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Papers by Thomas Rizzo

Research paper thumbnail of State-Resolved Gas-Surface Reactivity of Methane in the Symmetric C-H Stretch Vibration on Ni(100)

Physical Review Letters, Jun 22, 2005

Research paper thumbnail of Efficient stimulated Raman pumping for quantum state resolved surface reactivity measurements

Review of Scientific Instruments, May 1, 2006

We describe the use of stimulated Raman pumping in a molecular beam to perform quantum state reso... more We describe the use of stimulated Raman pumping in a molecular beam to perform quantum state resolved gas-surface reactivity measurements for molecules prepared in totally symmetric vibrational states. Vibrational states of homonuclear diatomics as well as totally symmetric vibrations of polyatomic molecules cannot be prepared by direct infrared excitation but are accessible through stimulated Raman pumping by two laser fields when the difference between the incident laser frequencies matches the vibration. We generate a suitable resonant pair of high-energy pump and Stokes laser beams in an injection seeded Raman amplifier filled with the sample gas and equipped with internal gas recirculation. The ability to partially saturate the Raman pumping process in the molecular beam is used to quantify the fraction of vibrationally excited molecules in the irradiated volume, which is needed for quantitative reactivity measurements. We illustrate the method with state resolved reactivity measurements for CH4, prepared in its symmetric C–H stretch vibration on a Ni(100) single crystal surface.

Research paper thumbnail of Identification of human milk oligosaccharide positional isomers by combining IMS-CID-IMS and cryogenic IR spectroscopy

The Analyst

Cryogenic infrared spectra of CID fragments separated by IMS are used to identify human milk olig... more Cryogenic infrared spectra of CID fragments separated by IMS are used to identify human milk oligiosaccharide isomers.

Research paper thumbnail of UV spectroscopic studies on cold host-guest complexes in 22-pole ion trap

Research paper thumbnail of Toward High-Throughput Cryogenic IR Fingerprinting of Mobility-Separated Glycan Isomers

ACS Measurement Science Au, 2021

Research paper thumbnail of The Structure of the Protonated Serine Octamer

Journal of the American Chemical Society, Jan 20, 2018

The amino acid serine has long been known to form a protonated "magic-number" cluster c... more The amino acid serine has long been known to form a protonated "magic-number" cluster containing eight monomer units that shows an unusually high abundance in mass spectra and has a remarkable homochiral preference. Despite many experimental and theoretical studies, there is no consensus on a SerH structure that is in agreement with all experimental observations. Here, we present the structure of SerH determined by a combination of infrared spectroscopy and ab initio molecular dynamics simulations. The three-dimensional structure that we determine is ∼25 kcal mol more stable than the previous most stable published structure and explains both the homochiral preference and the experimentally observed facile replacement of two serine units.

Research paper thumbnail of Cryogenic Ion Spectroscopy for Identification of Monosaccharide Anomers

The Journal of Physical Chemistry A, 2019

Research paper thumbnail of UV and IR spectroscopic studies of alkali metal ion-crown ether complexes in the gas phase and on gold surface

Gordon Research Conferences –Molecular & Ionic Clusters, from April 27 to May 2, 2014, Renaissanc... more Gordon Research Conferences –Molecular & Ionic Clusters, from April 27 to May 2, 2014, Renaissance Tuscany Il Ciocco, in Lucca (Barga), Italy

Research paper thumbnail of How General Is Anomeric Retention during Collision-Induced Dissociation of Glycans?

Journal of the American Chemical Society, 2020

Research paper thumbnail of Using SLIM-Based IMS-IMS Together with Cryogenic Infrared Spectroscopy for Glycan Analysis

Analytical Chemistry, 2020

Research paper thumbnail of Combining Cryogenic Infrared Spectroscopy with Selective Enzymatic Cleavage for Determining Glycan Primary Structure

Analytical Chemistry, 2020

Research paper thumbnail of Efficient stimulated Raman pumping for quantum state resolved surface reactivity measurements

Review of Scientific Instruments, 2006

We describe the use of stimulated Raman pumping in a molecular beam to perform quantum state reso... more We describe the use of stimulated Raman pumping in a molecular beam to perform quantum state resolved gas-surface reactivity measurements for molecules prepared in totally symmetric vibrational states. Vibrational states of homonuclear diatomics as well as totally symmetric vibrations of polyatomic molecules cannot be prepared by direct infrared excitation but are accessible through stimulated Raman pumping by two laser fields

Research paper thumbnail of Identifying Mixtures of Isomeric Human Milk Oligosaccharides by the Decomposition of IR Spectral Fingerprints

Research paper thumbnail of Infrared Spectroscopy as a Probe of Electronic Energy Transfer

The Journal of Physical Chemistry Letters, 2018

Research paper thumbnail of Cryogenic Vibrational Spectroscopy Provides Unique Fingerprints for Glycan Identification

Journal of The American Society for Mass Spectrometry, 2017

Research paper thumbnail of Unravelling the structures of sodiated β-cyclodextrin and its fragments

Physical Chemistry Chemical Physics

Experiment and theory unravel the structure and formation mechanism of β-cyclodextrin fragment ions.

Research paper thumbnail of A new approach for identifying positional isomers of glycans cleaved from monoclonal antibodies

The Analyst

We apply high-resolution ion mobility combined with cryogenic infrared spectroscopy to distinguis... more We apply high-resolution ion mobility combined with cryogenic infrared spectroscopy to distinguish isomeric N-glycans with different terminal galactose positions.

Research paper thumbnail of Analyzing glycans cleaved from a biotherapeutic protein using ultrahigh-resolution ion mobility spectrometry together with cryogenic ion spectroscopy

Research paper thumbnail of ChemInform Abstract: IR Spectrum of tert.-Butyl Hydroperoxide Excited to the 4νOH Vibrational Overtone Level

Research paper thumbnail of Separation and Identification of Glycan Anomers Using Ultrahigh-Resolution Ion-Mobility Spectrometry and Cryogenic Ion Spectroscopy

Journal of The American Society for Mass Spectrometry

Research paper thumbnail of State-Resolved Gas-Surface Reactivity of Methane in the Symmetric C-H Stretch Vibration on Ni(100)

Physical Review Letters, Jun 22, 2005

Research paper thumbnail of Efficient stimulated Raman pumping for quantum state resolved surface reactivity measurements

Review of Scientific Instruments, May 1, 2006

We describe the use of stimulated Raman pumping in a molecular beam to perform quantum state reso... more We describe the use of stimulated Raman pumping in a molecular beam to perform quantum state resolved gas-surface reactivity measurements for molecules prepared in totally symmetric vibrational states. Vibrational states of homonuclear diatomics as well as totally symmetric vibrations of polyatomic molecules cannot be prepared by direct infrared excitation but are accessible through stimulated Raman pumping by two laser fields when the difference between the incident laser frequencies matches the vibration. We generate a suitable resonant pair of high-energy pump and Stokes laser beams in an injection seeded Raman amplifier filled with the sample gas and equipped with internal gas recirculation. The ability to partially saturate the Raman pumping process in the molecular beam is used to quantify the fraction of vibrationally excited molecules in the irradiated volume, which is needed for quantitative reactivity measurements. We illustrate the method with state resolved reactivity measurements for CH4, prepared in its symmetric C–H stretch vibration on a Ni(100) single crystal surface.

Research paper thumbnail of Identification of human milk oligosaccharide positional isomers by combining IMS-CID-IMS and cryogenic IR spectroscopy

The Analyst

Cryogenic infrared spectra of CID fragments separated by IMS are used to identify human milk olig... more Cryogenic infrared spectra of CID fragments separated by IMS are used to identify human milk oligiosaccharide isomers.

Research paper thumbnail of UV spectroscopic studies on cold host-guest complexes in 22-pole ion trap

Research paper thumbnail of Toward High-Throughput Cryogenic IR Fingerprinting of Mobility-Separated Glycan Isomers

ACS Measurement Science Au, 2021

Research paper thumbnail of The Structure of the Protonated Serine Octamer

Journal of the American Chemical Society, Jan 20, 2018

The amino acid serine has long been known to form a protonated "magic-number" cluster c... more The amino acid serine has long been known to form a protonated "magic-number" cluster containing eight monomer units that shows an unusually high abundance in mass spectra and has a remarkable homochiral preference. Despite many experimental and theoretical studies, there is no consensus on a SerH structure that is in agreement with all experimental observations. Here, we present the structure of SerH determined by a combination of infrared spectroscopy and ab initio molecular dynamics simulations. The three-dimensional structure that we determine is ∼25 kcal mol more stable than the previous most stable published structure and explains both the homochiral preference and the experimentally observed facile replacement of two serine units.

Research paper thumbnail of Cryogenic Ion Spectroscopy for Identification of Monosaccharide Anomers

The Journal of Physical Chemistry A, 2019

Research paper thumbnail of UV and IR spectroscopic studies of alkali metal ion-crown ether complexes in the gas phase and on gold surface

Gordon Research Conferences –Molecular & Ionic Clusters, from April 27 to May 2, 2014, Renaissanc... more Gordon Research Conferences –Molecular & Ionic Clusters, from April 27 to May 2, 2014, Renaissance Tuscany Il Ciocco, in Lucca (Barga), Italy

Research paper thumbnail of How General Is Anomeric Retention during Collision-Induced Dissociation of Glycans?

Journal of the American Chemical Society, 2020

Research paper thumbnail of Using SLIM-Based IMS-IMS Together with Cryogenic Infrared Spectroscopy for Glycan Analysis

Analytical Chemistry, 2020

Research paper thumbnail of Combining Cryogenic Infrared Spectroscopy with Selective Enzymatic Cleavage for Determining Glycan Primary Structure

Analytical Chemistry, 2020

Research paper thumbnail of Efficient stimulated Raman pumping for quantum state resolved surface reactivity measurements

Review of Scientific Instruments, 2006

We describe the use of stimulated Raman pumping in a molecular beam to perform quantum state reso... more We describe the use of stimulated Raman pumping in a molecular beam to perform quantum state resolved gas-surface reactivity measurements for molecules prepared in totally symmetric vibrational states. Vibrational states of homonuclear diatomics as well as totally symmetric vibrations of polyatomic molecules cannot be prepared by direct infrared excitation but are accessible through stimulated Raman pumping by two laser fields

Research paper thumbnail of Identifying Mixtures of Isomeric Human Milk Oligosaccharides by the Decomposition of IR Spectral Fingerprints

Research paper thumbnail of Infrared Spectroscopy as a Probe of Electronic Energy Transfer

The Journal of Physical Chemistry Letters, 2018

Research paper thumbnail of Cryogenic Vibrational Spectroscopy Provides Unique Fingerprints for Glycan Identification

Journal of The American Society for Mass Spectrometry, 2017

Research paper thumbnail of Unravelling the structures of sodiated β-cyclodextrin and its fragments

Physical Chemistry Chemical Physics

Experiment and theory unravel the structure and formation mechanism of β-cyclodextrin fragment ions.

Research paper thumbnail of A new approach for identifying positional isomers of glycans cleaved from monoclonal antibodies

The Analyst

We apply high-resolution ion mobility combined with cryogenic infrared spectroscopy to distinguis... more We apply high-resolution ion mobility combined with cryogenic infrared spectroscopy to distinguish isomeric N-glycans with different terminal galactose positions.

Research paper thumbnail of Analyzing glycans cleaved from a biotherapeutic protein using ultrahigh-resolution ion mobility spectrometry together with cryogenic ion spectroscopy

Research paper thumbnail of ChemInform Abstract: IR Spectrum of tert.-Butyl Hydroperoxide Excited to the 4νOH Vibrational Overtone Level

Research paper thumbnail of Separation and Identification of Glycan Anomers Using Ultrahigh-Resolution Ion-Mobility Spectrometry and Cryogenic Ion Spectroscopy

Journal of The American Society for Mass Spectrometry

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