Terry Wilkins - Academia.edu (original) (raw)

Papers by Terry Wilkins

Clinical Chemistry

This paper compares a logistic curve and a mass-action curve in their ability to represent radioi... more This paper compares a logistic curve and a mass-action curve in their ability to represent radioimmunoassay standard curves. A data base from 10 different assays is used in this comparison. Six of the 10 assays could be modeled equally well by either the logistic or the mass-action curve. In one case the mass-action curve gave a slightly better fit, though the practical distinction was negligible. In the remaining three assays the mass-action curve performed very much worse than the logistic curve. It is shown that the mass-action curve can assume only a very limited range of shapes, which explains its difficulty with these three assays. In particular, the mass-action curve cannot represent assays where the standard curve slope is less than a specified value. The paper also discusses the extension of each of these curves to more complicated equations, and their application to immunoassay data.

Journal of Inorganic and Nuclear Chemistry, 1975

... FRAZER,* FB TAYLOR and TA WILKINSt Department of Chemistry, The Polytechnic of North London, ... more ... FRAZER,* FB TAYLOR and TA WILKINSt Department of Chemistry, The Polytechnic of North London, Holloway Road, London ... were obtained from samples sealed under vacuum in glass capillory tubes (0.01 mm dia) in a Philips PW 1024 DebyeScherrer camera using copper ...

Measurement and Control, 2007

These chapters discuss how structural defects in graphite give rise to localised magnetism and th... more These chapters discuss how structural defects in graphite give rise to localised magnetism and the published experimental results show examples of the transformation and magnetic ordering of graphite into a ferromagnetic phase when bombarded by protons. The book summarises recent and ongoing scientific developments in the subject and provides an explanation of what might cause magnetic behaviour in a structure made entirely of carbon. For the last 20 years chemists have taken an interest in developing new kinds of magnets based on molecules rather than on metals and their oxides and the idea driving this is the creation of a new class of materials with new properties. Fast growing nanotechnology techniques allow scientists to explore the world of molecular magnets on pi-electron systems in particular. The impact on future technology is yet to be determined. This book is highly theoretical and requires knowledge of physical chemistry and quantum physics, or quantum chemistry. The reader is introduced to "first principle" calculations for organic magnets based on established laws of nature. Experimental input to

We describe the first homogeneous, nonradioactive, high-sensitivity assay for human thyrotropin (... more We describe the first homogeneous, nonradioactive, high-sensitivity assay for human thyrotropin (TSH). The assay is based on particle immunoassay techniques, wherein 800-nm particles form the basis for the immunochemistry, delivery, and the detection technologies, respectively. Our assay also is the first to involve the use of fragmented monoclonal antibodies (to eliminate serum interferences) covalently cou-pled to particles without loss of their binding properties. Assays are performed in a semiautomated mode with use of a new modular system (Multipact’TM). Equilibrium is reached in <2 h. Precision profile, sensitivity, and clinical studies indicate that the assay is accurate, has good precision at low concentrations, and that detection-limit characteristics com-pare well with those of a leading commercial high-sensitivity immunoradiometric assay (IRMA) for TSH. Dilution character-

Nanomaterials (Basel, Switzerland), Jan 8, 2018

A central challenge for the safe design of nanomaterials (NMs) is the inherent variability of NM ... more A central challenge for the safe design of nanomaterials (NMs) is the inherent variability of NM properties, both as produced and as they interact with and evolve in, their surroundings. This has led to uncertainty in the literature regarding whether the biological and toxicological effects reported for NMs are related to specific NM properties themselves, or rather to the presence of impurities or physical effects such as agglomeration of particles. Thus, there is a strong need for systematic evaluation of the synthesis and processing parameters that lead to potential variability of different NM batches and the reproducible production of commonly utilized NMs. The work described here represents over three years of effort across 14 European laboratories to assess the reproducibility of nanoparticle properties produced by the same and modified synthesis routes for four of the OECD priority NMs (silica dioxide, zinc oxide, cerium dioxide and titanium dioxide) as well as amine-modified...

Physical Review

The absorption of solar energy by the Earth's atmosphere has been examined from 3p to 21' by mean... more The absorption of solar energy by the Earth's atmosphere has been examined from 3p to 21' by means of a spectroheliometer with intermediate resolving power. Very minute atmospheric windows on the long wave side of 13.5p admit a negligible amount of energy. The principal infrared cutoff of the terrestrial atmosphere occurs at this point and is due to the lowest frequency fundamental (s2) of the carbon dioxide molecule. To the long wave side of v2(CO2) the cutoff is occasioned principally by the pure rotation spectrum of the water molecule. Numerous absorption bands due to CO2, 03 and H20 were observed throughout the spectral limits recorded above. The spectrum is now being analyzed with high resolving power. Complete details of the investigation will be reported in a forthcoming issue of this journal.

Advances in experimental medicine and biology, 2017

Despite the clear benefits that nanotechnology can bring to various sectors of industry, there ar... more Despite the clear benefits that nanotechnology can bring to various sectors of industry, there are serious concerns about the potential health risks associated with engineered nanomaterials (ENMs), intensified by the limited understanding of what makes ENMs toxic and how to make them safe. As the use of ENMs for commercial purposes and the number of workers/end-users being exposed to these materials on a daily basis increases, the need for assessing the potential adverse effects of multifarious ENMs in a time- and cost-effective manner becomes more apparent. One strategy to alleviate the problem of testing a large number and variety of ENMs in terms of their toxicological properties is through the development of computational models that decode the relationships between the physicochemical features of ENMs and their toxicity. Such data-driven models can be used for hazard screening, early identification of potentially harmful ENMs and the toxicity-governing physicochemical propertie...

Journal of Thermal Analysis and Calorimetry, 2016

This is a repository copy of Application of isothermal titration calorimetry in evaluation of pro... more This is a repository copy of Application of isothermal titration calorimetry in evaluation of protein-nanoparticle interactions.

Background to the Study……………………………………………………………. 2. Terms of Reference…………………………………………………………………… 3... more Background to the Study……………………………………………………………. 2. Terms of Reference…………………………………………………………………… 3. Methodology…………………………………………………………………………… 4. The EIT's Business and Operational Model…………………………………….... 5. The KICs in Relation to Existing Open Innovation Ecosystems……………… 6. Progress of 3 Current KIC's Education and Training Programmes………….. 7. Role of EU Business Schools in Training Programmes………………………... 8. Relationship of the EIT to Horizon 2020 Research & Innovation Programme 9. Balanced Scorecard Assessment…………………………………………………… 10. Conclusions…………………………………………………………………………….. 11. Recommendations…………………………………………………………………….. 12. Acknowledgements…………………………………………………………………….

Nanotoxicology, Sep 8, 2016

The number of engineered nanomaterials (ENMs) being exploited commercially is growing rapidly, du... more The number of engineered nanomaterials (ENMs) being exploited commercially is growing rapidly, due to the novel properties they exhibit. Clearly, it is important to understand and minimize any risks to health or the environment posed by the presence of ENMs. Data-driven models that decode the relationships between the biological activities of ENMs and their physicochemical characteristics provide an attractive means of maximizing the value of scarce and expensive experimental data. Although such structure-activity relationship (SAR) methods have become very useful tools for modelling nanotoxicity endpoints (nanoSAR), they have limited robustness and predictivity and, most importantly, interpretation of the models they generate is often very difficult. New computational modelling tools or new ways of using existing tools are required to model the relatively sparse and sometimes lower quality data on the biological effects of ENMs. The most commonly used SAR modelling methods work bes...

Ceramics International, 2015

Page 31. Chapter 2 Recent Developments in Photomultipliers for Liquid Scintillation Counting DE P... more Page 31. Chapter 2 Recent Developments in Photomultipliers for Liquid Scintillation Counting DE PersykandT. T. Lewis RCA Corporation, Lancaster, Pennsylvania, USA INTRODUCTION Considerable new interest is being expressed in the field of liquid scintillation counting. ...