Thayyil Jayakrishnan - Academia.edu (original) (raw)
Papers by Thayyil Jayakrishnan
International Journal of Medicine and Public Health, 2013
International Journal of Environmental Health Engineering, 2013
North American Journal of Medical Sciences, 2012
Journal of Pharmacology and Pharmacotherapeutics, 2014
To assess the level of homocysteine (tHcy) in children taking AEDs and to study whether daily ora... more To assess the level of homocysteine (tHcy) in children taking AEDs and to study whether daily oral supplementation of folic acid for 1 month will reduce the tHcy level. Materials and Methods: This was a double-blinded, randomized control trial conducted in Institute of Maternal and Child Health, Kozhikode, India. Totally 60 children were recruited and of them, 48 were enrolled. Of these children, 32 were assigned to the experimental group and 16 to the control group. Baseline data collection and tHcy estimation were done. One mg folic acid tablets were given to the experimental group and placebo tablets to the control group for 30 days. tHcy levels were re-estimated after 1 month follow-up. Statistical significance was tested by χ 2 test, and paired and unpaired t-tests, as appropriate. Correlation was tested by Pearson correlation test and P value less than 0.05 was taken as the cut-off for statistical significance. Results: Baseline plasma tHcy concentrations in both groups were comparable [11.90 (6.3) and 13.02 (2.4) µmol/l, respectively]. During the follow-up period, no increase in seizure episodes or no serious adverse reactions were noticed in either group. The reduction of tHcy in the experimental group was 1.92 µmol/l (P = 0.04) and in the control group, there was an increase of 1.05 µmol/l (P = 0.16). Conclusions: In children on AED treatment, folic acid supplementation may reduce tHcy level and thus reduce CVD risk.
Innovative Publication, Jun 1, 2016
Background: Access to safe drinking water has long been a central aim of public health. In India ... more Background: Access to safe drinking water has long been a central aim of public health. In India 85% of rural house holds have access to drinking water within or near to their premises through any improved sources and 70% of the household water sources were polluted with sewage. Water borne disease (WBD) account for 10% of total burden of disease. Objectives: To assess the sanitary conditions of household drinking water sources, and hygienic practices of community and the incidence of water borne disease. To find out the relation of water borne disease with the former two parameters. Methodology: A longitudinal study was conducted in the Kerala state of India including 1459 persons from 300 households as study subjects. Water samples were collected and analysis was done. The data analysis was performed using SPPSS 16 version. Results: During the 12 month follow up period 72 episodes of water borne disease were reported with an incidence rate of 49/1000 person years. Dug wells were the major household water sources (93.3%)and up to 30% water sources contain indicator bacteria Escherichia coli ,and more than 60% water sources contain Fecal coli from >10MPN/100 ml in all the seasons. Stagnant water at their premises was found to be associated with WBD (RR=3.58, 95% CI 1.90-6.73, P=0.01) and proximity within 15meters from the septic tanks was found to be associated with increased incidence of WBD (RR=2.2, 95%CI 1.00-4.63, P=0.04). Conclusion: Our study found that improved water sources are not free from bacteriological contamination. The structures which included in the criteria for a sanitary well may not always protect the consumers from the risks of WBD.
International Journal of Medicine and Public Health, 2013
International Journal of Environmental Health Engineering, 2013
North American Journal of Medical Sciences, 2012
Journal of Pharmacology and Pharmacotherapeutics, 2014
To assess the level of homocysteine (tHcy) in children taking AEDs and to study whether daily ora... more To assess the level of homocysteine (tHcy) in children taking AEDs and to study whether daily oral supplementation of folic acid for 1 month will reduce the tHcy level. Materials and Methods: This was a double-blinded, randomized control trial conducted in Institute of Maternal and Child Health, Kozhikode, India. Totally 60 children were recruited and of them, 48 were enrolled. Of these children, 32 were assigned to the experimental group and 16 to the control group. Baseline data collection and tHcy estimation were done. One mg folic acid tablets were given to the experimental group and placebo tablets to the control group for 30 days. tHcy levels were re-estimated after 1 month follow-up. Statistical significance was tested by χ 2 test, and paired and unpaired t-tests, as appropriate. Correlation was tested by Pearson correlation test and P value less than 0.05 was taken as the cut-off for statistical significance. Results: Baseline plasma tHcy concentrations in both groups were comparable [11.90 (6.3) and 13.02 (2.4) µmol/l, respectively]. During the follow-up period, no increase in seizure episodes or no serious adverse reactions were noticed in either group. The reduction of tHcy in the experimental group was 1.92 µmol/l (P = 0.04) and in the control group, there was an increase of 1.05 µmol/l (P = 0.16). Conclusions: In children on AED treatment, folic acid supplementation may reduce tHcy level and thus reduce CVD risk.
Innovative Publication, Jun 1, 2016
Background: Access to safe drinking water has long been a central aim of public health. In India ... more Background: Access to safe drinking water has long been a central aim of public health. In India 85% of rural house holds have access to drinking water within or near to their premises through any improved sources and 70% of the household water sources were polluted with sewage. Water borne disease (WBD) account for 10% of total burden of disease. Objectives: To assess the sanitary conditions of household drinking water sources, and hygienic practices of community and the incidence of water borne disease. To find out the relation of water borne disease with the former two parameters. Methodology: A longitudinal study was conducted in the Kerala state of India including 1459 persons from 300 households as study subjects. Water samples were collected and analysis was done. The data analysis was performed using SPPSS 16 version. Results: During the 12 month follow up period 72 episodes of water borne disease were reported with an incidence rate of 49/1000 person years. Dug wells were the major household water sources (93.3%)and up to 30% water sources contain indicator bacteria Escherichia coli ,and more than 60% water sources contain Fecal coli from >10MPN/100 ml in all the seasons. Stagnant water at their premises was found to be associated with WBD (RR=3.58, 95% CI 1.90-6.73, P=0.01) and proximity within 15meters from the septic tanks was found to be associated with increased incidence of WBD (RR=2.2, 95%CI 1.00-4.63, P=0.04). Conclusion: Our study found that improved water sources are not free from bacteriological contamination. The structures which included in the criteria for a sanitary well may not always protect the consumers from the risks of WBD.