Thao Pham - Academia.edu (original) (raw)

Papers by Thao Pham

Research paper thumbnail of ARTIST (Arthrose Intervention STandardisée). Évaluation de l'impact d'une standardisation des consultations chez les malades atteints de gonarthrose. Un essai randomisé en cluster

Revue du Rhumatisme, 2007

Research paper thumbnail of Mise à jour des recommandations de la Société française de rhumatologie pour l'utilisation des agents anti-TNFα chez les personnes souffrant de spondylarthrite ankylosante (SA) et de rhumatisme psoriasique (RP)

Revue du Rhumatisme, 2007

Mise à jour des recommandations de la Société française de rhumatologie pour l'utilisation des ag... more Mise à jour des recommandations de la Société française de rhumatologie pour l'utilisation des agents anti-TNFα chez les personnes souffrant de spondylarthrite ankylosante (SA) et de rhumatisme psoriasique (RP)

Research paper thumbnail of MRI in axial spondyloarthritis: From light to shadow?

Joint Bone Spine, 2015

Joint Bone Spine - In Press.Proof corrected by the author Available online since mercredi 3 juin ... more Joint Bone Spine - In Press.Proof corrected by the author Available online since mercredi 3 juin 2015

Research paper thumbnail of Modalités pratiques d’utilisation des glucocorticoïdes chez les patients souffrant de polyarthrite rhumatoïde : élaboration de recommandations pour la pratique clinique, à partir d’une analyse systématique de la littérature et de l’opinion d’experts

Revue du Rhumatisme, 2008

... Ga l Mouterde c , Jean-Francis Maillefert d , Jacques Tebib e , Alain Cantagrel f , Pascal Cl... more ... Ga l Mouterde c , Jean-Francis Maillefert d , Jacques Tebib e , Alain Cantagrel f , Pascal Claudepierre g ... raideur matinale persistante et importante, il peut tre indiqu de proposer une prise de glucocortico des le soir. ... Ils ont t valu s selon l index de Ritchie et de Landsbury, le DM, l ...

Research paper thumbnail of L'évaluation clinique et biologique dans la prise en chargede personnes souffrant de polyarthrite rhumatoïde etablissement de recommandations pour la pratique clinique à partir de données de la littérature et d'opinions d'experts (Rencontres d'experts en rhumatologie)

Revue du Rhumatisme, 2004

... 321–327. Full Text via CrossRef | View Record in Scopus | Cited By in Scopus (67). HA Fuchs, ... more ... 321–327. Full Text via CrossRef | View Record in Scopus | Cited By in Scopus (67). HA Fuchs, RH Brooks, LF Callahan and T. Pincus, A simplified twentyeight-joint quantitative articular index in rheumatoid arthritis, Arthritis Rheum 32 (1989), pp. 531–537. ...

Research paper thumbnail of Définition et traitement d’une polyarthrite rhumatoïde sévère d’emblée en 2010 : analyse systématique de la littérature

Revue du Rhumatisme, 2011

Objectif.-Les formes sévères de polyarthrite rhumatoïde (PR) sont plus pourvoyeuses de destructio... more Objectif.-Les formes sévères de polyarthrite rhumatoïde (PR) sont plus pourvoyeuses de destructions articulaires, notamment dès le début de la maladie. Leur défi nition claire est une nécessité afi n de les traiter rapidement. L'objectif est de défi nir le diagnostic et le traitement d'une PR précoce sévère d'emblée en 2010. Méthodes.-Une revue systématique de la littérature utilisant Pubmed, Embase et Cochrane de 1966 à janvier 2010 a été réalisée. Les études donnant les caractéristiques d'une PR sévère et celles évaluant l'effi cacité du méthotrexate (MTX) en monothérapie versus MTX + anti-TNF prescrits d'emblée dans la PR précoce ont été inclues. Résultats.-Pour le diagnostic de PR sévère, 18 études ont été retenues. Les critères de sévérité d'une PR précoce sont l'atteinte structurale (14/18) et notamment les érosions radiographiques (11/18), le syndrome infl ammatoire biologique (10/18), le nombre de synovites (6/18) et la présence d'un facteur rhumatoïde positif (12/18). Le traitement de la PR sévère par l'association MTX + anti-TNF d'emblée est plus effi cace que le MTX seul sur la rémission clinique, l'aggravation structurale et le HAQ en cas de maintien de la monothérapie par MTX pendant 9 à 12 mois. Si l'ajout de l'anti-TNF à la monothérapie par MTX est différée de trois mois dans le cas d'une PR évolutive, il n'y a plus de différence statistique par rapport à l'association d'emblée anti-TNF + MTX. Conclusion.-Est défi nie comme sévère d'emblée une PR avec une atteinte structurale, des facteurs rhumatoïdes ou anti-CCP positifs, une infl ammation biologique ou plusieurs synovites. Du MTX seul peut être débuté avec l'ajout d'un anti-TNF après 3 mois de monothérapie si la PR reste active.

Research paper thumbnail of Infections induites par de faibles doses de corticoïdes dans la polyarthrite rhumatoïde : revue systématique de la littérature

Revue du Rhumatisme, 2010

Objectif.-Étudier l'association entre le risque infectieux et de faibles doses de corticoïdes (FD... more Objectif.-Étudier l'association entre le risque infectieux et de faibles doses de corticoïdes (FD-CT, définie par une posologie quotidienne inférieure à 10 mg par jour de prednisone) dans la polyarthrite rhumatoïde (PR). Méthodes.-Source des données : une revue systématique de la littérature jusqu'en juin 2009 a été réalisée. Extraction des données : tous les types d'infection : bactérienne, virale et postopératoire, sévérité de l'infection, activité de la PR, sévérité de la PR, comorbidités. Analyse des données: descriptive, comparant le risque infectieux des patients atteints de PR et traités par FD-CT et celui des patients non traités par FD-CT. Résultats.-Sur les 1310 publications dénombrées, l'analyse en a identifié 15 évaluant le risque infectieux chez des patients atteints de PR et traités par FD-CT. Parmi les huit références qui étudiaient tous les types d'infection, six articles n'ont pas trouvé d'association entre le risque infectieux et un traitement par FD-CT, un a montré une association entre les infections sévères et un traitement par FD-CT (Odds Ratio [OR] = 8 [1-64]), et un autre a montré une association dose-dépendante aussi bien pour des doses inférieures à 5 mg par jour : rapport de proportion du score de propension (RR) = 1,32 (1,06-1,63) que pour des doses comprises entre 6 et 10 mg par jour : RR=1,95 [1,53-2,46]. Parmi les trois essais qui se sont intéressés à au risque secondaire infectieux bactérien, un a montré une augmentation du risque (Hazard Ratio [HR] = 1,7 [1,5-2,0]) alors que cette augmentation n'était pas observée dans les deux autres articles (exposition respective à des doses inférieures à 5 mg par jour : OR = 1,34 [0,85-2,13] ; 6 à 9 mg par jour : OR=1,53 [0,95-2,48] et inférieure à 5 mg par jour : OR=1,49 [0,82-2,72] ; 5 à 10 mg par jour : OR=1,46 [0,84-2,54]). Aucun des trois essais portant sur le risque infectieux postopératoire n'a trouvé d'association entre le risque infectieux et un traitement par FD-CT. Deux articles se sont intéressés au risque de zona et n'ont identifié d'association avec le traitement par FD-CT. Conclusion.-Bien qu'il existe un manque de données concernant le risque infectieux associé aux traitements par FD-CT dans la PR, ce risque semble très peu augmenté. Ces résultats auront besoin d'être confirmés par d'autres études.

Research paper thumbnail of Comment définir l’activité d’une spondylarthrite ?

Revue du Rhumatisme, 2011

... Séverine Neveu a* , Yannick Degboé b , Divi Cornec c , Thao Pham d , Daniel Wendling e , Al... more ... Séverine Neveu a* , Yannick Degboé b , Divi Cornec c , Thao Pham d , Daniel Wendling e , Alain Cantagrel b , Bruno Fautrel fa Service de Rhumatologie, CHU Saint Antoine, Paris, France b Service de Rhumatologie, CHU Purpan ... 54] Madsen OR, Rytter A, Hansen LB, et al. ...

Research paper thumbnail of Spondylarthrite et gammapathie monoclonale

Revue du Rhumatisme, 2012

Research paper thumbnail of Spondylarthritis and monoclonal gammopathy

Research paper thumbnail of The DESIR cohort: A 10-year follow-up of early inflammatory back pain in France: Study design and baseline characteristics of the 708 recruited patients

Joint Bone Spine, 2011

Objectives: The French Society of Rheumatology has initiated a large national multicenter, longit... more Objectives: The French Society of Rheumatology has initiated a large national multicenter, longitudinal, prospective follow-up of patients presenting with early inflammatory back pain in order to set up a database to facilitate several investigations on diagnosis, prognosis, epidemiology, pathogenesis and medico-economics in the field of early inflammatory back pain and spondyloarthritis. Methods: Patients were recruited if they had inflammatory back pain of more than 3 months and less than 3 years. Patients will be followed every 6 months during the first 2 years then every year during at least 5 years. Apart from information collected on a Case Report Form (demographics, disease activity, severity, co-morbidities, socio-economics, treatments, radiological and MRI evaluation of the spine and the pelvis according to the local investigators, and for some centers bone densitometry and ultrasonography of entheses), the digital X-rays and MRI of the spine and pelvis are stored using a specific software (Carestream) and the biological samples (DNA, RNA, sera, urines) are centralized at the Biological Resources Center (Bichat Hospital). Results: The recruitment peri-B27 positive: 57%) in the 25 centers was 26 months (from December 2007 to April 2010). The modified New York criteria, Amor criteria, ESSG criteria and axial ASAS criteria were fulfilled by 26%, 77%, 76% and 67% of the patients at entry respectively. A history or current symptoms suggestive of peripheral arthritis, acute anterior uveitis and inflammatory bowel disease were observed in 21%, 9% and 4% of the patients respectively. The disease was a the patients. Conclusion: This large cohort should facilitate the conduct of researches in different areas (clinical, medico-economics, translational) in order to improve our knowledge on the pathogenesis and natural history of axial spondyloarthritis.

Research paper thumbnail of Structural evaluation in the management of patients with rheumatoid arthritis: development of recommendations for clinical practice based on published evidence and expert opinion

Joint Bone Spine, 2005

Objectives.-To develop French evidence-based recommendations for the structural evaluation of rhe... more Objectives.-To develop French evidence-based recommendations for the structural evaluation of rheumatoid arthritis (RA) in everyday practice. Methods.-A scientific committee selected 10 questions using the Delphi consensus procedure. Evidence-based responses to each question were sought by searching the PubMed and Ovid databases and the abstract databases for the 2002, 2003, and 2004 annual meetings of the French Society for Rheumatology, the EULAR, and the American College of Rheumatology. The following indexing terms were used: rheumatoid arthritis, arthritis, patient, diagnostic imaging, radiography, joint, erosion, and joint space width. All articles published in French or English prior to May 2004 were identified. The evidence from these articles was reported to a panel of 77 rheumatologists working in hospital or office practice. The panel developed detailed recommendations, filling gaps in evidence with their expert opinion. The strength of each recommendation was determined. Results.-The 10 questions probed the structural evaluation of RA by plain radiography, magnetic resonance imaging (MRI), and ultrasonography, both for diagnostic and monitoring purposes. The literature search retrieved 673 publications, of which 166 were selected and reviewed. The panel developed 10 recommendations, one for each question, which were accepted by consensus. Conclusion.-Recommendations relative to the diagnosis or monitoring of structural involvement in patients with RA in everyday practice were developed. They should help to improve practice uniformity and, ultimately, to improve the management of RA.

Research paper thumbnail of Methotrexate therapy for rheumatoid arthritis: clinical practice guidelines based on published evidence and expert opinion

Joint Bone Spine, 2006

... practice [13]. 2. Methods. The procedure for developing the recommendations involved several ... more ... practice [13]. 2. Methods. The procedure for developing the recommendations involved several steps, as detailed in the article by Pham et al. [14] and [15]. 2.1. Selection of topics by the scientific committee members. The scientific ...

Research paper thumbnail of Use of glucocorticoids in rheumatoid arthritis – Pratical modalities of glucocorticoid therapy: Recommendations for clinical practice based on data from the literature and expert opinion

Joint Bone Spine, 2010

To develop recommendations about the use of glucocorticoids in patients with established rheumato... more To develop recommendations about the use of glucocorticoids in patients with established rheumatoid arthritis (RA) managed in everyday practice, using the evidence-based approach and expert opinion. A three-step procedure was used: a scientific committee used a Delphi procedure to select five questions, which formed the basis for developing the recommendations; a systematic literature review was conducted by searching the Medline and Embase databases and the abstracts of meetings held by the Société Française de Rhumatologie (SFR), American College of Rheumatology (ACR), and European League Against Rheumatism (EULAR); and recommendations were developed and validated by a panel of experts based on the data from the literature review and on their experience. For each recommendation, the level of evidence and extent of agreement among experts were determined. The five questions pertained to the use of glucocorticoids in RA patients: role for intravenous glucocorticoid bolus therapy, role for intraarticular injections, and practical modalities of glucocorticoid administration and discontinuation. From the literature search, 93 articles were selected based on their titles and abstracts. Of these, 50 were selected for the literature review. Eight recommendations about the use of glucocorticoid therapy in everyday practice in patients with established RA were validated by a vote among all participating experts: bolus glucocorticoid therapy should be reserved for highly selected situations; triamcinolone hexacetonide is the preferred glucocorticoid for intraarticular therapy, and the joint should be rested for about 24h after the injection; for oral glucocorticoid therapy, agents with a short half-life taken once daily should be preferred; and when discontinuing glucocorticoid therapy, the patient and usual physician should be informed of the risk of adrenal insufficiency.

Research paper thumbnail of Recommendations of the French Society for Rheumatology (SFR) on the everyday management of patients with spondyloarthritis

Joint Bone Spine, 2014

The management of spondyloarthritis is challenging and has changed with the development of new co... more The management of spondyloarthritis is challenging and has changed with the development of new concepts and treatments. Objective: To develop practice guidelines for the everyday management of patients with spondyloarthritis (including psoriatic arthritis), by updating previous national and international recommendations, based on a review of recently published data. Methods: A task force and a multidisciplinary literature review group were established. The task force identified the issues that remained unresolved. Based on existing recommendations and recent publications, the task force developed practice guidelines, which were revised by the literature review group and graded according to AGREE. Results: Practice guidelines for the management of spondyloarthritis are reported. After a review of the general diagnostic principles, 30 practice guidelines are given: 5 on general principles, 4 on the management strategy, 5 on non-pharmacological treatments, 7 on conventional pharmacological treatments, 6 on biotherapies, and 3 on surgical treatments and follow-up. Conclusion: The updated practice guidelines reported here constitute a global framework that can guide physicians in the everyday management of spondyloarthritis.

Research paper thumbnail of Effect of response format for clinical vignettes on reporting quality of physician practice

BMC Health Services Research, 2009

Background: Clinical vignettes have been used widely to compare quality of clinical care and to a... more Background: Clinical vignettes have been used widely to compare quality of clinical care and to assess variation in practice, but the effect of different response formats has not been extensively evaluated. Our objective was to compare three clinical vignette-based survey response formats-open-ended questionnaire (A), closed-ended (multiple-choice) questionnaire with deceptive response items mixed with correct items (B), and closed-ended questionnaire with only correct items (C)-in rheumatologists' pre-treatment assessment for tumor-necrosis-factor (TNF) blocker therapy. Methods: Study design: Prospective randomized study. Setting: Rheumatologists attending the 2004 French Society of Rheumatology meeting. Physicians were given a vignette describing the history of a fictitious woman with active rheumatoid arthritis, who was a candidate for therapy with TNF blocking agents, and then were randomized to receive questionnaire A, B, or C, each containing the same four questions but with different response formats, that asked about their pretreatment assessment. Measurements: Long (recommended items) and short (mandatory items) checklists were developed for pretreatment assessment for TNF-blocker therapy, and scores were expressed on the basis of responses to questionnaires A, B, and C as the percentage of respondents correctly choosing explicit items on these checklists. Statistical analysis: Comparison of the selected items using pairwise Chi-square tests with Bonferonni correction for variables with statistically significant differences. Results: Data for all surveys distributed (114 As, 118 Bs, and 118 Cs) were complete and available for analysis. The percentage of questionnaire A, B, and C respondents for whom data was correctly complete for the short checklist was 50.4%, 84.0% and 95.0%, respectively, and was 0%, 5.0% and 5.9%, respectively, for the long version. As an example, 65.8%, 85.7% and 95.8% of the respondents of A, B, and C questionnaires, respectively, correctly identified the need for tuberculin skin test (p < 0.0001). Conclusion: In evaluating clinical practice with use of a clinical vignette, a multiple-choice format rather than an open-ended format overestimates physician performance. The insertion of deceptive response items mixed with correct items in closed-ended (multiple-choice) questionnaire failed to avoid this overestimation.

Research paper thumbnail of Maintenance of infliximab treatment in ankylosing spondylitis: Results of a one-year randomized controlled trial comparing systematic versus on-demand treatment

Arthritis & Rheumatism, 2007

Research paper thumbnail of Adenovirus-mediated delivery of relaxin reverses cardiac fibrosis in mice with fibrotic cardiomyopathy

Journal of Molecular and Cellular Cardiology, 2006

... cardiac extracellular matrix (ECM) due to fibroblast activation and excessive accumulation of... more ... cardiac extracellular matrix (ECM) due to fibroblast activation and excessive accumulation of collagen and other components ([Weber, 2000] and [Tyagi et al ... of collagen in the ECM of multiple organs including reproductive organs, skin, kidney, lung, liver, and heart ([Samuel et al ...

Research paper thumbnail of ARTIST (Arthrose Intervention STandardisée). Évaluation de l'impact d'une standardisation des consultations chez les malades atteints de gonarthrose. Un essai randomisé en cluster

Revue du Rhumatisme, 2007

Research paper thumbnail of Mise à jour des recommandations de la Société française de rhumatologie pour l'utilisation des agents anti-TNFα chez les personnes souffrant de spondylarthrite ankylosante (SA) et de rhumatisme psoriasique (RP)

Revue du Rhumatisme, 2007

Mise à jour des recommandations de la Société française de rhumatologie pour l'utilisation des ag... more Mise à jour des recommandations de la Société française de rhumatologie pour l'utilisation des agents anti-TNFα chez les personnes souffrant de spondylarthrite ankylosante (SA) et de rhumatisme psoriasique (RP)

Research paper thumbnail of MRI in axial spondyloarthritis: From light to shadow?

Joint Bone Spine, 2015

Joint Bone Spine - In Press.Proof corrected by the author Available online since mercredi 3 juin ... more Joint Bone Spine - In Press.Proof corrected by the author Available online since mercredi 3 juin 2015

Research paper thumbnail of Modalités pratiques d’utilisation des glucocorticoïdes chez les patients souffrant de polyarthrite rhumatoïde : élaboration de recommandations pour la pratique clinique, à partir d’une analyse systématique de la littérature et de l’opinion d’experts

Revue du Rhumatisme, 2008

... Ga l Mouterde c , Jean-Francis Maillefert d , Jacques Tebib e , Alain Cantagrel f , Pascal Cl... more ... Ga l Mouterde c , Jean-Francis Maillefert d , Jacques Tebib e , Alain Cantagrel f , Pascal Claudepierre g ... raideur matinale persistante et importante, il peut tre indiqu de proposer une prise de glucocortico des le soir. ... Ils ont t valu s selon l index de Ritchie et de Landsbury, le DM, l ...

Research paper thumbnail of L'évaluation clinique et biologique dans la prise en chargede personnes souffrant de polyarthrite rhumatoïde etablissement de recommandations pour la pratique clinique à partir de données de la littérature et d'opinions d'experts (Rencontres d'experts en rhumatologie)

Revue du Rhumatisme, 2004

... 321–327. Full Text via CrossRef | View Record in Scopus | Cited By in Scopus (67). HA Fuchs, ... more ... 321–327. Full Text via CrossRef | View Record in Scopus | Cited By in Scopus (67). HA Fuchs, RH Brooks, LF Callahan and T. Pincus, A simplified twentyeight-joint quantitative articular index in rheumatoid arthritis, Arthritis Rheum 32 (1989), pp. 531–537. ...

Research paper thumbnail of Définition et traitement d’une polyarthrite rhumatoïde sévère d’emblée en 2010 : analyse systématique de la littérature

Revue du Rhumatisme, 2011

Objectif.-Les formes sévères de polyarthrite rhumatoïde (PR) sont plus pourvoyeuses de destructio... more Objectif.-Les formes sévères de polyarthrite rhumatoïde (PR) sont plus pourvoyeuses de destructions articulaires, notamment dès le début de la maladie. Leur défi nition claire est une nécessité afi n de les traiter rapidement. L'objectif est de défi nir le diagnostic et le traitement d'une PR précoce sévère d'emblée en 2010. Méthodes.-Une revue systématique de la littérature utilisant Pubmed, Embase et Cochrane de 1966 à janvier 2010 a été réalisée. Les études donnant les caractéristiques d'une PR sévère et celles évaluant l'effi cacité du méthotrexate (MTX) en monothérapie versus MTX + anti-TNF prescrits d'emblée dans la PR précoce ont été inclues. Résultats.-Pour le diagnostic de PR sévère, 18 études ont été retenues. Les critères de sévérité d'une PR précoce sont l'atteinte structurale (14/18) et notamment les érosions radiographiques (11/18), le syndrome infl ammatoire biologique (10/18), le nombre de synovites (6/18) et la présence d'un facteur rhumatoïde positif (12/18). Le traitement de la PR sévère par l'association MTX + anti-TNF d'emblée est plus effi cace que le MTX seul sur la rémission clinique, l'aggravation structurale et le HAQ en cas de maintien de la monothérapie par MTX pendant 9 à 12 mois. Si l'ajout de l'anti-TNF à la monothérapie par MTX est différée de trois mois dans le cas d'une PR évolutive, il n'y a plus de différence statistique par rapport à l'association d'emblée anti-TNF + MTX. Conclusion.-Est défi nie comme sévère d'emblée une PR avec une atteinte structurale, des facteurs rhumatoïdes ou anti-CCP positifs, une infl ammation biologique ou plusieurs synovites. Du MTX seul peut être débuté avec l'ajout d'un anti-TNF après 3 mois de monothérapie si la PR reste active.

Research paper thumbnail of Infections induites par de faibles doses de corticoïdes dans la polyarthrite rhumatoïde : revue systématique de la littérature

Revue du Rhumatisme, 2010

Objectif.-Étudier l'association entre le risque infectieux et de faibles doses de corticoïdes (FD... more Objectif.-Étudier l'association entre le risque infectieux et de faibles doses de corticoïdes (FD-CT, définie par une posologie quotidienne inférieure à 10 mg par jour de prednisone) dans la polyarthrite rhumatoïde (PR). Méthodes.-Source des données : une revue systématique de la littérature jusqu'en juin 2009 a été réalisée. Extraction des données : tous les types d'infection : bactérienne, virale et postopératoire, sévérité de l'infection, activité de la PR, sévérité de la PR, comorbidités. Analyse des données: descriptive, comparant le risque infectieux des patients atteints de PR et traités par FD-CT et celui des patients non traités par FD-CT. Résultats.-Sur les 1310 publications dénombrées, l'analyse en a identifié 15 évaluant le risque infectieux chez des patients atteints de PR et traités par FD-CT. Parmi les huit références qui étudiaient tous les types d'infection, six articles n'ont pas trouvé d'association entre le risque infectieux et un traitement par FD-CT, un a montré une association entre les infections sévères et un traitement par FD-CT (Odds Ratio [OR] = 8 [1-64]), et un autre a montré une association dose-dépendante aussi bien pour des doses inférieures à 5 mg par jour : rapport de proportion du score de propension (RR) = 1,32 (1,06-1,63) que pour des doses comprises entre 6 et 10 mg par jour : RR=1,95 [1,53-2,46]. Parmi les trois essais qui se sont intéressés à au risque secondaire infectieux bactérien, un a montré une augmentation du risque (Hazard Ratio [HR] = 1,7 [1,5-2,0]) alors que cette augmentation n'était pas observée dans les deux autres articles (exposition respective à des doses inférieures à 5 mg par jour : OR = 1,34 [0,85-2,13] ; 6 à 9 mg par jour : OR=1,53 [0,95-2,48] et inférieure à 5 mg par jour : OR=1,49 [0,82-2,72] ; 5 à 10 mg par jour : OR=1,46 [0,84-2,54]). Aucun des trois essais portant sur le risque infectieux postopératoire n'a trouvé d'association entre le risque infectieux et un traitement par FD-CT. Deux articles se sont intéressés au risque de zona et n'ont identifié d'association avec le traitement par FD-CT. Conclusion.-Bien qu'il existe un manque de données concernant le risque infectieux associé aux traitements par FD-CT dans la PR, ce risque semble très peu augmenté. Ces résultats auront besoin d'être confirmés par d'autres études.

Research paper thumbnail of Comment définir l’activité d’une spondylarthrite ?

Revue du Rhumatisme, 2011

... Séverine Neveu a* , Yannick Degboé b , Divi Cornec c , Thao Pham d , Daniel Wendling e , Al... more ... Séverine Neveu a* , Yannick Degboé b , Divi Cornec c , Thao Pham d , Daniel Wendling e , Alain Cantagrel b , Bruno Fautrel fa Service de Rhumatologie, CHU Saint Antoine, Paris, France b Service de Rhumatologie, CHU Purpan ... 54] Madsen OR, Rytter A, Hansen LB, et al. ...

Research paper thumbnail of Spondylarthrite et gammapathie monoclonale

Revue du Rhumatisme, 2012

Research paper thumbnail of Spondylarthritis and monoclonal gammopathy

Research paper thumbnail of The DESIR cohort: A 10-year follow-up of early inflammatory back pain in France: Study design and baseline characteristics of the 708 recruited patients

Joint Bone Spine, 2011

Objectives: The French Society of Rheumatology has initiated a large national multicenter, longit... more Objectives: The French Society of Rheumatology has initiated a large national multicenter, longitudinal, prospective follow-up of patients presenting with early inflammatory back pain in order to set up a database to facilitate several investigations on diagnosis, prognosis, epidemiology, pathogenesis and medico-economics in the field of early inflammatory back pain and spondyloarthritis. Methods: Patients were recruited if they had inflammatory back pain of more than 3 months and less than 3 years. Patients will be followed every 6 months during the first 2 years then every year during at least 5 years. Apart from information collected on a Case Report Form (demographics, disease activity, severity, co-morbidities, socio-economics, treatments, radiological and MRI evaluation of the spine and the pelvis according to the local investigators, and for some centers bone densitometry and ultrasonography of entheses), the digital X-rays and MRI of the spine and pelvis are stored using a specific software (Carestream) and the biological samples (DNA, RNA, sera, urines) are centralized at the Biological Resources Center (Bichat Hospital). Results: The recruitment peri-B27 positive: 57%) in the 25 centers was 26 months (from December 2007 to April 2010). The modified New York criteria, Amor criteria, ESSG criteria and axial ASAS criteria were fulfilled by 26%, 77%, 76% and 67% of the patients at entry respectively. A history or current symptoms suggestive of peripheral arthritis, acute anterior uveitis and inflammatory bowel disease were observed in 21%, 9% and 4% of the patients respectively. The disease was a the patients. Conclusion: This large cohort should facilitate the conduct of researches in different areas (clinical, medico-economics, translational) in order to improve our knowledge on the pathogenesis and natural history of axial spondyloarthritis.

Research paper thumbnail of Structural evaluation in the management of patients with rheumatoid arthritis: development of recommendations for clinical practice based on published evidence and expert opinion

Joint Bone Spine, 2005

Objectives.-To develop French evidence-based recommendations for the structural evaluation of rhe... more Objectives.-To develop French evidence-based recommendations for the structural evaluation of rheumatoid arthritis (RA) in everyday practice. Methods.-A scientific committee selected 10 questions using the Delphi consensus procedure. Evidence-based responses to each question were sought by searching the PubMed and Ovid databases and the abstract databases for the 2002, 2003, and 2004 annual meetings of the French Society for Rheumatology, the EULAR, and the American College of Rheumatology. The following indexing terms were used: rheumatoid arthritis, arthritis, patient, diagnostic imaging, radiography, joint, erosion, and joint space width. All articles published in French or English prior to May 2004 were identified. The evidence from these articles was reported to a panel of 77 rheumatologists working in hospital or office practice. The panel developed detailed recommendations, filling gaps in evidence with their expert opinion. The strength of each recommendation was determined. Results.-The 10 questions probed the structural evaluation of RA by plain radiography, magnetic resonance imaging (MRI), and ultrasonography, both for diagnostic and monitoring purposes. The literature search retrieved 673 publications, of which 166 were selected and reviewed. The panel developed 10 recommendations, one for each question, which were accepted by consensus. Conclusion.-Recommendations relative to the diagnosis or monitoring of structural involvement in patients with RA in everyday practice were developed. They should help to improve practice uniformity and, ultimately, to improve the management of RA.

Research paper thumbnail of Methotrexate therapy for rheumatoid arthritis: clinical practice guidelines based on published evidence and expert opinion

Joint Bone Spine, 2006

... practice [13]. 2. Methods. The procedure for developing the recommendations involved several ... more ... practice [13]. 2. Methods. The procedure for developing the recommendations involved several steps, as detailed in the article by Pham et al. [14] and [15]. 2.1. Selection of topics by the scientific committee members. The scientific ...

Research paper thumbnail of Use of glucocorticoids in rheumatoid arthritis – Pratical modalities of glucocorticoid therapy: Recommendations for clinical practice based on data from the literature and expert opinion

Joint Bone Spine, 2010

To develop recommendations about the use of glucocorticoids in patients with established rheumato... more To develop recommendations about the use of glucocorticoids in patients with established rheumatoid arthritis (RA) managed in everyday practice, using the evidence-based approach and expert opinion. A three-step procedure was used: a scientific committee used a Delphi procedure to select five questions, which formed the basis for developing the recommendations; a systematic literature review was conducted by searching the Medline and Embase databases and the abstracts of meetings held by the Société Française de Rhumatologie (SFR), American College of Rheumatology (ACR), and European League Against Rheumatism (EULAR); and recommendations were developed and validated by a panel of experts based on the data from the literature review and on their experience. For each recommendation, the level of evidence and extent of agreement among experts were determined. The five questions pertained to the use of glucocorticoids in RA patients: role for intravenous glucocorticoid bolus therapy, role for intraarticular injections, and practical modalities of glucocorticoid administration and discontinuation. From the literature search, 93 articles were selected based on their titles and abstracts. Of these, 50 were selected for the literature review. Eight recommendations about the use of glucocorticoid therapy in everyday practice in patients with established RA were validated by a vote among all participating experts: bolus glucocorticoid therapy should be reserved for highly selected situations; triamcinolone hexacetonide is the preferred glucocorticoid for intraarticular therapy, and the joint should be rested for about 24h after the injection; for oral glucocorticoid therapy, agents with a short half-life taken once daily should be preferred; and when discontinuing glucocorticoid therapy, the patient and usual physician should be informed of the risk of adrenal insufficiency.

Research paper thumbnail of Recommendations of the French Society for Rheumatology (SFR) on the everyday management of patients with spondyloarthritis

Joint Bone Spine, 2014

The management of spondyloarthritis is challenging and has changed with the development of new co... more The management of spondyloarthritis is challenging and has changed with the development of new concepts and treatments. Objective: To develop practice guidelines for the everyday management of patients with spondyloarthritis (including psoriatic arthritis), by updating previous national and international recommendations, based on a review of recently published data. Methods: A task force and a multidisciplinary literature review group were established. The task force identified the issues that remained unresolved. Based on existing recommendations and recent publications, the task force developed practice guidelines, which were revised by the literature review group and graded according to AGREE. Results: Practice guidelines for the management of spondyloarthritis are reported. After a review of the general diagnostic principles, 30 practice guidelines are given: 5 on general principles, 4 on the management strategy, 5 on non-pharmacological treatments, 7 on conventional pharmacological treatments, 6 on biotherapies, and 3 on surgical treatments and follow-up. Conclusion: The updated practice guidelines reported here constitute a global framework that can guide physicians in the everyday management of spondyloarthritis.

Research paper thumbnail of Effect of response format for clinical vignettes on reporting quality of physician practice

BMC Health Services Research, 2009

Background: Clinical vignettes have been used widely to compare quality of clinical care and to a... more Background: Clinical vignettes have been used widely to compare quality of clinical care and to assess variation in practice, but the effect of different response formats has not been extensively evaluated. Our objective was to compare three clinical vignette-based survey response formats-open-ended questionnaire (A), closed-ended (multiple-choice) questionnaire with deceptive response items mixed with correct items (B), and closed-ended questionnaire with only correct items (C)-in rheumatologists' pre-treatment assessment for tumor-necrosis-factor (TNF) blocker therapy. Methods: Study design: Prospective randomized study. Setting: Rheumatologists attending the 2004 French Society of Rheumatology meeting. Physicians were given a vignette describing the history of a fictitious woman with active rheumatoid arthritis, who was a candidate for therapy with TNF blocking agents, and then were randomized to receive questionnaire A, B, or C, each containing the same four questions but with different response formats, that asked about their pretreatment assessment. Measurements: Long (recommended items) and short (mandatory items) checklists were developed for pretreatment assessment for TNF-blocker therapy, and scores were expressed on the basis of responses to questionnaires A, B, and C as the percentage of respondents correctly choosing explicit items on these checklists. Statistical analysis: Comparison of the selected items using pairwise Chi-square tests with Bonferonni correction for variables with statistically significant differences. Results: Data for all surveys distributed (114 As, 118 Bs, and 118 Cs) were complete and available for analysis. The percentage of questionnaire A, B, and C respondents for whom data was correctly complete for the short checklist was 50.4%, 84.0% and 95.0%, respectively, and was 0%, 5.0% and 5.9%, respectively, for the long version. As an example, 65.8%, 85.7% and 95.8% of the respondents of A, B, and C questionnaires, respectively, correctly identified the need for tuberculin skin test (p < 0.0001). Conclusion: In evaluating clinical practice with use of a clinical vignette, a multiple-choice format rather than an open-ended format overestimates physician performance. The insertion of deceptive response items mixed with correct items in closed-ended (multiple-choice) questionnaire failed to avoid this overestimation.

Research paper thumbnail of Maintenance of infliximab treatment in ankylosing spondylitis: Results of a one-year randomized controlled trial comparing systematic versus on-demand treatment

Arthritis & Rheumatism, 2007

Research paper thumbnail of Adenovirus-mediated delivery of relaxin reverses cardiac fibrosis in mice with fibrotic cardiomyopathy

Journal of Molecular and Cellular Cardiology, 2006

... cardiac extracellular matrix (ECM) due to fibroblast activation and excessive accumulation of... more ... cardiac extracellular matrix (ECM) due to fibroblast activation and excessive accumulation of collagen and other components ([Weber, 2000] and [Tyagi et al ... of collagen in the ECM of multiple organs including reproductive organs, skin, kidney, lung, liver, and heart ([Samuel et al ...