Tatiana Belokrinitskaya - Academia.edu (original) (raw)

Papers by Tatiana Belokrinitskaya

Research paper thumbnail of Ethnic and religious aspects of gender behavior and reproductive directions of young adult females living in Transbaikal region: a 10-year trend

DOAJ (DOAJ: Directory of Open Access Journals), May 1, 2015

We found some positive trends in reproductive paradigm and gender behavior: relatively stable age... more We found some positive trends in reproductive paradigm and gender behavior: relatively stable age of sexual debut, increasing role of health workers in young people reproductive education, a change of orientation in reproductive paradigm towards the model of multiple children family. The number of Orthodox believers significantly increased in Russian subpopulation.

Research paper thumbnail of 109 Intravaginal peloid therapy for preconception care in infertile women planning IVF

European Journal of Obstetrics & Gynecology and Reproductive Biology, Mar 1, 2022

Research paper thumbnail of Features of HPV infection in women of reproductive age and effective methods for diagnosing HPV-associated cervical pathology

Research paper thumbnail of New coronavirus infection COVID-19 in pregnant women: epidemiology, course, outcomes, prevention options

Research paper thumbnail of 145 Severe maternal morbidity and mortality associated with COVID-19 In russian far east

European Journal of Obstetrics & Gynecology and Reproductive Biology, Mar 1, 2022

Research paper thumbnail of Purpose of the study. Evaluate the prognostic value of an independent and medical fence of the vaginal discharge for the HPV test

Гинекология, Apr 15, 2018

Research paper thumbnail of H1N1 2009 influenza virus infection among pregnant women in Transbaikal, Russia

International journal of gynaecology and obstetrics, Jun 13, 2012

Transbaikal is a mountainous region to the east of Lake Baikal in Russia. In October 2009 it was ... more Transbaikal is a mountainous region to the east of Lake Baikal in Russia. In October 2009 it was one of the first regions in the Russian Federation to be hit by the H1N1 influenza virus pandemic, which persisted in the region for 12 weeks. According to the official epidemiological data, from a population of 1 117 308 people, 128 463 (11.5%) were infected with the H1N1 influenza virus. The maximum daily morbidity growth rate was 67% in adults and 111.4% in pregnant women. Pregnant women are at an increased risk for flu and its complications and the rate of hospital admissions among pregnant women is higher than for the general population [1-4]. During the pandemic there were 8570 pregnant women in the region, and 2394 developed the H1N1 virus infection. The incidence of viral pneumonia during pregnancy was 2.47-times higher than in the general population. During the pandemic, 3 pregnant women died. According to the regional epidemiological annual report, the mortality rate was 0.12% in pregnant women compared with 0.05% in the general population. A cross-sectional analysis was performed using the medical histories of 320 pregnant women from the regional hospital in Chita: 220 patients with H1N1 virus infection and 100 pregnant women from the region who did not develop flu. The virus was detected in respiratory

Research paper thumbnail of Pregnancy course, obstetric and therapeutic tactics for novel coronavirus infection (COVID­-19) in pregnant women

Akusherstvo i ginekologiia

The novel coronavirus infection (NCI) (COVID-19) pandemic has posed real social, political and he... more The novel coronavirus infection (NCI) (COVID-19) pandemic has posed real social, political and health challenges to the entire world Many aspects of the management and course of this infection are controversial The physiological characteristics of a pregnant woman's body place her, on the one hand, at risk for a more severe course of NCI, which has been confirmed in some studies However, other authors point out that COVID-19 in pregnant women occurs in the same fashion or even more easily than in the general population There are limited data on the prevalence of NCI among pregnant women in the Russian Federation There are reports of both maternal and neonatal NCI-related deaths worldwide There is a limited range of drugs used to treat NCI in pregnant women Etiotropic therapy with a combination of lopinavir and ritonavir can be performed Some publications have shown the efficacy and safety of hydroxychloroquine in patients with severe NCI A prevailing number of recommendations indicate that vaginal delivery is preferable for pregnant women with NCI;however, most of them deliver an infant via cesarean section Spousal presence during childbirth and the possibility of breastfeeding remain controversial: from ban (before having a negative COVID-19 test) to measures to support the women There are no convincing data on the possibility of COVID-19 vertical transmission, but this issue and the rehabilitation of pregnant women who have experienced NCI (COVID-19) require further investigations Conclusion Pregnancy and childbirth do not worsen the course of NCI (COVID-19) However, there are risks for some pregnancy complications, as well as neonatal ones, during both pregnancy and the long periods after the experienced NCI (COVID-19), especially its severe types There are no convincing data on the possibility of COVID-19 vertical transmission, but this issue and the rehabilitation of pregnant women who have experienced NCI (COVID-19) require further investigations © A group of authors, 2020

Research paper thumbnail of Amenorrea: guidelines and practice

Gynecology and reproductive endocrinology, 2020

Research paper thumbnail of An innovative approach to the treatment of high-risk HPV patients using allokin-alpha

Meditsinskiy sovet = Medical Council, 2021

Introduction. In the research literature, there have been recorded instances of imbalance of inte... more Introduction. In the research literature, there have been recorded instances of imbalance of interleukins and tumour necrosis factors in the cervix tissues, endocervical mucus, suggestive of the potential feasibility of the use of immunomodulatory therapy.Purpose of the study. To assess the effectiveness of the use of the domestic drug allokin-alpha in the treatment of high-risk HPV infection (HPV) in patients of reproductive age, without elimination of the virus within more than 6–12 months and planning pregnancy.Materials and methods. The study included 60 patients of reproductive age with chronic HPV carriage – BP infection. They are represented in the study by two groups: 1st: 30 people in whose therapy allokin-alpha was not used (control group); and 30 patients without HPV BPV elimination in terms of more than 6–12 months, planning pregnancy and taking the domestic cytokiton-like immunomodulator allokin-alpha.Results. Spontaneous pregnancy occurred in 2/30 (6.7%) in the group w...

Research paper thumbnail of H1N1 2009 influenza virus infection among pregnant women in Transbaikal, Russia

International Journal of Gynecology & Obstetrics, 2012

Transbaikal is a mountainous region to the east of Lake Baikal in Russia. In October 2009 it was ... more Transbaikal is a mountainous region to the east of Lake Baikal in Russia. In October 2009 it was one of the first regions in the Russian Federation to be hit by the H1N1 influenza virus pandemic, which persisted in the region for 12 weeks. According to the official epidemiological data, from a population of 1 117 308 people, 128 463 (11.5%) were infected with the H1N1 influenza virus. The maximum daily morbidity growth rate was 67% in adults and 111.4% in pregnant women. Pregnant women are at an increased risk for flu and its complications and the rate of hospital admissions among pregnant women is higher than for the general population [1-4]. During the pandemic there were 8570 pregnant women in the region, and 2394 developed the H1N1 virus infection. The incidence of viral pneumonia during pregnancy was 2.47-times higher than in the general population. During the pandemic, 3 pregnant women died. According to the regional epidemiological annual report, the mortality rate was 0.12% in pregnant women compared with 0.05% in the general population. A cross-sectional analysis was performed using the medical histories of 320 pregnant women from the regional hospital in Chita: 220 patients with H1N1 virus infection and 100 pregnant women from the region who did not develop flu. The virus was detected in respiratory

Research paper thumbnail of Antitumor immune cycle proteins and HPV status in patients with HSIL and cervical cancer

Gynecology

Background. Cervical cancer (CC) is a common malignant tumor among women worldwide. The anti-tumo... more Background. Cervical cancer (CC) is a common malignant tumor among women worldwide. The anti-tumor immune cycle (AIC) is a necessary molecular mechanism that prevents the occurrence and progression of a tumor. It is known that during the development of CC, several mechanisms disrupt the AIC and contribute to tumor progression. Recent data show the role of human papillomavirus (HPV) in the AIC regulation as a mechanism for the emergence of tumor resistance to the anti-tumor immune response. Aim. To study the levels of AIC proteins (sCD25, 4-1BB, B7.2, TGF-b1, CTLA-4, PD-L1, PD-1, Tim-3, LAG-3, Galectin-9, sCD27, PD-L2) in patients with high-grade squamous intraepithelial lesion (HSIL) and CC, depending on the HPV status. Materials and methods. A prospective study enrolled women of reproductive age with HSIL (n=53) and stage IIII СС (n=93). The control group included female volunteers without cervical abnormalities (n=30). The study material was the cervical epithelium. Study methods:...

Research paper thumbnail of Fatty Acid Composition of Precancerous Cervical Lesions and Cervical Cancer Tissues

Fundamental and Clinical Medicine

Журнал зарегистрирован в Федеральной службе по надзору в сфере связи, информационных технологий и... more Журнал зарегистрирован в Федеральной службе по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор), свидетельство о регистрации ПИ №ФС77-65159 от 28 марта 2016 г. Учредитель: федеральное государственное бюджетное образовательное учреждение высшего образования «Кемеровский государственный медицинский университет» Министерства здравоохранения Российской Федерации

Research paper thumbnail of Risk factors and features of COVID-19 course in pregnant women: a comparative analysis of epidemic outbreaks in 2020 and 2021

Gynecology, 2021

Aim. To compare risk factors, features of COVID-19 course and outcomes in pregnant women during e... more Aim. To compare risk factors, features of COVID-19 course and outcomes in pregnant women during epidemic increase in incidence in 2020 and 2021. Materials and methods. The study included 163 pregnant women with laboratory-confirmed SARS-CoV-2 infection within May December 2020 (1st2nd waves of the epidemic) and 158 pregnant women who had new coronavirus infection within May August 2021 (3rd wave of the epidemic). Patients in all groups were comparable in age (1835 years), social status, parity, body mass index, and had no known risk factors for COVID-19. Results. Iron deficiency anemia, smoking, belonging to the Buryat ethnic group were recognized as persistent risk factors for COVID-19 in pregnant women. Over the 1st year of the pandemic, in pregnant women, the following clinical manifestations of novel coronavirus infection were commonly seen: anosmia (87.7%), somnolence (68.7%), shortness of breath even with a mild lung damage (68.1%). In the 3rd wave of the 2nd year of the pande...

Research paper thumbnail of Using Vaginal Self-Sampling Devices for Detection of High-Risk Human Papillomavirus

Fundamental and Clinical Medicine, 2018

Журнал зарегистрирован в Федеральной службе по надзору в сфере связи, информационных технологий и... more Журнал зарегистрирован в Федеральной службе по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор), свидетельство о регистрации ПИ №ФС77-65159 от 28 марта 2016 г. Учредитель: федеральное государственное бюджетное образовательное учреждение высшего образования «Кемеровский государственный медицинский университет» Министерства здравоохранения Российской Федерации

Research paper thumbnail of Amenorrhea: Guidelines and practice

Amenorrhea is the absence of menstrual bleeding.There are two types of amenorrhea, primary and se... more Amenorrhea is the absence of menstrual bleeding.There are two types of amenorrhea, primary and secondary. Although amenorrhea may result from a number of different conditions, a systematic evaluation including a detailed history, physical examination, and laboratory assessment of selected serum hormone levels can usually identify the underlying cause. Treatment goals for patients with amenorrhea may vary considerably, and depend on the patient and the specific diagnosis.The objective of the presentation is to describe the guidelines for the diagnosis and treatment of different types of amenorrhea and relate the major recommendations for the patient management. Congenital malformations of the female genital tract are common miscellaneous deviations from normal anatomy with amenorrhea and reproductive consequences. Until now, three systems have been proposed for their categorization but all of them are associated with serious limitations. The ESHRE/ESGE classification system of female...

Research paper thumbnail of Preconception Screening for Gene Polymorphisms Associated with Thrombophilia and Hyperhomocysteinemia Risk in Healthy Young Women

International Journal of Biomedicine, 2013

The frequency characteristics of the gene polymorphisms (FVL G1691A, FII G20210A, MTHFR C677T, MT... more The frequency characteristics of the gene polymorphisms (FVL G1691A, FII G20210A, MTHFR C677T, MTHFR A1298C, MTRR A66G) associated with thrombophilia, hyperhomocysteinemia risk and different perinatal or pregnancy complications were studied. This examination was conducted among 130 planned-pregnancy healthy young women aged between 19 and 29 years. A gene mutation analysis was performed using a real-time polymerase chain reaction (real-time PCR). Factor V Leiden (FVL G1691A) and prothrombin gene (FII G20210A) mutations were not identified in the women surveyed. The frequency of the occurrence of the heterozygous FVL 1691G/A genotype associated with the risk of thrombosis during pregnancy was very low in these women (0.8%). The frequency of the MTHFR (methylenetetrahydrofolate reductase) 1298C/С mutant genotype was 11.5%, MTHFR 677T/Т – 5.4%, and MTRR (methionine synthase reductase) 66G/G – 31.5%. A combination of the MTHFR 677TT/1298CC and MTHFR 677TТ/ MTRR 66GG mutant genotypes, wh...

Research paper thumbnail of COVID-19 in pregnant and non-pregnant women of early reproductive age

Gynecology, 2021

Aim. To identify confounding factors, features of the clinical course and outcomes of COVID-19 in... more Aim. To identify confounding factors, features of the clinical course and outcomes of COVID-19 in pregnant and non-pregnant patients of early reproductive age who have no known risk factors and premorbid background. Materials and methods. The study included 163 pregnant women in the third trimester of gestation, 100 non-pregnant women with laboratory-confirmed SARS-CoV-2 infection and 100 pregnant women who did not get sick. Patients of all groups were comparable in age (1835 years), social status, parity, body mass index, had no known risk factors for COVID-19; those who got sick were treated simultaneously. Results. Statistically significant associations were revealed between COVID-19 infection in the pregnant and iron deficiency anemia, vegetovascular dystonia, belonging to the Buryat ethnicity, and smoking. Pregnant women with COVID-19 were more likely to have no symptoms (23.3% vs 5%; p0.001) or had a mild course of the disease (58.9% vs 24%; p0.001). In non-pregnant patients, ...

Research paper thumbnail of Dynamics of the epidemic process and the course of the COVID-19 in pregnant women of the Far Eastern and Siberian Federal Districts

Gynecology, 2020

The objective of the study was to evaluate an epidemiological characteristic and the course of CO... more The objective of the study was to evaluate an epidemiological characteristic and the course of COVID-19 in pregnant women from the Far East and Siberian Federal Districts of Russia. Materials and methods. The analysis of operational information on the incidence of COVID-19 and the its features in pregnant women and after childbirth provided by the chief obstetrician-gynecologists of the Far Eastern Federal District and Siberian Federal District on May 25, 2020 and August 25, 2020 is carried out. Mathematical analysis included descriptive statistics methods, analysis of contingency tables, where the 2 value, the achieved significance level (p) Results. On August 25, 2020, 2010 cases of COVID-19 in pregnant women were detected in two subjects, including 134 active cases. In the population, the proportion of pregnant women among cases of COVID-19 was 1.45%. Pneumonia in pregnant women was registered in 44.8% of cases, severe course of the disease - in 3.7%, hospitalization in RAW - in ...

Research paper thumbnail of Clinical course, maternal and neonatal outcomes of COVID-19 infection in pregnancy: an epidemiological study in Siberia and the Far East

Gynecology, 2021

Aim. To assess the incidence, clinical course, outcomes of a novel coronavirus infection (NKI) CO... more Aim. To assess the incidence, clinical course, outcomes of a novel coronavirus infection (NKI) COVID-19 for mother and child in the population of pregnant women in the Far Eastern (FEFD) and Siberian Federal Districts (SFD). Materials and methods. The study design: a population-based epidemiological prospective study. We analyzed operative information on NKI COVID-19 incidence and features of clinical course in pregnant women, women in labor and parturient women as well as maternal and perinatal outcomes for March 11 to December 25, 2020 which were provided by the FEFD and SFD chief obstetricians-gynecologists. Mathematical analysis included methods of descriptive statistics, analysis of contingency table, where the value of 2, the achieved level of significance (p) was estimated. Results. In the FEFD and SFD, over the COVID-19 2020 epidemic, the SARS-CoV-2 virus was revealed in 8485 pregnant women, women in labor and postpartum women (5.9% of pregnant women subjected to regular med...

Research paper thumbnail of Ethnic and religious aspects of gender behavior and reproductive directions of young adult females living in Transbaikal region: a 10-year trend

DOAJ (DOAJ: Directory of Open Access Journals), May 1, 2015

We found some positive trends in reproductive paradigm and gender behavior: relatively stable age... more We found some positive trends in reproductive paradigm and gender behavior: relatively stable age of sexual debut, increasing role of health workers in young people reproductive education, a change of orientation in reproductive paradigm towards the model of multiple children family. The number of Orthodox believers significantly increased in Russian subpopulation.

Research paper thumbnail of 109 Intravaginal peloid therapy for preconception care in infertile women planning IVF

European Journal of Obstetrics & Gynecology and Reproductive Biology, Mar 1, 2022

Research paper thumbnail of Features of HPV infection in women of reproductive age and effective methods for diagnosing HPV-associated cervical pathology

Research paper thumbnail of New coronavirus infection COVID-19 in pregnant women: epidemiology, course, outcomes, prevention options

Research paper thumbnail of 145 Severe maternal morbidity and mortality associated with COVID-19 In russian far east

European Journal of Obstetrics & Gynecology and Reproductive Biology, Mar 1, 2022

Research paper thumbnail of Purpose of the study. Evaluate the prognostic value of an independent and medical fence of the vaginal discharge for the HPV test

Гинекология, Apr 15, 2018

Research paper thumbnail of H1N1 2009 influenza virus infection among pregnant women in Transbaikal, Russia

International journal of gynaecology and obstetrics, Jun 13, 2012

Transbaikal is a mountainous region to the east of Lake Baikal in Russia. In October 2009 it was ... more Transbaikal is a mountainous region to the east of Lake Baikal in Russia. In October 2009 it was one of the first regions in the Russian Federation to be hit by the H1N1 influenza virus pandemic, which persisted in the region for 12 weeks. According to the official epidemiological data, from a population of 1 117 308 people, 128 463 (11.5%) were infected with the H1N1 influenza virus. The maximum daily morbidity growth rate was 67% in adults and 111.4% in pregnant women. Pregnant women are at an increased risk for flu and its complications and the rate of hospital admissions among pregnant women is higher than for the general population [1-4]. During the pandemic there were 8570 pregnant women in the region, and 2394 developed the H1N1 virus infection. The incidence of viral pneumonia during pregnancy was 2.47-times higher than in the general population. During the pandemic, 3 pregnant women died. According to the regional epidemiological annual report, the mortality rate was 0.12% in pregnant women compared with 0.05% in the general population. A cross-sectional analysis was performed using the medical histories of 320 pregnant women from the regional hospital in Chita: 220 patients with H1N1 virus infection and 100 pregnant women from the region who did not develop flu. The virus was detected in respiratory

Research paper thumbnail of Pregnancy course, obstetric and therapeutic tactics for novel coronavirus infection (COVID­-19) in pregnant women

Akusherstvo i ginekologiia

The novel coronavirus infection (NCI) (COVID-19) pandemic has posed real social, political and he... more The novel coronavirus infection (NCI) (COVID-19) pandemic has posed real social, political and health challenges to the entire world Many aspects of the management and course of this infection are controversial The physiological characteristics of a pregnant woman's body place her, on the one hand, at risk for a more severe course of NCI, which has been confirmed in some studies However, other authors point out that COVID-19 in pregnant women occurs in the same fashion or even more easily than in the general population There are limited data on the prevalence of NCI among pregnant women in the Russian Federation There are reports of both maternal and neonatal NCI-related deaths worldwide There is a limited range of drugs used to treat NCI in pregnant women Etiotropic therapy with a combination of lopinavir and ritonavir can be performed Some publications have shown the efficacy and safety of hydroxychloroquine in patients with severe NCI A prevailing number of recommendations indicate that vaginal delivery is preferable for pregnant women with NCI;however, most of them deliver an infant via cesarean section Spousal presence during childbirth and the possibility of breastfeeding remain controversial: from ban (before having a negative COVID-19 test) to measures to support the women There are no convincing data on the possibility of COVID-19 vertical transmission, but this issue and the rehabilitation of pregnant women who have experienced NCI (COVID-19) require further investigations Conclusion Pregnancy and childbirth do not worsen the course of NCI (COVID-19) However, there are risks for some pregnancy complications, as well as neonatal ones, during both pregnancy and the long periods after the experienced NCI (COVID-19), especially its severe types There are no convincing data on the possibility of COVID-19 vertical transmission, but this issue and the rehabilitation of pregnant women who have experienced NCI (COVID-19) require further investigations © A group of authors, 2020

Research paper thumbnail of Amenorrea: guidelines and practice

Gynecology and reproductive endocrinology, 2020

Research paper thumbnail of An innovative approach to the treatment of high-risk HPV patients using allokin-alpha

Meditsinskiy sovet = Medical Council, 2021

Introduction. In the research literature, there have been recorded instances of imbalance of inte... more Introduction. In the research literature, there have been recorded instances of imbalance of interleukins and tumour necrosis factors in the cervix tissues, endocervical mucus, suggestive of the potential feasibility of the use of immunomodulatory therapy.Purpose of the study. To assess the effectiveness of the use of the domestic drug allokin-alpha in the treatment of high-risk HPV infection (HPV) in patients of reproductive age, without elimination of the virus within more than 6–12 months and planning pregnancy.Materials and methods. The study included 60 patients of reproductive age with chronic HPV carriage – BP infection. They are represented in the study by two groups: 1st: 30 people in whose therapy allokin-alpha was not used (control group); and 30 patients without HPV BPV elimination in terms of more than 6–12 months, planning pregnancy and taking the domestic cytokiton-like immunomodulator allokin-alpha.Results. Spontaneous pregnancy occurred in 2/30 (6.7%) in the group w...

Research paper thumbnail of H1N1 2009 influenza virus infection among pregnant women in Transbaikal, Russia

International Journal of Gynecology & Obstetrics, 2012

Transbaikal is a mountainous region to the east of Lake Baikal in Russia. In October 2009 it was ... more Transbaikal is a mountainous region to the east of Lake Baikal in Russia. In October 2009 it was one of the first regions in the Russian Federation to be hit by the H1N1 influenza virus pandemic, which persisted in the region for 12 weeks. According to the official epidemiological data, from a population of 1 117 308 people, 128 463 (11.5%) were infected with the H1N1 influenza virus. The maximum daily morbidity growth rate was 67% in adults and 111.4% in pregnant women. Pregnant women are at an increased risk for flu and its complications and the rate of hospital admissions among pregnant women is higher than for the general population [1-4]. During the pandemic there were 8570 pregnant women in the region, and 2394 developed the H1N1 virus infection. The incidence of viral pneumonia during pregnancy was 2.47-times higher than in the general population. During the pandemic, 3 pregnant women died. According to the regional epidemiological annual report, the mortality rate was 0.12% in pregnant women compared with 0.05% in the general population. A cross-sectional analysis was performed using the medical histories of 320 pregnant women from the regional hospital in Chita: 220 patients with H1N1 virus infection and 100 pregnant women from the region who did not develop flu. The virus was detected in respiratory

Research paper thumbnail of Antitumor immune cycle proteins and HPV status in patients with HSIL and cervical cancer

Gynecology

Background. Cervical cancer (CC) is a common malignant tumor among women worldwide. The anti-tumo... more Background. Cervical cancer (CC) is a common malignant tumor among women worldwide. The anti-tumor immune cycle (AIC) is a necessary molecular mechanism that prevents the occurrence and progression of a tumor. It is known that during the development of CC, several mechanisms disrupt the AIC and contribute to tumor progression. Recent data show the role of human papillomavirus (HPV) in the AIC regulation as a mechanism for the emergence of tumor resistance to the anti-tumor immune response. Aim. To study the levels of AIC proteins (sCD25, 4-1BB, B7.2, TGF-b1, CTLA-4, PD-L1, PD-1, Tim-3, LAG-3, Galectin-9, sCD27, PD-L2) in patients with high-grade squamous intraepithelial lesion (HSIL) and CC, depending on the HPV status. Materials and methods. A prospective study enrolled women of reproductive age with HSIL (n=53) and stage IIII СС (n=93). The control group included female volunteers without cervical abnormalities (n=30). The study material was the cervical epithelium. Study methods:...

Research paper thumbnail of Fatty Acid Composition of Precancerous Cervical Lesions and Cervical Cancer Tissues

Fundamental and Clinical Medicine

Журнал зарегистрирован в Федеральной службе по надзору в сфере связи, информационных технологий и... more Журнал зарегистрирован в Федеральной службе по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор), свидетельство о регистрации ПИ №ФС77-65159 от 28 марта 2016 г. Учредитель: федеральное государственное бюджетное образовательное учреждение высшего образования «Кемеровский государственный медицинский университет» Министерства здравоохранения Российской Федерации

Research paper thumbnail of Risk factors and features of COVID-19 course in pregnant women: a comparative analysis of epidemic outbreaks in 2020 and 2021

Gynecology, 2021

Aim. To compare risk factors, features of COVID-19 course and outcomes in pregnant women during e... more Aim. To compare risk factors, features of COVID-19 course and outcomes in pregnant women during epidemic increase in incidence in 2020 and 2021. Materials and methods. The study included 163 pregnant women with laboratory-confirmed SARS-CoV-2 infection within May December 2020 (1st2nd waves of the epidemic) and 158 pregnant women who had new coronavirus infection within May August 2021 (3rd wave of the epidemic). Patients in all groups were comparable in age (1835 years), social status, parity, body mass index, and had no known risk factors for COVID-19. Results. Iron deficiency anemia, smoking, belonging to the Buryat ethnic group were recognized as persistent risk factors for COVID-19 in pregnant women. Over the 1st year of the pandemic, in pregnant women, the following clinical manifestations of novel coronavirus infection were commonly seen: anosmia (87.7%), somnolence (68.7%), shortness of breath even with a mild lung damage (68.1%). In the 3rd wave of the 2nd year of the pande...

Research paper thumbnail of Using Vaginal Self-Sampling Devices for Detection of High-Risk Human Papillomavirus

Fundamental and Clinical Medicine, 2018

Журнал зарегистрирован в Федеральной службе по надзору в сфере связи, информационных технологий и... more Журнал зарегистрирован в Федеральной службе по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор), свидетельство о регистрации ПИ №ФС77-65159 от 28 марта 2016 г. Учредитель: федеральное государственное бюджетное образовательное учреждение высшего образования «Кемеровский государственный медицинский университет» Министерства здравоохранения Российской Федерации

Research paper thumbnail of Amenorrhea: Guidelines and practice

Amenorrhea is the absence of menstrual bleeding.There are two types of amenorrhea, primary and se... more Amenorrhea is the absence of menstrual bleeding.There are two types of amenorrhea, primary and secondary. Although amenorrhea may result from a number of different conditions, a systematic evaluation including a detailed history, physical examination, and laboratory assessment of selected serum hormone levels can usually identify the underlying cause. Treatment goals for patients with amenorrhea may vary considerably, and depend on the patient and the specific diagnosis.The objective of the presentation is to describe the guidelines for the diagnosis and treatment of different types of amenorrhea and relate the major recommendations for the patient management. Congenital malformations of the female genital tract are common miscellaneous deviations from normal anatomy with amenorrhea and reproductive consequences. Until now, three systems have been proposed for their categorization but all of them are associated with serious limitations. The ESHRE/ESGE classification system of female...

Research paper thumbnail of Preconception Screening for Gene Polymorphisms Associated with Thrombophilia and Hyperhomocysteinemia Risk in Healthy Young Women

International Journal of Biomedicine, 2013

The frequency characteristics of the gene polymorphisms (FVL G1691A, FII G20210A, MTHFR C677T, MT... more The frequency characteristics of the gene polymorphisms (FVL G1691A, FII G20210A, MTHFR C677T, MTHFR A1298C, MTRR A66G) associated with thrombophilia, hyperhomocysteinemia risk and different perinatal or pregnancy complications were studied. This examination was conducted among 130 planned-pregnancy healthy young women aged between 19 and 29 years. A gene mutation analysis was performed using a real-time polymerase chain reaction (real-time PCR). Factor V Leiden (FVL G1691A) and prothrombin gene (FII G20210A) mutations were not identified in the women surveyed. The frequency of the occurrence of the heterozygous FVL 1691G/A genotype associated with the risk of thrombosis during pregnancy was very low in these women (0.8%). The frequency of the MTHFR (methylenetetrahydrofolate reductase) 1298C/С mutant genotype was 11.5%, MTHFR 677T/Т – 5.4%, and MTRR (methionine synthase reductase) 66G/G – 31.5%. A combination of the MTHFR 677TT/1298CC and MTHFR 677TТ/ MTRR 66GG mutant genotypes, wh...

Research paper thumbnail of COVID-19 in pregnant and non-pregnant women of early reproductive age

Gynecology, 2021

Aim. To identify confounding factors, features of the clinical course and outcomes of COVID-19 in... more Aim. To identify confounding factors, features of the clinical course and outcomes of COVID-19 in pregnant and non-pregnant patients of early reproductive age who have no known risk factors and premorbid background. Materials and methods. The study included 163 pregnant women in the third trimester of gestation, 100 non-pregnant women with laboratory-confirmed SARS-CoV-2 infection and 100 pregnant women who did not get sick. Patients of all groups were comparable in age (1835 years), social status, parity, body mass index, had no known risk factors for COVID-19; those who got sick were treated simultaneously. Results. Statistically significant associations were revealed between COVID-19 infection in the pregnant and iron deficiency anemia, vegetovascular dystonia, belonging to the Buryat ethnicity, and smoking. Pregnant women with COVID-19 were more likely to have no symptoms (23.3% vs 5%; p0.001) or had a mild course of the disease (58.9% vs 24%; p0.001). In non-pregnant patients, ...

Research paper thumbnail of Dynamics of the epidemic process and the course of the COVID-19 in pregnant women of the Far Eastern and Siberian Federal Districts

Gynecology, 2020

The objective of the study was to evaluate an epidemiological characteristic and the course of CO... more The objective of the study was to evaluate an epidemiological characteristic and the course of COVID-19 in pregnant women from the Far East and Siberian Federal Districts of Russia. Materials and methods. The analysis of operational information on the incidence of COVID-19 and the its features in pregnant women and after childbirth provided by the chief obstetrician-gynecologists of the Far Eastern Federal District and Siberian Federal District on May 25, 2020 and August 25, 2020 is carried out. Mathematical analysis included descriptive statistics methods, analysis of contingency tables, where the 2 value, the achieved significance level (p) Results. On August 25, 2020, 2010 cases of COVID-19 in pregnant women were detected in two subjects, including 134 active cases. In the population, the proportion of pregnant women among cases of COVID-19 was 1.45%. Pneumonia in pregnant women was registered in 44.8% of cases, severe course of the disease - in 3.7%, hospitalization in RAW - in ...

Research paper thumbnail of Clinical course, maternal and neonatal outcomes of COVID-19 infection in pregnancy: an epidemiological study in Siberia and the Far East

Gynecology, 2021

Aim. To assess the incidence, clinical course, outcomes of a novel coronavirus infection (NKI) CO... more Aim. To assess the incidence, clinical course, outcomes of a novel coronavirus infection (NKI) COVID-19 for mother and child in the population of pregnant women in the Far Eastern (FEFD) and Siberian Federal Districts (SFD). Materials and methods. The study design: a population-based epidemiological prospective study. We analyzed operative information on NKI COVID-19 incidence and features of clinical course in pregnant women, women in labor and parturient women as well as maternal and perinatal outcomes for March 11 to December 25, 2020 which were provided by the FEFD and SFD chief obstetricians-gynecologists. Mathematical analysis included methods of descriptive statistics, analysis of contingency table, where the value of 2, the achieved level of significance (p) was estimated. Results. In the FEFD and SFD, over the COVID-19 2020 epidemic, the SARS-CoV-2 virus was revealed in 8485 pregnant women, women in labor and postpartum women (5.9% of pregnant women subjected to regular med...