Thiago Corrêa - Academia.edu (original) (raw)

Papers by Thiago Corrêa

Behavioral Neuroscience, 2021

Attention Deficit Hyperactivity Disorder (ADHD) is a highly prevalent and disabling disorder that... more Attention Deficit Hyperactivity Disorder (ADHD) is a highly prevalent and disabling disorder that frequently persists into adulthood. Many patients are considered nonresponders to typical pharmacological treatments due to insufficient symptoms' reduction or the inability to tolerate the side effects of these medications. Agmatine is an endogenous neuromodulator with emotional- and cognitive-enhancing properties that arises as a promising agent to manage several Central Nervous System disorders. Here, we investigated the effects of chronic treatment with agmatine on behavioral impairments exhibited by adult Spontaneously Hypertensive Rats (SHR), an animal model for the study of ADHD. Adult male Wistar and SHR (3-4 months old) received intraperitoneal (i.p.) treatment with saline (NaCl 0.9%) or agmatine (30 mg/kg/day) during 20 consecutive days and were evaluated in a battery of behavioral tasks. Agmatine treatment improved olfactory and recognition memory impairments of SHR evaluated in the olfactory discrimination, object recognition, and social recognition memory tasks. In addition, agmatine administration improved the cognitive flexibility in the water maze test. Agmatine did not alter SHR's locomotor activity and hedonic-like behaviors observed in the open-field and splash tests, respectively. No changes were observed in SHR's systolic blood pressure following agmatine treatment. This study provides the first evidence that agmatine improves olfactory and cognitive impairments observed in an animal model of ADHD. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

British Journal of Pharmacology, 2019

BACKGROUND AND PURPOSE: It has been shown that bradykinin may induce vasoconstriction in selected... more BACKGROUND AND PURPOSE: It has been shown that bradykinin may induce vasoconstriction in selected vessels or under specific experimental conditions. We hypothesized that inflammatory stimuli, such as endotoxin challenge, may induce the dimerization of AT1/B2 receptors, altering the vascular effects of bradykinin. EXPERIMENTAL APPROACH: Wistar rats received LPS (1 mg kg-1 , i.p.) and were anesthetized for assessment of blood pressure. Mesenteric resistance arteries were used in organ baths and subjected to co-immunoprecipitation and Western blot approaches. KEY RESULTS: At 24 and 48 h after LPS, bradykinin-induced hypotension was followed by a sustained increase in blood pressure, which was not found in non-endotoxemic animals.

Canadian journal of physiology and pharmacology, Jan 24, 2016

We evaluated the effects of phenylephrine, norepinephrine, angiotensin II, and vasopressin in mes... more We evaluated the effects of phenylephrine, norepinephrine, angiotensin II, and vasopressin in mesenteric, renal, carotid, and tail arteries, and in perfused mesenteric vascular bed from rats subjected to the cecal ligation and puncture (CLP) model of sepsis. Phenylephrine and angiotensin II were less efficacious in mesenteric arteries from the CLP 6 h and CLP 18 h groups than in preparations from non-septic animals, but no differences were found for norepinephrine and vasopressin between the preparations. In renal arteries, none of the vasoconstrictors had impaired activity in the CLP groups. Nonetheless, carotid arteries from the CLP 18 h group presented reduced reactivity to all vasoconstrictors tested, but only phenylephrine and norepinephrine had their effects reduced in carotid arteries from the CLP 6 h group. Despite the reduced responsiveness to phenylephrine, tail arteries from septic rats were hyperreactive to vasopressin and norepinephrine at 6 h and 18 h after the CLP sur...

Orientadora: Maria Do Horto Fontoura Cartana FLORIANÓPOLIS 2012 Agradecemos A todos aqueles que n... more Orientadora: Maria Do Horto Fontoura Cartana FLORIANÓPOLIS 2012 Agradecemos A todos aqueles que nos apoiaram, nos deram forças e nos acompanharam nessa fase de crescimento profissional e pessoal, contribuindo para a construção deste trabalho. A Deus, por nos permitir concluir esta caminhada. Aos nossos Familiares: Obrigado pelo amor, palavras de incentivo e por entenderem nossa ausência e impaciência em determinados momentos. Às nossas mães, pais e irmãs obrigado pela imensa dedicação e apoio. Por serem grandes batalhadores, sempre nos incentivando em nossas escolhas e por propiciarem a realização deste sonho construído em conjunto. Aos amigos de longa data, que mesmo longe sempre se preocuparam conosco, se faziam presentes. Aos nossos colegas de faculdade, agradecemos pelas experiências e aprendizados. Vocês nos proporcionaram os melhores momentos durante as aulas, os estágios e as festas. À nossa orientadora Maria do Horto Fontoura Cartana, obrigado por toda dedicação, carinho, momentos de escuta, ensinamentos trocados e por acreditar em nossos ideais e confiar em nosso potencial. À Professora Marta Verdi, pelos ensinamentos em aula e como membro da banca. Aos enfermeiros supervisores de estágio, em especial a Enfermeira Vanessa Andrade e o Enfermeiro André de Bastiani Lancini, por nos proporcionar crescimento profissional. À toda equipe Multiprofissional do Centro de Saúde da Agronômica, agradecemos pela maravilhosa experiência de estar diariamente com vocês. Trocamos ensinamentos e aprendemos sobre o maravilhoso universo da saúde pública. Obrigado pela atenção e compreensão diária. À Universidade Federal de Santa Catarina e aos professores do Curso de Graduação em Enfermagem. A todos os anjos guias e protetores de luz, disfarçados de pacientes, amigos e pessoas que cruzaram nossas vidas e fizeram uma grande diferença.

Molecular Neurobiology, 2020

Attention deficit hyperactivity disorder (ADHD) is a prevalent and disabling disorder, mainly cha... more Attention deficit hyperactivity disorder (ADHD) is a prevalent and disabling disorder, mainly characterized by hyperactivity, inattention, and impulsivity, but also by olfactory and memory impairments that frequently persist throughout lifetime. The pathophysiology of ADHD is complex, involving several brain regions and neural pathways including alterations in adenosine neuromodulation. The administration of caffeine (a non-selective adenosine receptor antagonist) and physical exercise have been independently pointed as effective approaches for the management of ADHD symptoms. Here, we evaluated the effects of caffeine consumption (0.3 mg/mL in drinking water) plus physical exercise in running wheels during 6 weeks—starting during either adolescence (30 days old) or adulthood (4–5 months old)—on behavioral performance (including olfactory discrimination, open field, object recognition, and water maze tests) on the brain levels of monoamines (by high-performance liquid chromatography), on proteins related to synaptic plasticity and on brain-derived neurotrophic factor signaling (by Western blot analysis) in spontaneously hypertensive rats (SHRs), a validated animal model of ADHD. SHRs displayed persistent impairments of olfactory and short-term recognition memory from adolescence to adulthood, which were accompanied by lower levels of synaptosomal-associated protein 25 (SNAP-25) in the prefrontal cortex and hippocampus. The association of caffeine plus physical exercise during adolescence or adulthood restored the olfactory discrimination ability and, in an independent manner, improved short-term recognition memory of SHRs. These benefits were not associated to alterations in locomotor activity or in the hypertensive phenotype. The association of caffeine consumption plus physical exercise during adolescence increased the levels of SNAP-25, syntaxin, and serotonin in the hippocampus and prefrontal cortex, and striatal dopamine levels in SHRs. These results provide new evidence of the potential of caffeine and physical exercise, starting at adolescence or adult life, to improve behavioral impairments and stimulate neuroplasticity in ADHD.

Behavioral Neuroscience, 2021

Attention Deficit Hyperactivity Disorder (ADHD) is a highly prevalent and disabling disorder that... more Attention Deficit Hyperactivity Disorder (ADHD) is a highly prevalent and disabling disorder that frequently persists into adulthood. Many patients are considered nonresponders to typical pharmacological treatments due to insufficient symptoms' reduction or the inability to tolerate the side effects of these medications. Agmatine is an endogenous neuromodulator with emotional- and cognitive-enhancing properties that arises as a promising agent to manage several Central Nervous System disorders. Here, we investigated the effects of chronic treatment with agmatine on behavioral impairments exhibited by adult Spontaneously Hypertensive Rats (SHR), an animal model for the study of ADHD. Adult male Wistar and SHR (3-4 months old) received intraperitoneal (i.p.) treatment with saline (NaCl 0.9%) or agmatine (30 mg/kg/day) during 20 consecutive days and were evaluated in a battery of behavioral tasks. Agmatine treatment improved olfactory and recognition memory impairments of SHR evaluated in the olfactory discrimination, object recognition, and social recognition memory tasks. In addition, agmatine administration improved the cognitive flexibility in the water maze test. Agmatine did not alter SHR's locomotor activity and hedonic-like behaviors observed in the open-field and splash tests, respectively. No changes were observed in SHR's systolic blood pressure following agmatine treatment. This study provides the first evidence that agmatine improves olfactory and cognitive impairments observed in an animal model of ADHD. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

British Journal of Pharmacology, 2019

BACKGROUND AND PURPOSE: It has been shown that bradykinin may induce vasoconstriction in selected... more BACKGROUND AND PURPOSE: It has been shown that bradykinin may induce vasoconstriction in selected vessels or under specific experimental conditions. We hypothesized that inflammatory stimuli, such as endotoxin challenge, may induce the dimerization of AT1/B2 receptors, altering the vascular effects of bradykinin. EXPERIMENTAL APPROACH: Wistar rats received LPS (1 mg kg-1 , i.p.) and were anesthetized for assessment of blood pressure. Mesenteric resistance arteries were used in organ baths and subjected to co-immunoprecipitation and Western blot approaches. KEY RESULTS: At 24 and 48 h after LPS, bradykinin-induced hypotension was followed by a sustained increase in blood pressure, which was not found in non-endotoxemic animals.

Canadian journal of physiology and pharmacology, Jan 24, 2016

We evaluated the effects of phenylephrine, norepinephrine, angiotensin II, and vasopressin in mes... more We evaluated the effects of phenylephrine, norepinephrine, angiotensin II, and vasopressin in mesenteric, renal, carotid, and tail arteries, and in perfused mesenteric vascular bed from rats subjected to the cecal ligation and puncture (CLP) model of sepsis. Phenylephrine and angiotensin II were less efficacious in mesenteric arteries from the CLP 6 h and CLP 18 h groups than in preparations from non-septic animals, but no differences were found for norepinephrine and vasopressin between the preparations. In renal arteries, none of the vasoconstrictors had impaired activity in the CLP groups. Nonetheless, carotid arteries from the CLP 18 h group presented reduced reactivity to all vasoconstrictors tested, but only phenylephrine and norepinephrine had their effects reduced in carotid arteries from the CLP 6 h group. Despite the reduced responsiveness to phenylephrine, tail arteries from septic rats were hyperreactive to vasopressin and norepinephrine at 6 h and 18 h after the CLP sur...

Orientadora: Maria Do Horto Fontoura Cartana FLORIANÓPOLIS 2012 Agradecemos A todos aqueles que n... more Orientadora: Maria Do Horto Fontoura Cartana FLORIANÓPOLIS 2012 Agradecemos A todos aqueles que nos apoiaram, nos deram forças e nos acompanharam nessa fase de crescimento profissional e pessoal, contribuindo para a construção deste trabalho. A Deus, por nos permitir concluir esta caminhada. Aos nossos Familiares: Obrigado pelo amor, palavras de incentivo e por entenderem nossa ausência e impaciência em determinados momentos. Às nossas mães, pais e irmãs obrigado pela imensa dedicação e apoio. Por serem grandes batalhadores, sempre nos incentivando em nossas escolhas e por propiciarem a realização deste sonho construído em conjunto. Aos amigos de longa data, que mesmo longe sempre se preocuparam conosco, se faziam presentes. Aos nossos colegas de faculdade, agradecemos pelas experiências e aprendizados. Vocês nos proporcionaram os melhores momentos durante as aulas, os estágios e as festas. À nossa orientadora Maria do Horto Fontoura Cartana, obrigado por toda dedicação, carinho, momentos de escuta, ensinamentos trocados e por acreditar em nossos ideais e confiar em nosso potencial. À Professora Marta Verdi, pelos ensinamentos em aula e como membro da banca. Aos enfermeiros supervisores de estágio, em especial a Enfermeira Vanessa Andrade e o Enfermeiro André de Bastiani Lancini, por nos proporcionar crescimento profissional. À toda equipe Multiprofissional do Centro de Saúde da Agronômica, agradecemos pela maravilhosa experiência de estar diariamente com vocês. Trocamos ensinamentos e aprendemos sobre o maravilhoso universo da saúde pública. Obrigado pela atenção e compreensão diária. À Universidade Federal de Santa Catarina e aos professores do Curso de Graduação em Enfermagem. A todos os anjos guias e protetores de luz, disfarçados de pacientes, amigos e pessoas que cruzaram nossas vidas e fizeram uma grande diferença.

Molecular Neurobiology, 2020

Attention deficit hyperactivity disorder (ADHD) is a prevalent and disabling disorder, mainly cha... more Attention deficit hyperactivity disorder (ADHD) is a prevalent and disabling disorder, mainly characterized by hyperactivity, inattention, and impulsivity, but also by olfactory and memory impairments that frequently persist throughout lifetime. The pathophysiology of ADHD is complex, involving several brain regions and neural pathways including alterations in adenosine neuromodulation. The administration of caffeine (a non-selective adenosine receptor antagonist) and physical exercise have been independently pointed as effective approaches for the management of ADHD symptoms. Here, we evaluated the effects of caffeine consumption (0.3 mg/mL in drinking water) plus physical exercise in running wheels during 6 weeks—starting during either adolescence (30 days old) or adulthood (4–5 months old)—on behavioral performance (including olfactory discrimination, open field, object recognition, and water maze tests) on the brain levels of monoamines (by high-performance liquid chromatography), on proteins related to synaptic plasticity and on brain-derived neurotrophic factor signaling (by Western blot analysis) in spontaneously hypertensive rats (SHRs), a validated animal model of ADHD. SHRs displayed persistent impairments of olfactory and short-term recognition memory from adolescence to adulthood, which were accompanied by lower levels of synaptosomal-associated protein 25 (SNAP-25) in the prefrontal cortex and hippocampus. The association of caffeine plus physical exercise during adolescence or adulthood restored the olfactory discrimination ability and, in an independent manner, improved short-term recognition memory of SHRs. These benefits were not associated to alterations in locomotor activity or in the hypertensive phenotype. The association of caffeine consumption plus physical exercise during adolescence increased the levels of SNAP-25, syntaxin, and serotonin in the hippocampus and prefrontal cortex, and striatal dopamine levels in SHRs. These results provide new evidence of the potential of caffeine and physical exercise, starting at adolescence or adult life, to improve behavioral impairments and stimulate neuroplasticity in ADHD.