Terry Quinn - Academia.edu (original) (raw)

Papers by Terry Quinn

Age and Ageing, Feb 1, 2019

The Cochrane library, Dec 17, 2019

The Cochrane library, Apr 8, 2022

The Cochrane library, Jul 13, 2022

BMC Geriatrics, Mar 23, 2023

Journal of Internal Medicine

BackgroundAntithyroid antibodies increase the likelihood of developing overt hypothyroidism, but ... more BackgroundAntithyroid antibodies increase the likelihood of developing overt hypothyroidism, but their clinical utility remains unclear. No large randomized controlled trial (RCT) has assessed whether older adults with subclinical hypothyroidism (SHypo) caused by autoimmune thyroid disease derive more benefits from levothyroxine treatment (LT4).ObjectiveTo determine whether older adults with SHypo and positive antibodies derive more clinical benefits from LT4 than those with negative antibodies.MethodsWe pooled individual participant data from two RCTs, Thyroid Hormone Replacement for Untreated Older Adults with Subclinical Hypothyroidism and IEMO 80+. Participants with persistent SHypo were randomly assigned to receive LT4 or placebo. We compared the effects of LT4 versus placebo in participants with and without anti–thyroid peroxidase (TPO) at baseline. The two primary outcomes were 1‐year change in Hypothyroid Symptoms and Tiredness scores on the Thyroid‐Related Quality‐of‐Life P...

The Cochrane library, Feb 18, 2020

BMJ Open

IntroductionA growing evidence base demonstrates the effectiveness of supported self-management i... more IntroductionA growing evidence base demonstrates the effectiveness of supported self-management in stroke for stroke survivors and their families. However, there is significant variation in its implementation in community stroke care and little understanding about how supported self-management works and is delivered across different settings, models used and contexts of community stroke rehabilitation.Methods and analysisUsing a mixed method, realist approach across two phases, this protocol describes a study on community-based supported self-management. The aim is to identify the mechanisms and outcomes of supported self-management in stroke and to understand how supported self-management is implemented in different contexts of community stroke rehabilitation. Phase 1 involves (1) a realist synthesis, (2) a scoping and mapping of current community rehabilitation settings and (3) a Q-methodology study to develop initial programme theories about how community-based supported self-man...

The Journal of Clinical Endocrinology & Metabolism, 2022

Context Subclinical thyroid dysfunction and anemia are common disorders, and both have increasing... more Context Subclinical thyroid dysfunction and anemia are common disorders, and both have increasing prevalence with advancing age. Objective The aim of this study was to assess whether levothyroxine treatment leads to a rise in hemoglobin levels in older persons with subclinical hypothyroidism. Methods This preplanned combined analysis of 2 randomized controlled trials included community-dwelling persons aged 65 years and older with subclinical hypothyroidism who were randomly assigned to levothyroxine or placebo treatment. The levothyroxine dose was periodically titrated aiming at thyroid stimulating hormone (TSH) level within the reference range, with mock titrations in the placebo group. The main outcome measure was the change in hemoglobin level after 12 months. Results Analyses included 669 participants (placebo n = 337, levothyroxine n = 332) with a median age of 75 years (range, 65-97) and mean baseline hemoglobin of 13.8 ± 1.3 g/dL. Although levothyroxine treatment resulted in...

The British Journal of Psychiatry, 2021

Edited by Kiriakos Xenitidis and Colin Campbell Contents ▪ Lack of evidence to support the conclu... more Edited by Kiriakos Xenitidis and Colin Campbell Contents ▪ Lack of evidence to support the conclusion that dopaminergic imaging is useful to diagnose mild cognitive impairment with Lewy bodies

Cochrane Database of Systematic Reviews, 2021

Plasma and cerebrospinal fluid ABeta42 for the di erential diagnosis of Alzheimer's disease demen... more Plasma and cerebrospinal fluid ABeta42 for the di erential diagnosis of Alzheimer's disease dementia in participants diagnosed with any dementia subtype in a specialist care setting.

European Heart Journal, 2020

Introduction Atrial Fibrillation (AF) is an important cause of mortality and morbidity. The major... more Introduction Atrial Fibrillation (AF) is an important cause of mortality and morbidity. The major risk of AF is stroke, which can be reduced through anticoagulation. The burden of stroke, and AF-related stroke, is particularly high in Scotland. It is often reported that AF-related stroke is associated with poorer outcomes than other stroke types, it is also thought to lead to an increased institutionalisation. Data supporting these observations are historic, but major advances in AF assessment and treatment could have changed outcome patterns. Real world evidence on outcomes, collected at scale, can give a useful measure of contemporary AF stroke outcomes. Purpose To assess whether stroke patients, with and without AF on admission, differ in terms of al-cause mortality, recurrence of stroke, and care home admission using contemporary large-scale observational data. Methods A retrospective cohort study linking national hospital, prescribing, care home and stroke audit data was conduc...

Gait & Posture, 2019

Sit-to-stand and stand-to-sit transitions can be quantified in free-living condition  These are ... more Sit-to-stand and stand-to-sit transitions can be quantified in free-living condition  These are different between a healthy and a mobility-impaired population  Peak velocity and variation in peak velocity could provide novel outcomes  This information could be used to quantify impairment and monitor age-related changes

Cochrane Database of Systematic Reviews, 2019

Background Dementia assessment often involves initial screening, using a brief tool, followed by ... more Background Dementia assessment often involves initial screening, using a brief tool, followed by more detailed assessment where required. The AD-8 is a short questionnaire, completed by a suitable 'informant' who knows the person well. AD-8 is designed to assess change in functional performance secondary to cognitive change. Objectives To determine the diagnostic accuracy of the informant-based AD-8 questionnaire, in detection of all-cause (undifferentiated) dementia in adults. Where data were available, we described the following: the diagnostic accuracy of the AD-8 at various predefined threshold scores; the diagnostic accuracy of the AD-8 for each healthcare setting and the effects of heterogeneity on the reported diagnostic accuracy of the AD-8.

Annals of internal medicine, Jun 21, 2016

Review: evidence is insufficient to determine the risk-benefit ratio for vision acuity screening ... more Review: evidence is insufficient to determine the risk-benefit ratio for vision acuity screening in older adults. Annals of Internal Medicine, 164(12), JC64. There may be differences between this version and the published version. You are advised to consult the publisher's version if you wish to cite from it.

Cochrane Database of Systematic Reviews, 2015

Background Clinical trials and observational data have variously shown a protective, harmful or n... more Background Clinical trials and observational data have variously shown a protective, harmful or neutral effect of antihypertensives on cognitive function. In theory, withdrawal of antihypertensives could improve cerebral perfusion and reduce or delay cognitive decline. However, it is also plausible that withdrawal of antihypertensives may have a detrimental effect on cognition through increased incidence of stroke or other vascular events. Objectives To assess the effects of complete withdrawal of at least one antihypertensive medication on incidence of dementia, cognitive function, blood pressure and other safety outcomes in cognitively intact and cognitive impaired adults. Search methods We searched ALOIS, the specialised register of the Cochrane Dementia and Cognitive Improvement Group, with additional searches conducted in MEDLINE, Embase, PsycINFO, CINAHL, LILACS, Web of Science Core Collection, ClinicalTrials.gov and the World Health Organization Portal/ICTRP on 12 December 2015. There were no language or date restrictions applied to the electronic searches, and no methodological filters were used to restrict the search. Selection criteria We included randomised controlled trials (RCTs) and controlled clinical trials (CCTs) provided they compared withdrawal of antihypertensive medications with continuation of the medications and included an outcome measure assessing cognitive function or a clinical diagnosis of dementia. We included studies with healthy participants, but we also included studies with participants with all grades of severity of existing dementia or cognitive impairment. Data collection and analysis Two review authors examined titles and abstracts of citations identified by the search for eligibility, retrieving full texts where needed to identify studies for inclusion, with any disagreement resolved by involvement of a third author. Data were extracted independently on primary and secondary outcomes. We used standard methodological procedures expected by Cochrane.

Cochrane Database of Systematic Reviews, 2013

Non-pharmacological interventions for preventing venous insu iciency in a standing worker populat... more Non-pharmacological interventions for preventing venous insu iciency in a standing worker population.

The Lancet Neurology, 2003

Acta Anaesthesiologica Scandinavica, 2007

Background: Becoming critical ill or severely injured leads to a process of worry, anxiety and p... more Background: Becoming critical ill or severely injured leads to a process of worry, anxiety and pain. Patients in intensive care sometimes have strange and frightening experiences and may show symptoms of acute confusion or delirium. CAM‐ICU, the confusion assessment method for the intensive care unit, was based on the DSM IV, the Diagnostic and Statistic Manual of Mental Disorders IV, and today, healthcare professionals and researchers are increasingly accepting this concept of diagnosing ICU delirium. In Sweden, there is no commonly used, single instrument or method to test the development of ICU delirium. The aim of this study was to translate, retranslate and validate CAM‐ICU for use in Swedish ICU settings.Methods: The translation of the instrument was done according to the guidelines suggested by The Translation and Cultural Adaptation group which includes preparation, forward translation/reconciliation, back translation, back translation review, harmonization, cognitive debr...