (Sapotaceae) is used ethnomedicinally for treatment of several diseases, including diabetes mellitus. The aim of this work was to investigate the hypoglycemic effect of B. sartorum extracts, rich in polyphenolic compounds, and the possible mechanisms of action. Assessment of B. sartorum hypoglycemic activity was performed from the blood glucose level in normoglycemic mice after administration of the extract by oral gavage. The hypothesis that sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) inhibition could prolong the increase in cytoplasmic Ca2+ concentration, thus leading to an increase of insulin release was evaluated. The enzyme inhibition was measured by ATP hydrolysis using SERCA1 isolated from rabbit skeletal muscle. The total content of phenolic compounds was determined by the Folin-Ciocalteau method. The ethyl acetate (EtOAc) partition and F5 fraction obtained from B. sartorum, both of them rich in polyphenolics, were shown to have a hypoglycemic effect on ...
Oxidative Medicine and Cellular Longevity, 2018
Contact dermatitis produces an inflammatory reaction primarily via stimulation of keratinocytes a... more Contact dermatitis produces an inflammatory reaction primarily via stimulation of keratinocytes and cells of the immune system, which promote the release of cytokines, reactive oxygen species (ROS), and other chemical mediators. Eugenol (EUG, phenylpropanoid of essential oils) has attracted attention due to its anti-inflammatory properties, as well as antioxidant effect. On the other hand, it is volatile and insoluble and is a skin irritant. In this case, nanostructured systems have been successfully employed as a drug carrier for skin diseases since they improve both biological and pharmaceutical properties of active compounds. The cytotoxic, antioxidant, and anti-inflammatory effects of EUG were assessed in human neutrophils and keratinocytes. Additionally, polymeric nanocarries (NCEUG) were prepared to improve the chemical and irritant characteristics of EUG. EUG presented apparent safety and antioxidant and anti-inflammatory effects on human neutrophils, but presented cytotoxic ...
Extrato de cajá - Spondias mombin: padronização e avaliação do efeito anti-inflamatório em neutrófilo humano
Anais do Encontro do Programa de Pós-Graduação em Ciências Farmacêuticas, 2017
Avaliação da atividade anti-inflamatória, antioxidante e neuroprotetota da fração fenólica residual (FFAC) e do extrato seco de Amburana cearensis
Anais do Encontro do Programa de Pós-Graduação em Ciências Farmacêuticas, 2017
Anais do Encontro do Programa de Pós-Graduação em Ciências Farmacêuticas, 2017
Food Hydrocolloids, 2017
In this study, the potential therapeutic benefits of galactomannan from Caesalpinia ferrea (juca)... more In this study, the potential therapeutic benefits of galactomannan from Caesalpinia ferrea (juca) seeds on streptozotocin (STZ) induced diabetic Wistar rats were evaluated. After purification procedure, the purified juca seed galactomannan (JSG) was characterized by infrared spectroscopy (FTIR), surface tension, atomic force microscopy (AFM), zeta potential and particle
Caryocar coriaceum Wittm. (Pequi) fixed oil presents hypolipemic and anti-inflammatory effects in vivo and in vitro
Journal of Ethnopharmacology, 2016
Caryocar coriaceum Wittm. (Pequi) is found in southern Ceará, where the fruit is used as food and... more Caryocar coriaceum Wittm. (Pequi) is found in southern Ceará, where the fruit is used as food and in folk medicine as an anti-inflammatory, and to promote healing. However, little is known about the effects of repeated administration of its oil on the biochemical parameters of the blood. This work aimed to evaluate the effects Caryocar coriaceum fixed oil (OFCC); on the lipid profiles of healthy mice, on dyslipidemia induced by tyloxapol, and to study its anti-inflammatory effect both in vivo and in vitro. The results revealed significate reduction in total serum cholesterol and triglycerides, and an increase in HDL-C. The paw edema (induced by carrageenan) and myeloperoxidase (MPO), in polymorphonuclear culture cells, was reduced at all dose levels. Results demonstrated that Caryocar coriaceum's fix oil present anti-inflammatory activity and, for the first time describe the hypolipidemic effects, supporting its traditional use and suggest that present a potential cardioprotective effect.
Revista Brasileira de Hematologia e Hemoterapia, 2009
Marginal zone lymphoma is a low grade lymphoma with an indolent course and chance to relapse. We ... more Marginal zone lymphoma is a low grade lymphoma with an indolent course and chance to relapse. We present a case of a patient who suffered relapse after 25 years of apparently complete remission of a low-grade non-Hodgkin lymphoma. Rev. Bras. Hematol. Hemoter.
Ciência & Saúde Coletiva, 2015
Atualmente, no Brasil, configura-se um pensamento social em saúde, como campo científico, polític... more Atualmente, no Brasil, configura-se um pensamento social em saúde, como campo científico, político e atuante: Estudar os Congressos de Ciências Sociais em Saúde da Abrasco representa realizar uma genealogia parcial da área, apreendendo como se deu a constituição desse subcampo e seu desenvolvimento, além de mapear o atual ‘estado da arte’ dessa área de conhecimento. Este artigo analisa as falas de informantes-chave sobre as realizações dos Congressos. São 13 entrevistas com presidentes da Abrasco e coordenadores das Comissões de Ciências Sociais, em diferentes gestões – anos de realização dos Congressos Brasileiros de Ciências Sociais e Humanas em Saúde, entre 1995 e 2011. Os depoimentos permitiram identificar três momentos marcantes da realização dos Congressos: o primeiro, em 1995, quando da realização do I Congresso, que significou a maturação do conhecimento das ciências sociais em saúde, a demarcação do campo; o III Congresso, de 2005, referido como o de consolidação da área de...
Sensationalism in Pictures: An Analysis of the Portrayal of Suffering In Prize Winning News Images
Sensationalism in Pictures : An Analysis of the Portrayal of Suffering In Prize Winning News Images
Physis: Revista de Saúde Coletiva, 2014
Nos dias de hoje, é cada vez mais perceptível a importância das Ciências Sociais para a consolida... more Nos dias de hoje, é cada vez mais perceptível a importância das Ciências Sociais para a consolidação da Saúde Coletiva no Brasil. Compreender, portanto, a trajetória dos profissionais que de certa forma fundaram o campo e o mantiveram é, enfim, compreender a própria trajetória teórica e prática dessa área, evidenciada, também, nos congressos de Ciências Sociais em Saúde realizados pela Abrasco. No contexto dessa discussão, o presente artigo realiza um mapeamento do perfil dos presidentes da Abrasco e dos coordenadores das Comissões de Ciências Sociais que ocuparam esses cargos entre 1995 e 2011, anos em que aconteceram os Congressos Brasileiros de Ciências Sociais e Humanas em Saúde. Foram realizadas 13 entrevistas com presidentes da Abrasco e com os coordenadores das Comissões de Ciências Sociais, em suas diferentes gestões. Apesar de este artigo assumir caráter mais descritivo acerca da constituição e institucionalização das Ciências Sociais em Saúde na Abrasco, acredita-se que a ...