Thomas Huwae - Academia.edu (original) (raw)

Papers by Thomas Huwae

Zenodo (CERN European Organization for Nuclear Research), Feb 24, 2022

Zenodo (CERN European Organization for Nuclear Research), Oct 1, 2023

Introduction: The Galeazzi fracture consists of a radial shaft fracture occurring most commonly a... more Introduction: The Galeazzi fracture consists of a radial shaft fracture occurring most commonly at the junction of the middle and distal thirds of the radius and is accompanied by a dislocation of the distal radioulnar joint (DRUJ). Galeazzi fractures result from hyperpronation injuries to the forearm. They require stabilization by internal fixation. Reportedly, the incidence of distal ulna fracture with a galeazzi is rare. Case Presentation: A 48-year-old woman with displaced closed fracture of the distal shaft left radius and left distal intraarticular ulna. The patient experienced deformity and swelling in his left forearm after a motorcycle accident. Based on these, we diagnosed the patient with a Galeazzi equivalent fracture. Therefore, open reduction and internal fixation (ORIF) was conducted using an LC-DCP plate and screw technique. Discussion: From the report reviewed in this study, a quick diagnosis with prompt treatment makes like a Galeazzi-type fracture. Almost all four other studies apart from our study reported a good Galeazzi-type fracture. One case was initially treated operatively by internal fixation but later proceeded with distal ulna fracture with internal fixation, which ended with an excellent outcome. Conclusion: Distal ulna fracture with a galeazzi-type fracture. Risk correlated significantly or not is still need a further study to be done.

European Journal of Radiology Extra, 2011

Traumatic pseudoaneurysms of the superficial temporal artery (STA) are uncommon. The appearance o... more Traumatic pseudoaneurysms of the superficial temporal artery (STA) are uncommon. The appearance of a pulsatile preauricular mass after a traumatism is highly suggestive of the diagnosis. Diagnostic techniques are echo-doppler, CT-scan and arteriography. The most common treatment is surgical. Embolization may prove to be an alternative to surgery in some cases. We report a rare case of pseudoaneurysm arising from STA caused by blunt injury.

Zenodo (CERN European Organization for Nuclear Research), Aug 23, 2023

Electrical stimulation (ES) is known as one of the effective and efficient physical modalities in... more Electrical stimulation (ES) is known as one of the effective and efficient physical modalities in managing peripheral nerve injuries. Peripheral nerve injuries greatly impact an individual"s activities of daily living (ADL), which in turn affects the quality of life. Its effect focuses on the enhanced gene expression, which includes (NGF, BDNF, NT 4/5, cAMP, and VEGF), expedites and enhance guidance of axonal regeneration into its proper pathway. Thus, ES allows early onset of regeneration by reducing staggering time, which increases the likelihood for more axons to cross the coaptation site within a proper pathway instead of increasing its regeneration rate. This review aims to understand the physiological nerve regeneration process with the use of ES and the appropriate application to be given in peripheral nerve injuries.

Journal of Evolution of medical and Dental Sciences, Nov 30, 2022

Case Reports in Clinical Practice

Tuberculosis (TB) is a respiratory disease that primarily affects the lungs. The challenge is to ... more Tuberculosis (TB) is a respiratory disease that primarily affects the lungs. The challenge is to recognize the characteristic of TB disease, including extrapulmonary presentation. TB arthritis is an extrapulmonary TB presentation in the joint, which is frequently neglected and misdiagnosed. A 41-year-old female patient was presented with a major complaint of chronic pain in her left wrist for three months. The patient had a low-grade fever without respiratory symptoms. Local examination revealed swelling, warmth and tenderness. Erythrocyte sedimentation rate (ESR) was increased and chest radiograph demonstrated pulmonary TB. She underwent arthrotomy debridement and culture examination. We initiated adjuvant anti-tuberculous treatment. On the evaluation, she reported relief from pain and showed improvement in general condition. TB arthritis is unique due to its rare incidence and unspecific clinical manifestations. A better understanding of these issues will prevent possible diagnost...

Russian Journal of Infection and Immunity

Introduction. Candida is the cause of most systemic fungal infections that plays a role in the pa... more Introduction. Candida is the cause of most systemic fungal infections that plays a role in the pathophysiology of sepsis in newborns, especially in premature infants with late-onset sepsis. The Candida score can be used to assess the occurrence of systemic candidosis where a Candida score 2.5 can accurately identify patients who are at high risk for candidiasis infection. Monocytes also play an important role in preventing candida invasion. Materials and methods. This study used a cross sectional research design. Data was collected from premature infants with late-onset sepsis being suspected of systemic candidosis in neonatology inpatient ward. It was submitted from the period of November-December 2021. It takes a minimum of 31 samples to meet the criteria to process and analyze the data. The data obtained were processed and analyzed using the Receiver Operating Characteristic (ROC) method to obtain the Area Under Curve (AUC) value. Based on the AUC curve, the search for the most o...

Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

Partial Tear Rotator Cuff Tendinopathy (PTRCT) impacts 15% to 50% of the population and increases... more Partial Tear Rotator Cuff Tendinopathy (PTRCT) impacts 15% to 50% of the population and increases in prevalence with individuals' age. Several first-line management strategies for treating rotator cuff disease, such as physical rehabilitation and/or injection, have been reported. However, optimum management is debatable. This study aims to explore the outcome management combination of prolotherapy and physical rehabilitation with physical rehabilitation only for PTRCT. Randomized Control Trial (RCT) studies From PubMed, Cochrane Library, ScienceDirect, ProQuest, And Google Scholar were included. Two independent reviewers evaluated the quality of RCTs using the Cochrane Risk of Bias Tool. The primary result was pain reduction, with functional improvement as a secondary outcome. Meta-analysis was performed using Review Manager 5.4 software. Our meta-analysis included 5 RCT studies involving 263 patients. Standardized mean difference (SMD) was collected from all of the studies. In ...

Journal of Public Health in Africa

Background: The sodium may aggravate synovial inflammation and cartilage thinning. This incidence... more Background: The sodium may aggravate synovial inflammation and cartilage thinning. This incidence can cause joint pain and reduce functional activity. Not many people know the effect of sodium on the incidence of OA. Objective: This study aims to determine the relationship between sodium in the body and knee joint pain which results in functional activity. Methods: The quantitative descriptive study used accidental sampling. The study was conducted at three outpatient polyclinic orthopedics of hospitals and was approved by the Health Ethics Committee. All data were collected during the interview. The Semi-Quantitative Food Frequency Questionnaire (SQ-FFQ) and the Nutrisurvey Indonesia 2007 application were used as a tool to collect daily sodium intake (mg). Knee joint pain score was measured using the Visual Analog Scale (VAS) while functional body activity was measured using the Western Ontario McMaster Osteoarthritis Index (WOMAC). The Pearson and Spearman test (p<0.05) were us...

Annals of Medicine & Surgery

Clinical and Research Journal in Internal Medicine

Background: Osteoporosis is an increasing health problem in Indonesia. Fractures that occur in th... more Background: Osteoporosis is an increasing health problem in Indonesia. Fractures that occur in the spine and pelvis are considered to be the most common fracture sites for osteoporosis. Aim: to determine the differences in bone mineral density values in postmenopausal women with fracture and non-fracture. Methods: Survey was carried out in postmenopausal female patients with fractures and without fractures who were included in the inclusion criteria with a case-control study approach and had bone mass density data. For the group of cases with fracture, the amount of vertebral compression was measured using Gennant's measurement criteria. Interviews were conducted regarding the characteristics of patients with and without fracture. The differences in BMD values ​​were analyzed in postmenpausal female patients with fracture and without fracture by using unpaired T test on normal data distribution and Mann-Whitney test on abnormal data distribution. The measured BMD value is the T-...

Open Access Macedonian Journal of Medical Sciences

Background: Trans-scaphoid lunate dislocation is an orthopaedic injury, mostly because of high en... more Background: Trans-scaphoid lunate dislocation is an orthopaedic injury, mostly because of high energy trauma. Due to subtle clinical and radiological findings, it might be easily left undiagnosed, with estimated 25% cases are missed at initial assessment in emergency department. Non-union scaphoid, which accounts for 5-10% of all scaphoid fractures treated with K-wires fixation, mostly occurs in young and active individual. Case Presentation: Thirty-seven-years-old right-handed man complained pain, and restricted range of motion (ROM) on his right wrist after fell from 2m height. Loss of symmetry and parallelism of joint space in Gilula's line shown in X-ray, possible for a trans-scaphoid lunate dislocation. We performed dorsal approach and internal fixation using Kirschner wire (1.0). The patient had a short arm cast for 4 weeks. The K-wires were removed 5 weeks postoperatively. We achieved good result clinically in 3, 9, and 36 months of follow up (Mayo Wrist Score of 70, 80, ...

Journal of Public Health Research

Background: Osteoporosis is characterized by a low bone mass of bone tissue. If osteoporosis is n... more Background: Osteoporosis is characterized by a low bone mass of bone tissue. If osteoporosis is not treated properly, it will increase the high risk of fracture. The common causes of fracture on osteoporosis condition due to falls. This study aims to find the correlation between the risk of osteoporosis with fall risk (ONTARIO) based on osteoporosis fracture risk (FRAX) Methods: This study is an analytic study with a cross-sectional method. We collected the sample using random cluster sampling in the six primary health care in Malang on different times service since August–September 2021. Total patient 139, however only 132 patients were included in this study. After collecting data is complete, we analyze using Chi-square tests. Results: The mean age of participants was 63.9 ± 7.14. with the age group was dominated by the range of 60–64. It was found that the result of the FRAX SCORE had a low-risk category for major fracture osteoporosis and risk hip fracture. In contrast, from th...

International Journal of Surgery Case Reports

Open Access Macedonian Journal of Medical Sciences

Introduction: A tourniquet is a typical equipment used in the orthopedics surgery to decrease blo... more Introduction: A tourniquet is a typical equipment used in the orthopedics surgery to decrease blood loss and create a better operating environment. Ischemic-reperfusion damage, which happens when the tourniquet is deflated, is one of the tourniquet's negative effects. Antioxidants can be used to minimize oxidative stress, which is one strategy to mitigate ischemic-reperfusion injury. Aloe vera, for example, is widely known for its antioxidant and anti-inflammatory properties. Method: The tibias of male Wistar strain rats (Rattus norvegicus) were fractured in this experiment, and Aloe vera gel was given orally as an antioxidant. A total of 18 rats were utilized in this research, which were separated into 6 groups. Varying amounts of Aloe vera extract were given to the treatment groups: 40 mg/kgBW, 60 mg/kgBW, and 80 mg/kgBW. The tourniquet would be inflated for two hours then deflated after application of the Aloe vera extract. Superoxide dismutase (SOD) and malondialdehyde level...

F1000Research, Mar 30, 2022

Background: Tourniquet is a common instrument used in Orthopedics field to reduce blood loss, pro... more Background: Tourniquet is a common instrument used in Orthopedics field to reduce blood loss, providing a better operating field. One of the deleterious effects of tourniquet is ischemic-reperfusion injury, which occurs after deflation of the tourniquet. One of the possible ways to mitigate ischemic-reperfusion injury is by administrating antioxidants to reduce oxidative stress. Natural ingredients like Aloe vera are well known for its antioxidant and anti-inflammatory activities. This experimental study was conducted by fracturing the tibia of male Wistar strain rats (Rattus norvegicus) and administering Aloe vera gel orally as antioxidant. Method: A total of 18 rats were used in this study, divided into 6 groups. The first group was the control group, that included rats with fractured tibia not receiving torniquet and aloe vera treatment. The second and third groups were rats with fracture, who received torniquet application for one hour and two hours respectively without aloe vera treatment. The rest were the treatment groups, the rats with factures were given different dosages of Aloe vera extract: 40 mg/kg bodyweight (BW), 60 mg/kg BW, and 80 mg/kg BW. Three hours after administration, the tourniquet was inflated for two hours, followed by its deflation. The tibia was harvested to examine levels of superoxide dismutase (SOD), Malondialdehyde (MDA), and Bone morphogenetic protein 7 (BMP-7), and callus diameter, and osteoblast numbers were evaluated. Result: Administration of Aloe vera extract reduced the oxidative stress parameters (SOD and MDA). Tourniquet application decreased the osteoblast cell count and callus diameter, and administration of Aloe vera extract increased both variables close to the control value (p&lt;0.05). Conclusion: The result of this study suggests that Aloe vera extract could be used to ameliorate ischemic-reperfusion injury.

International Journal of Medical Reviews and Case Reports, 2022

Open Access Macedonian Journal of Medical Sciences, 2021

Introduction: Osteomyelitis is a serious infection of the bone. One of the therapies for osteomye... more Introduction: Osteomyelitis is a serious infection of the bone. One of the therapies for osteomyelitis is antibiotic treatment. Antibiotic treatment has evolved substantially, but bone infections are still a challenge. Antimicrobial therapy is also difficult, caused by antibiotic-resistant organisms. Therefore, a systematic review is needed to assess antibiotic use in osteomyelitis infection. Method: Articles were searched using Pubmed with keywords “antibiotics”, “osteomyelitis”, and its combination. The authors used five years publication date and English language to select the appropriate journal. Result: The author identified 13 relevant articles with antibiotics use in osteomyelitis. All of the cases were about chronic osteomyelitis and osteomyelitis in diabetic foot ulcers. Osteomyelitis in other sites of long bones needs longer duration treatment than long bone osteomyelitis. In acute osteomyelitis in children, antibiotic treatment can switch from IV to oral antibiotics. Fur...

Zenodo (CERN European Organization for Nuclear Research), Feb 24, 2022

Zenodo (CERN European Organization for Nuclear Research), Oct 1, 2023

Introduction: The Galeazzi fracture consists of a radial shaft fracture occurring most commonly a... more Introduction: The Galeazzi fracture consists of a radial shaft fracture occurring most commonly at the junction of the middle and distal thirds of the radius and is accompanied by a dislocation of the distal radioulnar joint (DRUJ). Galeazzi fractures result from hyperpronation injuries to the forearm. They require stabilization by internal fixation. Reportedly, the incidence of distal ulna fracture with a galeazzi is rare. Case Presentation: A 48-year-old woman with displaced closed fracture of the distal shaft left radius and left distal intraarticular ulna. The patient experienced deformity and swelling in his left forearm after a motorcycle accident. Based on these, we diagnosed the patient with a Galeazzi equivalent fracture. Therefore, open reduction and internal fixation (ORIF) was conducted using an LC-DCP plate and screw technique. Discussion: From the report reviewed in this study, a quick diagnosis with prompt treatment makes like a Galeazzi-type fracture. Almost all four other studies apart from our study reported a good Galeazzi-type fracture. One case was initially treated operatively by internal fixation but later proceeded with distal ulna fracture with internal fixation, which ended with an excellent outcome. Conclusion: Distal ulna fracture with a galeazzi-type fracture. Risk correlated significantly or not is still need a further study to be done.

European Journal of Radiology Extra, 2011

Traumatic pseudoaneurysms of the superficial temporal artery (STA) are uncommon. The appearance o... more Traumatic pseudoaneurysms of the superficial temporal artery (STA) are uncommon. The appearance of a pulsatile preauricular mass after a traumatism is highly suggestive of the diagnosis. Diagnostic techniques are echo-doppler, CT-scan and arteriography. The most common treatment is surgical. Embolization may prove to be an alternative to surgery in some cases. We report a rare case of pseudoaneurysm arising from STA caused by blunt injury.

Zenodo (CERN European Organization for Nuclear Research), Aug 23, 2023

Electrical stimulation (ES) is known as one of the effective and efficient physical modalities in... more Electrical stimulation (ES) is known as one of the effective and efficient physical modalities in managing peripheral nerve injuries. Peripheral nerve injuries greatly impact an individual"s activities of daily living (ADL), which in turn affects the quality of life. Its effect focuses on the enhanced gene expression, which includes (NGF, BDNF, NT 4/5, cAMP, and VEGF), expedites and enhance guidance of axonal regeneration into its proper pathway. Thus, ES allows early onset of regeneration by reducing staggering time, which increases the likelihood for more axons to cross the coaptation site within a proper pathway instead of increasing its regeneration rate. This review aims to understand the physiological nerve regeneration process with the use of ES and the appropriate application to be given in peripheral nerve injuries.

Journal of Evolution of medical and Dental Sciences, Nov 30, 2022

Case Reports in Clinical Practice

Tuberculosis (TB) is a respiratory disease that primarily affects the lungs. The challenge is to ... more Tuberculosis (TB) is a respiratory disease that primarily affects the lungs. The challenge is to recognize the characteristic of TB disease, including extrapulmonary presentation. TB arthritis is an extrapulmonary TB presentation in the joint, which is frequently neglected and misdiagnosed. A 41-year-old female patient was presented with a major complaint of chronic pain in her left wrist for three months. The patient had a low-grade fever without respiratory symptoms. Local examination revealed swelling, warmth and tenderness. Erythrocyte sedimentation rate (ESR) was increased and chest radiograph demonstrated pulmonary TB. She underwent arthrotomy debridement and culture examination. We initiated adjuvant anti-tuberculous treatment. On the evaluation, she reported relief from pain and showed improvement in general condition. TB arthritis is unique due to its rare incidence and unspecific clinical manifestations. A better understanding of these issues will prevent possible diagnost...

Russian Journal of Infection and Immunity

Introduction. Candida is the cause of most systemic fungal infections that plays a role in the pa... more Introduction. Candida is the cause of most systemic fungal infections that plays a role in the pathophysiology of sepsis in newborns, especially in premature infants with late-onset sepsis. The Candida score can be used to assess the occurrence of systemic candidosis where a Candida score 2.5 can accurately identify patients who are at high risk for candidiasis infection. Monocytes also play an important role in preventing candida invasion. Materials and methods. This study used a cross sectional research design. Data was collected from premature infants with late-onset sepsis being suspected of systemic candidosis in neonatology inpatient ward. It was submitted from the period of November-December 2021. It takes a minimum of 31 samples to meet the criteria to process and analyze the data. The data obtained were processed and analyzed using the Receiver Operating Characteristic (ROC) method to obtain the Area Under Curve (AUC) value. Based on the AUC curve, the search for the most o...

Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya

Partial Tear Rotator Cuff Tendinopathy (PTRCT) impacts 15% to 50% of the population and increases... more Partial Tear Rotator Cuff Tendinopathy (PTRCT) impacts 15% to 50% of the population and increases in prevalence with individuals' age. Several first-line management strategies for treating rotator cuff disease, such as physical rehabilitation and/or injection, have been reported. However, optimum management is debatable. This study aims to explore the outcome management combination of prolotherapy and physical rehabilitation with physical rehabilitation only for PTRCT. Randomized Control Trial (RCT) studies From PubMed, Cochrane Library, ScienceDirect, ProQuest, And Google Scholar were included. Two independent reviewers evaluated the quality of RCTs using the Cochrane Risk of Bias Tool. The primary result was pain reduction, with functional improvement as a secondary outcome. Meta-analysis was performed using Review Manager 5.4 software. Our meta-analysis included 5 RCT studies involving 263 patients. Standardized mean difference (SMD) was collected from all of the studies. In ...

Journal of Public Health in Africa

Background: The sodium may aggravate synovial inflammation and cartilage thinning. This incidence... more Background: The sodium may aggravate synovial inflammation and cartilage thinning. This incidence can cause joint pain and reduce functional activity. Not many people know the effect of sodium on the incidence of OA. Objective: This study aims to determine the relationship between sodium in the body and knee joint pain which results in functional activity. Methods: The quantitative descriptive study used accidental sampling. The study was conducted at three outpatient polyclinic orthopedics of hospitals and was approved by the Health Ethics Committee. All data were collected during the interview. The Semi-Quantitative Food Frequency Questionnaire (SQ-FFQ) and the Nutrisurvey Indonesia 2007 application were used as a tool to collect daily sodium intake (mg). Knee joint pain score was measured using the Visual Analog Scale (VAS) while functional body activity was measured using the Western Ontario McMaster Osteoarthritis Index (WOMAC). The Pearson and Spearman test (p<0.05) were us...

Annals of Medicine & Surgery

Clinical and Research Journal in Internal Medicine

Background: Osteoporosis is an increasing health problem in Indonesia. Fractures that occur in th... more Background: Osteoporosis is an increasing health problem in Indonesia. Fractures that occur in the spine and pelvis are considered to be the most common fracture sites for osteoporosis. Aim: to determine the differences in bone mineral density values in postmenopausal women with fracture and non-fracture. Methods: Survey was carried out in postmenopausal female patients with fractures and without fractures who were included in the inclusion criteria with a case-control study approach and had bone mass density data. For the group of cases with fracture, the amount of vertebral compression was measured using Gennant's measurement criteria. Interviews were conducted regarding the characteristics of patients with and without fracture. The differences in BMD values ​​were analyzed in postmenpausal female patients with fracture and without fracture by using unpaired T test on normal data distribution and Mann-Whitney test on abnormal data distribution. The measured BMD value is the T-...

Open Access Macedonian Journal of Medical Sciences

Background: Trans-scaphoid lunate dislocation is an orthopaedic injury, mostly because of high en... more Background: Trans-scaphoid lunate dislocation is an orthopaedic injury, mostly because of high energy trauma. Due to subtle clinical and radiological findings, it might be easily left undiagnosed, with estimated 25% cases are missed at initial assessment in emergency department. Non-union scaphoid, which accounts for 5-10% of all scaphoid fractures treated with K-wires fixation, mostly occurs in young and active individual. Case Presentation: Thirty-seven-years-old right-handed man complained pain, and restricted range of motion (ROM) on his right wrist after fell from 2m height. Loss of symmetry and parallelism of joint space in Gilula's line shown in X-ray, possible for a trans-scaphoid lunate dislocation. We performed dorsal approach and internal fixation using Kirschner wire (1.0). The patient had a short arm cast for 4 weeks. The K-wires were removed 5 weeks postoperatively. We achieved good result clinically in 3, 9, and 36 months of follow up (Mayo Wrist Score of 70, 80, ...

Journal of Public Health Research

Background: Osteoporosis is characterized by a low bone mass of bone tissue. If osteoporosis is n... more Background: Osteoporosis is characterized by a low bone mass of bone tissue. If osteoporosis is not treated properly, it will increase the high risk of fracture. The common causes of fracture on osteoporosis condition due to falls. This study aims to find the correlation between the risk of osteoporosis with fall risk (ONTARIO) based on osteoporosis fracture risk (FRAX) Methods: This study is an analytic study with a cross-sectional method. We collected the sample using random cluster sampling in the six primary health care in Malang on different times service since August–September 2021. Total patient 139, however only 132 patients were included in this study. After collecting data is complete, we analyze using Chi-square tests. Results: The mean age of participants was 63.9 ± 7.14. with the age group was dominated by the range of 60–64. It was found that the result of the FRAX SCORE had a low-risk category for major fracture osteoporosis and risk hip fracture. In contrast, from th...

International Journal of Surgery Case Reports

Open Access Macedonian Journal of Medical Sciences

Introduction: A tourniquet is a typical equipment used in the orthopedics surgery to decrease blo... more Introduction: A tourniquet is a typical equipment used in the orthopedics surgery to decrease blood loss and create a better operating environment. Ischemic-reperfusion damage, which happens when the tourniquet is deflated, is one of the tourniquet's negative effects. Antioxidants can be used to minimize oxidative stress, which is one strategy to mitigate ischemic-reperfusion injury. Aloe vera, for example, is widely known for its antioxidant and anti-inflammatory properties. Method: The tibias of male Wistar strain rats (Rattus norvegicus) were fractured in this experiment, and Aloe vera gel was given orally as an antioxidant. A total of 18 rats were utilized in this research, which were separated into 6 groups. Varying amounts of Aloe vera extract were given to the treatment groups: 40 mg/kgBW, 60 mg/kgBW, and 80 mg/kgBW. The tourniquet would be inflated for two hours then deflated after application of the Aloe vera extract. Superoxide dismutase (SOD) and malondialdehyde level...

F1000Research, Mar 30, 2022

Background: Tourniquet is a common instrument used in Orthopedics field to reduce blood loss, pro... more Background: Tourniquet is a common instrument used in Orthopedics field to reduce blood loss, providing a better operating field. One of the deleterious effects of tourniquet is ischemic-reperfusion injury, which occurs after deflation of the tourniquet. One of the possible ways to mitigate ischemic-reperfusion injury is by administrating antioxidants to reduce oxidative stress. Natural ingredients like Aloe vera are well known for its antioxidant and anti-inflammatory activities. This experimental study was conducted by fracturing the tibia of male Wistar strain rats (Rattus norvegicus) and administering Aloe vera gel orally as antioxidant. Method: A total of 18 rats were used in this study, divided into 6 groups. The first group was the control group, that included rats with fractured tibia not receiving torniquet and aloe vera treatment. The second and third groups were rats with fracture, who received torniquet application for one hour and two hours respectively without aloe vera treatment. The rest were the treatment groups, the rats with factures were given different dosages of Aloe vera extract: 40 mg/kg bodyweight (BW), 60 mg/kg BW, and 80 mg/kg BW. Three hours after administration, the tourniquet was inflated for two hours, followed by its deflation. The tibia was harvested to examine levels of superoxide dismutase (SOD), Malondialdehyde (MDA), and Bone morphogenetic protein 7 (BMP-7), and callus diameter, and osteoblast numbers were evaluated. Result: Administration of Aloe vera extract reduced the oxidative stress parameters (SOD and MDA). Tourniquet application decreased the osteoblast cell count and callus diameter, and administration of Aloe vera extract increased both variables close to the control value (p&lt;0.05). Conclusion: The result of this study suggests that Aloe vera extract could be used to ameliorate ischemic-reperfusion injury.

International Journal of Medical Reviews and Case Reports, 2022

Open Access Macedonian Journal of Medical Sciences, 2021

Introduction: Osteomyelitis is a serious infection of the bone. One of the therapies for osteomye... more Introduction: Osteomyelitis is a serious infection of the bone. One of the therapies for osteomyelitis is antibiotic treatment. Antibiotic treatment has evolved substantially, but bone infections are still a challenge. Antimicrobial therapy is also difficult, caused by antibiotic-resistant organisms. Therefore, a systematic review is needed to assess antibiotic use in osteomyelitis infection. Method: Articles were searched using Pubmed with keywords “antibiotics”, “osteomyelitis”, and its combination. The authors used five years publication date and English language to select the appropriate journal. Result: The author identified 13 relevant articles with antibiotics use in osteomyelitis. All of the cases were about chronic osteomyelitis and osteomyelitis in diabetic foot ulcers. Osteomyelitis in other sites of long bones needs longer duration treatment than long bone osteomyelitis. In acute osteomyelitis in children, antibiotic treatment can switch from IV to oral antibiotics. Fur...