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Research paper thumbnail of Non-surgical treatment of peri-implant pathology

International Journal of Dental Hygiene, 2006

Abstract: Introduction: Peri-implant pathologies consist of an inflammatory process affecting the... more Abstract: Introduction: Peri-implant pathologies consist of an inflammatory process affecting the soft and hard tissues surrounding the implants. Chlorhexidine is considered the gold standard antiseptic, with a large variety of choice in administration. In this study, a protocol for the irrigation of peri-implant pockets with a chlorhexidine gel, using a plastic needle for the delivery of the product into the peri-implant pockets is described. Study participants and methods: Nine patients with at least one implant presenting peri-implant pathology (inflamed soft tissue associated with bone loss around the implant) were enrolled in this prospective clinical study, and followed-up for 1 year, where clinical parameters such as modified plaque index, modified bleeding index, probing pocket depths, attachment levels were assessed at baseline, 1 month, and 1 year after implementation of the treatment protocol. Results: Treatment success was achieved in eight of the nine patients (and in 11 of the 13 implants) according to the success criteria adopted by the authors of this study. Discussion: Infection control lies at the heart of peri-implant treatment. The control of three factors such as optimal diagnosis, removal of the aetiological factor of the disease (proper removal of debris and decontamination of the peri-implant sulcus/pocket) and a good patient's oral hygiene self-care represents the key to success, resulting in good treatment outcomes when managing peri-implant pathologies. The protocol used (irrigation of peri-implant pockets with chlorhexidine gel delivered by a plastic needle) is considered to be of utility.

Research paper thumbnail of Chronic fatigue, unrefreshing sleep and nocturnal polysomnography

Background and purpose: To investigate the complaint of unrefreshing sleep with study of sleep el... more Background and purpose: To investigate the complaint of unrefreshing sleep with study of sleep electroencephalogram (EEG) in patients with chronic fatigue. Patients and methods: Fourteen successively seen patients (mean age: 41.1 9.8) who complained of chronic fatigue but denied sleepiness and agreed to participate were compared to 14 controls (33.6G10.2 years) who were monitored during sleep recorded in parallel. After performing conventional sleep scoring we applied Fast Fourier Transformation (FFT) for the delta 1, delta 2, theta, alpha, sigma 1, sigma 2, beta EEG frequency bands. The presence of non-rapid eye movement (NREM) sleep instability was studied with calculation of cyclic alternating pattern (CAP) rate. Two-way analysis of variance (ANOVA) was performed to analyze FFT results and Mann-Whitney U-test to compare CAP rate in both groups of subjects. Results: Slow wave sleep (SWS) percentage and sleep efficiency were lower, but there was a significant increase in delta 1 (slow delta) relative power in the chronic fatigue group when compared to normals (P!0.01). All the other frequency bands were proportionally and significantly decreased compared to controls. CAP rate was also significantly greater in subjects with chronic fatigue than in normals (PZ 0.04). An increase in respiratory effort and nasal flow limitation were noted with chronic fatigue. Conclusions: The complaints of chronic fatigue and unrefreshing sleep were associated with an abnormal CAP rate, with increase in slow delta power spectrum, affirming the presence of an abnormal sleep progression and NREM sleep instability. These specific patterns were related to subtle, undiagnosed sleep-disordered breathing. q

Research paper thumbnail of Chronic fatigue, unrefreshing sleep and nocturnal polysomnography

Sleep Medicine, 2006

Background and purpose: To investigate the complaint of unrefreshing sleep with study of sleep el... more Background and purpose: To investigate the complaint of unrefreshing sleep with study of sleep electroencephalogram (EEG) in patients with chronic fatigue. Patients and methods: Fourteen successively seen patients (mean age: 41.1 9.8) who complained of chronic fatigue but denied sleepiness and agreed to participate were compared to 14 controls (33.6G10.2 years) who were monitored during sleep recorded in parallel. After performing conventional sleep scoring we applied Fast Fourier Transformation (FFT) for the delta 1, delta 2, theta, alpha, sigma 1, sigma 2, beta EEG frequency bands. The presence of non-rapid eye movement (NREM) sleep instability was studied with calculation of cyclic alternating pattern (CAP) rate. Two-way analysis of variance (ANOVA) was performed to analyze FFT results and Mann-Whitney U-test to compare CAP rate in both groups of subjects. Results: Slow wave sleep (SWS) percentage and sleep efficiency were lower, but there was a significant increase in delta 1 (slow delta) relative power in the chronic fatigue group when compared to normals (P!0.01). All the other frequency bands were proportionally and significantly decreased compared to controls. CAP rate was also significantly greater in subjects with chronic fatigue than in normals (PZ 0.04). An increase in respiratory effort and nasal flow limitation were noted with chronic fatigue. Conclusions: The complaints of chronic fatigue and unrefreshing sleep were associated with an abnormal CAP rate, with increase in slow delta power spectrum, affirming the presence of an abnormal sleep progression and NREM sleep instability. These specific patterns were related to subtle, undiagnosed sleep-disordered breathing. q

Research paper thumbnail of APC/CTNNB1 (beta-catenin) pathway alterations in human prostate cancers

Genetic alterations serve as beacons for the involvement of specific pathways in tumorigenesis. I... more Genetic alterations serve as beacons for the involvement of specific pathways in tumorigenesis. It was previously shown that 5% of prostate tumors harbor CTNNB1 mutations, suggesting that this tumor type may involve a deregulated APC/CTNNB1 pathway. To explore this possibility further, we searched for mutations in genes implicated in this pathway in 22 samples that included cell lines, xenografts, and primary tumors. We identified seven alterations: two in CTNNB1, three in APC, and two in hTRCP1 (also known as BTRC) which controls the degradation of CTNNB1. Alterations in the CTNNB1 regulatory domain, APC, and hTRCP1 were mutually exclusive, consistent with their equivalent effects on CTNNB1 stability. These results suggest that CTNNB1 signaling plays a critical role in the development of a significant fraction of prostate cancers. Moreover, they provide the first evidence that hTRCP1 plays a role in human neoplasia.

Research paper thumbnail of Academica-2392

A falta de tratamento de esgoto é um dos maiores problemas ambientais da população brasileira, pr... more A falta de tratamento de esgoto é um dos maiores problemas ambientais da população brasileira, principalmente nas comunidades rurais de baixa renda. Nesse sentido, a busca por tecnologias alternativas e de baixo custo para o tratamento desses efluentes torna-se imprescindível. Uma tecnologia alternativa aos métodos convencionais e que tem se mostrado bastante eficaz é o tratamento de esgoto por zona de raízes. Esse sistema baseia-se em princípios físicos (filtração) e biológicos, em que parte do filtro é constituída de plantas, sendo colocado à jusante de um tratamento primário (fossa séptica). Essas plantas devem ter raízes com aerênquimas bem desenvolvidos, como o copo-de-leite, que foi utilizada na ETE (Estação de Tratamento de Efluentes) proposta nesse trabalho. O mesmo teve como objetivo implantar uma estação por zona de raízes numa comunidade rural do município de Irati/PR. A ETE aqui proposta tem volume de 6 m 3 , foi impermeabilizada com lona plástica e é composta por um filtro físico contendo brita e areia de granulometria pré-definida. Verificou-se que a maior parte dos custos dessa ETE (totalizado em R$ 844,50) deveu-se às canalizações, uma vez que ela atendeu a duas residências. Esse valor, entretanto, situa-se na faixa de valores especificada em literatura (entre 500 e 1200 reais) e pode ficar ainda mais barato caso se preveja uma otimização no arranjo dos canos. Atualmente, a ETE está servindo ainda para trabalhos de educação ambiental nas escolas da região, além de conscientizar a comunidade local acerca da importância do tratamento de seu esgoto.

Research paper thumbnail of Non-surgical treatment of peri-implant pathology

International Journal of Dental Hygiene, 2006

Abstract: Introduction: Peri-implant pathologies consist of an inflammatory process affecting the... more Abstract: Introduction: Peri-implant pathologies consist of an inflammatory process affecting the soft and hard tissues surrounding the implants. Chlorhexidine is considered the gold standard antiseptic, with a large variety of choice in administration. In this study, a protocol for the irrigation of peri-implant pockets with a chlorhexidine gel, using a plastic needle for the delivery of the product into the peri-implant pockets is described. Study participants and methods: Nine patients with at least one implant presenting peri-implant pathology (inflamed soft tissue associated with bone loss around the implant) were enrolled in this prospective clinical study, and followed-up for 1 year, where clinical parameters such as modified plaque index, modified bleeding index, probing pocket depths, attachment levels were assessed at baseline, 1 month, and 1 year after implementation of the treatment protocol. Results: Treatment success was achieved in eight of the nine patients (and in 11 of the 13 implants) according to the success criteria adopted by the authors of this study. Discussion: Infection control lies at the heart of peri-implant treatment. The control of three factors such as optimal diagnosis, removal of the aetiological factor of the disease (proper removal of debris and decontamination of the peri-implant sulcus/pocket) and a good patient's oral hygiene self-care represents the key to success, resulting in good treatment outcomes when managing peri-implant pathologies. The protocol used (irrigation of peri-implant pockets with chlorhexidine gel delivered by a plastic needle) is considered to be of utility.

Research paper thumbnail of Chronic fatigue, unrefreshing sleep and nocturnal polysomnography

Background and purpose: To investigate the complaint of unrefreshing sleep with study of sleep el... more Background and purpose: To investigate the complaint of unrefreshing sleep with study of sleep electroencephalogram (EEG) in patients with chronic fatigue. Patients and methods: Fourteen successively seen patients (mean age: 41.1 9.8) who complained of chronic fatigue but denied sleepiness and agreed to participate were compared to 14 controls (33.6G10.2 years) who were monitored during sleep recorded in parallel. After performing conventional sleep scoring we applied Fast Fourier Transformation (FFT) for the delta 1, delta 2, theta, alpha, sigma 1, sigma 2, beta EEG frequency bands. The presence of non-rapid eye movement (NREM) sleep instability was studied with calculation of cyclic alternating pattern (CAP) rate. Two-way analysis of variance (ANOVA) was performed to analyze FFT results and Mann-Whitney U-test to compare CAP rate in both groups of subjects. Results: Slow wave sleep (SWS) percentage and sleep efficiency were lower, but there was a significant increase in delta 1 (slow delta) relative power in the chronic fatigue group when compared to normals (P!0.01). All the other frequency bands were proportionally and significantly decreased compared to controls. CAP rate was also significantly greater in subjects with chronic fatigue than in normals (PZ 0.04). An increase in respiratory effort and nasal flow limitation were noted with chronic fatigue. Conclusions: The complaints of chronic fatigue and unrefreshing sleep were associated with an abnormal CAP rate, with increase in slow delta power spectrum, affirming the presence of an abnormal sleep progression and NREM sleep instability. These specific patterns were related to subtle, undiagnosed sleep-disordered breathing. q

Research paper thumbnail of Chronic fatigue, unrefreshing sleep and nocturnal polysomnography

Sleep Medicine, 2006

Background and purpose: To investigate the complaint of unrefreshing sleep with study of sleep el... more Background and purpose: To investigate the complaint of unrefreshing sleep with study of sleep electroencephalogram (EEG) in patients with chronic fatigue. Patients and methods: Fourteen successively seen patients (mean age: 41.1 9.8) who complained of chronic fatigue but denied sleepiness and agreed to participate were compared to 14 controls (33.6G10.2 years) who were monitored during sleep recorded in parallel. After performing conventional sleep scoring we applied Fast Fourier Transformation (FFT) for the delta 1, delta 2, theta, alpha, sigma 1, sigma 2, beta EEG frequency bands. The presence of non-rapid eye movement (NREM) sleep instability was studied with calculation of cyclic alternating pattern (CAP) rate. Two-way analysis of variance (ANOVA) was performed to analyze FFT results and Mann-Whitney U-test to compare CAP rate in both groups of subjects. Results: Slow wave sleep (SWS) percentage and sleep efficiency were lower, but there was a significant increase in delta 1 (slow delta) relative power in the chronic fatigue group when compared to normals (P!0.01). All the other frequency bands were proportionally and significantly decreased compared to controls. CAP rate was also significantly greater in subjects with chronic fatigue than in normals (PZ 0.04). An increase in respiratory effort and nasal flow limitation were noted with chronic fatigue. Conclusions: The complaints of chronic fatigue and unrefreshing sleep were associated with an abnormal CAP rate, with increase in slow delta power spectrum, affirming the presence of an abnormal sleep progression and NREM sleep instability. These specific patterns were related to subtle, undiagnosed sleep-disordered breathing. q

Research paper thumbnail of APC/CTNNB1 (beta-catenin) pathway alterations in human prostate cancers

Genetic alterations serve as beacons for the involvement of specific pathways in tumorigenesis. I... more Genetic alterations serve as beacons for the involvement of specific pathways in tumorigenesis. It was previously shown that 5% of prostate tumors harbor CTNNB1 mutations, suggesting that this tumor type may involve a deregulated APC/CTNNB1 pathway. To explore this possibility further, we searched for mutations in genes implicated in this pathway in 22 samples that included cell lines, xenografts, and primary tumors. We identified seven alterations: two in CTNNB1, three in APC, and two in hTRCP1 (also known as BTRC) which controls the degradation of CTNNB1. Alterations in the CTNNB1 regulatory domain, APC, and hTRCP1 were mutually exclusive, consistent with their equivalent effects on CTNNB1 stability. These results suggest that CTNNB1 signaling plays a critical role in the development of a significant fraction of prostate cancers. Moreover, they provide the first evidence that hTRCP1 plays a role in human neoplasia.

Research paper thumbnail of Academica-2392

A falta de tratamento de esgoto é um dos maiores problemas ambientais da população brasileira, pr... more A falta de tratamento de esgoto é um dos maiores problemas ambientais da população brasileira, principalmente nas comunidades rurais de baixa renda. Nesse sentido, a busca por tecnologias alternativas e de baixo custo para o tratamento desses efluentes torna-se imprescindível. Uma tecnologia alternativa aos métodos convencionais e que tem se mostrado bastante eficaz é o tratamento de esgoto por zona de raízes. Esse sistema baseia-se em princípios físicos (filtração) e biológicos, em que parte do filtro é constituída de plantas, sendo colocado à jusante de um tratamento primário (fossa séptica). Essas plantas devem ter raízes com aerênquimas bem desenvolvidos, como o copo-de-leite, que foi utilizada na ETE (Estação de Tratamento de Efluentes) proposta nesse trabalho. O mesmo teve como objetivo implantar uma estação por zona de raízes numa comunidade rural do município de Irati/PR. A ETE aqui proposta tem volume de 6 m 3 , foi impermeabilizada com lona plástica e é composta por um filtro físico contendo brita e areia de granulometria pré-definida. Verificou-se que a maior parte dos custos dessa ETE (totalizado em R$ 844,50) deveu-se às canalizações, uma vez que ela atendeu a duas residências. Esse valor, entretanto, situa-se na faixa de valores especificada em literatura (entre 500 e 1200 reais) e pode ficar ainda mais barato caso se preveja uma otimização no arranjo dos canos. Atualmente, a ETE está servindo ainda para trabalhos de educação ambiental nas escolas da região, além de conscientizar a comunidade local acerca da importância do tratamento de seu esgoto.