Terry Hammons - Academia.edu (original) (raw)

Papers by Terry Hammons

Research paper thumbnail of Managing for Survival: How Successful Academic Medical Centers Cope With Harsh Environments

Research paper thumbnail of Development and regression of exercise-induced cardiac hypertrophy in rats

American Journal of Physiology-heart and Circulatory Physiology, Feb 1, 1979

Adult female rats were exercised by daily swimming. All the increase in heart weight induced by t... more Adult female rats were exercised by daily swimming. All the increase in heart weight induced by the exercise occurred within 14 days and averaged 30%. The half times of the increases in heart weight and total protein content were about 4.5 days, whereas that of cytochrome c, which was used as a mitochondrial marker, was 6.5 days. The total amounts of DNA and of hydroxyproline in the heart, which were used to evaluate the degree of connective tissue hyperplasia, increased only slightly (8% and 10%, respectively). Other animals were subjected to the same swimming program for 21 days. Groups of rats were killed at various time intervals after stopping exercise. Heart weight, total protein content, and total cytochrome c content decreased rapidly initially, with 60% of the total regression of hypertrophy occurring during the first week. Thereafter, heart weight fell more gradually toward the sedentary control value. The hydroxyproline content of the heart, which was increased 10%, did not decrease during the regression of the hypertrophy.

Research paper thumbnail of Adaptation of fat cells to exercise: response of glucose uptake and oxidation to insulin

Journal of Applied Physiology, Dec 1, 1981

The purpose of this study was to determine whether exercise training alters the sensitivity and r... more The purpose of this study was to determine whether exercise training alters the sensitivity and responsiveness to insulin of glucose uptake and oxidation in fat cells. Female rats were exercised by swimming 6 h/day, 5 days/wk for 12 wk. The swimmers' fat cells were smaller than those of sedentary controls of the same age and similar body weight. A larger amount of insulin was specifically bound by fat cells of the trained rats because of an increase in the number of insulin receptors. The rates of 2-deoxyglucose uptake and of glucose oxidation were higher in fat cells of trained compared with sedentary rats at all insulin concentrations. A maximal insulin stimulus resulted in rates of sugar uptake and oxidation that were about sixfold higher in trained than in sedentary rats' fat cells. This greater responsiveness to insulin could not be explained by the increase in insulin binding but appears to be mediated by adaptation/s) at a step(s) beyond the binding of insulin to its receptors. Our findings suggest that fat cells of exercise-trained animals are adapted for rapid replenishment of energy stores.

Research paper thumbnail of Inhibition by bacitracin of rat adipocyte plasma membrane degradation of 125I-insulin is associated with an increase in plasma membrane bound insulin and a potentiation of glucose oxidation by adipocytes

Journal of Biological Chemistry, Oct 1, 1982

Research paper thumbnail of Time Course of the Development of Cardiac Hypertrophy with Endurance Training

Medicine and Science in Sports and Exercise, 1976

Research paper thumbnail of Physician Payment Reform: An Idea Whose Time Has Come

Medical care review, Jun 1, 1990

... Medicine at the Institute for Health Policy Studies, University of California, San Francisco,... more ... Medicine at the Institute for Health Policy Studies, University of California, San Francisco, and Chairman, Physician Payment Re-view Commission; Lauren B. LeRoy ... This literature has been reviewed critically by Langwell and Nelson (1986) and by Wilensky and Rossiter (1986 ...

Research paper thumbnail of Changing Physician Payment for Medicare Patients

Research paper thumbnail of Glycosylated Hemoglobin and Diabetes Mellitus

Research paper thumbnail of Clinical Trials to Evaluate Cost-Effectiveness

Investigative Radiology, Feb 1, 1989

Research paper thumbnail of Learning to See Simplicity within a Complex Project Through the Lens of Pull Planning

Ideally, project teams should get feedback from foremen from key trades to help guide work struct... more Ideally, project teams should get feedback from foremen from key trades to help guide work structuring decisions early in the design process. Doing so enables project teams to reveal the constructability implications intrinsic to different design options. Then, project owners may make product design decisions that would better support the construction process and thus improve the likelihood of meeting their project goals. Unfortunately, if trade foremen missed the opportunity to influence a project’s product design at project inception, the project team may later face daunting challenges to construct project components that appear complex at first glance. This paper describes such a scenario in the building out of an atrium for a $220 million new hospital addition in the U.S. It explores how the project team used pull planning to reveal production lines that needed to be created to build out the hospital’s fivestory atrium. It explains how the project team considered various work st...

Research paper thumbnail of Initiating Clinical Trials: A Case Study of a Proposed Clinical Trial for Acute Myocardial Infarction

Research paper thumbnail of Managing for Survival: How Successful Academic Medical Centers Cope with Harsh Environments

Research paper thumbnail of Evaluation of three minicolumn procedures for measuring hemoglobin A1

Clinical Chemistry, 1982

We have evaluated three commercially available column-chromatographic methods (Isolab, Helena, an... more We have evaluated three commercially available column-chromatographic methods (Isolab, Helena, and Bio-Rad) for the determination of "fast" hemoglobin (HbA1). All three methods correlated with HbA1c measurements by "high-performance" liquid chromatography for 121 samples from diabetic patients, with the Isolab method showing the highest correlation (r = 0.921). The Isolab and Helena methods gave results that were linear with proportions of HbA1 as great as 30%; results by the Bio-Rad method were slightly nonlinear at values greater than 15%. The Isolab method showed better within- and between-assay precision (CV) than the other two methods and was considered the simplest to perform by each of four different technologists. We recommend use of the Isolab method over the other two tested and believe that this procedure will be valuable for monitoring long-term glycemic control in diabetic patients.

Research paper thumbnail of Variation in Methicillin-ResistantStaphylococcus aureusOccurrence by Geographic Location and Hospital Characteristics

Infection Control, 1987

A survey of 162 Veterans Administration Medical Center (VAMC) laboratories performing antimicrobi... more A survey of 162 Veterans Administration Medical Center (VAMC) laboratories performing antimicrobial susceptibility testing was performed to determine variation in reported rates of methicillin-resistantStaphylococcus aureus(MRSA) isolation by geographic location and hospital characteristics. Of the 162 VAMC laboratories surveyed, 136 (84%) provided usable data. The percentage ofS aureusisolates reported as resistant to methicillin ranged from 0% to 52% with a mean value of 10% among the 136 survey respondents. MRSA were isolated in every VA Medical District and 96% of all respondent laboratories reported isolating at least one MRSA isolate during the preceding year. These data are considered an underestimate of the time MRSA rate in the VA system due to the fact that many laboratories failed to follow key methodologic guidelines for optimal detection of MRSA. A positive correlation was found between MRSA isolation rate and several measures of hospital size and activity including tot...

Research paper thumbnail of Variation from Standards inStaphylococcus aureusSusceptibility Testing

American Journal of Clinical Pathology, 1987

In an effort to assess the degree of methodologic variation and adherence to current guidelines f... more In an effort to assess the degree of methodologic variation and adherence to current guidelines for detection of methicillin-resistant Staphylococcus aureus (MRSA), the authors surveyed the susceptibility testing practices of all 162 microbiology laboratories in the Veterans Administration (VA) system. Completed questionnaires were returned by 136 (84%) of the laboratories. Overall, 96 (71%) laboratories used disk diffusion testing, 54 (40%) used manual broth dilution, and 36 (26%) used an automated method. The percentage of MRSA detected ranged from 0 to 52%, with a mean of 10%. In general, fewer than 60% of laboratories followed the current susceptibility testing guidelines for key methodologic variables such as inoculum preparation, duration of incubation, and medium supplementation. Failure to adhere to these guidelines may result in suboptimal detection of MRSA.

Research paper thumbnail of Glycosylated Hemoglobin and Diabetes Mellitus

Laboratory Medicine, 1981

Research paper thumbnail of Evaluation of the Effects on the Quality of Care of Selected Alternatives for Paying Physicians Under the Medicare Program

This report tries to anticipate the kinds of effects on the quality of personal health care servi... more This report tries to anticipate the kinds of effects on the quality of personal health care services that would result from each of several alternative ways of paying for physician's services to Medicare patients.

Research paper thumbnail of Evaluation of Laboratory Methods for the Classification of Oxacillin-Resistant and Oxacillin-Susceptible Staphylococcus aureus

American Journal of Clinical Pathology, 1988

The purpose of this study was to examine the efficacy of the oxacillin disk diffusion test and th... more The purpose of this study was to examine the efficacy of the oxacillin disk diffusion test and the methicillin and oxacillin agar screen tests as predictors of oxacillin resistance as defined by the reference broth microdilution method. A total of 444 clinical isolates of Staphylococcus aureus collected from individual patients over a four-year period were tested by (1) the oxacillin disk diffusion test, with particular attention to the presence of fine growth of a resistant subpopulation within the zone of inhibition (Ox Grow interpretive criteria); (2) the agar screen method using agar plates with 4% NaCl and either 6 mg/L oxacillin or 10 mg/L methicillin; and (3) the oxacillin and methicillin broth microdilution test methods with 2% NaCl supplementation. Overall, 62 (14%) isolates were resistant and 382 (86%) isolates were susceptible to oxacillin with the use of the reference broth microdilution system. The results indicate that the disk diffusion test with the use of the Ox Grow criteria had a high sensitivity (94%) and negative predictive value (98%) but a low specificity (67%) and positive predictive value (32%) when compared with the reference broth dilution test. Similarly, the agar screen tests had a high sensitivity (95-97%) and negative predictive values (99%) but low specificity (64-74%) and positive predictive values (30-37%). These data indicate that the agar screen tests and the oxacillin disk test with the use of the Ox Grow interpretive criteria may be useful as screening tests for detecting resistance to the penicillinase-resistant penicillins but that all resistant isolates should be confirmed by the reference broth dilution method because of the large number of false-resistant screening test results.

Research paper thumbnail of Evaluation of effects of the quality of care of selected alternatives for paying physicians under the Medicare program

Research paper thumbnail of Physician Payment Reform: Implications for Geriatrics

Journal of the American Geriatrics Society, 1989

A consensus has developed on the need for a major revision of physician reimbursement in the Medi... more A consensus has developed on the need for a major revision of physician reimbursement in the Medicare program. The Physician Payment Review Commission has recommended to Congress a series of far‐reaching changes in the payment system, based on the development of a fee schedule using a Resource Based Relative Value System (RBRVS). This article explores the rationale for the recommendations and the probable impact on Medicare beneficiaries and their physicians if the changes are enacted. Special consideration is given to unique aspects of geriatric medicine, including comprehensive geriatric assessment.

Research paper thumbnail of Managing for Survival: How Successful Academic Medical Centers Cope With Harsh Environments

Research paper thumbnail of Development and regression of exercise-induced cardiac hypertrophy in rats

American Journal of Physiology-heart and Circulatory Physiology, Feb 1, 1979

Adult female rats were exercised by daily swimming. All the increase in heart weight induced by t... more Adult female rats were exercised by daily swimming. All the increase in heart weight induced by the exercise occurred within 14 days and averaged 30%. The half times of the increases in heart weight and total protein content were about 4.5 days, whereas that of cytochrome c, which was used as a mitochondrial marker, was 6.5 days. The total amounts of DNA and of hydroxyproline in the heart, which were used to evaluate the degree of connective tissue hyperplasia, increased only slightly (8% and 10%, respectively). Other animals were subjected to the same swimming program for 21 days. Groups of rats were killed at various time intervals after stopping exercise. Heart weight, total protein content, and total cytochrome c content decreased rapidly initially, with 60% of the total regression of hypertrophy occurring during the first week. Thereafter, heart weight fell more gradually toward the sedentary control value. The hydroxyproline content of the heart, which was increased 10%, did not decrease during the regression of the hypertrophy.

Research paper thumbnail of Adaptation of fat cells to exercise: response of glucose uptake and oxidation to insulin

Journal of Applied Physiology, Dec 1, 1981

The purpose of this study was to determine whether exercise training alters the sensitivity and r... more The purpose of this study was to determine whether exercise training alters the sensitivity and responsiveness to insulin of glucose uptake and oxidation in fat cells. Female rats were exercised by swimming 6 h/day, 5 days/wk for 12 wk. The swimmers' fat cells were smaller than those of sedentary controls of the same age and similar body weight. A larger amount of insulin was specifically bound by fat cells of the trained rats because of an increase in the number of insulin receptors. The rates of 2-deoxyglucose uptake and of glucose oxidation were higher in fat cells of trained compared with sedentary rats at all insulin concentrations. A maximal insulin stimulus resulted in rates of sugar uptake and oxidation that were about sixfold higher in trained than in sedentary rats' fat cells. This greater responsiveness to insulin could not be explained by the increase in insulin binding but appears to be mediated by adaptation/s) at a step(s) beyond the binding of insulin to its receptors. Our findings suggest that fat cells of exercise-trained animals are adapted for rapid replenishment of energy stores.

Research paper thumbnail of Inhibition by bacitracin of rat adipocyte plasma membrane degradation of 125I-insulin is associated with an increase in plasma membrane bound insulin and a potentiation of glucose oxidation by adipocytes

Journal of Biological Chemistry, Oct 1, 1982

Research paper thumbnail of Time Course of the Development of Cardiac Hypertrophy with Endurance Training

Medicine and Science in Sports and Exercise, 1976

Research paper thumbnail of Physician Payment Reform: An Idea Whose Time Has Come

Medical care review, Jun 1, 1990

... Medicine at the Institute for Health Policy Studies, University of California, San Francisco,... more ... Medicine at the Institute for Health Policy Studies, University of California, San Francisco, and Chairman, Physician Payment Re-view Commission; Lauren B. LeRoy ... This literature has been reviewed critically by Langwell and Nelson (1986) and by Wilensky and Rossiter (1986 ...

Research paper thumbnail of Changing Physician Payment for Medicare Patients

Research paper thumbnail of Glycosylated Hemoglobin and Diabetes Mellitus

Research paper thumbnail of Clinical Trials to Evaluate Cost-Effectiveness

Investigative Radiology, Feb 1, 1989

Research paper thumbnail of Learning to See Simplicity within a Complex Project Through the Lens of Pull Planning

Ideally, project teams should get feedback from foremen from key trades to help guide work struct... more Ideally, project teams should get feedback from foremen from key trades to help guide work structuring decisions early in the design process. Doing so enables project teams to reveal the constructability implications intrinsic to different design options. Then, project owners may make product design decisions that would better support the construction process and thus improve the likelihood of meeting their project goals. Unfortunately, if trade foremen missed the opportunity to influence a project’s product design at project inception, the project team may later face daunting challenges to construct project components that appear complex at first glance. This paper describes such a scenario in the building out of an atrium for a $220 million new hospital addition in the U.S. It explores how the project team used pull planning to reveal production lines that needed to be created to build out the hospital’s fivestory atrium. It explains how the project team considered various work st...

Research paper thumbnail of Initiating Clinical Trials: A Case Study of a Proposed Clinical Trial for Acute Myocardial Infarction

Research paper thumbnail of Managing for Survival: How Successful Academic Medical Centers Cope with Harsh Environments

Research paper thumbnail of Evaluation of three minicolumn procedures for measuring hemoglobin A1

Clinical Chemistry, 1982

We have evaluated three commercially available column-chromatographic methods (Isolab, Helena, an... more We have evaluated three commercially available column-chromatographic methods (Isolab, Helena, and Bio-Rad) for the determination of "fast" hemoglobin (HbA1). All three methods correlated with HbA1c measurements by "high-performance" liquid chromatography for 121 samples from diabetic patients, with the Isolab method showing the highest correlation (r = 0.921). The Isolab and Helena methods gave results that were linear with proportions of HbA1 as great as 30%; results by the Bio-Rad method were slightly nonlinear at values greater than 15%. The Isolab method showed better within- and between-assay precision (CV) than the other two methods and was considered the simplest to perform by each of four different technologists. We recommend use of the Isolab method over the other two tested and believe that this procedure will be valuable for monitoring long-term glycemic control in diabetic patients.

Research paper thumbnail of Variation in Methicillin-ResistantStaphylococcus aureusOccurrence by Geographic Location and Hospital Characteristics

Infection Control, 1987

A survey of 162 Veterans Administration Medical Center (VAMC) laboratories performing antimicrobi... more A survey of 162 Veterans Administration Medical Center (VAMC) laboratories performing antimicrobial susceptibility testing was performed to determine variation in reported rates of methicillin-resistantStaphylococcus aureus(MRSA) isolation by geographic location and hospital characteristics. Of the 162 VAMC laboratories surveyed, 136 (84%) provided usable data. The percentage ofS aureusisolates reported as resistant to methicillin ranged from 0% to 52% with a mean value of 10% among the 136 survey respondents. MRSA were isolated in every VA Medical District and 96% of all respondent laboratories reported isolating at least one MRSA isolate during the preceding year. These data are considered an underestimate of the time MRSA rate in the VA system due to the fact that many laboratories failed to follow key methodologic guidelines for optimal detection of MRSA. A positive correlation was found between MRSA isolation rate and several measures of hospital size and activity including tot...

Research paper thumbnail of Variation from Standards inStaphylococcus aureusSusceptibility Testing

American Journal of Clinical Pathology, 1987

In an effort to assess the degree of methodologic variation and adherence to current guidelines f... more In an effort to assess the degree of methodologic variation and adherence to current guidelines for detection of methicillin-resistant Staphylococcus aureus (MRSA), the authors surveyed the susceptibility testing practices of all 162 microbiology laboratories in the Veterans Administration (VA) system. Completed questionnaires were returned by 136 (84%) of the laboratories. Overall, 96 (71%) laboratories used disk diffusion testing, 54 (40%) used manual broth dilution, and 36 (26%) used an automated method. The percentage of MRSA detected ranged from 0 to 52%, with a mean of 10%. In general, fewer than 60% of laboratories followed the current susceptibility testing guidelines for key methodologic variables such as inoculum preparation, duration of incubation, and medium supplementation. Failure to adhere to these guidelines may result in suboptimal detection of MRSA.

Research paper thumbnail of Glycosylated Hemoglobin and Diabetes Mellitus

Laboratory Medicine, 1981

Research paper thumbnail of Evaluation of the Effects on the Quality of Care of Selected Alternatives for Paying Physicians Under the Medicare Program

This report tries to anticipate the kinds of effects on the quality of personal health care servi... more This report tries to anticipate the kinds of effects on the quality of personal health care services that would result from each of several alternative ways of paying for physician's services to Medicare patients.

Research paper thumbnail of Evaluation of Laboratory Methods for the Classification of Oxacillin-Resistant and Oxacillin-Susceptible Staphylococcus aureus

American Journal of Clinical Pathology, 1988

The purpose of this study was to examine the efficacy of the oxacillin disk diffusion test and th... more The purpose of this study was to examine the efficacy of the oxacillin disk diffusion test and the methicillin and oxacillin agar screen tests as predictors of oxacillin resistance as defined by the reference broth microdilution method. A total of 444 clinical isolates of Staphylococcus aureus collected from individual patients over a four-year period were tested by (1) the oxacillin disk diffusion test, with particular attention to the presence of fine growth of a resistant subpopulation within the zone of inhibition (Ox Grow interpretive criteria); (2) the agar screen method using agar plates with 4% NaCl and either 6 mg/L oxacillin or 10 mg/L methicillin; and (3) the oxacillin and methicillin broth microdilution test methods with 2% NaCl supplementation. Overall, 62 (14%) isolates were resistant and 382 (86%) isolates were susceptible to oxacillin with the use of the reference broth microdilution system. The results indicate that the disk diffusion test with the use of the Ox Grow criteria had a high sensitivity (94%) and negative predictive value (98%) but a low specificity (67%) and positive predictive value (32%) when compared with the reference broth dilution test. Similarly, the agar screen tests had a high sensitivity (95-97%) and negative predictive values (99%) but low specificity (64-74%) and positive predictive values (30-37%). These data indicate that the agar screen tests and the oxacillin disk test with the use of the Ox Grow interpretive criteria may be useful as screening tests for detecting resistance to the penicillinase-resistant penicillins but that all resistant isolates should be confirmed by the reference broth dilution method because of the large number of false-resistant screening test results.

Research paper thumbnail of Evaluation of effects of the quality of care of selected alternatives for paying physicians under the Medicare program

Research paper thumbnail of Physician Payment Reform: Implications for Geriatrics

Journal of the American Geriatrics Society, 1989

A consensus has developed on the need for a major revision of physician reimbursement in the Medi... more A consensus has developed on the need for a major revision of physician reimbursement in the Medicare program. The Physician Payment Review Commission has recommended to Congress a series of far‐reaching changes in the payment system, based on the development of a fee schedule using a Resource Based Relative Value System (RBRVS). This article explores the rationale for the recommendations and the probable impact on Medicare beneficiaries and their physicians if the changes are enacted. Special consideration is given to unique aspects of geriatric medicine, including comprehensive geriatric assessment.