Theognosia Chimona - Academia.edu (original) (raw)

Papers by Theognosia Chimona

Hippokratia, 2016

OBJECTIVE Comparison of the efficacy of Transitory Evoked Otoacoustic Emissions (TEOAEs) and Dist... more OBJECTIVE Comparison of the efficacy of Transitory Evoked Otoacoustic Emissions (TEOAEs) and Distortion Product Otoacoustic Emissions (DPOAEs) in a neonatal hearing screening protocol, based on a three-stage strategy. METHODS In the first stage, a hearing screening using both evoked emissions was conducted in 3,480 neonates from March 2006 through January 2012. Both TEOAEs and DPOAEs were recorded. Neonates, who did not undergo the test before being discharged, were examined within 30 days at a scheduled appointment. Follow-up of the referred newborns (second-stage screening) was performed as an outpatient re-screening, within a month. The third-stage evaluation, i.e., the diagnostic testing, included a clinical otolaryngological examination, high-frequency tympanometry at 1,000 Hz and Auditory Brainstem Response (ABR) measurements. RESULTS A total of 3,480 (97%) newborns (n =1,765 males) out of 3,595 infants were enrolled in the study. In the first-stage evaluation, 8.9 % of the in...

Pediatrics, Jan 7, 2018

We evaluated the efficacy of adenotonsillectomy (T/A) in children with sleepdisordered breathing ... more We evaluated the efficacy of adenotonsillectomy (T/A) in children with sleepdisordered breathing (SDB) in a controlled study using oximetry. We hypothesized that children with SDB and abnormal nocturnal oximetry in a community setting will have improved hypoxemia indices after T/A. METHODS: Children with snoring and tonsillar hypertrophy (4-10 years old) who were candidates for T/A were randomly assigned to 2 oximetry sequences (baseline and 3-month follow-up): (1) oximetry immediately before T/A and at the 3-month follow-up, which occurred postoperatively (T/A group); or (2) oximetry at the initial visit and at the end of the usual 3-month waiting period for surgery (control group). Outcomes were (1) proportion of subjects with McGill oximetry score (MOS) >1 at baseline acquiring MOS of 1 at follow-up and (2) proportion of subjects achieving oxygen desaturation (≥3%) of hemoglobin index (ODI3) <2 episodes per hour at follow-up if they had ODI3 ≥3.5 episodes per hour at baseline. RESULTS: One hundred and forty children had quality oximetry tracings. Twelve of 17 (70.6%) children with MOS >1 in the T/A group and 10 of 21 (47.6%) children with MOS >1 in the control group had MOS of 1 at follow-up (P = .14). More subjects in the T/A than in the control group achieved ODI3 <2 episodes per hour at follow-up (14 of 32 [43.8%] vs 2 of 38 [5.3%]; P < .001). Three children with elevated ODI3 were treated to prevent persistently abnormal ODI3 in 1 child at follow-up.

Journal of Medical Case Reports, 2009

Introduction: Brown tumors are rare focal giant-cell lesions that arise as a direct result of the... more Introduction: Brown tumors are rare focal giant-cell lesions that arise as a direct result of the effect of parathyroid hormone on bone tissue in some patients with hyperparathyroidism. Brown tumors can affect the mandible, maxilla, clavicle, ribs, and pelvic bones. Therefore, diagnosis requires a systemic investigation for lesion differentiation. Case presentation: We present a 42-year-old Greek woman, with a rare case of brown tumor of the maxillary sinus due to primary hyperparathyroidism. Primary hyperparathyroidism is caused by a solitary adenoma in 80% of cases and by glandular hyperplasia in 20%. Conclusions: Differential diagnosis is important for the right treatment choice. It should exclude other giant cell lesions that affect the maxillae.

Journal of Cancer Therapy, 2017

Journal of vestibular research : equilibrium & orientation, Jan 2, 2015

The aim of the present study was the investigation of age influenced changes in ocular motility t... more The aim of the present study was the investigation of age influenced changes in ocular motility testing in healthy subjects. Two hundred and fifty subjects between 18 and 70 years old were enrolled in a prospective study. Study population was divided in 5 groups of 50 subjects each (group A: 18-30 years old, group B: 31-40 years old, group C: 41-50 years old, group D: 51-60 years old and group E: 61-70 years old). Ocular motility was recorded by video-oculography and age related normative data were obtained with respect to: a) gain and slow phase velocity of smooth pursuit tracking, b) latency, velocity and accuracy of saccade eye movements and c) gain and slow phase velocity of optokinetic eye movements. The influence of age on all parameters was examined by one-way ANOVA. A statistically significant difference was found in all parameters analyzed for smooth pursuit test, saccade eye movements and optokinetic eye movements in between groups. In conclusion, aging influences the majo...

Allergic rhinitis remains a common disease that affects people of all ages and is considered as a... more Allergic rhinitis remains a common disease that affects people of all ages and is considered as a risk factor to the development of associated diseases such as asthma, sinusitis, otitis media with effusion, and nasal polyps. Thus, meticulous assessment of this condition is of great importance.

B-ENT

Branchial cleft anomalies are developmental disorders of the neck. Our aim is to report the diagn... more Branchial cleft anomalies are developmental disorders of the neck. Our aim is to report the diagnostic and treatment procedure followed in three cases of second branchial cleft abnormalities in adults. A patient aged over 40 underwent surgical excision of a well-encapsulated cystic neck structure and two further patients of a branchial sinus and branchial fistula respectively. Prior to surgery the patients were assessed by means of imaging techniques, FNA cytology and cytometric DNA analysis. Neutrophils, debris, mature squamous epithelial cells including degenerate forms and lymphoid cells were the key features in the cytological diagnosis. DNA analysis of the pre-operative cytological material in two cases revealed euploidy, thus indicating no malignancy. Histological examination of the lesions after excision established the diagnosis in all cases. No recurrences were reported. Although congenital lesions, the second branchial cleft abnormalities usually present in adulthood and h...

Einleitung: Die Häufigkeit der chronischen Sinusitis in der allgemeinen Bevölkerung in Europa sch... more Einleitung: Die Häufigkeit der chronischen Sinusitis in der allgemeinen Bevölkerung in Europa schwankt zwischen 5–15%, während in USA 12% der Einwohner unter 45 Jahren alt an chronischen Sinusitis leiden. Die konservative und chirurgische Behandlung ist verschieden. Obwohl[for full text, please go to the a.m. URL]

Einleitung: Die Arterie auditiva interna versorgt das Innenohr. Sie entspringt aus der Basilarisa... more Einleitung: Die Arterie auditiva interna versorgt das Innenohr. Sie entspringt aus der Basilarisarterie oder aus der Arterie cerebelli inferior anterior. Die Kleinhirninfarktsymptome sind die Gesichtschwäche. Der Schwindel. Die Dysarthrie, die Sinnesunterempfindlichkeit, der Nystagmus und die Innenohrschwerhörigkeit.[for full text, please go to the a.m. URL]

Objective: Foreign bodies (FB) aspiration in the tracheobronchial tree is a common medical emerge... more Objective: Foreign bodies (FB) aspiration in the tracheobronchial tree is a common medical emergency in childhood, with serious and potentially lethal consequences. The suspicion for FB aspiration should be raised in children with a suggestive history, even though the clinical symptoms or radiographic findings are not pathognomonic for foreign body aspiration. We reviewed our experience in children with suspected airway FB in the Department of Otolaryngology from 1993 to 2003 and report the incidence of FB aspiration in the tracheobronchial tree by bronchoscopy in children, during a 10-year period of time. Methods: We reviewed the records of 264 paediatric patients who were admitted to our hospital during a 10-year period for the treatment of aspirated foreign body into the tracheobronchial tree by bronchoscopy. In all cases bronchoscopy was performed under general anesthesia using a Stortz ventilation bronchoscope with distal cold light illumination. Results: In 166 patients (62.8%...

Otology & Neurotology, 2012

HYPOTHESIS: Limiting spatial overlap between electrical stimulation (ES) and acoustical stimulati... more HYPOTHESIS: Limiting spatial overlap between electrical stimulation (ES) and acoustical stimulation (AS) in the cochlea reduces the effects of AS on electrically evoked auditory nerve activity. BACKGROUND: Some hybrid cochlear implant systems have a regular array, whereas others have short arrays that spatially segregate ES from AS. AS settings in hybrid implants may also affect electroacoustic interaction. METHODS: ES (900 μA) was delivered in the high-frequency part of the cochlea, and the electrically evoked compound action potential (eCAP) was recorded to assess auditory nerve activity. Maximal spatial overlap of ES and AS was tested by using normal-hearing animals (NH, n = 6), whereas minimal overlap was modeled by using animals with high-frequency hearing loss (HFHL, n = 6). AS consisted of broadband (BB) or low-frequency (LF) noise (0-100 dB SPL). Effects of AS on eCAP amplitude were statistically tested using 1-sample t tests (α = 0.05). RESULTS: BB noise at 60 dB SPL significantly suppressed eCAP amplitude in NH animals but not in HFHL animals up to a 30 dB higher level. Suppression with LF noise at 60 dB SPL was not significant in either the NH or the HFHL group, but at 90 dB SPL, suppression was significant in both groups. CONCLUSION: Minimizing spatial overlap between ES and AS reduces eCAP suppression when moderate sound levels are applied. Overlap can be reduced by applying ES in an acoustically insensitive part of the cochlea or by limiting the acoustic spectrum to low frequencies when ES is applied in acoustically sensitive areas.

Otolaryngology - Head and Neck Surgery, 2003

enlarging over a 6-month period. Other than a cosmetic deformity of her upper neck, the patient w... more enlarging over a 6-month period. Other than a cosmetic deformity of her upper neck, the patient was asymptomatic. After surgical removal of the bony neoplasm, the patient was noted to have a high-frequency sensorinueral hearing loss. Methods: This case study presents clinical, radiological, intraoperative, pathologic, and audiometric findings of a mastoid osteoma and a review of the literature. Results: Preoperatively, the patient had normal hearing and facial nerve function. CT images showed a well-circumscribed uniformly dense mass arising from the tip of the left mastoid, encroaching on the fallopian canal and sigmoid sinus. At surgery, a 5 ϫ 4 ϫ 3-cm sessile bony mass at the mastoid tip was found to be adherent to bone directly overlying the sigmoid sinus, fallopian canal, and stylomastoid foramen. Complete removal of the sessile mass required extensive drilling. Histopathology revealed dense cortical bone consistent with osteoma confirming the preoperative diagnosis. Postoperatively, audiometric testing revealed a high-frequency sensorineural hearing loss. Conclusion: Surgical resection was undertaken because of growth of the tumor encroaching on the fallopian canal and the cosmetic deformity. Although sensorineural hearing loss from drill-induced acoustic trauma occurs infrequently in otologic surgery, the extensive drilling needed to remove this lesion is thought to have caused this complication. Intraoperative administration of dexamethasone did not prevent this complication.

The Journal of Laryngology & Otology, 2009

Objective:The aim of this study was to investigate the contribution of electronystagmography and ... more Objective:The aim of this study was to investigate the contribution of electronystagmography and magnetic resonance imaging to the aetiological diagnosis of vertigo and unsteadiness, in a population in which the history and clinical examination provide no conclusive diagnosis of the origin of the dysfunction (i.e. peripheral or central).Patients and methods:This retrospective study included 102 patients, who underwent full ENT clinical evaluation, history and neurotological assessment (including pure tone audiography, auditory brainstem response testing, electronystagmography and magnetic resonance imaging).Results:Electronystagmography contributed to establishment of a diagnosis in 53/102 patients (52 per cent), whereas magnetic resonance imaging did the same in four of 102 patients (3.9 per cent).Conclusion:Electronystagmography remains the most useful examination for aetiological diagnosis of patients with vertigo and unsteadiness, since the actual number of patients with vertigo...

European Journal of Internal Medicine, 2011

ABSTRACT Purpose: To present the diagnostic approach and treatment of two rare neoplasms, hemangi... more ABSTRACT Purpose: To present the diagnostic approach and treatment of two rare neoplasms, hemangiopericytoma and hemangioleiomyoma, treated in the ENT Dept. of Chania General Hospital. Description of the cases: A female, 65 years old, with severe nasal congestion, diplopia and exophthalmos and an 82 years old male with unilateral, recurrent, moderate epistaxis were admitted in the ENT Dept. In both cases assessment included full ENT examination, laboratory tests and imaging with CT and MRI scans. For the first patient, due to extension of the lesion in the right maxillary sinus and orbit, excision biopsy with combined Caldwell-Luc and endoscopic approach was decided. Five months after initial intervention she had local recurrence and distance metastasis and underwent adjuvant chemotherapy. She is on follow up without any indication of expansion of the preexisting disease. For the second patient, specimen from the lesion in the left nostril was sent for histology and he denied any further intervention. The patient is on regular follow up without any change from the initial diagnosis. Conclusion: While clinical examination raises the suspicion, diagnosis is confirmed by histology, and extent of disease is evaluated with CT-MRI scans. Imaging should precede biopsy because of high vascularity of these tumors. Appropriate treatment is extensive removal of the lesion.

European Archives of Oto-Rhino-Laryngology, 2008

Allergy is thought to be one of the etiologic factors in otitis media. The purpose of this study ... more Allergy is thought to be one of the etiologic factors in otitis media. The purpose of this study was to determine the histopathologic eVects of H1 histamine receptor antagonists in an experimental histamine-induced middle ear inXammation model. In group A (20 rabbits), histamine challenge followed a 3-day intramuscular pretreatment with a single dose of 0.1 ml hydroxyzine hydrochloride (50 mg/ml) per day. In group B (20 rabbits), histamine challenge followed a 3-day pretreatment with a single dose 1.2 mg desloratadine per day orally. In group C (20 rabbits), histamine challenge followed a 3-day pretreatment with a single dose 1.2 mg levocetirizine per day orally. On the fourth day after baseline otomicroscopy 0.5 ml histamine 20 mg/ml was injected transtympanically on the right. Middle ear mucosa was removed and the following parameters were assessed: edema, vascular dilatation and congestion, inXammation, acute inXammatory component, presence of eosinophils, activity of the inXammation and Wbrosis. A semi-quantitative grading system of 0-3 was used for grading of all parameters and statistical analysis performed by using the Mann-Whitney non-parametric test. Group A mucosae showed lower grades of all the parameters evaluated compared with those of group B. Histopathology of the mucosae of group C showed lower grade of inXammation compared with group B with signiWcant statistical diVerence for the seven parameters tested. Our data validate the use of antihistamines in the treatment of refractory OME of allergic origin. Oldest H1 antagonists can be replaced by the newest agents who counteract successfully histamine eVects, without any interactions or adverse eVects from central nervous system.

Auris Nasus Larynx, 2006

Parotid gland is the most common location of malignant mixed tumors. Three different subtypes of ... more Parotid gland is the most common location of malignant mixed tumors. Three different subtypes of these tumors exist: carcinoma ex pleomorphic adenoma, carcinosarcoma, and metastasizing mixed tumor. Carcinoma ex-pleomorphic adenoma is by far the most common subtype. Although unusual sites of these tumors have been published, we report an extremely rare case of a malignant mixed tumor located in the nasal cavity.

Cases Journal, 2010

Introduction: Leiomyosarcomas are rare tumors. The most common site for head and neck leiomyosarc... more Introduction: Leiomyosarcomas are rare tumors. The most common site for head and neck leiomyosarcomas is the oral cavity, followed by sinonasal tract and skin. Subcutaneous leiomyosarcomas are thought to arise from small to medium-sized blood vessels in the subcutaneous tissue. Case Presentation: A 67-year-old female patient underwent excision of a slow growing neck mass of the left posterior neck triangle after a thorough clinical and laboratory examination. The lesion was located in the subcutis and fine needle aspiration biopsy revealed malignant features. Histology revealed subcutaneous leiomyosarcoma and the patient is free from local recurrence and distant metastases 3 years after wide excision of the lesion. Conclusions: The primary modality of therapy of subcutaneous leiomyosarcoma is surgery, adjuvant radiotherapy or chemotherapy may be used for control of local recurrence, in case of positive surgical margins, high-grade or large tumors.