Tevfik Özlü - Academia.edu (original) (raw)
Papers by Tevfik Özlü
International Journal of Chronic Obstructive Pulmonary Disease, 2020
In order to determine the clinical and sociodemographic characteristics of newly diagnosed treatm... more In order to determine the clinical and sociodemographic characteristics of newly diagnosed treatment-naïve asthma and COPD patients in Turkey, a multicenter study in 2012 was initiated. We aimed to investigate the characteristics and therapies of COPD patients in the original study in more detail. Patients and Methods: This nationwide , multicentric, non-interventional, prospective, reallife observational cohort study was conducted in 122 centers. The newly diagnosed patients were not receiving any treatment before the recruitment. Their general characteristics, the combined GOLD 2011 COPD categories and exacerbation histories were noted. The patients were followed up with 3 voluntary visits for 1 year. Their adherence to the inhaled treatment according to GOLD 2011 was evaluated during follow-up visits. Results: The study included 776 COPD patients. Their mean age was 59.4±9.1 years, and 11.9% of the patients were female. 35.1% of the patients were in the GOLD 2011 C and D category. 12.6% are frequent exacerbators, and 52.8% had at least one comorbid condition. 71.8% overtreatment rate was detected. Their attendance rates for three follow-up visits became 55.9%, 32.9% and 18.7%, respectively. The adherence rate to the treatment was measured as 81.9%. Conclusion: Although these patients were diagnosed for the first time, the GOLD C and D categories and frequent exacerbator phenotype were found at a high rate. They were usually prescribed an overtreatment regimen. We think that newly diagnosed COPD patients should be evaluated carefully, and best effort should be made to treat these patients in accordance with the recommendations of the major COPD guidelines.
Journal of Allergy and Clinical Immunology, 2014
Clinical challenges in elderly asthma Introduction: Understanding the difference of elderly asthm... more Clinical challenges in elderly asthma Introduction: Understanding the difference of elderly asthma is essential to provide better healthcare for this vulnerable population. The aim of this study was to evaluate the differences between young and elderly asthma patients. Materials and Methods: This real-life study was designed as a cross-sectional analysis. All data collected with structured web based asthma program. In sum, 373 (89.9%) young asthma (YA, age < 65) and 42 (10.1%) elderly asthma (EA, age ≥ 65) patients followed at least one year and compared statistically. results: Cough is found higher in EA (p< 0.01) despite lower smoking rate in EA (p< 0.001). Allergic rhinitis and allergic conjunctivitis were more common in YA (p< 0.05, p< 0.01) which is consistent with higher allergy rate in YA (p< 0.05). On the other hand, diabetes and hypertension were determined significantly higher in EA (p< 0.01, p< 0.01). 52.4% of EA patients were found to have low diffusion capacity (DLCO < 80%). Although EA patients use combined therapies with inhaled corticosteroids and long acting beta agonists more than YA patients (p< 0.01), both emergency room visit (ERV) and hospitalization ratios are founded significantly higher in EA (p< 0.001, p< 0.001). Conclusion: EA patients were presented with cough in general. They possess an increased risk of hypertension, diabetes and low levels of diffusion capacity. ERV and hospitalization ratios have founded higher despite higher usage of combined therapies.
Mucosa, 2020
The World Health Organization reported in the early days of 2020 that the world was facing a new ... more The World Health Organization reported in the early days of 2020 that the world was facing a new coronavirus, a potential pandemic agent. Its etiological agent is the SARS-CoV-2 from the Coronaviridae family, located in the same subfamily as the SARS-CoV, which also appeared in China in November 2002. The agent is an enveloped, positive-stranded RNA virus. It is thought to be of bat origin. While its disease has been initially described as a non-fatal pneumonia, it is now described as Covid-19 disease with a 3.4% mortality rate. The virus, hence the disease, which began in China in late 2019, has spread to 133 countries and autonomous regions, including Turkey in mid-March of 2020. High fever, following dry cough, fatigue, sputum production, respiratory distress, sore throat, headache, muscle and joint pain are the most common symptoms. It can be fatal in the elderly and those with some comorbid diseases. Although various antivirals are tried for its treatment, no approved specific ...
International Journal of Chronic Obstructive Pulmonary Disease, 2020
In order to determine the clinical and sociodemographic characteristics of newly diagnosed treatm... more In order to determine the clinical and sociodemographic characteristics of newly diagnosed treatment-naïve asthma and COPD patients in Turkey, a multicenter study in 2012 was initiated. We aimed to investigate the characteristics and therapies of COPD patients in the original study in more detail. Patients and Methods: This nationwide , multicentric, non-interventional, prospective, reallife observational cohort study was conducted in 122 centers. The newly diagnosed patients were not receiving any treatment before the recruitment. Their general characteristics, the combined GOLD 2011 COPD categories and exacerbation histories were noted. The patients were followed up with 3 voluntary visits for 1 year. Their adherence to the inhaled treatment according to GOLD 2011 was evaluated during follow-up visits. Results: The study included 776 COPD patients. Their mean age was 59.4±9.1 years, and 11.9% of the patients were female. 35.1% of the patients were in the GOLD 2011 C and D category. 12.6% are frequent exacerbators, and 52.8% had at least one comorbid condition. 71.8% overtreatment rate was detected. Their attendance rates for three follow-up visits became 55.9%, 32.9% and 18.7%, respectively. The adherence rate to the treatment was measured as 81.9%. Conclusion: Although these patients were diagnosed for the first time, the GOLD C and D categories and frequent exacerbator phenotype were found at a high rate. They were usually prescribed an overtreatment regimen. We think that newly diagnosed COPD patients should be evaluated carefully, and best effort should be made to treat these patients in accordance with the recommendations of the major COPD guidelines.
Journal of Allergy and Clinical Immunology, 2014
Clinical challenges in elderly asthma Introduction: Understanding the difference of elderly asthm... more Clinical challenges in elderly asthma Introduction: Understanding the difference of elderly asthma is essential to provide better healthcare for this vulnerable population. The aim of this study was to evaluate the differences between young and elderly asthma patients. Materials and Methods: This real-life study was designed as a cross-sectional analysis. All data collected with structured web based asthma program. In sum, 373 (89.9%) young asthma (YA, age < 65) and 42 (10.1%) elderly asthma (EA, age ≥ 65) patients followed at least one year and compared statistically. results: Cough is found higher in EA (p< 0.01) despite lower smoking rate in EA (p< 0.001). Allergic rhinitis and allergic conjunctivitis were more common in YA (p< 0.05, p< 0.01) which is consistent with higher allergy rate in YA (p< 0.05). On the other hand, diabetes and hypertension were determined significantly higher in EA (p< 0.01, p< 0.01). 52.4% of EA patients were found to have low diffusion capacity (DLCO < 80%). Although EA patients use combined therapies with inhaled corticosteroids and long acting beta agonists more than YA patients (p< 0.01), both emergency room visit (ERV) and hospitalization ratios are founded significantly higher in EA (p< 0.001, p< 0.001). Conclusion: EA patients were presented with cough in general. They possess an increased risk of hypertension, diabetes and low levels of diffusion capacity. ERV and hospitalization ratios have founded higher despite higher usage of combined therapies.
Mucosa, 2020
The World Health Organization reported in the early days of 2020 that the world was facing a new ... more The World Health Organization reported in the early days of 2020 that the world was facing a new coronavirus, a potential pandemic agent. Its etiological agent is the SARS-CoV-2 from the Coronaviridae family, located in the same subfamily as the SARS-CoV, which also appeared in China in November 2002. The agent is an enveloped, positive-stranded RNA virus. It is thought to be of bat origin. While its disease has been initially described as a non-fatal pneumonia, it is now described as Covid-19 disease with a 3.4% mortality rate. The virus, hence the disease, which began in China in late 2019, has spread to 133 countries and autonomous regions, including Turkey in mid-March of 2020. High fever, following dry cough, fatigue, sputum production, respiratory distress, sore throat, headache, muscle and joint pain are the most common symptoms. It can be fatal in the elderly and those with some comorbid diseases. Although various antivirals are tried for its treatment, no approved specific ...