Tayyaba Faisal - Academia.edu (original) (raw)

Papers by Tayyaba Faisal

Pakistan Armed Forces Medical Journal

Objective: To determine the toxic effect of mosquito coil smoke inhalation on gross parameters of... more Objective: To determine the toxic effect of mosquito coil smoke inhalation on gross parameters of rat testis and explore the protective effect of Coenzyme Q10on testicular toxicity profile. Study Design: Laboratory-based experimental study. Place and Duration of Study: Department of Anatomy Army Medical College, Rawalpindi in collaboration with National Institute of Health, Islamabad, from Jan 2020 to Dec 2020. Methodology: This study was carried out among 30 male Sprague Dawley rats, distributed into three groups as 10 rats/group; group A served as control group, rats in group B were exposed to allethrin-based mosquito coil smoke 4hours/day for 12 weeks. Rats in group C were administered Coenzyme Q10 (10 mg/kg/day) via oral gavage for 12 weeks along with mosquito coil smoke exposure. At the end of study, gross parameters of body weight gain, testicular weight and volume, and relative tissue body weight index of testis were compared among groups. Results: Rats exposed to mosquito co...

Pakistan Armed Forces Medical Journal

Objective: To evaluate the effects of autologous platelet-rich plasma on arrangement of collagen ... more Objective: To evaluate the effects of autologous platelet-rich plasma on arrangement of collagen fibers at injured Achilles tendon entheses in rabbits. Study Design: Laboratory-based experimental study. Place and Duration of Study: Department of Anatomy, Army Medical College, Rawalpindi, in collaboration with National Institute of Health, Islamabad, from March to May, 2018. Material and Methods: Forty, healthy, male, “New Zealand white rabbits”, 4-6 months of age, weighing 2000- 2500g, were randomly divided into 4 equal groups (A, B, C and D). Group A served as control, while B, C and D were experimental groups. Injuries were surgically induced at Achilles tendon entheses of rabbits of experimental groups, which were treated with injections of autologous platelet-rich plasma, either at the time of inducing injury or two weeks after injury in groups C and D respectively while group B was left untreated. Animals were sacrificed after 12 weeks. Tissues were processed and stained for hi...

Pakistan Armed Forces Medical Journal

Objective: To assess the ameliorative effects of Prolotherapy on the pain score of the gait cycle... more Objective: To assess the ameliorative effects of Prolotherapy on the pain score of the gait cycle in Monosodium Iodoacetate (MIA) induced osteoarthritis in the rat knee joint. Study Design: Laboratory-based experimental study. Place and Duration of Study: Department of Anatomy, Army Medical College, Rawalpindi in collaboration with the National Institute of Health (NIH), Islamabad and Pathology Lab Pak Emirates Rawalpindi, Pakistan, from Aug to Nov 2021. Methodology: Thirty male Sprague Dawley rats were randomly divided into three groups (n=10 in each group). The control group was Group-A. To induce osteoarthritic changes in Group-B, a single dose of 1mg Monosodium Iodoacetate was injected intra-articularly into the right knee. Group-C received a single dose of 1mg Monosodium Iodoacetate injection in the right knee intra articularly to induce osteoarthritic changes, and was followed by 0.1ml Prolotherapy (3ml of 25% dextrose, 2ml of 2% Xylocaine, 1ml of injection thiamine, and 1ml o...

Objective: To observe the effect of noise on reepithelialization in rat skin wound. Methodology: ... more Objective: To observe the effect of noise on reepithelialization in rat skin wound. Methodology: A Quasi experimental study was conducted in Anatomy Department of Al-Nafees Medical College Isra University Islamabad & National Institute of Health (NIH) Islamabad from June 2015 to February 2016. Thirty male sprague Dawley rats were divided into control and experimental groups by convenient sampling. Each main group comprised of 15 rats. An incision of 2 cm was made on dorsal region of all rats. Control sub groups were left to heal with routine background noise exposure, while experimental sub groups underwent a 4 hour/day intermittent noise exposure of 85-95 db, five days a week for two consecutive weeks. Five rats from each group were sacrificed on day 3, 7 and 14. Wounds were excised, fixed and processed for haematoxilin and eosin stain to see the thickness of epithelium in rat skin wounds Results: Process of reepithelialization was not as significant in noise induced group as notic...

Journal of the College of Physicians and Surgeons Pakistan, 2019

Objective: To evaluate the effects of platelet-rich plasma injection on histological changes of o... more Objective: To evaluate the effects of platelet-rich plasma injection on histological changes of osteoarthritis using the modified Mankin score in monoiodoacetate-induced rat knee model.

Journal of the College of Physicians and Surgeons Pakistan, 2019

Journal of the Pakistan Medical Association, 2020

The aim of this study was to identify the effectiveness of peer-assisted learning while giving pr... more The aim of this study was to identify the effectiveness of peer-assisted learning while giving presentation on assigned anatomy topics in class by medical students for enhancement of their learning and communication skills. Sixty top performing students were selected for the study. They were given assigned topics related to anatomy to presented in the class after taking their consent. The duration of the study was 32 weeks. At the completion of the projects by the students, each of them was interviewed for three to five minutes; the questions were very precise and few in number and were then analysed. Focal group discussions were conducted from the rest of the class who were the audience and enjoyed the activity. The study showed that by conducting such an activity among medical students their knowledge about the subject, communication and teaching skills and confidence are enhanced.

Journal of Islamabad Medical and Dental College, Apr 8, 2024

Pakistan Armed Forces Medical Journal, Dec 27, 2023

Annals of PIMS-Shaheed Zulfiqar Ali Bhutto Medical University, Jul 27, 2019

Objective: To observe the effect of noise on reepithelialization in rat skin wound. Methodology: ... more Objective: To observe the effect of noise on reepithelialization in rat skin wound. Methodology: A Quasi experimental study was conducted in Anatomy Department of Al-Nafees Medical College Isra University Islamabad & National Institute of Health (NIH) Islamabad from June 2015 to February 2016. Thirty male sprague Dawley rats were divided into control and experimental groups by convenient sampling. Each main group comprised of 15 rats. An incision of 2 cm was made on dorsal region of all rats. Control sub groups were left to heal with routine background noise exposure, while experimental sub groups underwent a 4 hour/day intermittent noise exposure of 85-95 db, five days a week for two consecutive weeks. Five rats from each group were sacrificed on day 3, 7 and 14. Wounds were excised, fixed and processed for haematoxilin and eosin stain to see the thickness of epithelium in rat skin wounds Results: Process of reepithelialization was not as significant in noise induced group as noticed in control group (routine noise exposed) Conclusion: Noise adversely affects the skin wound healing by interfering with epidermal regeneration

PubMed, Jul 1, 2023

Objective: To evaluate the histomorphological response of alpha-tocopherol co-administration with... more Objective: To evaluate the histomorphological response of alpha-tocopherol co-administration with carboplatin chemotherapy. Study design: A laboratory-based experimental study. Place and Duration of the Study: Anatomy Department, Army Medical College / National University of Medical Sciences (NUMS), Rawalpindi, Pakistan, from January to December 2021. Methodology: Thirty adult Sprague-Dawley rats were divided into three groups of ten rats each. Control group A received normal diet and water, experimental group B was administered single injection of carboplatin 2.5 mg/Kg intraperitoneally; and experimental group C along with carboplatin injection also received alpha-tocopherol 62.7 mg/Kg daily. At the end of 12 weeks, the euthanasia of animals was done and kidneys were dissected out. Right-sided kidneys were stained with Haematoxylin and Eosin. Micrometry was done to measure the diameters of renal cortical tubules and renal corpuscles. Results: The proximal and distal tubular and luminal diameter and transvertical diameter of renal corpuscle were increased in group B as compared to control group A. In group C, the proximal and distal tubular diameters were 5.175 ± 0.39 µm and 3.88 ± 0.364 µm, respectively; proximal and distal luminal diameters were 2.67 ± 0.35 µm and 1.64 ± 0.24 µm, respectively and transvertical diameter of renal corpuscle was 12.16 ± 0.870 µm. These values were less than experimental group B and closer to that of control group A. Conclusion: Renal microscopic parameters showed improvement in the group administered with alpha-tocopherol. Therefore, alpha-tocopherol has ameliorative effects on carboplatin-induced renal damage. Key words: Alpha-tocopherol, Carboplatin, Renal corpuscle, Tubules.

Pakistan Armed Forces Medical Journal, 2019

Objective: To study the histomorphological effects of platelet rich plasma infusion on number of ... more Objective: To study the histomorphological effects of platelet rich plasma infusion on number of chondrocytes in articular cartilage of monosodium iodoacetate induced osteoarthritic rat knee model. Study Design: Experimental study. Place and Duration of Study: Department of Anatomy, Army Medical College, Rawalpindi from March to May 2018. Methodology: Thirty two healthy adult male rats of 3-4 months of age weighing 200-300 gm were taken. Animals were divided into two groups A and B as control and experimental with 8 and 24 animals respectively. Group B was further subdivided into B1, B2 and B3 with 8 animals in each group. All rats were injected with 50 μl of monoiodoacetate solution in the right knee. Group B1 along with group A was sacrificed on day 14 for establishing the presence of histological features of osteoarthritis (OA). Group B2 was injected with single dose of platelet rich plasma on day 18. Group B3 was not given any treatment. All animals were sacrificed 4 weeks after...

Pakistan Armed Forces Medical Journal, 2019

Objective: To evaluate the effects of autologous platelet-rich plasma on arrangement of collagen ... more Objective: To evaluate the effects of autologous platelet-rich plasma on arrangement of collagen fibers at injured Achilles tendon entheses in rabbits. Study Design: Laboratory-based experimental study. Place and Duration of Study: Department of Anatomy, Army Medical College, Rawalpindi, in collaboration with National Institute of Health, Islamabad, from March to May, 2018. Material and Methods: Forty, healthy, male, “New Zealand white rabbits”, 4-6 months of age, weighing 2000- 2500g, were randomly divided into 4 equal groups (A, B, C and D). Group A served as control, while B, C and D were experimental groups. Injuries were surgically induced at Achilles tendon entheses of rabbits of experimental groups, which were treated with injections of autologous platelet-rich plasma, either at the time of inducing injury or two weeks after injury in groups C and D respectively while group B was left untreated. Animals were sacrificed after 12 weeks. Tissues were processed and stained for hi...

Pakistan Armed Forces Medical Journal

Objective: To determine the toxic effect of mosquito coil smoke inhalation on gross parameters of... more Objective: To determine the toxic effect of mosquito coil smoke inhalation on gross parameters of rat testis and explore the protective effect of Coenzyme Q10on testicular toxicity profile. Study Design: Laboratory-based experimental study. Place and Duration of Study: Department of Anatomy Army Medical College, Rawalpindi in collaboration with National Institute of Health, Islamabad, from Jan 2020 to Dec 2020. Methodology: This study was carried out among 30 male Sprague Dawley rats, distributed into three groups as 10 rats/group; group A served as control group, rats in group B were exposed to allethrin-based mosquito coil smoke 4hours/day for 12 weeks. Rats in group C were administered Coenzyme Q10 (10 mg/kg/day) via oral gavage for 12 weeks along with mosquito coil smoke exposure. At the end of study, gross parameters of body weight gain, testicular weight and volume, and relative tissue body weight index of testis were compared among groups. Results: Rats exposed to mosquito co...

Pakistan Armed Forces Medical Journal

Objective: To evaluate the effects of autologous platelet-rich plasma on arrangement of collagen ... more Objective: To evaluate the effects of autologous platelet-rich plasma on arrangement of collagen fibers at injured Achilles tendon entheses in rabbits. Study Design: Laboratory-based experimental study. Place and Duration of Study: Department of Anatomy, Army Medical College, Rawalpindi, in collaboration with National Institute of Health, Islamabad, from March to May, 2018. Material and Methods: Forty, healthy, male, “New Zealand white rabbits”, 4-6 months of age, weighing 2000- 2500g, were randomly divided into 4 equal groups (A, B, C and D). Group A served as control, while B, C and D were experimental groups. Injuries were surgically induced at Achilles tendon entheses of rabbits of experimental groups, which were treated with injections of autologous platelet-rich plasma, either at the time of inducing injury or two weeks after injury in groups C and D respectively while group B was left untreated. Animals were sacrificed after 12 weeks. Tissues were processed and stained for hi...

Pakistan Armed Forces Medical Journal

Objective: To assess the ameliorative effects of Prolotherapy on the pain score of the gait cycle... more Objective: To assess the ameliorative effects of Prolotherapy on the pain score of the gait cycle in Monosodium Iodoacetate (MIA) induced osteoarthritis in the rat knee joint. Study Design: Laboratory-based experimental study. Place and Duration of Study: Department of Anatomy, Army Medical College, Rawalpindi in collaboration with the National Institute of Health (NIH), Islamabad and Pathology Lab Pak Emirates Rawalpindi, Pakistan, from Aug to Nov 2021. Methodology: Thirty male Sprague Dawley rats were randomly divided into three groups (n=10 in each group). The control group was Group-A. To induce osteoarthritic changes in Group-B, a single dose of 1mg Monosodium Iodoacetate was injected intra-articularly into the right knee. Group-C received a single dose of 1mg Monosodium Iodoacetate injection in the right knee intra articularly to induce osteoarthritic changes, and was followed by 0.1ml Prolotherapy (3ml of 25% dextrose, 2ml of 2% Xylocaine, 1ml of injection thiamine, and 1ml o...

Objective: To observe the effect of noise on reepithelialization in rat skin wound. Methodology: ... more Objective: To observe the effect of noise on reepithelialization in rat skin wound. Methodology: A Quasi experimental study was conducted in Anatomy Department of Al-Nafees Medical College Isra University Islamabad & National Institute of Health (NIH) Islamabad from June 2015 to February 2016. Thirty male sprague Dawley rats were divided into control and experimental groups by convenient sampling. Each main group comprised of 15 rats. An incision of 2 cm was made on dorsal region of all rats. Control sub groups were left to heal with routine background noise exposure, while experimental sub groups underwent a 4 hour/day intermittent noise exposure of 85-95 db, five days a week for two consecutive weeks. Five rats from each group were sacrificed on day 3, 7 and 14. Wounds were excised, fixed and processed for haematoxilin and eosin stain to see the thickness of epithelium in rat skin wounds Results: Process of reepithelialization was not as significant in noise induced group as notic...

Journal of the College of Physicians and Surgeons Pakistan, 2019

Objective: To evaluate the effects of platelet-rich plasma injection on histological changes of o... more Objective: To evaluate the effects of platelet-rich plasma injection on histological changes of osteoarthritis using the modified Mankin score in monoiodoacetate-induced rat knee model.

Journal of the College of Physicians and Surgeons Pakistan, 2019

Journal of the Pakistan Medical Association, 2020

The aim of this study was to identify the effectiveness of peer-assisted learning while giving pr... more The aim of this study was to identify the effectiveness of peer-assisted learning while giving presentation on assigned anatomy topics in class by medical students for enhancement of their learning and communication skills. Sixty top performing students were selected for the study. They were given assigned topics related to anatomy to presented in the class after taking their consent. The duration of the study was 32 weeks. At the completion of the projects by the students, each of them was interviewed for three to five minutes; the questions were very precise and few in number and were then analysed. Focal group discussions were conducted from the rest of the class who were the audience and enjoyed the activity. The study showed that by conducting such an activity among medical students their knowledge about the subject, communication and teaching skills and confidence are enhanced.

Journal of Islamabad Medical and Dental College, Apr 8, 2024

Pakistan Armed Forces Medical Journal, Dec 27, 2023

Annals of PIMS-Shaheed Zulfiqar Ali Bhutto Medical University, Jul 27, 2019

Objective: To observe the effect of noise on reepithelialization in rat skin wound. Methodology: ... more Objective: To observe the effect of noise on reepithelialization in rat skin wound. Methodology: A Quasi experimental study was conducted in Anatomy Department of Al-Nafees Medical College Isra University Islamabad & National Institute of Health (NIH) Islamabad from June 2015 to February 2016. Thirty male sprague Dawley rats were divided into control and experimental groups by convenient sampling. Each main group comprised of 15 rats. An incision of 2 cm was made on dorsal region of all rats. Control sub groups were left to heal with routine background noise exposure, while experimental sub groups underwent a 4 hour/day intermittent noise exposure of 85-95 db, five days a week for two consecutive weeks. Five rats from each group were sacrificed on day 3, 7 and 14. Wounds were excised, fixed and processed for haematoxilin and eosin stain to see the thickness of epithelium in rat skin wounds Results: Process of reepithelialization was not as significant in noise induced group as noticed in control group (routine noise exposed) Conclusion: Noise adversely affects the skin wound healing by interfering with epidermal regeneration

PubMed, Jul 1, 2023

Objective: To evaluate the histomorphological response of alpha-tocopherol co-administration with... more Objective: To evaluate the histomorphological response of alpha-tocopherol co-administration with carboplatin chemotherapy. Study design: A laboratory-based experimental study. Place and Duration of the Study: Anatomy Department, Army Medical College / National University of Medical Sciences (NUMS), Rawalpindi, Pakistan, from January to December 2021. Methodology: Thirty adult Sprague-Dawley rats were divided into three groups of ten rats each. Control group A received normal diet and water, experimental group B was administered single injection of carboplatin 2.5 mg/Kg intraperitoneally; and experimental group C along with carboplatin injection also received alpha-tocopherol 62.7 mg/Kg daily. At the end of 12 weeks, the euthanasia of animals was done and kidneys were dissected out. Right-sided kidneys were stained with Haematoxylin and Eosin. Micrometry was done to measure the diameters of renal cortical tubules and renal corpuscles. Results: The proximal and distal tubular and luminal diameter and transvertical diameter of renal corpuscle were increased in group B as compared to control group A. In group C, the proximal and distal tubular diameters were 5.175 ± 0.39 µm and 3.88 ± 0.364 µm, respectively; proximal and distal luminal diameters were 2.67 ± 0.35 µm and 1.64 ± 0.24 µm, respectively and transvertical diameter of renal corpuscle was 12.16 ± 0.870 µm. These values were less than experimental group B and closer to that of control group A. Conclusion: Renal microscopic parameters showed improvement in the group administered with alpha-tocopherol. Therefore, alpha-tocopherol has ameliorative effects on carboplatin-induced renal damage. Key words: Alpha-tocopherol, Carboplatin, Renal corpuscle, Tubules.

Pakistan Armed Forces Medical Journal, 2019

Objective: To study the histomorphological effects of platelet rich plasma infusion on number of ... more Objective: To study the histomorphological effects of platelet rich plasma infusion on number of chondrocytes in articular cartilage of monosodium iodoacetate induced osteoarthritic rat knee model. Study Design: Experimental study. Place and Duration of Study: Department of Anatomy, Army Medical College, Rawalpindi from March to May 2018. Methodology: Thirty two healthy adult male rats of 3-4 months of age weighing 200-300 gm were taken. Animals were divided into two groups A and B as control and experimental with 8 and 24 animals respectively. Group B was further subdivided into B1, B2 and B3 with 8 animals in each group. All rats were injected with 50 μl of monoiodoacetate solution in the right knee. Group B1 along with group A was sacrificed on day 14 for establishing the presence of histological features of osteoarthritis (OA). Group B2 was injected with single dose of platelet rich plasma on day 18. Group B3 was not given any treatment. All animals were sacrificed 4 weeks after...

Pakistan Armed Forces Medical Journal, 2019

Objective: To evaluate the effects of autologous platelet-rich plasma on arrangement of collagen ... more Objective: To evaluate the effects of autologous platelet-rich plasma on arrangement of collagen fibers at injured Achilles tendon entheses in rabbits. Study Design: Laboratory-based experimental study. Place and Duration of Study: Department of Anatomy, Army Medical College, Rawalpindi, in collaboration with National Institute of Health, Islamabad, from March to May, 2018. Material and Methods: Forty, healthy, male, “New Zealand white rabbits”, 4-6 months of age, weighing 2000- 2500g, were randomly divided into 4 equal groups (A, B, C and D). Group A served as control, while B, C and D were experimental groups. Injuries were surgically induced at Achilles tendon entheses of rabbits of experimental groups, which were treated with injections of autologous platelet-rich plasma, either at the time of inducing injury or two weeks after injury in groups C and D respectively while group B was left untreated. Animals were sacrificed after 12 weeks. Tissues were processed and stained for hi...