Taner Erdağ - Academia.edu (original) (raw)

Papers by Taner Erdağ

Research paper thumbnail of Accelerated radiotherapy in locally advanced head and neck cancer – early results

"Radiation and Risk" Bulletin of the National Radiation and Epidemiological Registry, 2018

Research paper thumbnail of Involvement of Level I Neck Lymph Nodes in Advanced Squamous Carcinoma of the Larynx

Annals of Otology, Rhinology & Laryngology, 2001

This study was performed to evaluate the incidence of metastasis at level I in patients with squa... more This study was performed to evaluate the incidence of metastasis at level I in patients with squamous laryngeal cancer. One hundred consecutive patients with squamous carcinoma of the larynx were submitted to surgical treatment including radical neck dissection. The tumor stage was T3 or T4, and the neck stage was N1-N2c. Lymph node metastases were pathologically confirmed in 80 patients. Metastases were concentrated within level II in 59% of cases, level III in 17% of cases, level IV in 11% of cases, and level V in 6% of cases. Only 2 patients (2%) had detectable tumors in the lymph nodes of the submandibular triangle (level IB). This study shows that patients with laryngeal cancer rarely present metastases at the submandibular triangle, even in advanced local disease with cervical metastasis staged as N1 to N2c. Therefore, dissection of the submandibular triangle is indicated only in the presence of clinical, radiographic, or cytologic evidence of metastatic disease at level I.

Research paper thumbnail of Exploring the immunological basis of periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome: immunohistochemical staining features of palatine tonsils

Research paper thumbnail of The Journey of a Manuscript Submitted to the Turkish Archives of Otorhinolaryngology: From Receipt to Decision

Turkish Archives of Otorhinolaryngology

Research paper thumbnail of Whole Transcriptome Sequencing Reveals Cancer-Related, Prognostically Significant Transcripts and Tumor-Infiltrating Immunocytes in Mantle Cell Lymphoma

Cells

Mantle cell lymphoma (MCL) is an aggressive B-cell non-Hodgkin lymphoma (NHL) subtype characteriz... more Mantle cell lymphoma (MCL) is an aggressive B-cell non-Hodgkin lymphoma (NHL) subtype characterized by overexpression of CCND1 and SOX11 genes. It is generally associated with clinically poor outcomes despite recent improvements in therapeutic approaches. The genes associated with the development and prognosis of MCL are still largely unknown. Through whole transcriptome sequencing (WTS), we identified mRNAs, lncRNAs, and alternative transcripts differentially expressed in MCL cases compared with reactive tonsil B-cell subsets. CCND1, VCAM1, and VWF mRNAs, as well as MIR100HG and ROR1-AS1 lncRNAs, were among the top 10 most significantly overexpressed, oncogenesis-related transcripts. Survival analyses with each of the top upregulated transcripts showed that MCL cases with high expression of VWF mRNA and low expression of FTX lncRNA were associated with poor overall survival. Similarly, high expression of MSTRG.153013.3, an overexpressed alternative transcript, was associated with s...

Research paper thumbnail of Web of Science Kulak Burun Boğaz Dergilerinde En Çok Atıf Alan 100 Türk Makalesi

Türk otorinolarengoloji arşivi, 2015

Research paper thumbnail of Ekstrakraniyal baş boyun schwannomları: 14 hastalık seri

Kulak burun boğaz ihtisas dergisi, 2017

Research paper thumbnail of Dört ulusal KBB dergisinin 2002-2010 yılları arasındaki niceliksel ve niteliksel analizi

Kulak burun boğaz ihtisas dergisi, 2013

Research paper thumbnail of Tonsillektomi sonrası kanama: 10 yıllık deneyimimiz

Kulak burun boğaz ihtisas dergisi, 2017

Research paper thumbnail of Kulak burun boğaz uzmanlık tezleri yayına dönüşüyor mu

Kulak burun boğaz ihtisas dergisi, 2017

Research paper thumbnail of Tyroglossal duct cyst with endolaryngeal extension

Türk otolarengoloji arşivi, 2014

Research paper thumbnail of Türk Ulusal Kulak Burun Boğaz ve Baş Boyun Cerrahisi Kongre bildirilerinin analizi ve yayımlanma oranları

Kulak burun boğaz ihtisas dergisi, 2014

Research paper thumbnail of Çocuklarda Orta Kulak Patolojisini Belirlemede Geniş Bant Absorbans Ölçümünün Etkinliğinin Araştırılması

Amaç: Çocuklarda iletim tipi işitme kaybının öngörülmesinde ve efüzyonlu otitis media'nın belirle... more Amaç: Çocuklarda iletim tipi işitme kaybının öngörülmesinde ve efüzyonlu otitis media'nın belirlenmesinde geniş bant absorbans ölçümünün etkinliği değerlendirildi. Gereç ve Yöntem: Geniş bant absorbans ve saf ses odyometri testi normal olan 34 çocuğun 56 kulağı kontrol grubu (yaş ortalaması 7.01 yıl) ve iletim tipi işitme kayıplı 40 çocuğun 73 kulağı (yaş ortalaması 6.04 yıl) iletim tipi işitme kayıplı grubu temsil etmek üzere değerlendirildi. Hava-kemik aralığı en az bir frekansta 20 dB HL ya da en az iki frekansta 15 dB HL olan katılımcılar iletim tipi işitme kayıplı gruba dahil edildi. İletim tipi işitme kaybının muhtemel nedeni effüzyonlu otitis media ya da tuba eustachii disfonksiyonu olarak değerlendirildi. Bu iki ölçüm verisi geniş bant absorbans ve iletim tipi işitme kaybının derecesi arasındaki ilişkiyi açıklamak amacıyla incelendi. Geniş bant absorbansın öngörü yeteneğini değerlendirmek Pearson korelasyonu ve regresyon analizi, duyarlılık ve özgüllük oranlarını belirlemek için ROC analizi uygulandı. Bulgular: Absorbans iletim tipi işitme kaybı grubunda tüm frekanslarda kontrol grubundan daha düşük gözlendi. Pearson korelasyon analizinde hava kemik aralığı ile ortam basıncındaki geniş bant absorbans arasında güçlü, anlamlı, negatif korelasyon (R>0,69, p<0,000) bulundu. Regresyon analizinde hava kemik aralığı ile ortam basıncındaki geniş bant absorbans arasında, lineer modelde R-kare=0,779, kübik modelde R-kare=0,810, logaritmik modelde R-kare=0,783 bulundu. Sonuç: ROC eğrisi altında kalan alana göre, ortam basıncındaki geniş bant absorbans 226 Hz komplians ve timpanometrik genişliğe göre iletim tipi işitme kaybı için daha iyi bir öngörü faktörü olarak düşünülebilir. Geniş bant absorbans testi orta kulağın mekanik özelliklerini ölçmek için klinik bir tanı aracı olarak kullanılabilir ve aynı zamanda effüzyonlu otitis media hakkında daha ayrıntılı bilgi verebilir.

Research paper thumbnail of Giant Congenital Sialolipoma of Parotid Gland with Parapharyngeal Extension

Iranian Journal of Otorhinolaryngology, 2019

Introduction: Sialolipoma is an extremely rare salivary gland tumor characterized by a well circu... more Introduction: Sialolipoma is an extremely rare salivary gland tumor characterized by a well circumscribed mass composed of glandular tissue and mature adipose elements. Herein our aim was to present the fifth case of congenital sialolipoma, which was firstly followed up as a parotid gland hemangioma, and underline the fact that sialolipomas should be kept in mind in the differential diagnosis of congenital parotid gland masses. Case Report: A 10-month old male presented with a left-sided huge neck mass which progressed after birth. Radiologic examination revealed a tumor originating from the parotid gland filling the parapharyngeal space. Histopathologic examination of an incisional biopsy was consistent with sialolipoma. A total parotidectomy with preservation of the facial nerve was performed at the age of 1 year. The postoperative recovery was uneventful with normal facial nerve function. There was no recurrence at the 24-month follow-up. Conclusion: Although it is a very rare be...

Research paper thumbnail of Submandibular gland invasion and feasibility of gland-sparing neck dissection in oral cavity carcinoma

The Journal of Laryngology & Otology, 2018

Objective:This study investigated the incidence and routes of submandibular gland involvement in ... more Objective:This study investigated the incidence and routes of submandibular gland involvement in oral cavity carcinoma to determine the feasibility of submandibular gland sparing neck dissection.Methods:The records of 155 patients diagnosed with oral cavity squamous cell carcinoma, with a total of 183 neck specimens, including those involving level I, were reviewed retrospectively.Results:Submandibular gland involvement, via direct invasion from the anatomical proximity of T4a tumours, was evident in two patients. The floor of mouth location, either primarily or as an extension of the primary tumour, was the only risk factor for submandibular gland involvement in oral cavity carcinoma (p = 0.042). Tumour location, clinical and pathological tumour (T) and nodal (N) stages, and radiological suspicion of mandible invasion, were not found to be statistically relevant (p > 0.05).Conclusion:The results suggest the feasibility of preserving the submandibular gland in early stage oral ca...

Research paper thumbnail of The Microdébrider and Its Complications in Endoscopic Surgery for Nasal Polyposis

Yearbook of Otolaryngology-Head and Neck Surgery, 2009

Research paper thumbnail of Carcinome papillaire métastatique de l'os mandibulaire : à propos d'un cas

Revue De Laryngologie D Otologie Et De Rhinologie, 1999

Un cas de carcinome papillaire metastatique de l'os mandibulaire est rapporte. Malgre sa rare... more Un cas de carcinome papillaire metastatique de l'os mandibulaire est rapporte. Malgre sa rarete, la tumeur metastatique de l'os mandibulaire doit etre inclu dans le diagnostic differentiel des tumeurs de la region parotidienne. Situe au cou, l'otorhinolaryngologiste doit evaluer le corps thyroide pour l'identification du carcinome primaire.

Research paper thumbnail of Analysis of histopathological aspects and bone destruction characteristics in acquired middle ear cholesteatoma of pediatric and adult patients

International Journal of Pediatric Otorhinolaryngology, 2016

The aim of this study was to investigate the proliferative and apoptotic activity of middle ear c... more The aim of this study was to investigate the proliferative and apoptotic activity of middle ear cholesteatoma in pediatric and adult patients, in addition to comparing its histopathological aspects and the severity of advanced bone destruction. Medical records of 223 patients treated for chronic otitis media with cholesteatoma at the Otolaryngology Department of Dokuz Eylul University between January 1992 and December 2013 were retrospectively evaluated. Sixty-one patients subjected to tympanomastoidectomy due to middle ear cholesteatoma, with sufficient specimens for histopathological examination, were included in the study. Sections of archived tissues in paraffin blocks were subjected to new histopathological examinations. The proliferative and apoptotic activities of cholesteatoma were determined by immunohistochemical staining for epithelial thickness (ET), and Ki-67 and caspase-3 expression. A novel scoring system, the Bone Erosion Score (BES), was developed to estimate the severity of bone destruction. The Austin-Kartush classification score (AKCS) was also calculated. ET and Ki-67 expression was higher in adult patients than in the pediatric patients (p=0.009 and 0.01, respectively); however, caspase-3 immunopositivity did not show any significant intergroup differences (p=0.106). The differences in AKCS and BES between pediatric and adult patients were not statistically significant. According to the correlation analysis, a significant positive correlation was observed between AKCS and BES (p=0.001), and between ET and Ki-67 expression (when histopathological data were compared) (p=0.001). The proliferative activity of cholesteatoma was higher in adult patients. Therefore, these findings do not support the theory that the aggressive clinical course of cholesteatoma in pediatric patients is correlated with its histopathological characteristics.

Research paper thumbnail of Effect of steroids for nasal polyposis surgery: A placebo-controlled, randomized, double-blind study

The Laryngoscope, 2015

Objectives/Hypothesis: Although medical intervention is the first option for treatment of nasal p... more Objectives/Hypothesis: Although medical intervention is the first option for treatment of nasal polyps, surgery is still a therapeutic option for symptomatic cases that do not respond or partially respond to medical intervention. However, there is a need for high-level evidence for the preoperative use of steroids in nasal polyposis surgery. We aimed to assess the perioperative effect of preoperative use of oral prednisolone for advanced-stage diffuse nasal polyposis. Study Design: Prospective, double-blind, randomized, placebo-controlled study. Methods: A visual analog scale (VAS) was evaluated for smell, nasal discharge, nasal obstruction, facial pressure, headache, butanol smell threshold, and peak nasal inspiratory flow (PNIF) before and after the use of study drug. Perioperative bleeding volume, visibility of operative field, operative time, hospital stay, and complication rate were also evaluated. Results: The improvement in the corticosteroid group (CG) in the VAS scores, butanol thresholds, and PNIF values showed statistically significant differences compared to the placebo group (PG) (P <.05). The perioperative bleeding volume, visibility score, operative time, and hospital stay for CG/PG were 141 mL/384 mL, 2.4/3.4, 61 min/71.6 min, and 1.1 day/1.8 day, respectively (P <.05). The difference between the complication rates for the two groups did not show any statistically significant difference (P 5.214). Conclusions: Preoperative administration of systemic corticosteroids improves the perioperative visibility by reducing blood loss and shortens the operation time. We recommend the use of preoperative corticosteroid for the safety of the patients. The optimum dose and duration have not been established and require further studies.

Research paper thumbnail of A randomized clinical study: outcome of submucous resection of compensatory inferior turbinate during septoplasty

Rhinology, 2011

Septoplasty and/or turbinate surgery are commonly used surgical techniques for the treatment of m... more Septoplasty and/or turbinate surgery are commonly used surgical techniques for the treatment of mechanical nasal obstruction. The aim of this study was to define the effectiveness of submucous resection of a hypertrophied turbinate together with simultaneous septoplasty for the treatment of nasal obstruction. Forty-two patients with septum deviation and compensatory contralateral inferior turbinate hypertrophy were recruited in this study. The inferior turbinate hypertrophy was diagnosed based on examination. The patients were randomly divided into two groups. In group A, a submucous resection was performed to treat a hypertrophied inferior turbinate, together with a septoplasty. In group B, only a septoplasty was performed. Acoustic rhinometry and rhinomanometry tests were conducted for an objective evaluation of nasal patency. A visual analog scale (VAS) was applied to the patients for the subjective evaluation of nasal obstruction complaints. The application of submucous resectio...

Research paper thumbnail of Accelerated radiotherapy in locally advanced head and neck cancer – early results

"Radiation and Risk" Bulletin of the National Radiation and Epidemiological Registry, 2018

Research paper thumbnail of Involvement of Level I Neck Lymph Nodes in Advanced Squamous Carcinoma of the Larynx

Annals of Otology, Rhinology & Laryngology, 2001

This study was performed to evaluate the incidence of metastasis at level I in patients with squa... more This study was performed to evaluate the incidence of metastasis at level I in patients with squamous laryngeal cancer. One hundred consecutive patients with squamous carcinoma of the larynx were submitted to surgical treatment including radical neck dissection. The tumor stage was T3 or T4, and the neck stage was N1-N2c. Lymph node metastases were pathologically confirmed in 80 patients. Metastases were concentrated within level II in 59% of cases, level III in 17% of cases, level IV in 11% of cases, and level V in 6% of cases. Only 2 patients (2%) had detectable tumors in the lymph nodes of the submandibular triangle (level IB). This study shows that patients with laryngeal cancer rarely present metastases at the submandibular triangle, even in advanced local disease with cervical metastasis staged as N1 to N2c. Therefore, dissection of the submandibular triangle is indicated only in the presence of clinical, radiographic, or cytologic evidence of metastatic disease at level I.

Research paper thumbnail of Exploring the immunological basis of periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome: immunohistochemical staining features of palatine tonsils

Research paper thumbnail of The Journey of a Manuscript Submitted to the Turkish Archives of Otorhinolaryngology: From Receipt to Decision

Turkish Archives of Otorhinolaryngology

Research paper thumbnail of Whole Transcriptome Sequencing Reveals Cancer-Related, Prognostically Significant Transcripts and Tumor-Infiltrating Immunocytes in Mantle Cell Lymphoma

Cells

Mantle cell lymphoma (MCL) is an aggressive B-cell non-Hodgkin lymphoma (NHL) subtype characteriz... more Mantle cell lymphoma (MCL) is an aggressive B-cell non-Hodgkin lymphoma (NHL) subtype characterized by overexpression of CCND1 and SOX11 genes. It is generally associated with clinically poor outcomes despite recent improvements in therapeutic approaches. The genes associated with the development and prognosis of MCL are still largely unknown. Through whole transcriptome sequencing (WTS), we identified mRNAs, lncRNAs, and alternative transcripts differentially expressed in MCL cases compared with reactive tonsil B-cell subsets. CCND1, VCAM1, and VWF mRNAs, as well as MIR100HG and ROR1-AS1 lncRNAs, were among the top 10 most significantly overexpressed, oncogenesis-related transcripts. Survival analyses with each of the top upregulated transcripts showed that MCL cases with high expression of VWF mRNA and low expression of FTX lncRNA were associated with poor overall survival. Similarly, high expression of MSTRG.153013.3, an overexpressed alternative transcript, was associated with s...

Research paper thumbnail of Web of Science Kulak Burun Boğaz Dergilerinde En Çok Atıf Alan 100 Türk Makalesi

Türk otorinolarengoloji arşivi, 2015

Research paper thumbnail of Ekstrakraniyal baş boyun schwannomları: 14 hastalık seri

Kulak burun boğaz ihtisas dergisi, 2017

Research paper thumbnail of Dört ulusal KBB dergisinin 2002-2010 yılları arasındaki niceliksel ve niteliksel analizi

Kulak burun boğaz ihtisas dergisi, 2013

Research paper thumbnail of Tonsillektomi sonrası kanama: 10 yıllık deneyimimiz

Kulak burun boğaz ihtisas dergisi, 2017

Research paper thumbnail of Kulak burun boğaz uzmanlık tezleri yayına dönüşüyor mu

Kulak burun boğaz ihtisas dergisi, 2017

Research paper thumbnail of Tyroglossal duct cyst with endolaryngeal extension

Türk otolarengoloji arşivi, 2014

Research paper thumbnail of Türk Ulusal Kulak Burun Boğaz ve Baş Boyun Cerrahisi Kongre bildirilerinin analizi ve yayımlanma oranları

Kulak burun boğaz ihtisas dergisi, 2014

Research paper thumbnail of Çocuklarda Orta Kulak Patolojisini Belirlemede Geniş Bant Absorbans Ölçümünün Etkinliğinin Araştırılması

Amaç: Çocuklarda iletim tipi işitme kaybının öngörülmesinde ve efüzyonlu otitis media'nın belirle... more Amaç: Çocuklarda iletim tipi işitme kaybının öngörülmesinde ve efüzyonlu otitis media'nın belirlenmesinde geniş bant absorbans ölçümünün etkinliği değerlendirildi. Gereç ve Yöntem: Geniş bant absorbans ve saf ses odyometri testi normal olan 34 çocuğun 56 kulağı kontrol grubu (yaş ortalaması 7.01 yıl) ve iletim tipi işitme kayıplı 40 çocuğun 73 kulağı (yaş ortalaması 6.04 yıl) iletim tipi işitme kayıplı grubu temsil etmek üzere değerlendirildi. Hava-kemik aralığı en az bir frekansta 20 dB HL ya da en az iki frekansta 15 dB HL olan katılımcılar iletim tipi işitme kayıplı gruba dahil edildi. İletim tipi işitme kaybının muhtemel nedeni effüzyonlu otitis media ya da tuba eustachii disfonksiyonu olarak değerlendirildi. Bu iki ölçüm verisi geniş bant absorbans ve iletim tipi işitme kaybının derecesi arasındaki ilişkiyi açıklamak amacıyla incelendi. Geniş bant absorbansın öngörü yeteneğini değerlendirmek Pearson korelasyonu ve regresyon analizi, duyarlılık ve özgüllük oranlarını belirlemek için ROC analizi uygulandı. Bulgular: Absorbans iletim tipi işitme kaybı grubunda tüm frekanslarda kontrol grubundan daha düşük gözlendi. Pearson korelasyon analizinde hava kemik aralığı ile ortam basıncındaki geniş bant absorbans arasında güçlü, anlamlı, negatif korelasyon (R>0,69, p<0,000) bulundu. Regresyon analizinde hava kemik aralığı ile ortam basıncındaki geniş bant absorbans arasında, lineer modelde R-kare=0,779, kübik modelde R-kare=0,810, logaritmik modelde R-kare=0,783 bulundu. Sonuç: ROC eğrisi altında kalan alana göre, ortam basıncındaki geniş bant absorbans 226 Hz komplians ve timpanometrik genişliğe göre iletim tipi işitme kaybı için daha iyi bir öngörü faktörü olarak düşünülebilir. Geniş bant absorbans testi orta kulağın mekanik özelliklerini ölçmek için klinik bir tanı aracı olarak kullanılabilir ve aynı zamanda effüzyonlu otitis media hakkında daha ayrıntılı bilgi verebilir.

Research paper thumbnail of Giant Congenital Sialolipoma of Parotid Gland with Parapharyngeal Extension

Iranian Journal of Otorhinolaryngology, 2019

Introduction: Sialolipoma is an extremely rare salivary gland tumor characterized by a well circu... more Introduction: Sialolipoma is an extremely rare salivary gland tumor characterized by a well circumscribed mass composed of glandular tissue and mature adipose elements. Herein our aim was to present the fifth case of congenital sialolipoma, which was firstly followed up as a parotid gland hemangioma, and underline the fact that sialolipomas should be kept in mind in the differential diagnosis of congenital parotid gland masses. Case Report: A 10-month old male presented with a left-sided huge neck mass which progressed after birth. Radiologic examination revealed a tumor originating from the parotid gland filling the parapharyngeal space. Histopathologic examination of an incisional biopsy was consistent with sialolipoma. A total parotidectomy with preservation of the facial nerve was performed at the age of 1 year. The postoperative recovery was uneventful with normal facial nerve function. There was no recurrence at the 24-month follow-up. Conclusion: Although it is a very rare be...

Research paper thumbnail of Submandibular gland invasion and feasibility of gland-sparing neck dissection in oral cavity carcinoma

The Journal of Laryngology & Otology, 2018

Objective:This study investigated the incidence and routes of submandibular gland involvement in ... more Objective:This study investigated the incidence and routes of submandibular gland involvement in oral cavity carcinoma to determine the feasibility of submandibular gland sparing neck dissection.Methods:The records of 155 patients diagnosed with oral cavity squamous cell carcinoma, with a total of 183 neck specimens, including those involving level I, were reviewed retrospectively.Results:Submandibular gland involvement, via direct invasion from the anatomical proximity of T4a tumours, was evident in two patients. The floor of mouth location, either primarily or as an extension of the primary tumour, was the only risk factor for submandibular gland involvement in oral cavity carcinoma (p = 0.042). Tumour location, clinical and pathological tumour (T) and nodal (N) stages, and radiological suspicion of mandible invasion, were not found to be statistically relevant (p > 0.05).Conclusion:The results suggest the feasibility of preserving the submandibular gland in early stage oral ca...

Research paper thumbnail of The Microdébrider and Its Complications in Endoscopic Surgery for Nasal Polyposis

Yearbook of Otolaryngology-Head and Neck Surgery, 2009

Research paper thumbnail of Carcinome papillaire métastatique de l'os mandibulaire : à propos d'un cas

Revue De Laryngologie D Otologie Et De Rhinologie, 1999

Un cas de carcinome papillaire metastatique de l'os mandibulaire est rapporte. Malgre sa rare... more Un cas de carcinome papillaire metastatique de l'os mandibulaire est rapporte. Malgre sa rarete, la tumeur metastatique de l'os mandibulaire doit etre inclu dans le diagnostic differentiel des tumeurs de la region parotidienne. Situe au cou, l'otorhinolaryngologiste doit evaluer le corps thyroide pour l'identification du carcinome primaire.

Research paper thumbnail of Analysis of histopathological aspects and bone destruction characteristics in acquired middle ear cholesteatoma of pediatric and adult patients

International Journal of Pediatric Otorhinolaryngology, 2016

The aim of this study was to investigate the proliferative and apoptotic activity of middle ear c... more The aim of this study was to investigate the proliferative and apoptotic activity of middle ear cholesteatoma in pediatric and adult patients, in addition to comparing its histopathological aspects and the severity of advanced bone destruction. Medical records of 223 patients treated for chronic otitis media with cholesteatoma at the Otolaryngology Department of Dokuz Eylul University between January 1992 and December 2013 were retrospectively evaluated. Sixty-one patients subjected to tympanomastoidectomy due to middle ear cholesteatoma, with sufficient specimens for histopathological examination, were included in the study. Sections of archived tissues in paraffin blocks were subjected to new histopathological examinations. The proliferative and apoptotic activities of cholesteatoma were determined by immunohistochemical staining for epithelial thickness (ET), and Ki-67 and caspase-3 expression. A novel scoring system, the Bone Erosion Score (BES), was developed to estimate the severity of bone destruction. The Austin-Kartush classification score (AKCS) was also calculated. ET and Ki-67 expression was higher in adult patients than in the pediatric patients (p=0.009 and 0.01, respectively); however, caspase-3 immunopositivity did not show any significant intergroup differences (p=0.106). The differences in AKCS and BES between pediatric and adult patients were not statistically significant. According to the correlation analysis, a significant positive correlation was observed between AKCS and BES (p=0.001), and between ET and Ki-67 expression (when histopathological data were compared) (p=0.001). The proliferative activity of cholesteatoma was higher in adult patients. Therefore, these findings do not support the theory that the aggressive clinical course of cholesteatoma in pediatric patients is correlated with its histopathological characteristics.

Research paper thumbnail of Effect of steroids for nasal polyposis surgery: A placebo-controlled, randomized, double-blind study

The Laryngoscope, 2015

Objectives/Hypothesis: Although medical intervention is the first option for treatment of nasal p... more Objectives/Hypothesis: Although medical intervention is the first option for treatment of nasal polyps, surgery is still a therapeutic option for symptomatic cases that do not respond or partially respond to medical intervention. However, there is a need for high-level evidence for the preoperative use of steroids in nasal polyposis surgery. We aimed to assess the perioperative effect of preoperative use of oral prednisolone for advanced-stage diffuse nasal polyposis. Study Design: Prospective, double-blind, randomized, placebo-controlled study. Methods: A visual analog scale (VAS) was evaluated for smell, nasal discharge, nasal obstruction, facial pressure, headache, butanol smell threshold, and peak nasal inspiratory flow (PNIF) before and after the use of study drug. Perioperative bleeding volume, visibility of operative field, operative time, hospital stay, and complication rate were also evaluated. Results: The improvement in the corticosteroid group (CG) in the VAS scores, butanol thresholds, and PNIF values showed statistically significant differences compared to the placebo group (PG) (P <.05). The perioperative bleeding volume, visibility score, operative time, and hospital stay for CG/PG were 141 mL/384 mL, 2.4/3.4, 61 min/71.6 min, and 1.1 day/1.8 day, respectively (P <.05). The difference between the complication rates for the two groups did not show any statistically significant difference (P 5.214). Conclusions: Preoperative administration of systemic corticosteroids improves the perioperative visibility by reducing blood loss and shortens the operation time. We recommend the use of preoperative corticosteroid for the safety of the patients. The optimum dose and duration have not been established and require further studies.

Research paper thumbnail of A randomized clinical study: outcome of submucous resection of compensatory inferior turbinate during septoplasty

Rhinology, 2011

Septoplasty and/or turbinate surgery are commonly used surgical techniques for the treatment of m... more Septoplasty and/or turbinate surgery are commonly used surgical techniques for the treatment of mechanical nasal obstruction. The aim of this study was to define the effectiveness of submucous resection of a hypertrophied turbinate together with simultaneous septoplasty for the treatment of nasal obstruction. Forty-two patients with septum deviation and compensatory contralateral inferior turbinate hypertrophy were recruited in this study. The inferior turbinate hypertrophy was diagnosed based on examination. The patients were randomly divided into two groups. In group A, a submucous resection was performed to treat a hypertrophied inferior turbinate, together with a septoplasty. In group B, only a septoplasty was performed. Acoustic rhinometry and rhinomanometry tests were conducted for an objective evaluation of nasal patency. A visual analog scale (VAS) was applied to the patients for the subjective evaluation of nasal obstruction complaints. The application of submucous resectio...