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Papers by Tatiana Lauxen Peruzzolo

Research paper thumbnail of Pharmacotherapy of bipolar disorder in children and adolescents: an update

Revista Brasileira de Psiquiatria, 2013

Research paper thumbnail of Correlação entre os níveis periféricos de fator neurotrófico derivado do cérebro e volume de hipocampo em crianças e adolescentes com transtorno bipolar

Ao meu orientador, Prof. Dr. Cristian Patrick Zeni, não somente pelas orientações e ensinamentos ... more Ao meu orientador, Prof. Dr. Cristian Patrick Zeni, não somente pelas orientações e ensinamentos acadêmico-profissionais, mas também pelo apoio durante todo o período em que passei pelo ProCAB. À Dra. Silzá Tramontina, pelas lições de vida.

Research paper thumbnail of Prevalência das dificuldades e transtornos de aprendizagem em crianças e adolescentes com transtorno bipolar

Research paper thumbnail of Impacto na qualidade de vida em crianças e adolescentes com transtorno do humor bipolar em uma coorte no tempo de seis meses

Research paper thumbnail of Prevalência de comorbidades em crianças e adolescentes com transtorno bipolar ao redor do mundo

Research paper thumbnail of Correlation between Peripheral Levels of Brain-Derived Neurotrophic Factor and Hippocampal Volume in Children and Adolescents with Bipolar Disorder

Pediatric bipolar disorder (PBD) is a serious mental disorder that affects the development and em... more Pediatric bipolar disorder (PBD) is a serious mental disorder that affects the development and emotional growth of affected patients. The brain derived neurotrophic factor (BDNF) is recognized as one of the possible markers of the framework and its evolution. Abnormalities in BDNF signaling in the hippocampus could explain the cognitive decline seen in patients with TB. Our aim with this study was to evaluate possible changes in hippocampal volume in children and adolescents with BD and associate them to serum BDNF. Subjects included 30 patients aged seven to seventeen years from the ProCAB (Program for Children and Adolescents with Bipolar Disorder). We observed mean right and left hippocampal volumes of 41910.55 and 41747.96 mm 3 , respectively. No statistically significant correlations between peripheral BDNF levels and hippocampal volumes were found. We believe that the lack of correlation observed in this study is due to the short time of evolution of BD in children and adolesc...

Research paper thumbnail of Pharmacotherapy of bipolar disorder in children and adolescents: an update

Pharmacotherapy of bipolar disorder in children and adolescents: an update, 2013

Objective: To review the options for acute and maintenance pharmacological treatment of bipolar d... more Objective: To review the options for acute and maintenance pharmacological treatment of bipolar disorder in children and adolescents, including the treatment of bipolar depression and comorbid attention deficit/hyperactivity disorder (ADHD). Methods: Narrative review of randomized clinical trials and open-label studies published from 2000 to 2012. The PubMed and PsycINFO websites were queried. Case series were included when a higher level of evidence was not available. Results: Published data from randomized controlled trials (RCTs) in acute mania/hypomania with significant responses are available for lithium, topiramate, risperidone, olanzapine, and aripiprazole. Open trials of lithium and lamotrigine show that these drugs may be effective in the treatment of depressive episodes. No trials of selective serotonin reuptake inhibitors (SSRIs) have been conducted. In the treatment of comorbid ADHD, there are encouraging findings with mixed amphetamine salts and atomoxetine; conflicting results are observed with methylphenidate. Conclusions: Published RCTs of traditional mood stabilizers are scarce, but the best available evidence (results from meta-analytic regression) suggests that second-generation antipsychotics (SGAs) as a group are more effective in reducing manic symptoms. Risperidone was the only one included in head-to-head comparisons (vs. lithium and divalproex), showing superiority in terms of efficacy, but with more metabolic side effects, which were also more common in most of the SGAs. There are few studies addressing the treatment of ADHD and depression. Brazilian guidelines for the treatment of pediatric bipolar disorder should also include some SGAs (especially risperidone and aripiprazole) as first-line treatment, and these drugs should be provided by the public health services.

Research paper thumbnail of Correlação entre os níveis periféricos de fator neurotrófico derivado do cérebro e volume de hipocampo em crianças e adolescentes com transtorno bipolar

Research paper thumbnail of Avoiding Stimulants May Not Prevent Manic Switch: A Case Report With Atomoxetine

The Journal of Neuropsychiatry and Clinical Neurosciences, Nov 10, 2014

Research paper thumbnail of Correlation between Peripheral Levels of Brain-Derived Neurotrophic Factor and Hippocampal Volume in Children and Adolescents with Bipolar Disorder

Neural Plasticity, 2015

Pediatric bipolar disorder (PBD) is a serious mental disorder that affects the development and em... more Pediatric bipolar disorder (PBD) is a serious mental disorder that affects the development and emotional growth of affected patients. The brain derived neurotrophic factor (BDNF) is recognized as one of the possible markers of the framework and its evolution. Abnormalities in BDNF signaling in the hippocampus could explain the cognitive decline seen in patients with TB. Our aim with this study was to evaluate possible changes in hippocampal volume in children and adolescents with BD and associate them to serum BDNF. Subjects included 30 patients aged seven to seventeen years from the ProCAB (Program for Children and Adolescents with Bipolar Disorder). We observed mean right and left hippocampal volumes of 41910.55 and 41747.96 mm3, respectively. No statistically significant correlations between peripheral BDNF levels and hippocampal volumes were found. We believe that the lack of correlation observed in this study is due to the short time of evolution of BD in children and adolescen...

Research paper thumbnail of Avoiding Stimulants May Not Prevent Manic Switch: A Case Report With Atomoxetine

The Journal of Neuropsychiatry and Clinical Neurosciences, 2014

Research paper thumbnail of Pharmacotherapy of bipolar disorder in children and adolescents: an update

Objective: To review the options for acute and maintenance pharmacological treatment of bipolar d... more Objective: To review the options for acute and maintenance pharmacological treatment of bipolar disorder in children and adolescents, including the treatment of bipolar depression and comorbid attention deficit/hyperactivity disorder (ADHD). Methods: Narrative review of randomized clinical trials and open-label studies published from 2000 to 2012. The PubMed and PsycINFO websites were queried. Case series were included when a higher level of evidence was not available. Results: Published data from randomized controlled trials (RCTs) in acute mania/hypomania with significant responses are available for lithium, topiramate, risperidone, olanzapine, and aripiprazole. Open trials of lithium and lamotrigine show that these drugs may be effective in the treatment of depressive episodes. No trials of selective serotonin reuptake inhibitors (SSRIs) have been conducted. In the treatment of comorbid ADHD, there are encouraging findings with mixed amphetamine salts and atomoxetine; conflicting results are observed with methylphenidate. Conclusions: Published RCTs of traditional mood stabilizers are scarce, but the best available evidence (results from meta-analytic regression) suggests that second-generation antipsychotics (SGAs) as a group are more effective in reducing manic symptoms. Risperidone was the only one included in head-to-head comparisons (vs. lithium and divalproex), showing superiority in terms of efficacy, but with more metabolic side effects, which were also more common in most of the SGAs. There are few studies addressing the treatment of ADHD and depression. Brazilian guidelines for the treatment of pediatric bipolar disorder should also include some SGAs (especially risperidone and aripiprazole) as first-line treatment, and these drugs should be provided by the public health services.

Research paper thumbnail of Pharmacotherapy of bipolar disorder in children and adolescents: an update

Revista Brasileira de Psiquiatria, 2013

Research paper thumbnail of Correlação entre os níveis periféricos de fator neurotrófico derivado do cérebro e volume de hipocampo em crianças e adolescentes com transtorno bipolar

Ao meu orientador, Prof. Dr. Cristian Patrick Zeni, não somente pelas orientações e ensinamentos ... more Ao meu orientador, Prof. Dr. Cristian Patrick Zeni, não somente pelas orientações e ensinamentos acadêmico-profissionais, mas também pelo apoio durante todo o período em que passei pelo ProCAB. À Dra. Silzá Tramontina, pelas lições de vida.

Research paper thumbnail of Prevalência das dificuldades e transtornos de aprendizagem em crianças e adolescentes com transtorno bipolar

Research paper thumbnail of Impacto na qualidade de vida em crianças e adolescentes com transtorno do humor bipolar em uma coorte no tempo de seis meses

Research paper thumbnail of Prevalência de comorbidades em crianças e adolescentes com transtorno bipolar ao redor do mundo

Research paper thumbnail of Correlation between Peripheral Levels of Brain-Derived Neurotrophic Factor and Hippocampal Volume in Children and Adolescents with Bipolar Disorder

Pediatric bipolar disorder (PBD) is a serious mental disorder that affects the development and em... more Pediatric bipolar disorder (PBD) is a serious mental disorder that affects the development and emotional growth of affected patients. The brain derived neurotrophic factor (BDNF) is recognized as one of the possible markers of the framework and its evolution. Abnormalities in BDNF signaling in the hippocampus could explain the cognitive decline seen in patients with TB. Our aim with this study was to evaluate possible changes in hippocampal volume in children and adolescents with BD and associate them to serum BDNF. Subjects included 30 patients aged seven to seventeen years from the ProCAB (Program for Children and Adolescents with Bipolar Disorder). We observed mean right and left hippocampal volumes of 41910.55 and 41747.96 mm 3 , respectively. No statistically significant correlations between peripheral BDNF levels and hippocampal volumes were found. We believe that the lack of correlation observed in this study is due to the short time of evolution of BD in children and adolesc...

Research paper thumbnail of Pharmacotherapy of bipolar disorder in children and adolescents: an update

Pharmacotherapy of bipolar disorder in children and adolescents: an update, 2013

Objective: To review the options for acute and maintenance pharmacological treatment of bipolar d... more Objective: To review the options for acute and maintenance pharmacological treatment of bipolar disorder in children and adolescents, including the treatment of bipolar depression and comorbid attention deficit/hyperactivity disorder (ADHD). Methods: Narrative review of randomized clinical trials and open-label studies published from 2000 to 2012. The PubMed and PsycINFO websites were queried. Case series were included when a higher level of evidence was not available. Results: Published data from randomized controlled trials (RCTs) in acute mania/hypomania with significant responses are available for lithium, topiramate, risperidone, olanzapine, and aripiprazole. Open trials of lithium and lamotrigine show that these drugs may be effective in the treatment of depressive episodes. No trials of selective serotonin reuptake inhibitors (SSRIs) have been conducted. In the treatment of comorbid ADHD, there are encouraging findings with mixed amphetamine salts and atomoxetine; conflicting results are observed with methylphenidate. Conclusions: Published RCTs of traditional mood stabilizers are scarce, but the best available evidence (results from meta-analytic regression) suggests that second-generation antipsychotics (SGAs) as a group are more effective in reducing manic symptoms. Risperidone was the only one included in head-to-head comparisons (vs. lithium and divalproex), showing superiority in terms of efficacy, but with more metabolic side effects, which were also more common in most of the SGAs. There are few studies addressing the treatment of ADHD and depression. Brazilian guidelines for the treatment of pediatric bipolar disorder should also include some SGAs (especially risperidone and aripiprazole) as first-line treatment, and these drugs should be provided by the public health services.

Research paper thumbnail of Correlação entre os níveis periféricos de fator neurotrófico derivado do cérebro e volume de hipocampo em crianças e adolescentes com transtorno bipolar

Research paper thumbnail of Avoiding Stimulants May Not Prevent Manic Switch: A Case Report With Atomoxetine

The Journal of Neuropsychiatry and Clinical Neurosciences, Nov 10, 2014

Research paper thumbnail of Correlation between Peripheral Levels of Brain-Derived Neurotrophic Factor and Hippocampal Volume in Children and Adolescents with Bipolar Disorder

Neural Plasticity, 2015

Pediatric bipolar disorder (PBD) is a serious mental disorder that affects the development and em... more Pediatric bipolar disorder (PBD) is a serious mental disorder that affects the development and emotional growth of affected patients. The brain derived neurotrophic factor (BDNF) is recognized as one of the possible markers of the framework and its evolution. Abnormalities in BDNF signaling in the hippocampus could explain the cognitive decline seen in patients with TB. Our aim with this study was to evaluate possible changes in hippocampal volume in children and adolescents with BD and associate them to serum BDNF. Subjects included 30 patients aged seven to seventeen years from the ProCAB (Program for Children and Adolescents with Bipolar Disorder). We observed mean right and left hippocampal volumes of 41910.55 and 41747.96 mm3, respectively. No statistically significant correlations between peripheral BDNF levels and hippocampal volumes were found. We believe that the lack of correlation observed in this study is due to the short time of evolution of BD in children and adolescen...

Research paper thumbnail of Avoiding Stimulants May Not Prevent Manic Switch: A Case Report With Atomoxetine

The Journal of Neuropsychiatry and Clinical Neurosciences, 2014

Research paper thumbnail of Pharmacotherapy of bipolar disorder in children and adolescents: an update

Objective: To review the options for acute and maintenance pharmacological treatment of bipolar d... more Objective: To review the options for acute and maintenance pharmacological treatment of bipolar disorder in children and adolescents, including the treatment of bipolar depression and comorbid attention deficit/hyperactivity disorder (ADHD). Methods: Narrative review of randomized clinical trials and open-label studies published from 2000 to 2012. The PubMed and PsycINFO websites were queried. Case series were included when a higher level of evidence was not available. Results: Published data from randomized controlled trials (RCTs) in acute mania/hypomania with significant responses are available for lithium, topiramate, risperidone, olanzapine, and aripiprazole. Open trials of lithium and lamotrigine show that these drugs may be effective in the treatment of depressive episodes. No trials of selective serotonin reuptake inhibitors (SSRIs) have been conducted. In the treatment of comorbid ADHD, there are encouraging findings with mixed amphetamine salts and atomoxetine; conflicting results are observed with methylphenidate. Conclusions: Published RCTs of traditional mood stabilizers are scarce, but the best available evidence (results from meta-analytic regression) suggests that second-generation antipsychotics (SGAs) as a group are more effective in reducing manic symptoms. Risperidone was the only one included in head-to-head comparisons (vs. lithium and divalproex), showing superiority in terms of efficacy, but with more metabolic side effects, which were also more common in most of the SGAs. There are few studies addressing the treatment of ADHD and depression. Brazilian guidelines for the treatment of pediatric bipolar disorder should also include some SGAs (especially risperidone and aripiprazole) as first-line treatment, and these drugs should be provided by the public health services.