Tejpal Dhewa - Academia.edu (original) (raw)

Papers by Tejpal Dhewa

Nutrition Reviews

Millet is consumed as a staple food, particularly in developing countries, is part of the traditi... more Millet is consumed as a staple food, particularly in developing countries, is part of the traditional diet in a number of relatively affluent countries, and is gaining popularity throughout the world. It is a valuable dietary energy source. In addition to high caloric value, several health-promoting attributes have been reported for millet seeds. This review describes many nutritional characteristics of millet seeds and their derivatives that are important to human health: antioxidant, antihypertensive, immunomodulatory or anti-inflammatory, antibacterial or antimicrobial, hypocholesterolemic, hypoglycemic, and anti-carcinogenic potential, and their role as modulators of gut health. There are several varieties, but the main focus of this review is on pearl millet (Cenchrus americanus [synonym Pennisetum glaucum]), one of the most widely eaten millet crops grown in India, though other millet types are also covered. In this article, the health-promoting properties of the natural compo...

Foods

Antimicrobial resistance (AMR) remains of major interest for different types of food stakeholders... more Antimicrobial resistance (AMR) remains of major interest for different types of food stakeholders since it can negatively impact human health on a global scale. Antimicrobial-resistant bacteria and/or antimicrobial resistance genes (transfer in pathogenic bacteria) may contaminate food at any stage, from the field to retail. Research demonstrates that antimicrobial-resistant bacterial infection(s) occur more frequently in low- and middle-income countries (LMICs) than in developed countries. Worldwide, foodborne pathogens are a primary cause of morbidity and mortality. The spread of pathogenic bacteria from food to consumers may occur by direct or indirect routes. Therefore, an array of approaches both at the national and international level to control the spread of foodborne pathogens and promote food safety and security are essential. Zoonotic microbes can spread through the environment, animals, humans, and the food chain. Antimicrobial drugs are used globally to treat infections ...

Journal of Food Processing and Technology, Aug 23, 2016

Nutrients

Milk-derived bioactive peptides (BAPs) possess several potential attributes in terms of therapeut... more Milk-derived bioactive peptides (BAPs) possess several potential attributes in terms of therapeutic capacity and their nutritional value. BAPs from milk proteins can be liberated by bacterial fermentation, in vitro enzymatic hydrolysis, food processing, and gastrointestinal digestion. Previous evidence suggested that milk protein-derived BAPs have numerous health-beneficial characteristics, including anti-cancerous activity, anti-microbial activity, anti-oxidative, anti-hypertensive, lipid-lowering, anti-diabetic, and anti-osteogenic. In this literature overview, we briefly discussed the production of milk protein-derived BAPs and their mechanisms of action. Milk protein-derived BAPs are gaining much interest worldwide due to their immense potential as health-promoting agents. These BAPs are now used to formulate products sold in the market, which reflects their safety as natural compounds. However, enhanced commercialization of milk protein-derived BAPs depends on knowledge of thei...

Journal of Applied Biology & Biotechnology

Industrialization plays a major role in strengthening the economy of any country. However, these ... more Industrialization plays a major role in strengthening the economy of any country. However, these industries directly or indirectly affect the environment. Industrial wastewater discharge has been reported with certain heavy metals such as chromium, lead, cobalt, and others which are a potential hazard to the water bodies and humans as well. Biofilm is an applied method in the fields of bioremediation for reliving this emerging problem and in the efficient removal of heavy metals from wastewater. Biofilms of Escherichia coli and petroleum soil isolated microorganisms (PSIM) were developed at the V bottom of 96 well microtiter plate. The contaminated water sample was collected from the textile industry, Solan, Himachal Pradesh, India. The biofilms were incubated with the industrial water tested for heavy metals assuming the microbes have the potential to assimilate the heavy metals up to 5 mg/mL of concentration. After the incubation for 1-2 weeks, the microorganisms were able to reduce the level of heavy metals present in the samples which was conveyed by biomass comparison of microorganisms in the successive intervals of time. 0.74 × 10 10 cells/mL and 0.77 × 10 10 cell/mL of E. coli and PSIM biofilms were able to tolerate the metal toxicity on incubation for 2 weeks at the highest concentration due to the functional group present extracellular polymeric substance which forms complexes with heavy metals. This leads to the fact that these biofilms have assimilated the heavy metals and are potent for the removal of heavy metals from industrial wastewater.

Journal of Food and Dietetics Research, 2022

Objectives: The present study assessed the microbial population dynamics and physicochemical test... more Objectives: The present study assessed the microbial population dynamics and physicochemical test during the spontaneous fermentation of pearl millet flour and buttermilk blend. Materials and Methods: Pearl millet flour samples were taken from the local market of Rewari and Mahendergarh district of Haryana, whereas buttermilk samples were taken from nearby villages of Mahendergarh, Haryana. pH and total titratable acidity were estimated for physicochemical analysis of the blend sample. Microbiological analysis has been carried out to estimate the microbiological population dynamics of samples using different media i.e., 1) Potato Dextrose Agar; 2) Plate Count Agar; 3) Lactobacillus MRS agar; 4) Eosin Methylene Blue Agar. Results: The subject study mainly deals with the physicochemical test and microbiological analysis of pearl millet, i.e., pH ranges from 3.0 to 6.84 where it was lowest in buttermilk sample at 72 h, and highest is 6.84 in flour sample at 0 h, temperature ranges from...

Human Nutrition & Metabolism, 2022

Although the scientific studies on the applications of nanotechnology in the agriculture are less... more Although the scientific studies on the applications of nanotechnology in the agriculture are less than a decade old yet the prospects of nanotechnology in this field are considerable. The rapid developments in the nanosciences have a great impact on agricultural practices and food manufacturing industries. Nanotechnology has an enormous potential to offer smarter, stronger, cost-effective packaging materials, biosensors for the rapid detection of the food pathogens, toxins and other contaminants or food adulterants. It is also plays an important role in developing new generation of pesticides with the safe carriers, preservation and packaging of food and food additives, strengthening of natural fibre, removal of various contaminants from the soil and water bodies by using functionalized nanoparticles and improving the shelf-life of the vegetables, flowers and fruits. In spite of the above mentioned immense uses, the competency is being exhibited in some of success business models in...

Journal of Food Biochemistry, 2021

Alzheimer's disease (AD) is the leading type of dementia in aging people and is a progressive... more Alzheimer's disease (AD) is the leading type of dementia in aging people and is a progressive condition that causes neurodegeneration, resulting in confusion, memory loss, and deterioration of mental functions. AD happens because of abnormal twisting of the microtubule tau protein in neurons into a tangled neurofibrillary structure. Different factors responsible for AD pathogenesis include heavy metals, aging, cardiovascular disease, and environmental and genetic factors. Market available drugs for AD have several side effects that include hepato-toxicity, accelerated cognitive decline, worsened neuropsychiatric symptoms, and triggered suicidal ideation. Therefore, an emerging alternative therapeutic approach is probiotics, which can improve AD by modulating the gut-brain axis. Probiotics modulate different neurochemical pathways by regulating the signalling pathways associated with inflammation, histone deacetylation, and microglial cell activation and maturation. In addition, probiotics-derived metabolites (i.e., short-chain fatty acid, neurotransmitters, and antioxidants) have shown ameliorative effects against AD. Probiotics also modulate gut microbiota, with a beneficial impact on neural signalling and cognitive activity, which can attenuate AD progression. Therefore, the current review describes the etiology and mechanism of AD progression as well as various treatment options with a focus on the use of probiotics. PRACTICAL APPLICATIONS: In an aging population, dementia concerns are quite prevalent globally. AD is one of the most commonly occurring cognition disorders, which is linked to diminished brain functions. Scientific evidence supports the findings that probiotics and gut microbiota can regulate/modulate brain functions, one of the finest strategies to alleviate such disorders through the gut-brain axis. Thus, gut microbiota modulation, especially through probiotic supplementation, could become an effective solution to ameliorate AD.

Journal of Biologically Active Products from Nature, 2021

Abstract This article presents the pharmacological potential of numerous conopeptides as antidiab... more Abstract This article presents the pharmacological potential of numerous conopeptides as antidiabetic and anticancer agents. Different mechanisms, pharmacology with their peptide chemistry are also discussed. The study uses a comprehensive, transparent review approach with the analysis of available scientific literature focusing the medicinal applications. It involves the exploration of available literature using databases like Google Scholar, PubMed, Research Gate, and ISI web of knowledge. The relevant data and information were collected from different data sources including scientific databases, peer-review of previous and recently published research, and review articles. It has been found that limited research and comprehensive reviews have focused on investigating the possible antidiabetic and anticancer potential of different conopeptides. It is concluded that conopeptides are highly potent in the development of new generation medicines for diabetes and cancer cure which provide further possibilities in exploring drugs from the marine ecosystem.

Journal of Scientific & Industrial Research, 2018

Nanoparticles have been suggested as useful antibacterial and anti-plaque solutions for patients ... more Nanoparticles have been suggested as useful antibacterial and anti-plaque solutions for patients with dental caries. The purpose of this study was to compare the antimicrobial and antiplaque effects of silver nanoparticles synthesized by using Viola serpens plant. Furthermore, oral cavities are inhabited by both commensal and pathogenic bacterial species. In some conditions bacteria belonging to the indigenous or resident oral microorganisms can lead to infectious dental diseases. The total 40 samples were collected analyzed for the prevalence of Streptococcus mutans (S. mutans ) in dental plaque. Total recovered isolates were 32 out of which 18 S. mutans were isolated, and the prevalence of recovered isolates was found to be 45%. In the present investigation, the evaluation of efficacy of biologically synthesized silver nanoparticles against recovered isolates was performed using agar well diffusion method and were found to be moderately effective against the three strains of S. mu...

Foods, 2021

Edible seeds play a significant role in contributing essential nutritional needs and impart sever... more Edible seeds play a significant role in contributing essential nutritional needs and impart several health benefits to improve the quality of human life. Previous literature evidence has confirmed that edible seed proteins, their enzymatic hydrolysates, and bioactive peptides (BAPs) have proven and potential attributes to ameliorate numerous chronic disorders through the modulation of activities of several molecular markers. Edible seed-derived proteins and peptides have gained much interest from researchers worldwide as ingredients to formulate therapeutic functional foods and nutraceuticals. In this review, four main methods are discussed (enzymatic hydrolysis, gastrointestinal digestion, fermentation, and genetic engineering) that are used for the production of BAPs, including their purification and characterization. This article’s main aim is to provide current knowledge regarding several health-promoting properties of edible seed BAPs in terms of antihypertensive, anti-cancer, ...

Food Production, Processing and Nutrition, 2020

Legumes and cereals contain high amounts of macronutrients and micronutrients but also anti-nutri... more Legumes and cereals contain high amounts of macronutrients and micronutrients but also anti-nutritional factors. Major anti-nutritional factors, which are found in edible crops include saponins, tannins, phytic acid, gossypol, lectins, protease inhibitors, amylase inhibitor, and goitrogens. Anti-nutritional factors combine with nutrients and act as the major concern because of reduced nutrient bioavailability. Various other factors like trypsin inhibitors and phytates, which are present mainly in legumes and cereals, reduce the digestibility of proteins and mineral absorption. Anti-nutrients are one of the key factors, which reduce the bioavailability of various components of the cereals and legumes. These factors can cause micronutrient malnutrition and mineral deficiencies. There are various traditional methods and technologies, which can be used to reduce the levels of these anti-nutrient factors. Several processing techniques and methods such as fermentation, germination, debran...

Probiotics and Antimicrobial Proteins, 2019

Bovicin is a type AII lantibiotic, possessing two β-methyllanthionine and a disulfide bridge enco... more Bovicin is a type AII lantibiotic, possessing two β-methyllanthionine and a disulfide bridge encoded by bovA gene hitherto unknown a couple of decades ago. Bacteriocins can be useful in directly inhibiting methanogens and/or redirecting H 2 to other reductive microorganisms, in particular, propionate producers or reductive acetogens. So far, the role of nisin and bovicin to suppress greenhouse gas (GHG) production under in vitro conditions has been documented. GHG emissions from ruminants are a threat to the environment, because of their role in global warming as well as in climate change. Methane (CH 4) produced from livestock farming practices is a potent GHG, comprising 18% of total GHG emissions in the world. Therefore, minimizing enteric CH 4 production is quite essential from both the economical livestock production as well as environment perspectives. Strategies for the abatement of CH 4 have provided two-way opportunities, viz., improved livestock productivity and reduced GHG emissions. In the past, different strategies have been proposed and tested to mitigate CH 4 , such as the dietary composition of feeds, ionophores, antibiotics, vaccines, analogues, probiotics, and secondary metabolites of plants and fungi. However, quite a few of these strategies have been adopted at farm level due to their varied effect on animal health and/or residues on animal products. The use of bacteriocins might have potential in inhibiting methanogens in the rumen. A bacteriocin produced by Streptococcus bovis (an isolate from rumen) named bovicin HC5 has been exhibited to decrease CH 4 production to an extent of 50%. In this review, authors intend to discuss the sources, structure, biochemical properties, and antimicrobial spectra of bovicins, besides the potential applications with special reference to CH 4 mitigation.

ABSTRACT The study was to determine the probiotic and functional attributes of lactobacilli isola... more ABSTRACT The study was to determine the probiotic and functional attributes of lactobacilli isolates of human origin. For this, faecal samples (n=15) were collected from healthy humans and inoculated on lactobacillus selection agar. Thirty-eight colonies having apparently different morphological characteristics were picked-up and characterized biochemically as six different species of lactobacillus, Lactobacillus casei being the most prevalent one followed by L. acidophilus, L. plantarum, L. fermentum, L. helveticus and L. rhamnosus. All these lactobacillus species were screened for their tolerance to low pH, high bile salt concentrations, and antimicrobial activity against some common microbial pathogens. The tolerance level varied among all the isolates tested, where L. casei showed better survival. All lactobacilli isolates inhibited the growth of E. coli, Staphylococcus aureus, Salmonella typhi and Bacillus cereus. The results for cell surface hydrophobicity, susceptibility against antibiotics, lysozyme tolerance, bile salt hydrolase activity and antioxidative properties also showed that L. casei fulfilled the criteria of a better probiotic during in-vitro screening. Pant. Probiotic and functional attributes of Lactobacillus spp Isolated from human faeces.

Journal of Food Science and Technology

Seven indigenous pearl millet varieties, including non-bio-fortified (HC-10 & HC-20) and bio-... more Seven indigenous pearl millet varieties, including non-bio-fortified (HC-10 & HC-20) and bio-fortified (Dhanashakti) and bio-fortified hybrids, viz., AHB-1200, HHB-299, HHB-311, and RHB-233, were studied in the present work. There was not any significant difference observed in the crucial anti-nutrients content, i.e., phytate (24.88–32.56 mg/g), tannin (3.07–4.35 mg/g), and oxalate (0.33–0.43 mg/g). Phytochemical content and antioxidant activity showed significantly high (p < 0.05) TPC and FRAP, TFC, and DPPH radical scavenging activity in the HHB 299 and Dhanashakti, respectively. Quantitative analysis of polyphenols by HPLC (first report on these varieties) revealed that HHB-299 has the highest amount of gallic acid. Fatty acid profiling by GC-FID showed that Dhanashakti, AHB-1200, and HHB-299 have rich monounsaturated fatty acid (MUFA) and polyunsaturated fatty acids (PUFA). Mineral analysis by ICP-OES showed high iron (87.79 and 84.26 mg/kg) and zinc (55.05 and 52.43 mg/kg) content in the HHB-311 and Dhanashakti, respectively. Results of the present study would help facilitate the formulation of various processed functional food products (RTC/RTE) that are currently not reported/unavailable.