Tam Nguyen - Academia.edu (original) (raw)
Papers by Tam Nguyen
Cancer Immunology Immunotherapy, 2004
Previous studies have suggested that immunotherapy with dendritic cell (DC) vaccines may be effec... more Previous studies have suggested that immunotherapy with dendritic cell (DC) vaccines may be effective in treatment of patients with AJCC stage IV melanoma. We examined this treatment in phase I/II studies in 33 patients with good performance status and low volume disease. Nineteen patients received DCs plus autologous lysates and 14 patients DCs plus peptides from the melanoma antigens MAGE-3.A2, tyrosinase, gp100, and MART-1. Keyhole limpet hemocyanin (KLH) was used as a helper protein and influenza peptide was given as a positive control. DCs were produced from adherent cells in blood lymphocytes (monocytic DCs), grown in IL-4 and GM-CSF without a maturation step. The DCs were injected into inguinal lymph nodes at weekly intervals (×4), 2 weeks (×1), and 4-weekly intervals (×2). There were 3 responses (3 partial responses) and 1 mixed response in the 19 patients treated with DCs plus autologous lysates. No responses were seen in the group treated with DCs plus peptides. Stable disease (defined as no progression over a period of 3 months) was seen in 4 patients in group 1 and 5 patients in group 2. Treatment was not associated with significant side effects. We examined whether DTH skin tests or assays of IFN-γ cytokine production may be useful predictors of clinical responses. Twenty-two of 30 patients had DTH responses to KLH and 12 of 13 patients had DTH responses to the influenza peptide. Five of 15 DTH responses were seen against autologous lysates. This was strongly correlated with clinical responses. Approximately half the patients had responses to MART-1 peptide and a third to the other melanoma peptides. Similarly, cytokine production assays showed responses to influenza in 7 of 13 patients, and approximately one third of patients had responses to the other peptides. No IFN-γ responses were seen in 5 patients against their autologous lysates. There was no correlation between assays of IFN-γ production and clinical responses. The present studies suggest that autologous lysates may be more effective than the melanoma peptides used in the study as the source of antigen for DC vaccines. DTH responses to autologous lysates appear useful predictors of clinical responses, but further work is needed to identify other measures associated with clinical responses.
Sigmod Record, 1996
Page 1. Accessing Relational Databases from the World Wide Web Tam Nguyen V. Srinivasan ... layou... more Page 1. Accessing Relational Databases from the World Wide Web Tam Nguyen V. Srinivasan ... layout paradigm, which encapsulates HTML, the stan-dard markup language of the Web, and SQL, the stan-dard query language of relational databases [SQL92]. ...
A program to develop planetary rover technology is underway at the Jet Propulsion Laboratory (JPL... more A program to develop planetary rover technology is underway at the Jet Propulsion Laboratory (JPL) under sponsorship of NASA. Developmental systems with the necessary sensing, computing, power, and mobility resources to demonstrate realistic forms of control for various missions have been developed, and initial testing has been completed. These testbed systems and the associated navigation techniques used are described. Particular emphasis is placed on three technologies: Computer-Aided Remote Driving (CARD), Semiautonomous Navigation (SAN), and behavior control. It is concluded that, through the development and evaluation of such technologies, research at JPL has expanded the set of viable planetary rover mission possibilities beyond the limits of remotely teleoperated systems such as Lunakhod. These are potentially applicable to exploration of all the solid planetary surfaces in the solar system, including Mars, Venus, and the moons of the gas giant planets
Applied Intelligence, 1992
Future missions to the moon, Mars, or other planetary surfaces will use planetary rovers for expl... more Future missions to the moon, Mars, or other planetary surfaces will use planetary rovers for exploration or other tasks. Operation of these rovers as unmanned robotic vehicles with some form of remote or semi-autonomous control is desirable to reduce the cost and increase the capability and safety of many types of missions. However, the long time delays and relatively low bandwidths associated with radio communications between planets precludes a total “telepresence” approach to controlling the vehicle. A program to develop planetary rover technology has been initiated at the Jet Propulsion Laboratory (JPL) under sponsorship of the National Aeronautics and Space Administration (NASA). Developmental systems with the necessary sensing, computing, power, and mobility resources to demonstrate realistic forms of control for various missions have been developed and initial testing has been completed. These testbed systems, the associated navigation techniques currently used and planned for implementation, and long-term mission strategies employing them are described.
Electronic Notes in Theoretical Computer Science, 2005
Cancer Immunology Immunotherapy, 2004
Previous studies have suggested that immunotherapy with dendritic cell (DC) vaccines may be effec... more Previous studies have suggested that immunotherapy with dendritic cell (DC) vaccines may be effective in treatment of patients with AJCC stage IV melanoma. We examined this treatment in phase I/II studies in 33 patients with good performance status and low volume disease. Nineteen patients received DCs plus autologous lysates and 14 patients DCs plus peptides from the melanoma antigens MAGE-3.A2, tyrosinase, gp100, and MART-1. Keyhole limpet hemocyanin (KLH) was used as a helper protein and influenza peptide was given as a positive control. DCs were produced from adherent cells in blood lymphocytes (monocytic DCs), grown in IL-4 and GM-CSF without a maturation step. The DCs were injected into inguinal lymph nodes at weekly intervals (×4), 2 weeks (×1), and 4-weekly intervals (×2). There were 3 responses (3 partial responses) and 1 mixed response in the 19 patients treated with DCs plus autologous lysates. No responses were seen in the group treated with DCs plus peptides. Stable disease (defined as no progression over a period of 3 months) was seen in 4 patients in group 1 and 5 patients in group 2. Treatment was not associated with significant side effects. We examined whether DTH skin tests or assays of IFN-γ cytokine production may be useful predictors of clinical responses. Twenty-two of 30 patients had DTH responses to KLH and 12 of 13 patients had DTH responses to the influenza peptide. Five of 15 DTH responses were seen against autologous lysates. This was strongly correlated with clinical responses. Approximately half the patients had responses to MART-1 peptide and a third to the other melanoma peptides. Similarly, cytokine production assays showed responses to influenza in 7 of 13 patients, and approximately one third of patients had responses to the other peptides. No IFN-γ responses were seen in 5 patients against their autologous lysates. There was no correlation between assays of IFN-γ production and clinical responses. The present studies suggest that autologous lysates may be more effective than the melanoma peptides used in the study as the source of antigen for DC vaccines. DTH responses to autologous lysates appear useful predictors of clinical responses, but further work is needed to identify other measures associated with clinical responses.
Sigmod Record, 1996
Page 1. Accessing Relational Databases from the World Wide Web Tam Nguyen V. Srinivasan ... layou... more Page 1. Accessing Relational Databases from the World Wide Web Tam Nguyen V. Srinivasan ... layout paradigm, which encapsulates HTML, the stan-dard markup language of the Web, and SQL, the stan-dard query language of relational databases [SQL92]. ...
A program to develop planetary rover technology is underway at the Jet Propulsion Laboratory (JPL... more A program to develop planetary rover technology is underway at the Jet Propulsion Laboratory (JPL) under sponsorship of NASA. Developmental systems with the necessary sensing, computing, power, and mobility resources to demonstrate realistic forms of control for various missions have been developed, and initial testing has been completed. These testbed systems and the associated navigation techniques used are described. Particular emphasis is placed on three technologies: Computer-Aided Remote Driving (CARD), Semiautonomous Navigation (SAN), and behavior control. It is concluded that, through the development and evaluation of such technologies, research at JPL has expanded the set of viable planetary rover mission possibilities beyond the limits of remotely teleoperated systems such as Lunakhod. These are potentially applicable to exploration of all the solid planetary surfaces in the solar system, including Mars, Venus, and the moons of the gas giant planets
Applied Intelligence, 1992
Future missions to the moon, Mars, or other planetary surfaces will use planetary rovers for expl... more Future missions to the moon, Mars, or other planetary surfaces will use planetary rovers for exploration or other tasks. Operation of these rovers as unmanned robotic vehicles with some form of remote or semi-autonomous control is desirable to reduce the cost and increase the capability and safety of many types of missions. However, the long time delays and relatively low bandwidths associated with radio communications between planets precludes a total “telepresence” approach to controlling the vehicle. A program to develop planetary rover technology has been initiated at the Jet Propulsion Laboratory (JPL) under sponsorship of the National Aeronautics and Space Administration (NASA). Developmental systems with the necessary sensing, computing, power, and mobility resources to demonstrate realistic forms of control for various missions have been developed and initial testing has been completed. These testbed systems, the associated navigation techniques currently used and planned for implementation, and long-term mission strategies employing them are described.
Electronic Notes in Theoretical Computer Science, 2005