Tamas Doczi - Academia.edu (original) (raw)
Papers by Tamas Doczi
Neuroscience, Oct 14, 2016
The aim of the present work was to characterize neurons in the archi- and neocortical white matte... more The aim of the present work was to characterize neurons in the archi- and neocortical white matter, and to investigate their distribution in mesial temporal sclerosis. Immunohistochemistry and quantification of neurons were performed on surgically resected tissue sections of patients with therapy-resistant temporal lobe epilepsy. Temporal lobe tissues of patients with tumor but without epilepsy and that from autopsy were used as controls. Neurons were identified with immunohistochemistry using antibodies against NeuN, calcium-binding proteins, transcription factor Tbr1 and neurofilaments. We found significantly higher density of neurons in the archi- and neocortical white matter of patients with temporal lobe epilepsy than in that of controls. Based on their morphology and neurochemical content, both excitatory and inhibitory cells were present among these neurons. A subset of neurons in the white matter was Tbr-1-immunoreactive and these neurons coexpressed NeuN and neurofilament m...
Journal of Neuropathology & Experimental Neurology, 2002
Parkinson's Disease, 2015
Objectives. Our investigation aimed at evaluating if bilateral subthalamic deep brain stimulation... more Objectives. Our investigation aimed at evaluating if bilateral subthalamic deep brain stimulation (DBS) could preserve working capability in Parkinson’s disease (PD).Materials. We reviewed the data of 40 young (<60 year-old) PD patients who underwent DBS implantation and had at least 2 years of follow-up. Patients were categorized based on their working capability at time of surgery: “active job” group (n=20) and “no job” group (n=20). Baseline characteristics were comparable. Quality of life (EQ-5D) and presence of active job were evaluated preoperatively and 2 years postoperatively.Results. Although similar (approximately 50%) improvement was achieved in the severity of motor and major nonmotor symptoms in both groups, the postoperative quality of life was significantly better in the “active job” group (0.687 versus 0.587, medians,p<0.05). Majority (80%) of “active job” group members were able to preserve their job 2 years after the operation. However, only a minimal portion...
Ideggyógyászati szemle, Jan 30, 2010
Bilateral deep brain stimulation of the subthalamic nuclei (STN) is a well-established and cost-e... more Bilateral deep brain stimulation of the subthalamic nuclei (STN) is a well-established and cost-effective treatment in advanced PD. To quantitatively analyze the change in use of antiparkinsonian drugs one year after subthalamic deep brain stimulator (DBS) implantation in patients with idiopathic Parkinson's disease (PD). Eighteen consecutive patients with advanced PD underwent bilateral STN DBS implantation were involved in the study. The stimulation achieved a stable and clear clinical benefit in all of the cases. One year after the implantation, drug usage of patients was analyzed and correlated with the postoperative symptomatic improvement measured by the modified Hoehn-Yahr, Schwab and England, and Unified Parkinson's Disease Rating Scales. Because none of the investigated variables followed the normal distribution, non-parametric Wilcoxon signed-rank, McNemar and Kendell's T tests were applied. Preoperatively, the patients used 12.05 +/- 4.57 tablets a day out of ...
Prague medical report, 2004
Granule cells of the human hippocampal dentate gyrus were examined. In controls, granule cells di... more Granule cells of the human hippocampal dentate gyrus were examined. In controls, granule cells displayed somatic spines and cell nuclei with small infoldings. In addition, the cytoplasm of human granule cells always displayed lipofuscin. Subsurface cisterns of endoplasmic reticulum were frequently observed in the human granule cells. Two types of axosomatic synapses were found; most frequently symmetric and less frequently asymmetric. Many of the axosomatic synapses were isolated by glial processes in tumour or lesion-related epileptic patients, but the ultrastructural characteristics of granule cells were not different from those of the control patients. Large bundles of reactive astroglial fibres appeared regularly in all layers of the dentate gyrus. In tumour infiltrated hippocampi, glial processes dominated the neuropil and the number of perisomatic synapses was markedly reduced. Reduction in the number of perisomatic synapses did not correlate with severity and duration of seiz...
Diagnostic Pathology, 2012
Journal of Neurosurgical Anesthesiology, 2000
Acta Neurochirurgica, 1999
Purpose. To correlate the jugular bulb oxygen saturation (SjvO 2) and brain tissue oxygen pressur... more Purpose. To correlate the jugular bulb oxygen saturation (SjvO 2) and brain tissue oxygen pressure (PbtO 2) during carbon dioxide (CO 2) and oxygen (O 2) reactivity tests in severely head-injured patients. Methods and Results. In nine patients (7 men, 2 women, age: 26 q 6X5 years, GCS of 6X5 q 2X9), a polarographic microcatheter (Clark-type) was inserted into nonlesioned white matter (frontal lobe). PbtO 2 and SjvO 2 were monitored simultaneously and cerebral vasoreactivity to CO 2 and O 2 was tested on days three, ®ve and seven after injury. Simultaneous measurements of vasoreactivity by transcranial Doppler (TCD) were undertaken. A total of twenty-one CO 2 and O 2 reactivity tests were performed. Critical values of PbtO 2 (`15 mm Hg) during induced hyperventilation could be observed four times in two patients. High PbtO 2 values up to 80 mm Hg were observed during hyperoxygenation (FiO 2 100%). CO 2 vasoreactivity by means of PbtO 2 was absent in four tests in which measurements by TCD showed intact responses. A stronger correlation between SjvO 2 and PbtO 2 during the O 2 reactivity tests was observed (r 0X6, p`0X001), in comparison to values obtained during the CO 2 reactivity tests (r 0X33, p`0X001). In addition, there was no statistically signi®cant correlation (r 0X22, p 0X26) between CO 2 reactivity values measured by TCD 4X5 q 5X7% and PbtO 2 3 q 2X8%. Conclusions. Correlation between SjvO 2 and PbtO 2 during CO 2 reactivity test is low, even if signi®cant di¨erences between normoand hyperventilation values are present. In comparison to SjvO 2 , monitoring of PbtO 2 might more accurately detect possible focal ischaemic events during rapidly induced hyperventilation in severely head-injured patients. The CO 2 vasoreactivity by means of changes in Vm MCA seems to be higher in comparison to changes of PbtO 2. These observations lead to the hypothesis that vasoreactivity measured by TCD overestimates the cerebrovascular response to CO 2 .
Journal of Neural Transmission, 1982
The influence of chronic arterial hypertension upon the permeability to albumin of the cerebral c... more The influence of chronic arterial hypertension upon the permeability to albumin of the cerebral capillaries, i.e. the blood-brain barrier, was studied in normotensive Wistar and spontaneously hypertensive Wistar rats with experimental subarachnoid hemorrhage. The blood-brain barrier permeability to albumin was assessed quantitatively by spectrophotometric determination of Evans blue extravasation. Subarachnoid hemorrhage was produced by injecting autologous blood into the cortical subarachnoid space. A significant increase of Evans blue albumin extravasation was found in the spontaneously hypertensive rats with subarachnoid hemorrhage as compared with normotensive animals suffering from subarachnoid hemorrhage. Subarachnoid hemorrhage in this model alone caused a significant Evans blue extravasation, whereas sham-operation did not. These findings emphasize the necessity for effective attempts to reduce the leakage of the capillary system in the early stage of subarachnoid hemorrhage.
Current Translational Geriatrics and Experimental Gerontology Reports, 2012
While the incidence of traumatic brain injury (TBI) is decreasing in the young, active population... more While the incidence of traumatic brain injury (TBI) is decreasing in the young, active population, injuries are getting more frequent among the elderly; as the geriatric population is in a constant rise and the relative cost of care is particularly high in this group of patients, the economic burden of TBI does not decline. This review is aimed to identify predisposing factors and characteristic features of geriatric brain injury, primarily focusing on the comparison between Eastern and Western European countries. While economically each of these is a high-or middle-income country, the differences in mortality and morbidity, approaches, and policies applied by health care providers are substantial. On the basis of the disappointing outcome results in Eastern Europe, one may conclude that therapeutic guidelines defined on the basis of the "Western experience" should only be applied in conjunction with a systematic reorganization of health care in Eastern Europe.
SoftwareX, 2022
Currently the most widespread way of reporting in radiology is dictation mainly due to performanc... more Currently the most widespread way of reporting in radiology is dictation mainly due to performance benefits. The 30 output of this method is plain text, which varies in style (structure, nomenclature, abbreviations, etc.) and content 31 between doctors even when reporting the exact same case. Templated radiology provides a structure for reporting and aims to help in generating more unified reports. We propose a web-based system for creating and using 33 radiological structured reporting templates. 34 We developed our software based on web technologies. We wrote the system with modular design in mind. We 35 have separate libraries for the different functionalities: a rendering library which renders the templates based on a 36 schema, an editor library which handles template creation, and an evaluator library, which parses, and executes 37 our custom domain specific language, FormScript, which enables dynamic behaviour in our templates. We also 38 developed a Single Page Application to create, browse, use and share templating reports. The backend of the 39 application is powered by Firebase from Google.
Ideggyógyászati szemle, Jan 30, 2012
Bilateral pallidal deep brain stimulation (DBS) is an established treatment option for primary ge... more Bilateral pallidal deep brain stimulation (DBS) is an established treatment option for primary generalized and segmental dystonia. In the present study we evaluated the results of our dystonia patients treated by DBS. The surgical results of forty consecutive dystonia patients underwent DBS implantation were analyzed (age: 43.7 +/- 17.7 years; sex: 22 men; etiology: 24 primary and 16 secondary dystonia; topography: 24 generalized, 12 segmental and four hemidystonia; disease duration: 16.1 +/- 9.3 years). Severity of dystonia measured by Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) and health-related quality of life measured by EQ-5D scale were obtained preoperatively and compared to the scores obtained at postoperative six months and subsequent yearly follow-ups. The average follow-up lasted 2.5 years (median, 0.5-8 years). In all cases the BFMDRS scores were re-evaluated by a rater blinded to the treatment. Treatment responsiveness was defined as an at least 25% improvement on...
![Research paper thumbnail of [Diffusion tensor and functional MR imaging of severe traumatic craniocerebral injury at low magnetic field]](https://attachments.academia-assets.com/99646577/thumbnails/1.jpg)
](Ideggyógyászati szemle, Jan 30, 2007
Presentation of diffusion tensor imaging (DTI) performed at low magnetic field (1 Tesla) in the a... more Presentation of diffusion tensor imaging (DTI) performed at low magnetic field (1 Tesla) in the algorithm of work-up of a patient suffering from severe traumatic brain injury (TBI). DTI and functional MRI (fMRI) were applied at 1 Tesla for visualization of neural pathways and examination of sensory functions of a patient with severe TBI. DTI-measurement was also performed on a healthy patient for comparison. DTI acquired at low magnetic field yielded appropriate visualization of neural pathways. DTI confirmed the results of the clinical and fMRI examinations in the patient suffering from severe TBI. An optimized DTI can be useful in the examination of patients with TBI, moreover, it may also help in the establishment of diagnoses of other central nervous system diseases affecting neuronal pathways. The presented results suggest that DTI of appropriate quality can be performed at low magnetic field.
Célkitûzés-Súlyos koponya-agy sérülés (traumatic brain injury, TBI) következtében elszenvedett id... more Célkitûzés-Súlyos koponya-agy sérülés (traumatic brain injury, TBI) következtében elszenvedett idegpályakárosodás pontos kimutatása-Magyarországon széles körben elérhetô-alacsony térerejû (1 Tesla) MRkészüléken, diffúzióstenzor-képalkotással (DTI) nyert képek segítségével. Módszer-A súlyos koponya-agy sérülést szenvedett beteget funkcionális MR (fMR) és DTI segítségével vizsgáltuk 1 T térerôn. A DTI-mérést-az összehasonlítás érdekében-egészséges alanyon is elvégeztük. Eredmények-Alacsony térerôn készített DTI-képek láthatóvá tették az egyes idegpályákat, igazolták a súlyos koponya-agy sérült beteg pályakárosodásait, amelyeket a klinikai vizsgálatokkal összhangban az fMR-eredmények is alátámasztottak. Következtetés-Az optimalizált, alacsony térerôn végzett DTI hasznos lehet koponya-agy sérülést elszenvedett beteg átvizsgálása során, sôt, segítséget nyújthat számos más agyi pályákat érintô betegség diagnosztikájában. A bemutatott eredménnyel bizonyítottuk, hogy alacsony térerôn megbízhatóan lehet és érdemes DTI-t végezni.
Ideggyógyászati szemle, Jan 20, 2002
Although significant improvement of motor function following bilateral pallidotomy for the treatm... more Although significant improvement of motor function following bilateral pallidotomy for the treatment of Parkinson's disease has been proved, the cognitive sequelae have not been clearly defined. There are recurrent loops interconnecting specific areas of the frontal cortex and the basal ganglia, suggesting the continuity or complementary functioning between these areas. Pre- and postoperative cognitive function was evaluated in 19 Parkinsonian patients who underwent bilateral pallidotomy in order to clarify its effects on cognitive function. All patients were evaluated one day before the procedure and 12+ months after surgery using neuropsychological tests (Raven Progressive Matrices and Bergen Facial Recognition Test). Proper performance in these tests requires reasoning, abstraction and spatial memory, involving strongly the frontal functions. These functions could be described in terms of the "working memory" concept. Hand Mental Rotation Test was used as comparing ...
Acta Neurochirurgica, 2011
Background Numerous studies with conflicting results have tried to prove the influence of seasona... more Background Numerous studies with conflicting results have tried to prove the influence of seasonal variations or different meteorological factors on the occurrence of aneurysmal subarachnoidal hemorrhage (SAH). The aim of this study was to establish a mathematical model of a series of aneurysmal rupture dates in different patients and verify a temporal pattern in the occurrence of SAH. Methods We analyzed a group of 563 patients with the exact aneurysm rupture dates, hospitalized at the Clinic of
BMC Neurology, 2021
Background When MRI fails to detect a potentially epileptogenic lesion, the chance of a favorable... more Background When MRI fails to detect a potentially epileptogenic lesion, the chance of a favorable outcome after epilepsy surgery becomes significantly lower (from 60 to 90% to 20–65%). Hybrid FDG-PET/MRI may provide additional information for identifying the epileptogenic zone. We aimed to investigate the possible effect of the introduction of hybrid FDG-PET/MRI into the algorithm of the decision-making in both lesional and non-lesional drug-resistant epileptic patients. Methods In a prospective study of patients suffering from drug-resistant focal epilepsy, 30 nonlesional and 30 lesional cases with discordant presurgical results were evaluated using hybrid FDG-PET/MRI. Results The hybrid imaging revealed morphological lesion in 18 patients and glucose hypometabolism in 29 patients within the nonlesional group. In the MRI positive group, 4 patients were found to be nonlesional, and in 9 patients at least one more epileptogenic lesion was discovered, while in another 17 cases the ori...
Epilepsy & behavior : E&B, Aug 24, 2016
In mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS), structural abnormalities a... more In mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS), structural abnormalities are present not only in the hippocampus but also in the white matter with ipsilateral predominance. Although the timing of epilepsy onset is commonly associated with clinical and semiological dissimilarities, limited data exist regarding white matter diffusion changes with respect to age at epilepsy onset. The aim of this study was to investigate diffusion changes in the white matter of patients with unilateral MTLE-HS with respect to clinical parameters and to compare them with an age- and sex-matched healthy control group. Apparent diffusion coefficients (ADCs) were derived using monoexponential approaches from 22 (11 early and 11 late age at onset) patients with unilateral MTLE-HS and 22 age- and sex-matched control subjects after acquiring diffusion-weighted images on a 3T MRI system. Data were analyzed using two-tailed t-tests and multiple linear regression models. In the group with ...
Neuroscience, Oct 14, 2016
The aim of the present work was to characterize neurons in the archi- and neocortical white matte... more The aim of the present work was to characterize neurons in the archi- and neocortical white matter, and to investigate their distribution in mesial temporal sclerosis. Immunohistochemistry and quantification of neurons were performed on surgically resected tissue sections of patients with therapy-resistant temporal lobe epilepsy. Temporal lobe tissues of patients with tumor but without epilepsy and that from autopsy were used as controls. Neurons were identified with immunohistochemistry using antibodies against NeuN, calcium-binding proteins, transcription factor Tbr1 and neurofilaments. We found significantly higher density of neurons in the archi- and neocortical white matter of patients with temporal lobe epilepsy than in that of controls. Based on their morphology and neurochemical content, both excitatory and inhibitory cells were present among these neurons. A subset of neurons in the white matter was Tbr-1-immunoreactive and these neurons coexpressed NeuN and neurofilament m...
Journal of Neuropathology & Experimental Neurology, 2002
Parkinson's Disease, 2015
Objectives. Our investigation aimed at evaluating if bilateral subthalamic deep brain stimulation... more Objectives. Our investigation aimed at evaluating if bilateral subthalamic deep brain stimulation (DBS) could preserve working capability in Parkinson’s disease (PD).Materials. We reviewed the data of 40 young (<60 year-old) PD patients who underwent DBS implantation and had at least 2 years of follow-up. Patients were categorized based on their working capability at time of surgery: “active job” group (n=20) and “no job” group (n=20). Baseline characteristics were comparable. Quality of life (EQ-5D) and presence of active job were evaluated preoperatively and 2 years postoperatively.Results. Although similar (approximately 50%) improvement was achieved in the severity of motor and major nonmotor symptoms in both groups, the postoperative quality of life was significantly better in the “active job” group (0.687 versus 0.587, medians,p<0.05). Majority (80%) of “active job” group members were able to preserve their job 2 years after the operation. However, only a minimal portion...
Ideggyógyászati szemle, Jan 30, 2010
Bilateral deep brain stimulation of the subthalamic nuclei (STN) is a well-established and cost-e... more Bilateral deep brain stimulation of the subthalamic nuclei (STN) is a well-established and cost-effective treatment in advanced PD. To quantitatively analyze the change in use of antiparkinsonian drugs one year after subthalamic deep brain stimulator (DBS) implantation in patients with idiopathic Parkinson's disease (PD). Eighteen consecutive patients with advanced PD underwent bilateral STN DBS implantation were involved in the study. The stimulation achieved a stable and clear clinical benefit in all of the cases. One year after the implantation, drug usage of patients was analyzed and correlated with the postoperative symptomatic improvement measured by the modified Hoehn-Yahr, Schwab and England, and Unified Parkinson's Disease Rating Scales. Because none of the investigated variables followed the normal distribution, non-parametric Wilcoxon signed-rank, McNemar and Kendell's T tests were applied. Preoperatively, the patients used 12.05 +/- 4.57 tablets a day out of ...
Prague medical report, 2004
Granule cells of the human hippocampal dentate gyrus were examined. In controls, granule cells di... more Granule cells of the human hippocampal dentate gyrus were examined. In controls, granule cells displayed somatic spines and cell nuclei with small infoldings. In addition, the cytoplasm of human granule cells always displayed lipofuscin. Subsurface cisterns of endoplasmic reticulum were frequently observed in the human granule cells. Two types of axosomatic synapses were found; most frequently symmetric and less frequently asymmetric. Many of the axosomatic synapses were isolated by glial processes in tumour or lesion-related epileptic patients, but the ultrastructural characteristics of granule cells were not different from those of the control patients. Large bundles of reactive astroglial fibres appeared regularly in all layers of the dentate gyrus. In tumour infiltrated hippocampi, glial processes dominated the neuropil and the number of perisomatic synapses was markedly reduced. Reduction in the number of perisomatic synapses did not correlate with severity and duration of seiz...
Diagnostic Pathology, 2012
Journal of Neurosurgical Anesthesiology, 2000
Acta Neurochirurgica, 1999
Purpose. To correlate the jugular bulb oxygen saturation (SjvO 2) and brain tissue oxygen pressur... more Purpose. To correlate the jugular bulb oxygen saturation (SjvO 2) and brain tissue oxygen pressure (PbtO 2) during carbon dioxide (CO 2) and oxygen (O 2) reactivity tests in severely head-injured patients. Methods and Results. In nine patients (7 men, 2 women, age: 26 q 6X5 years, GCS of 6X5 q 2X9), a polarographic microcatheter (Clark-type) was inserted into nonlesioned white matter (frontal lobe). PbtO 2 and SjvO 2 were monitored simultaneously and cerebral vasoreactivity to CO 2 and O 2 was tested on days three, ®ve and seven after injury. Simultaneous measurements of vasoreactivity by transcranial Doppler (TCD) were undertaken. A total of twenty-one CO 2 and O 2 reactivity tests were performed. Critical values of PbtO 2 (`15 mm Hg) during induced hyperventilation could be observed four times in two patients. High PbtO 2 values up to 80 mm Hg were observed during hyperoxygenation (FiO 2 100%). CO 2 vasoreactivity by means of PbtO 2 was absent in four tests in which measurements by TCD showed intact responses. A stronger correlation between SjvO 2 and PbtO 2 during the O 2 reactivity tests was observed (r 0X6, p`0X001), in comparison to values obtained during the CO 2 reactivity tests (r 0X33, p`0X001). In addition, there was no statistically signi®cant correlation (r 0X22, p 0X26) between CO 2 reactivity values measured by TCD 4X5 q 5X7% and PbtO 2 3 q 2X8%. Conclusions. Correlation between SjvO 2 and PbtO 2 during CO 2 reactivity test is low, even if signi®cant di¨erences between normoand hyperventilation values are present. In comparison to SjvO 2 , monitoring of PbtO 2 might more accurately detect possible focal ischaemic events during rapidly induced hyperventilation in severely head-injured patients. The CO 2 vasoreactivity by means of changes in Vm MCA seems to be higher in comparison to changes of PbtO 2. These observations lead to the hypothesis that vasoreactivity measured by TCD overestimates the cerebrovascular response to CO 2 .
Journal of Neural Transmission, 1982
The influence of chronic arterial hypertension upon the permeability to albumin of the cerebral c... more The influence of chronic arterial hypertension upon the permeability to albumin of the cerebral capillaries, i.e. the blood-brain barrier, was studied in normotensive Wistar and spontaneously hypertensive Wistar rats with experimental subarachnoid hemorrhage. The blood-brain barrier permeability to albumin was assessed quantitatively by spectrophotometric determination of Evans blue extravasation. Subarachnoid hemorrhage was produced by injecting autologous blood into the cortical subarachnoid space. A significant increase of Evans blue albumin extravasation was found in the spontaneously hypertensive rats with subarachnoid hemorrhage as compared with normotensive animals suffering from subarachnoid hemorrhage. Subarachnoid hemorrhage in this model alone caused a significant Evans blue extravasation, whereas sham-operation did not. These findings emphasize the necessity for effective attempts to reduce the leakage of the capillary system in the early stage of subarachnoid hemorrhage.
Current Translational Geriatrics and Experimental Gerontology Reports, 2012
While the incidence of traumatic brain injury (TBI) is decreasing in the young, active population... more While the incidence of traumatic brain injury (TBI) is decreasing in the young, active population, injuries are getting more frequent among the elderly; as the geriatric population is in a constant rise and the relative cost of care is particularly high in this group of patients, the economic burden of TBI does not decline. This review is aimed to identify predisposing factors and characteristic features of geriatric brain injury, primarily focusing on the comparison between Eastern and Western European countries. While economically each of these is a high-or middle-income country, the differences in mortality and morbidity, approaches, and policies applied by health care providers are substantial. On the basis of the disappointing outcome results in Eastern Europe, one may conclude that therapeutic guidelines defined on the basis of the "Western experience" should only be applied in conjunction with a systematic reorganization of health care in Eastern Europe.
SoftwareX, 2022
Currently the most widespread way of reporting in radiology is dictation mainly due to performanc... more Currently the most widespread way of reporting in radiology is dictation mainly due to performance benefits. The 30 output of this method is plain text, which varies in style (structure, nomenclature, abbreviations, etc.) and content 31 between doctors even when reporting the exact same case. Templated radiology provides a structure for reporting and aims to help in generating more unified reports. We propose a web-based system for creating and using 33 radiological structured reporting templates. 34 We developed our software based on web technologies. We wrote the system with modular design in mind. We 35 have separate libraries for the different functionalities: a rendering library which renders the templates based on a 36 schema, an editor library which handles template creation, and an evaluator library, which parses, and executes 37 our custom domain specific language, FormScript, which enables dynamic behaviour in our templates. We also 38 developed a Single Page Application to create, browse, use and share templating reports. The backend of the 39 application is powered by Firebase from Google.
Ideggyógyászati szemle, Jan 30, 2012
Bilateral pallidal deep brain stimulation (DBS) is an established treatment option for primary ge... more Bilateral pallidal deep brain stimulation (DBS) is an established treatment option for primary generalized and segmental dystonia. In the present study we evaluated the results of our dystonia patients treated by DBS. The surgical results of forty consecutive dystonia patients underwent DBS implantation were analyzed (age: 43.7 +/- 17.7 years; sex: 22 men; etiology: 24 primary and 16 secondary dystonia; topography: 24 generalized, 12 segmental and four hemidystonia; disease duration: 16.1 +/- 9.3 years). Severity of dystonia measured by Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) and health-related quality of life measured by EQ-5D scale were obtained preoperatively and compared to the scores obtained at postoperative six months and subsequent yearly follow-ups. The average follow-up lasted 2.5 years (median, 0.5-8 years). In all cases the BFMDRS scores were re-evaluated by a rater blinded to the treatment. Treatment responsiveness was defined as an at least 25% improvement on...
Ideggyógyászati szemle, Jan 30, 2007
Presentation of diffusion tensor imaging (DTI) performed at low magnetic field (1 Tesla) in the a... more Presentation of diffusion tensor imaging (DTI) performed at low magnetic field (1 Tesla) in the algorithm of work-up of a patient suffering from severe traumatic brain injury (TBI). DTI and functional MRI (fMRI) were applied at 1 Tesla for visualization of neural pathways and examination of sensory functions of a patient with severe TBI. DTI-measurement was also performed on a healthy patient for comparison. DTI acquired at low magnetic field yielded appropriate visualization of neural pathways. DTI confirmed the results of the clinical and fMRI examinations in the patient suffering from severe TBI. An optimized DTI can be useful in the examination of patients with TBI, moreover, it may also help in the establishment of diagnoses of other central nervous system diseases affecting neuronal pathways. The presented results suggest that DTI of appropriate quality can be performed at low magnetic field.
Célkitûzés-Súlyos koponya-agy sérülés (traumatic brain injury, TBI) következtében elszenvedett id... more Célkitûzés-Súlyos koponya-agy sérülés (traumatic brain injury, TBI) következtében elszenvedett idegpályakárosodás pontos kimutatása-Magyarországon széles körben elérhetô-alacsony térerejû (1 Tesla) MRkészüléken, diffúzióstenzor-képalkotással (DTI) nyert képek segítségével. Módszer-A súlyos koponya-agy sérülést szenvedett beteget funkcionális MR (fMR) és DTI segítségével vizsgáltuk 1 T térerôn. A DTI-mérést-az összehasonlítás érdekében-egészséges alanyon is elvégeztük. Eredmények-Alacsony térerôn készített DTI-képek láthatóvá tették az egyes idegpályákat, igazolták a súlyos koponya-agy sérült beteg pályakárosodásait, amelyeket a klinikai vizsgálatokkal összhangban az fMR-eredmények is alátámasztottak. Következtetés-Az optimalizált, alacsony térerôn végzett DTI hasznos lehet koponya-agy sérülést elszenvedett beteg átvizsgálása során, sôt, segítséget nyújthat számos más agyi pályákat érintô betegség diagnosztikájában. A bemutatott eredménnyel bizonyítottuk, hogy alacsony térerôn megbízhatóan lehet és érdemes DTI-t végezni.
Ideggyógyászati szemle, Jan 20, 2002
Although significant improvement of motor function following bilateral pallidotomy for the treatm... more Although significant improvement of motor function following bilateral pallidotomy for the treatment of Parkinson's disease has been proved, the cognitive sequelae have not been clearly defined. There are recurrent loops interconnecting specific areas of the frontal cortex and the basal ganglia, suggesting the continuity or complementary functioning between these areas. Pre- and postoperative cognitive function was evaluated in 19 Parkinsonian patients who underwent bilateral pallidotomy in order to clarify its effects on cognitive function. All patients were evaluated one day before the procedure and 12+ months after surgery using neuropsychological tests (Raven Progressive Matrices and Bergen Facial Recognition Test). Proper performance in these tests requires reasoning, abstraction and spatial memory, involving strongly the frontal functions. These functions could be described in terms of the "working memory" concept. Hand Mental Rotation Test was used as comparing ...
Acta Neurochirurgica, 2011
Background Numerous studies with conflicting results have tried to prove the influence of seasona... more Background Numerous studies with conflicting results have tried to prove the influence of seasonal variations or different meteorological factors on the occurrence of aneurysmal subarachnoidal hemorrhage (SAH). The aim of this study was to establish a mathematical model of a series of aneurysmal rupture dates in different patients and verify a temporal pattern in the occurrence of SAH. Methods We analyzed a group of 563 patients with the exact aneurysm rupture dates, hospitalized at the Clinic of
BMC Neurology, 2021
Background When MRI fails to detect a potentially epileptogenic lesion, the chance of a favorable... more Background When MRI fails to detect a potentially epileptogenic lesion, the chance of a favorable outcome after epilepsy surgery becomes significantly lower (from 60 to 90% to 20–65%). Hybrid FDG-PET/MRI may provide additional information for identifying the epileptogenic zone. We aimed to investigate the possible effect of the introduction of hybrid FDG-PET/MRI into the algorithm of the decision-making in both lesional and non-lesional drug-resistant epileptic patients. Methods In a prospective study of patients suffering from drug-resistant focal epilepsy, 30 nonlesional and 30 lesional cases with discordant presurgical results were evaluated using hybrid FDG-PET/MRI. Results The hybrid imaging revealed morphological lesion in 18 patients and glucose hypometabolism in 29 patients within the nonlesional group. In the MRI positive group, 4 patients were found to be nonlesional, and in 9 patients at least one more epileptogenic lesion was discovered, while in another 17 cases the ori...
Epilepsy & behavior : E&B, Aug 24, 2016
In mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS), structural abnormalities a... more In mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS), structural abnormalities are present not only in the hippocampus but also in the white matter with ipsilateral predominance. Although the timing of epilepsy onset is commonly associated with clinical and semiological dissimilarities, limited data exist regarding white matter diffusion changes with respect to age at epilepsy onset. The aim of this study was to investigate diffusion changes in the white matter of patients with unilateral MTLE-HS with respect to clinical parameters and to compare them with an age- and sex-matched healthy control group. Apparent diffusion coefficients (ADCs) were derived using monoexponential approaches from 22 (11 early and 11 late age at onset) patients with unilateral MTLE-HS and 22 age- and sex-matched control subjects after acquiring diffusion-weighted images on a 3T MRI system. Data were analyzed using two-tailed t-tests and multiple linear regression models. In the group with ...