Terence Harrist - Academia.edu (original) (raw)

Papers by Terence Harrist

PubMed, Dec 1, 1984

Histologic changes in skin exposed to psoralen photochemotherapy (PUVA) may be classified as acut... more Histologic changes in skin exposed to psoralen photochemotherapy (PUVA) may be classified as acute or chronic. The acute set of histologic alterations includes changes associated with lesion regression and PUVA toxicity. The chronic set of changes related primarily to the side effects of PUVA therapy. In psoriatic epidermis, morphologic evidence of cellular hyperactivity ceases with accompanying loss of psoriasiform hyperplasia, whereas in other inflammatory disorders the lymphocytic infiltrate is cleared in the epidermis and papillary dermis. In short-term therapy, changes include melanocytic hyperplasia and increased activity with marked keratinocyte hypermelaninosis. In skin chronically exposed to PUVA, all cutaneous compartments are affected with an epidermal maturation disorder, melanocyte activation, as well as dermal collagen and elastic tissue degeneration, some of which persist after cessation of therapy.

PubMed, May 1, 1985

Three cases of adult linear IgA bullous dermatosis were examined to determine the types of IgA pr... more Three cases of adult linear IgA bullous dermatosis were examined to determine the types of IgA present in the basement membrane zone. IgA 1 subclass, without IgA2, was identified in all three cases; J chain was identified in only one case. Secretory component was absent in all cases. Two observations can be made from this study. First, the predominance of monomeric IgA1 is more compatible with the pattern of antibody secretion of plasma cells present in extragut sites than in intestinal sites. These findings are further evidence of the distinction between dermatitis herpetiformis, which has polymeric IgA1, and adult linear IgA bullous dermatosis and may suggest an extragut site for the origin of the antibodies. The second observation is that the antibodies in adult linear IgA bullous dermatosis show limited expression of heavy and light chains and molecular size that cannot be explained by origin in any compartment. The origin of this limitation cannot be determined from the present data, but possible explanations include a monoclonal or oligoclonal origin of the plasma cells secreting the anti-basement membrane antibodies, genetic restriction of either the immunoglobulin repertoire or helper T-cell response such that only an IgA subpopulation is permitted to be produced in response to the antigen, and selective absorption from the sera or deposition in the skin.

Pediatric Dermatology, Nov 1, 2003

We wish to comment on the Clinicopathologic Conference case entitled, ''Yellowish Papules on Flex... more We wish to comment on the Clinicopathologic Conference case entitled, ''Yellowish Papules on Flexural Areas of a Child'' (1). Because of the clinicopathologic Correspondence 543

PubMed, Apr 1, 1996

Vascular permeability factor (VPF), also known as vascular endothelial growth factor (VEGF), play... more Vascular permeability factor (VPF), also known as vascular endothelial growth factor (VEGF), plays an important role in the angiogenesis associated with the growth of many human and animal tumors. VPF/VEGF stimulates endothelial cell growth and increases microvascular permeability by interacting with two endothelial cell tyrosine kinase receptors, KDR and flt-1. We studied 16 cases of AIDS-associated Kaposi's sarcoma (KS), 2 cases of cutaneous angiosarcoma, and 6 cases of capillary hemangioma by in situ hybridization for expression of VPF/VEGF, KDR, and flt-1 mRNAs. We also performed immunohistochemical staining for VPF/VEGF protein in 15 cases. Tumor cells in KS and angiosarcoma strongly expressed KDR but not flt-1 mRNA. Endothelial cells in small stromal vessels in and around these tumors strongly expressed both KDR and flt-1 mRNAs. Tumor cells expressed VPF/VEGF mRNA strongly in only one case of KS, adjacent to an area of necrosis. This was also the only case in which the tumor cells stained substantially for VPF/VEGF protein. VPF/VEGF mRNA and protein were, however, strongly expressed by squamous epithelium in areas of hyperplasia and near areas of ulceration overlying tumors. VPF/VEGF mRNA was also expressed focally at lower levels by infiltrating inflammatory cells, probably macrophages. The strong expression of both KDR and flt-1 in small stromal vessels in and around tumors suggests that VPF/VEGF may be an important regulator of the edema and angiogenesis seen in these tumors. The strong expression of KDR by tumor cells in KS and angiosarcoma implies that VPF/VEGF may also have a direct effect on tumor cells. Tumor cells in four of six capillary hemangiomas strongly expressed both KDR and flt-1 mRNAs in contrast to the high level expression of only KDR observed in the malignant vascular tumors studied. Neither VPF/VEGF mRNA or protein were strongly expressed in capillary hemangiomas. VPF/VEGF and its receptors may play an important but as yet incompletely understood role in the pathogenesis of both benign and malignant vascular tumors.

American Journal of Surgery, Feb 1, 1980

Two cases are described in which therapeutic transcatheter Gelfoam embolization was complicated b... more Two cases are described in which therapeutic transcatheter Gelfoam embolization was complicated by fatal hepatic infarction in one patient and splenic infarction with abscess formation in another patient. These are unusual complications of this widely used therapeutic technique. The probable pathophysiology of these complications is discussed and suggestions for managing and avoiding them are made.

Archives of Dermatology, Apr 1, 1982

On two occasions, erythematous edematous plaques developed on the left side of the neck and the l... more On two occasions, erythematous edematous plaques developed on the left side of the neck and the left shoulder of a man undergoing induction chemotherapy for acute myelogenous leukemia. The lesions resolved after several days in both instances. Histologically, numerous neutrophils surrounded and focally infiltrated the eccrine secretory coils, in which epithelial necrosis was observed. The "fixed" nature of the plaques and temporal relationship to chemotherapy suggest that the lesions represent an unusual reaction to chemotherapeutic agents. It is possible that this unique clinicopathologic picture represents a neutrophilic dermatosis associated with leukemia.

The New England Journal of Medicine, Jun 29, 1978

Presentation of Case A 52-year-old woman was admitted to the hospital because of abdominal pain. ... more Presentation of Case A 52-year-old woman was admitted to the hospital because of abdominal pain. The patient was a poor historian. She was apparently well until 12 years earlier, when polyarthralgi...

Archives of Dermatology, Aug 1, 1980

ABSTRACT

Cancer, Dec 1, 1979

An osteosarcoma developed near the right lesser trochanter of a 55-year-old woman. The neoplasm f... more An osteosarcoma developed near the right lesser trochanter of a 55-year-old woman. The neoplasm fulfilled the generally accepted criteria for a Thorotrast related malignancy. Strenghening this relationship was the occurrence of the tumor in an unusual location and uncommon age group. Thorium waas confirmed both in the tumor and in bone marrow histiocytes by its characteristic x-ray spectrum. Including this

Cancer, Dec 1, 1977

A metastasis from a bronchial carcinoid tumor presented as an isolated breast mass in a 58-year-o... more A metastasis from a bronchial carcinoid tumor presented as an isolated breast mass in a 58-year-old female. A review of the English literature revealed four cases of metastatic carcinoid to the breast that presented as a n isolated breast mass, In each case, radical mastectomy was performed after the lesion had been interpreted clinically and pathologically as a primary carcinoma. When the primary tumor was excised, all cases had either regional lymph node o r liver involvement. A mass was the usual presenting sign of the metastatic deposit. N o metastasis was reported to be greater than 2 cm in diameter. No axillary lymph nodes were reported to contain tumor. Frozen section preparations may not be adequate to differentiate a primary carcinoma of the breast from a metastatic carcinoid tumor, thereby necessitating permanent sections, special stains, review of previously resected neoplasms, o r electron microscopy. The first mammogram of a metastatic carcinoid to the breast is reported with this case.

The New England Journal of Medicine, Apr 29, 1982

Presentation of Case A 77-year-old man was admitted to the hospital because of fever and subcutan... more Presentation of Case A 77-year-old man was admitted to the hospital because of fever and subcutaneous masses. He was well until three months previously, when a dry cough developed. Two months before admission the temperature rose to 38.9°C, accompanied by chills, pleuritic pain, and anorexia. Erythromycin was administered for two weeks, without improvement. He was admitted to another hospital. X-ray films of the chest showed small bilateral pleural effusions. A tuberculin skin test was markedly positive. Repeated blood cultures and cultures of urine and pleural fluid yielded no microorganisms. Cytologic examination of the pleural fluid and microscopical examination of a . . .

Archives of Dermatology, Nov 1, 1981

Two cases of cutaneous malignant mixed tumor occurred in a 70-year-old man and a 69-year-old man.... more Two cases of cutaneous malignant mixed tumor occurred in a 70-year-old man and a 69-year-old man. Nine previously described patients with cutaneous malignant mixed tumor resembled the two patients in this report, both clinically and histologically. All cases with adequate long-term follow-up evaluations were characterized by recurrence or metastasis. In contrast to benign mixed tumors, these tumors tend to occur on the extremities, are of larger size, and may exhibit rapid growth. Histologically, cellular atypism, increased cellularity, increased mitotic rate, invasion of surrounding tissue, and necrosis may be identified.

Archives of Dermatology, Sep 1, 1982

Two unusual sacrococcygeal neuroepithelial heterotopias manifested as masses associated with cuta... more Two unusual sacrococcygeal neuroepithelial heterotopias manifested as masses associated with cutaneous signs. In a 13-month-old infant, a cystic coccygeal medullary vestige was associated with a midline epidermal nevus. In another patient, a lipomeningocele with neuroepithelial heterotopia manifested as a skin tag and mass in the right buttock. In both cases, the malformations probably resulted from abnormal canalization and retrograde differentiation of the distal neural tube. Cystic coccygeal medullary vestige results from dilation of a persistent ependymal cyst present commonly in neonates at the distal part of the coccyx. The lipomeningocele appears to have arisen from an aberrantly formed ependymal canal. The embryologic events that gave rise to the lesions, the differential diagnosis of postrectal masses, and the common association of midline lesions of skin and soft tissue with neural defects are stressed.

The American Journal of Surgical Pathology, May 1, 1989

PubMed, Mar 1, 1984

Linear IgA bullous dermatosis (LAD), also known as "atypical dermatitis herpetiformis," is a diso... more Linear IgA bullous dermatosis (LAD), also known as "atypical dermatitis herpetiformis," is a disorder that is distinct from classic dermatitis herpetiformis (DH). In eight patients with DH and six with LAD, quantitative assessment of a variety of histopathologic variables was made. The number of rete tips with neutrophils in basal vacuoles and the length of the epidermal basement membrane zone (BMZ) associated with these findings were greater in LAD than DH. The number of microabscesses of neutrophils in the dermal papillae and the length of epidermal BMZ associated with them were greater in DH than in LAD. By using the number of microabscesses and the number of rete tips with neutrophils in basal vacuoles in a probability model, we found by retrospective analysis that a correct diagnosis could be made for LAD in 75% of biopsy specimens with a probability of 97% and in all cases of DH with a probability of 92%. Using this model, we made no misdiagnoses. This is the first diagnostic probability model in dermatopathology that expresses a confidence level in diagnosis.

Journal of Investigative Dermatology, Feb 1, 1983

Journal of The American Academy of Dermatology, 1984

We describe a 13-year-old girl with a cardiocutaneous syndrome characterized by an atrial myxoma,... more We describe a 13-year-old girl with a cardiocutaneous syndrome characterized by an atrial myxoma, pigmented lesions of the skin and genital mucosa, and opalescent papules and dermal nodules of the skin and tongue. Her pigmented lesions included black macules of the face and vulva, brown macules of the lips and perioral skin, multiple blue nevi, and a congenital nevomelanocytic nevus. The black and brown macules of the face and vulva consisted of lentiginous proliferations of large, intensely dopa-reactive melanocytes. The opalescent papules and dermal nodules had histologic, ultrastructural, and histochemical characteristics of myxomas. During follow-up, the patient developed thyroid nodules, which were composed of mixed papillary and follicular hyperplasia. This case emphasizes the necessity of a cardiac evaluation for a potentially fatal (and surgically treatable) atrial myxoma in individuals with multiple melanocytic and myxomatous tumors of the skin and mucosa.

Arthritis & Rheumatism, Apr 1, 1980

such as cutaneous vasculitis (4,s) and rOSacea (5-7) give rise to epidermal basement membrane zon... more such as cutaneous vasculitis (4,s) and rOSacea (5-7) give rise to epidermal basement membrane zone immunoglobulin deposition. The bands of immunoglobulin present in these disorders tend to he less intense and more irregular than the immunoglobulin band found in vised form December 26. IY79.

American Journal of Clinical Pathology, Mar 1, 1983

Cutaneous lesions in three cases of histiocytosis-X were studied by light microscopy, electron mi... more Cutaneous lesions in three cases of histiocytosis-X were studied by light microscopy, electron microscopy, and immunoperoxidase technics. In each case, Birbeck granule-containing histiocytosis-X cells infiltrated the epidermis and were apposed to lymphocytes. The histiocytosis-X cells and normal Langerhans cells stained with anti-T6 and anti-U (la-like) antibodies but were negative with anti-T3, anti-T8, anti-Mi, and antilysozyme antibodies. In addition, the histiocytosis-X cells also stained with anti-T4 antibodies, which react with T-cells associated with helper/inducer phenotype. This study supports the hypothesis that histiocytosis-X cells are abnormal Langerhans cells. The presence of T4/T6-positive cells in cutaneous disease may be a marker for abnormal Langerhans cells.