Teguh Julianto - Academia.edu (original) (raw)

Papers by Teguh Julianto

2009 IEEE Symposium on Industrial Electronics & Applications, 2009

Nanoparticles now have various pharmaceutical and biomedical applications due to the many advanta... more Nanoparticles now have various pharmaceutical and biomedical applications due to the many advantages such as improvement in drug bioavailability, ability to cross barriers after oral and parentral administration, and being an excellent drug carrier for insoluble drugs. However, size and morphological characteristics of nanoparticles are critical for drug release in the body, warranting understanding the parameters controlling the above characteristics. This paper describes, firstly, preparation parameters to optimize the size of polylactic-co-glycolic acid (PLGA)-based nanoparticles, and secondly, study the morphology of the same nanoparticles, formed by the emulsion solvent evaporation technique. The solvent evaporation technique involves an aqueous phase containing polyvinyl alcohol (PVA) as a stabilizing agent. After washing, the samples were freeze-dried and analyzed using particle size analyzer and scanning electron microscope. The preparation parameters studied included; homogenizing speed, homogenizing time, stabilizer concentration and temperature.

Realization assessment of stabilizer with presonication on size-distribution of itraconazole nanoparticulate in wet-nanomilling

2009 IEEE Symposium on Industrial Electronics & Applications, 2009

Abstract The paper investigates fabrication of itraconazole nanoparticulate in wet-nanomilling by... more Abstract The paper investigates fabrication of itraconazole nanoparticulate in wet-nanomilling by appropriate alteration of the suspension properties and the milling parameters. By wet-nanomilling, stable nano-scale particulate can be prepared which have better physical properties. In this study, effects of adding stabilizer on nanoparticulate size and polydispersity index were performed during production of itraconazole nanoparticulate. In addition, the effect of pre-sonication followed by wet grinding was assessed on the ...

Food Science and Technology Research, 2012

A fast and simple high-performance liquid chromatographic UV-Vis method for the determination of ... more A fast and simple high-performance liquid chromatographic UV-Vis method for the determination of astaxanthin in human plasma was developed and validated. The method involved direct injection of plasma sample after deproteinization using a 1:9 mixture of ethanol-tetrahydrofuran. The mobile phase comprised methanol:water:ethyl acetate (82:8:10% (v/v)) with a total run time of 5 min. Analysis was run at a flow rate of 1.5 mL/min with the detector set at 474nm. This method is specific and sensitive, with a quantification limit of approximately 0.25 µg/mL. The calibration curve was linear over a concentration range of 0.39 − 50.0 µg/mL. The method have a mean absolute recovery of 99%, while the within-day and between day coefficients of variation and percentage errors were all less than 3%. The speed, specificity, sensitivity, reproducibility and stability of this method make it suitable for the determination of human plasma astaxanthin in routine analysis.

Food Science and Technology Research, 2012

Astaxanthin is a naturally xanthophyll abundantly found in Haematococcus pluvaris with strong ant... more Astaxanthin is a naturally xanthophyll abundantly found in Haematococcus pluvaris with strong antioxidant property and it is found to be useful in many biological functions. Recent scientific findings indicate that astaxanthin shows low oral bioavailability due to its lipophilicity. However, the influence of emulsion droplet size on astaxanthin bioavailability is yet to be studied. This study was performed to investigate the effects of emulsion droplet size reduction on the bioavailability of astaxanthin emulsion through oral administration. In vivo study was carried out to evaluate the rate and extent of absorption of macro and nanosized emulsion against oil solution formulation. The nanosized emulsion shows increased C max and AUC 0-∞ and decreased T max values with a reduction of the emulsion globule size. The AUC 0-∞ of nanosize compared to macrosize emulsion and oil solution was increased by 110% − 140% and 140% − 200% respectively.

2009 IEEE Symposium on Industrial Electronics & Applications, 2009

Nanoparticles now have various pharmaceutical and biomedical applications due to the many advanta... more Nanoparticles now have various pharmaceutical and biomedical applications due to the many advantages such as improvement in drug bioavailability, ability to cross barriers after oral and parentral administration, and being an excellent drug carrier for insoluble drugs. However, size and morphological characteristics of nanoparticles are critical for drug release in the body, warranting understanding the parameters controlling the above characteristics. This paper describes, firstly, preparation parameters to optimize the size of polylactic-co-glycolic acid (PLGA)-based nanoparticles, and secondly, study the morphology of the same nanoparticles, formed by the emulsion solvent evaporation technique. The solvent evaporation technique involves an aqueous phase containing polyvinyl alcohol (PVA) as a stabilizing agent. After washing, the samples were freeze-dried and analyzed using particle size analyzer and scanning electron microscope. The preparation parameters studied included; homogenizing speed, homogenizing time, stabilizer concentration and temperature.

Realization assessment of stabilizer with presonication on size-distribution of itraconazole nanoparticulate in wet-nanomilling

2009 IEEE Symposium on Industrial Electronics & Applications, 2009

Abstract The paper investigates fabrication of itraconazole nanoparticulate in wet-nanomilling by... more Abstract The paper investigates fabrication of itraconazole nanoparticulate in wet-nanomilling by appropriate alteration of the suspension properties and the milling parameters. By wet-nanomilling, stable nano-scale particulate can be prepared which have better physical properties. In this study, effects of adding stabilizer on nanoparticulate size and polydispersity index were performed during production of itraconazole nanoparticulate. In addition, the effect of pre-sonication followed by wet grinding was assessed on the ...

Food Science and Technology Research, 2012

A fast and simple high-performance liquid chromatographic UV-Vis method for the determination of ... more A fast and simple high-performance liquid chromatographic UV-Vis method for the determination of astaxanthin in human plasma was developed and validated. The method involved direct injection of plasma sample after deproteinization using a 1:9 mixture of ethanol-tetrahydrofuran. The mobile phase comprised methanol:water:ethyl acetate (82:8:10% (v/v)) with a total run time of 5 min. Analysis was run at a flow rate of 1.5 mL/min with the detector set at 474nm. This method is specific and sensitive, with a quantification limit of approximately 0.25 µg/mL. The calibration curve was linear over a concentration range of 0.39 − 50.0 µg/mL. The method have a mean absolute recovery of 99%, while the within-day and between day coefficients of variation and percentage errors were all less than 3%. The speed, specificity, sensitivity, reproducibility and stability of this method make it suitable for the determination of human plasma astaxanthin in routine analysis.

Food Science and Technology Research, 2012

Astaxanthin is a naturally xanthophyll abundantly found in Haematococcus pluvaris with strong ant... more Astaxanthin is a naturally xanthophyll abundantly found in Haematococcus pluvaris with strong antioxidant property and it is found to be useful in many biological functions. Recent scientific findings indicate that astaxanthin shows low oral bioavailability due to its lipophilicity. However, the influence of emulsion droplet size on astaxanthin bioavailability is yet to be studied. This study was performed to investigate the effects of emulsion droplet size reduction on the bioavailability of astaxanthin emulsion through oral administration. In vivo study was carried out to evaluate the rate and extent of absorption of macro and nanosized emulsion against oil solution formulation. The nanosized emulsion shows increased C max and AUC 0-∞ and decreased T max values with a reduction of the emulsion globule size. The AUC 0-∞ of nanosize compared to macrosize emulsion and oil solution was increased by 110% − 140% and 140% − 200% respectively.