Tarachand Devrajani - Academia.edu (original) (raw)

Papers by Tarachand Devrajani

Scientific Reports, Oct 18, 2023

Aging is considered one of the major risk factors for several human disorders. The telomere plays... more Aging is considered one of the major risk factors for several human disorders. The telomere plays a crucial role in regulating cellular responsiveness to stress and growth stimuli as well as maintaining the integrity of the Deoxyribonucleic Acid (DNA), and aging leads to the progressive decline in the telomere length (TL) due to continuous cell division. The aim of this study was to determine the relationship between TL and advancing age and the impact of metabolic syndrome (MetS) on TL. Firstly, we determined the association of advancing age and TL, by measuring telomere length (T/S ratio) in healthy volunteers (n = 90). The TL was compared between normal population and patients with metabolic syndrome (n = 298). The age matched controlled and uncontrolled MetS patients (n = 149) were also compared for their TL T/S ratio. The TL showed negative correlation with advancing age, whereas the significant change was observed at the cutoffs of 40 and 70 years defining 40 with longer TL and 70 as shorter TL. The longest T/S ratio at 2.46 was measured at the age range of 1 year in healthy volunteers, while elderly population showed considerably shorter TL. The patients older than 60 years with poor or uncontrolled MetS had shorter TL, as compared to the controlled MetS. In conclusion our findings suggest that TL was negatively correlated with advancing age. Uncontrolled metabolic syndrome appeared to have worsening effects on TL. Telomere length appears to have potential to be used a parameter to determine age. However, further large scale studies are recommended to make firm guidelines. Aging is genetically characterized as the accretion due to modifications occurring over the period of time 1 , and it is also considered as one of the major risk factors for a number of human disorders 2. Globally, 150,000 individuals die daily and nearly 2/3rd of them die due to age related factors. Aging process however is not constant, but the process gets modified or expedited due to comorbidities such as, cardiovascular and metabolic disorders. Aging is a genetically controlled phenomenon, and telomeres are essential element to maintain the integrity of the genome and regulating cellular responses to stress and growth factors 3. In normal cells, under physiological conditions, the telomere length (TL) decreases with each cell division. Given that TL decreases with each cell division, it progressively shortens with advancing age, therefore can be considered a biological marker of aging. This age-related decline in TL has been associated with a number of age-related diseases, including hypertension, diabetes, cancer, Alzheimer's disease, and many others 4. In addition, there are number of factors that affect TL including oxidative stress, inflammation, and repetitive cell divisions, which correlate TL to chronological aging and age related diseases 5. The chronological age may differ from biological age due to comorbidities and other influencing factors. During normal cellular activities, free radicals and reactive oxygen species (ROS) are regularly generated. Excessive ROS formation causes oxidative damage and eventually leads to cell abnormalities and cell death. 6. Higher ROS levels, mitochondrial malfunction, additional double-strand Deoxyribonucleic Acid (DNA) breaks, and shortening of telomeres are indicators of cellular senescence 7. Furthermore, it was

The professional medical journal, Feb 10, 2021

To evaluate the effect of atypical antipsychotics on serum glucose levels and HbA1C in patients o... more To evaluate the effect of atypical antipsychotics on serum glucose levels and HbA1C in patients of schizophrenia and bipolar disorder. Study Design: Quasiexperimental study.

Saudi Journal of Biological Sciences

To determine the frequency of Helicobacter pylori infection in patients with lichen planus presen... more To determine the frequency of Helicobacter pylori infection in patients with lichen planus presented to tertiary care hospital Hyderabad. Patiehts and Methods This cross sectional descriptive study of six months was carried at Liaquat University Hospital Hyderabad Sindh, Pakistan from February 2008 to July 2008. All patients above 12 years of age, of either gender, were known / already diagnosed and newly diagnosed cases of lichen planus (LP) were came through outdoor patient department (OPD), indoor patient and causality outdoor department (COD) were evaluated and enrolled in the study. All such patients were screened for Helicobacter pylori infection by Helicobacter pylori stool antigen (HpSA). For getting result the data was saved and analyzed in SPSS version 10.00. RESULT: One hundred and five patients (105) were identified as lichen planus and screened for Helicobacter pylori infection. The Helicobacter pylori stool antigen (HpSA) was positive in 81 (77%) subjects with mean age 42.89 ± ±13.32 (SD). Majority of the patient were presented in the department of dermatology; were females and belonged to the rural areas of Sindh province. Other features and presentation identified in such patients were epigastric pain (69%), retrosternal pain (17%) and haemetemesis in 07 patients.CONCLUSION: The patients with lichen planus are more prone to acquire the Helicobacter pylori infection.

The professional medical journal, Oct 15, 2013

from 1st October 2010 to 31st March 2011. Subjects and methods: All the patients diagnosed as cas... more from 1st October 2010 to 31st March 2011. Subjects and methods: All the patients diagnosed as case of uterine rupture was taken as study subject. Data was collected in a pre-designed porforma. Variable analyzed were frequency, demographic characters, maternal morbidity and mortality. Results: During the study, 34 patients out of 1400 deliveries presented with uterine rupture resulting in a frequency of 2.42%or 1: 41deliveries. 64.7%(22) patients were between 26 to 35 years age and 67.64%(23) were multipara.26.47%(9) presented with extension of tears, 17.6%(6) with shock,20.5%(7) with septicemia and 20.5%(7) with wound infection. Conclusions: Uterine rupture is yet a common obstetrical emergency in our area. The significant morbidity and mortality deserves our special attention by a collaborative approach. Regular ante natal checkups, careful selection of patients for vaginal delivery, vigilantly monitoring during labor with smooth switch over to operative delivery can reduce this drastic obstetrical complication.

The main objective was to determine the complications of laparoscopic cholecystectomy (LC) and it... more The main objective was to determine the complications of laparoscopic cholecystectomy (LC) and its causes at Liaquat University of Medical and Heath Sciences, Jamshoro. It was a prospective study carried out from February 2008 to January 2011. Data of all patients undergoing elective laparoscopic cholecystectomy during the study period and fulfilling the selection criteria was collected and entered in standardized proforma and analyzed on SPSS 10. A total of 100 patients underwent laparoscopic cholecystectomy with an overwhelming majority of females (87 out of 100). The age range from 22 to 60 years, mean age being 38 years. The overall complication rate was 9%. The complications included bleeding (4/100, 4%) from cystic artery and gall bladder bed, port site infection (4/100, 4%) One patient developed collection in pouch of Morrison and one patient developed stitch granuloma. There was no bile duct injury and colonic injury. The common causes of these complications were accident injury to cystic artery and gross spillage of infected bile. Bleeding and Port site infections were the commonest complications. The commonest cause of bleeding was cystic artery injury whereas the commonest cause of port site infection was gross spillage of infected bile.

Pakistan Journal of Medical and Health Sciences, Sep 30, 2021

The professional medical journal, Dec 8, 2018

Journal of the Liaquat University of Medical and Health Sciences, 2009

... Diabetes Mellitus. In: Frier BM, Todd WT, Lock-wood DN, Sundar S, editors. Davidson&a... more ... Diabetes Mellitus. In: Frier BM, Todd WT, Lock-wood DN, Sundar S, editors. Davidson's princi-ples and practice of medicine. ... Scand J Infect Dis 1991; 80:S15–20. 4. Gilden DH, Cohrs RJ,Mahalingam R. Clinical and molecular pathogenesis of varicella virus infection. ...

The professional medical journal, Mar 25, 2013

Article Citation ABSTRACT…..Background & Objective: Acute renal failure is one of serious complic... more Article Citation ABSTRACT…..Background & Objective: Acute renal failure is one of serious complication in pregnancy, in first trimester is usually related to unregulated and septic miscarriage while in third trimester it is due to obstetric complications. This prospective case serious descriptive study was conducted to determine the frequency, etiology and outcome of patients suffering from acute renal failure.

PubMed, Oct 1, 2009

Objective: To determine the precipitating factors of hepatic encephalopathy (HE) in patients with... more Objective: To determine the precipitating factors of hepatic encephalopathy (HE) in patients with liver cirrhosis at Liaquat University Hospital Hyderabad/Jamshoro. Methods: This hospital based descriptive study was conducted from April 2007 to September 2007. All the patients who were more than 12 years of age and were diagnosed as hepatic encephalopathy were studied. During this period, 87 patients of hepatic encephalopathy were admitted. All patients were carefully examined, relevant investigations were performed and data was collected through pre-designed proforma. Results: Male patients were 65 (75%), above 40 years of age 58 (67%), belonging to interior/periphery of Sindh 54 (62%), in grade IV of hepatic encephalopathy 70 (80%) and Anti-HCV positive were 52 (60%). The most common precipitating factors detected were infection 58 (67%), constipation 43 (49%) and gastrointestinal bleeding 39 (45%). Out of 87 patients, 68 had increased total leucocytes count, 09 patients had hypokalaemia, 24 patients, hyponatraemia, 64 hypoalbuminaemia and 54 patients had a disturbed coagulation profile. Fifty nine patients recovered and were discharged while 20 patients expired. Majority of expired patients had Child-Pugh score 10-15 and were in grade IV of hepatic encephalopathy. Conclusion: The study concluded that there were different factors which play a key role in hepatic encephalopathy. In these factors, infection was the most common.

Clinical Therapeutics, 2020

Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on ... more Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre-including this research content-immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

Age and Ageing, 1997

Aim: to determine the safety of simple laparoscopic cholecystectomy in ageing patients. Method: t... more Aim: to determine the safety of simple laparoscopic cholecystectomy in ageing patients. Method: the outcome of patients between 60 and 70 years of age and patients over 70 who underwent laparoscopic cholecystectomy for symptomatic non-malignant gallbladder disease was comparatively analysed. All patients over 60 years of age with symptomatic gallbladder disease and without cholecholithiasis, septic shock, diffuse peritonitis, gallbladder malignancy, portal hypertension or contraindication for general anaesthesia were selected for simple laparoscopic cholecystectomy (n = 158). This group represents over 80% of all elderly patients undergoing biliary surgery at our department over this period. Group A (n = 97) included patients from 60 to 69 years of age. Group B (n-61) comprised patients over 70 years. Results: there was no difference in sex distribution between groups. Operative time and conversion rates were similar in both groups. The overall morbidity rate was 14.5%, with no statistically significant increase in group B (11% for group Avs20% for group B). No perioperative mortality occurred. Recurrent biliary surgery was required in two patients from group B (3%). Postoperative endoscopic retrograde cholangiography and sphincterotomy was done in four patients from group A (4%). The mean postoperative stay was longer for older patients (group A, 3.1 (2.5) days; group B, 4.2 (4.3) days; i>=0.05). Conclusion: simple laparoscopic cholecystectomy is safe in the aged, even for patients over 70. This procedure is associated with a short hospital stay and low rates of re-admission and recurrent biliary surgery.

Journal of Pharmaceutical Research, 2021

Background: Alopecia induced by androgens in genetically predisposed individuals is termed as And... more Background: Alopecia induced by androgens in genetically predisposed individuals is termed as Androgenetic alopecia (AGA). There is proof appearance the relationship between Androgenetic alopecia and metabolic condition. Objective: To determine frequency of metabolic syndrome in Androgenetic alopecia as a biomarker of disease in adult male patients. Materials and methods: It was a Cross Sectional Study conducted at the Department of Dermatology, Liaquat University of Medical and Health Sciences Hospital, Jamshoro/Hyderabad. Total 178 diagnosed male patients of Androgenetic alopecia were included. The grading of male Original Research Article Memon et al.; JPRI, 33(30A): 146-153, 2021; Article no.JPRI.69360 147 pattern Androgenetic alopecia was done according to modified Norwood-Hamilton classification. Norwood-Hamilton Stage I-III were regarded to be mild to moderate and Stage IV and higher were regarded as severe. Vein was engorged by a tourniquet applied above the cubital fossa. B...

OBJECTIVE To determine the precipitating factors of hepatic encephalopathy (HE) in patients with ... more OBJECTIVE To determine the precipitating factors of hepatic encephalopathy (HE) in patients with liver cirrhosis at Liaquat University Hospital Hyderabad/Jamshoro. METHODS This hospital based descriptive study was conducted from April 2007 to September 2007. All the patients who were more than 12 years of age and were diagnosed as hepatic encephalopathy were studied. During this period, 87 patients of hepatic encephalopathy were admitted. All patients were carefully examined, relevant investigations were performed and data was collected through pre-designed proforma. RESULTS Male patients were 65 (75%), above 40 years of age 58 (67%), belonging to interior/periphery of Sindh 54 (62%), in grade IV of hepatic encephalopathy 70 (80%) and Anti-HCV positive were 52 (60%). The most common precipitating factors detected were infection 58 (67%), constipation 43 (49%) and gastrointestinal bleeding 39 (45%). Out of 87 patients, 68 had increased total leucocytes count, 09 patients had hypokala...

Background: Rheumatic Heart disease (RHD) is the leading cause of acquired heart disease and more... more Background: Rheumatic Heart disease (RHD) is the leading cause of acquired heart disease and more prevalent in developing countries. The objective of the study was to determine the clinical and echocardiographic profiles of patients with rheumatic heart disease (RHD). Materials and Methods: All patients above the age of 12 years of either gender diagnosed with Rheumatic heart disease from January 2018 to December 2019 at tertiary care hospital, Hyderabad were enrolled in the study. Detailed patient data was obtained from the hospital records. Information regarding gender, age, Electrocardiogram findings, clinical and echocardiographic manifestations was obtained. Original Research Article Dall et al.; JPRI, 33(27B): 1-7, 2021; Article no.JPRI.67809 2 Results: Throughout the two-year study period, a total of fifty patients with RHD were studied. The mean age of the population was 33.71 years. Females (64%) outnumbered males and 60% were rural population. The clinical features observe...

European Journal of Medical Research, 2017

Forensic Odontology or Forensic Dentistry is an important and well established Dental Specialty i... more Forensic Odontology or Forensic Dentistry is an important and well established Dental Specialty in the Advanced World and its formal teaching has existed for more than a century. Time has come for this to be introduced in Pakistan for all its Academic, Research and Practical reasons pertaining to Justice System & Crime. Its significance in terms of reporting, sharing scientific evidence, handling Crime is influenced by the people who are properly Qualified and trained as Forensic Odontologists and unfortunately we have none. As our society is rapidly changing, becoming more commercial & losing its cultural, ethical & human touch, therefore we feel it is high time for this neglected Dental Specialty to be given birth-introduced as we aim for National Paradigm Shift and share this Presentation.

The Professional Medical Journal, 2013

Background & Objective: Acute renal failure is one of serious complication in pregnancy, in first... more Background & Objective: Acute renal failure is one of serious complication in pregnancy, in first trimester is usuallyrelated to unregulated and septic miscarriage while in third trimester it is due to obstetric complications. This prospective case seriousdescriptive study was conducted to determine the frequency, etiology and outcome of patients suffering from acute renal failure.Settings: Department of Gynecology & Obstetric at Liaquat University Hospital Hyderabad. Duration: One year (from 1st June 2011 to31st May 2012) Patients and Methods: Patients admitted in labor room during antepartum, intrapartum or post partum period werescrutinized by history, clinical examination, and investigations. Those with urine output less than 50cc in 24hours were defined as case ofARF. Predesigned proforma filled to analyze etiology and outcome of patients with acute renal failure. Results: Out of 3220 patientsadmitted, 35 patients presented with acute renal failure giving incidence of 1.080%. A...

The Professional Medical Journal, 2013

objective: To evaluate frequency, maternal morbidity and mortality in patients with uterine ruptu... more objective: To evaluate frequency, maternal morbidity and mortality in patients with uterine rupture at Gynae Unit -II of civilHospital Hyderabad. Study design: Prospective descriptive study. Study setting: Department of Obstetrics and Gynecology, unit-IILiaquat University Hospital Hyderabad Sindh Pakistan; from 1st October 2010 to 31st March 2011. Subjects and methods: All thepatients diagnosed as case of uterine rupture was taken as study subject. Data was collected in a pre-designed porforma. Variableanalyzed were frequency, demographic characters, maternal morbidity and mortality. Results: During the study, 34 patients out of 1400deliveries presented with uterine rupture resulting in a frequency of 2.42%or 1: 41deliveries. 64.7%(22) patients were between 26 to 35years age and 67.64%(23) were multipara.26.47%(9) presented with extension of tears, 17.6%(6) with shock,20.5%(7) with septicemiaand 20.5%(7) with wound infection. Conclusions: Uterine rupture is yet a common obstetrical ...

Scientific Reports, Oct 18, 2023

Aging is considered one of the major risk factors for several human disorders. The telomere plays... more Aging is considered one of the major risk factors for several human disorders. The telomere plays a crucial role in regulating cellular responsiveness to stress and growth stimuli as well as maintaining the integrity of the Deoxyribonucleic Acid (DNA), and aging leads to the progressive decline in the telomere length (TL) due to continuous cell division. The aim of this study was to determine the relationship between TL and advancing age and the impact of metabolic syndrome (MetS) on TL. Firstly, we determined the association of advancing age and TL, by measuring telomere length (T/S ratio) in healthy volunteers (n = 90). The TL was compared between normal population and patients with metabolic syndrome (n = 298). The age matched controlled and uncontrolled MetS patients (n = 149) were also compared for their TL T/S ratio. The TL showed negative correlation with advancing age, whereas the significant change was observed at the cutoffs of 40 and 70 years defining 40 with longer TL and 70 as shorter TL. The longest T/S ratio at 2.46 was measured at the age range of 1 year in healthy volunteers, while elderly population showed considerably shorter TL. The patients older than 60 years with poor or uncontrolled MetS had shorter TL, as compared to the controlled MetS. In conclusion our findings suggest that TL was negatively correlated with advancing age. Uncontrolled metabolic syndrome appeared to have worsening effects on TL. Telomere length appears to have potential to be used a parameter to determine age. However, further large scale studies are recommended to make firm guidelines. Aging is genetically characterized as the accretion due to modifications occurring over the period of time 1 , and it is also considered as one of the major risk factors for a number of human disorders 2. Globally, 150,000 individuals die daily and nearly 2/3rd of them die due to age related factors. Aging process however is not constant, but the process gets modified or expedited due to comorbidities such as, cardiovascular and metabolic disorders. Aging is a genetically controlled phenomenon, and telomeres are essential element to maintain the integrity of the genome and regulating cellular responses to stress and growth factors 3. In normal cells, under physiological conditions, the telomere length (TL) decreases with each cell division. Given that TL decreases with each cell division, it progressively shortens with advancing age, therefore can be considered a biological marker of aging. This age-related decline in TL has been associated with a number of age-related diseases, including hypertension, diabetes, cancer, Alzheimer's disease, and many others 4. In addition, there are number of factors that affect TL including oxidative stress, inflammation, and repetitive cell divisions, which correlate TL to chronological aging and age related diseases 5. The chronological age may differ from biological age due to comorbidities and other influencing factors. During normal cellular activities, free radicals and reactive oxygen species (ROS) are regularly generated. Excessive ROS formation causes oxidative damage and eventually leads to cell abnormalities and cell death. 6. Higher ROS levels, mitochondrial malfunction, additional double-strand Deoxyribonucleic Acid (DNA) breaks, and shortening of telomeres are indicators of cellular senescence 7. Furthermore, it was

The professional medical journal, Feb 10, 2021

To evaluate the effect of atypical antipsychotics on serum glucose levels and HbA1C in patients o... more To evaluate the effect of atypical antipsychotics on serum glucose levels and HbA1C in patients of schizophrenia and bipolar disorder. Study Design: Quasiexperimental study.

Saudi Journal of Biological Sciences

To determine the frequency of Helicobacter pylori infection in patients with lichen planus presen... more To determine the frequency of Helicobacter pylori infection in patients with lichen planus presented to tertiary care hospital Hyderabad. Patiehts and Methods This cross sectional descriptive study of six months was carried at Liaquat University Hospital Hyderabad Sindh, Pakistan from February 2008 to July 2008. All patients above 12 years of age, of either gender, were known / already diagnosed and newly diagnosed cases of lichen planus (LP) were came through outdoor patient department (OPD), indoor patient and causality outdoor department (COD) were evaluated and enrolled in the study. All such patients were screened for Helicobacter pylori infection by Helicobacter pylori stool antigen (HpSA). For getting result the data was saved and analyzed in SPSS version 10.00. RESULT: One hundred and five patients (105) were identified as lichen planus and screened for Helicobacter pylori infection. The Helicobacter pylori stool antigen (HpSA) was positive in 81 (77%) subjects with mean age 42.89 ± ±13.32 (SD). Majority of the patient were presented in the department of dermatology; were females and belonged to the rural areas of Sindh province. Other features and presentation identified in such patients were epigastric pain (69%), retrosternal pain (17%) and haemetemesis in 07 patients.CONCLUSION: The patients with lichen planus are more prone to acquire the Helicobacter pylori infection.

The professional medical journal, Oct 15, 2013

from 1st October 2010 to 31st March 2011. Subjects and methods: All the patients diagnosed as cas... more from 1st October 2010 to 31st March 2011. Subjects and methods: All the patients diagnosed as case of uterine rupture was taken as study subject. Data was collected in a pre-designed porforma. Variable analyzed were frequency, demographic characters, maternal morbidity and mortality. Results: During the study, 34 patients out of 1400 deliveries presented with uterine rupture resulting in a frequency of 2.42%or 1: 41deliveries. 64.7%(22) patients were between 26 to 35 years age and 67.64%(23) were multipara.26.47%(9) presented with extension of tears, 17.6%(6) with shock,20.5%(7) with septicemia and 20.5%(7) with wound infection. Conclusions: Uterine rupture is yet a common obstetrical emergency in our area. The significant morbidity and mortality deserves our special attention by a collaborative approach. Regular ante natal checkups, careful selection of patients for vaginal delivery, vigilantly monitoring during labor with smooth switch over to operative delivery can reduce this drastic obstetrical complication.

The main objective was to determine the complications of laparoscopic cholecystectomy (LC) and it... more The main objective was to determine the complications of laparoscopic cholecystectomy (LC) and its causes at Liaquat University of Medical and Heath Sciences, Jamshoro. It was a prospective study carried out from February 2008 to January 2011. Data of all patients undergoing elective laparoscopic cholecystectomy during the study period and fulfilling the selection criteria was collected and entered in standardized proforma and analyzed on SPSS 10. A total of 100 patients underwent laparoscopic cholecystectomy with an overwhelming majority of females (87 out of 100). The age range from 22 to 60 years, mean age being 38 years. The overall complication rate was 9%. The complications included bleeding (4/100, 4%) from cystic artery and gall bladder bed, port site infection (4/100, 4%) One patient developed collection in pouch of Morrison and one patient developed stitch granuloma. There was no bile duct injury and colonic injury. The common causes of these complications were accident injury to cystic artery and gross spillage of infected bile. Bleeding and Port site infections were the commonest complications. The commonest cause of bleeding was cystic artery injury whereas the commonest cause of port site infection was gross spillage of infected bile.

Pakistan Journal of Medical and Health Sciences, Sep 30, 2021

The professional medical journal, Dec 8, 2018

Journal of the Liaquat University of Medical and Health Sciences, 2009

... Diabetes Mellitus. In: Frier BM, Todd WT, Lock-wood DN, Sundar S, editors. Davidson&a... more ... Diabetes Mellitus. In: Frier BM, Todd WT, Lock-wood DN, Sundar S, editors. Davidson's princi-ples and practice of medicine. ... Scand J Infect Dis 1991; 80:S15–20. 4. Gilden DH, Cohrs RJ,Mahalingam R. Clinical and molecular pathogenesis of varicella virus infection. ...

The professional medical journal, Mar 25, 2013

Article Citation ABSTRACT…..Background & Objective: Acute renal failure is one of serious complic... more Article Citation ABSTRACT…..Background & Objective: Acute renal failure is one of serious complication in pregnancy, in first trimester is usually related to unregulated and septic miscarriage while in third trimester it is due to obstetric complications. This prospective case serious descriptive study was conducted to determine the frequency, etiology and outcome of patients suffering from acute renal failure.

PubMed, Oct 1, 2009

Objective: To determine the precipitating factors of hepatic encephalopathy (HE) in patients with... more Objective: To determine the precipitating factors of hepatic encephalopathy (HE) in patients with liver cirrhosis at Liaquat University Hospital Hyderabad/Jamshoro. Methods: This hospital based descriptive study was conducted from April 2007 to September 2007. All the patients who were more than 12 years of age and were diagnosed as hepatic encephalopathy were studied. During this period, 87 patients of hepatic encephalopathy were admitted. All patients were carefully examined, relevant investigations were performed and data was collected through pre-designed proforma. Results: Male patients were 65 (75%), above 40 years of age 58 (67%), belonging to interior/periphery of Sindh 54 (62%), in grade IV of hepatic encephalopathy 70 (80%) and Anti-HCV positive were 52 (60%). The most common precipitating factors detected were infection 58 (67%), constipation 43 (49%) and gastrointestinal bleeding 39 (45%). Out of 87 patients, 68 had increased total leucocytes count, 09 patients had hypokalaemia, 24 patients, hyponatraemia, 64 hypoalbuminaemia and 54 patients had a disturbed coagulation profile. Fifty nine patients recovered and were discharged while 20 patients expired. Majority of expired patients had Child-Pugh score 10-15 and were in grade IV of hepatic encephalopathy. Conclusion: The study concluded that there were different factors which play a key role in hepatic encephalopathy. In these factors, infection was the most common.

Clinical Therapeutics, 2020

Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on ... more Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre-including this research content-immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

Age and Ageing, 1997

Aim: to determine the safety of simple laparoscopic cholecystectomy in ageing patients. Method: t... more Aim: to determine the safety of simple laparoscopic cholecystectomy in ageing patients. Method: the outcome of patients between 60 and 70 years of age and patients over 70 who underwent laparoscopic cholecystectomy for symptomatic non-malignant gallbladder disease was comparatively analysed. All patients over 60 years of age with symptomatic gallbladder disease and without cholecholithiasis, septic shock, diffuse peritonitis, gallbladder malignancy, portal hypertension or contraindication for general anaesthesia were selected for simple laparoscopic cholecystectomy (n = 158). This group represents over 80% of all elderly patients undergoing biliary surgery at our department over this period. Group A (n = 97) included patients from 60 to 69 years of age. Group B (n-61) comprised patients over 70 years. Results: there was no difference in sex distribution between groups. Operative time and conversion rates were similar in both groups. The overall morbidity rate was 14.5%, with no statistically significant increase in group B (11% for group Avs20% for group B). No perioperative mortality occurred. Recurrent biliary surgery was required in two patients from group B (3%). Postoperative endoscopic retrograde cholangiography and sphincterotomy was done in four patients from group A (4%). The mean postoperative stay was longer for older patients (group A, 3.1 (2.5) days; group B, 4.2 (4.3) days; i>=0.05). Conclusion: simple laparoscopic cholecystectomy is safe in the aged, even for patients over 70. This procedure is associated with a short hospital stay and low rates of re-admission and recurrent biliary surgery.

Journal of Pharmaceutical Research, 2021

Background: Alopecia induced by androgens in genetically predisposed individuals is termed as And... more Background: Alopecia induced by androgens in genetically predisposed individuals is termed as Androgenetic alopecia (AGA). There is proof appearance the relationship between Androgenetic alopecia and metabolic condition. Objective: To determine frequency of metabolic syndrome in Androgenetic alopecia as a biomarker of disease in adult male patients. Materials and methods: It was a Cross Sectional Study conducted at the Department of Dermatology, Liaquat University of Medical and Health Sciences Hospital, Jamshoro/Hyderabad. Total 178 diagnosed male patients of Androgenetic alopecia were included. The grading of male Original Research Article Memon et al.; JPRI, 33(30A): 146-153, 2021; Article no.JPRI.69360 147 pattern Androgenetic alopecia was done according to modified Norwood-Hamilton classification. Norwood-Hamilton Stage I-III were regarded to be mild to moderate and Stage IV and higher were regarded as severe. Vein was engorged by a tourniquet applied above the cubital fossa. B...

OBJECTIVE To determine the precipitating factors of hepatic encephalopathy (HE) in patients with ... more OBJECTIVE To determine the precipitating factors of hepatic encephalopathy (HE) in patients with liver cirrhosis at Liaquat University Hospital Hyderabad/Jamshoro. METHODS This hospital based descriptive study was conducted from April 2007 to September 2007. All the patients who were more than 12 years of age and were diagnosed as hepatic encephalopathy were studied. During this period, 87 patients of hepatic encephalopathy were admitted. All patients were carefully examined, relevant investigations were performed and data was collected through pre-designed proforma. RESULTS Male patients were 65 (75%), above 40 years of age 58 (67%), belonging to interior/periphery of Sindh 54 (62%), in grade IV of hepatic encephalopathy 70 (80%) and Anti-HCV positive were 52 (60%). The most common precipitating factors detected were infection 58 (67%), constipation 43 (49%) and gastrointestinal bleeding 39 (45%). Out of 87 patients, 68 had increased total leucocytes count, 09 patients had hypokala...

Background: Rheumatic Heart disease (RHD) is the leading cause of acquired heart disease and more... more Background: Rheumatic Heart disease (RHD) is the leading cause of acquired heart disease and more prevalent in developing countries. The objective of the study was to determine the clinical and echocardiographic profiles of patients with rheumatic heart disease (RHD). Materials and Methods: All patients above the age of 12 years of either gender diagnosed with Rheumatic heart disease from January 2018 to December 2019 at tertiary care hospital, Hyderabad were enrolled in the study. Detailed patient data was obtained from the hospital records. Information regarding gender, age, Electrocardiogram findings, clinical and echocardiographic manifestations was obtained. Original Research Article Dall et al.; JPRI, 33(27B): 1-7, 2021; Article no.JPRI.67809 2 Results: Throughout the two-year study period, a total of fifty patients with RHD were studied. The mean age of the population was 33.71 years. Females (64%) outnumbered males and 60% were rural population. The clinical features observe...

European Journal of Medical Research, 2017

Forensic Odontology or Forensic Dentistry is an important and well established Dental Specialty i... more Forensic Odontology or Forensic Dentistry is an important and well established Dental Specialty in the Advanced World and its formal teaching has existed for more than a century. Time has come for this to be introduced in Pakistan for all its Academic, Research and Practical reasons pertaining to Justice System & Crime. Its significance in terms of reporting, sharing scientific evidence, handling Crime is influenced by the people who are properly Qualified and trained as Forensic Odontologists and unfortunately we have none. As our society is rapidly changing, becoming more commercial & losing its cultural, ethical & human touch, therefore we feel it is high time for this neglected Dental Specialty to be given birth-introduced as we aim for National Paradigm Shift and share this Presentation.

The Professional Medical Journal, 2013

Background & Objective: Acute renal failure is one of serious complication in pregnancy, in first... more Background & Objective: Acute renal failure is one of serious complication in pregnancy, in first trimester is usuallyrelated to unregulated and septic miscarriage while in third trimester it is due to obstetric complications. This prospective case seriousdescriptive study was conducted to determine the frequency, etiology and outcome of patients suffering from acute renal failure.Settings: Department of Gynecology & Obstetric at Liaquat University Hospital Hyderabad. Duration: One year (from 1st June 2011 to31st May 2012) Patients and Methods: Patients admitted in labor room during antepartum, intrapartum or post partum period werescrutinized by history, clinical examination, and investigations. Those with urine output less than 50cc in 24hours were defined as case ofARF. Predesigned proforma filled to analyze etiology and outcome of patients with acute renal failure. Results: Out of 3220 patientsadmitted, 35 patients presented with acute renal failure giving incidence of 1.080%. A...

The Professional Medical Journal, 2013

objective: To evaluate frequency, maternal morbidity and mortality in patients with uterine ruptu... more objective: To evaluate frequency, maternal morbidity and mortality in patients with uterine rupture at Gynae Unit -II of civilHospital Hyderabad. Study design: Prospective descriptive study. Study setting: Department of Obstetrics and Gynecology, unit-IILiaquat University Hospital Hyderabad Sindh Pakistan; from 1st October 2010 to 31st March 2011. Subjects and methods: All thepatients diagnosed as case of uterine rupture was taken as study subject. Data was collected in a pre-designed porforma. Variableanalyzed were frequency, demographic characters, maternal morbidity and mortality. Results: During the study, 34 patients out of 1400deliveries presented with uterine rupture resulting in a frequency of 2.42%or 1: 41deliveries. 64.7%(22) patients were between 26 to 35years age and 67.64%(23) were multipara.26.47%(9) presented with extension of tears, 17.6%(6) with shock,20.5%(7) with septicemiaand 20.5%(7) with wound infection. Conclusions: Uterine rupture is yet a common obstetrical ...