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Papers by Tiffany Sheehan

Research paper thumbnail of Hospital Characteristics and Mortality in Aneurysmal Subarachnoid Hemorrhage

Journal of Neuroscience Nursing

Research paper thumbnail of Emergency Department Length of Stay and Other Factors Contributing to Intracerebral Hemorrhage Patient Outcomes: An Executive Summary

Journal of Neuroscience Nursing

Research paper thumbnail of Factors Associated With Emergency Department Length of Stay and In-hospital Mortality in Intracerebral Hemorrhage Patients

Journal of Neuroscience Nursing

Research paper thumbnail of Factors Associated With Recurrent Ischemic Stroke in the Medical Group of the SAMMPRIS Trial

JAMA neurology, Jan 4, 2016

The Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial St... more The Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) Trial showed that aggressive medical therapy was more effective than stenting for preventing stroke in patients with symptomatic intracranial stenosis. However, 15% of patients in the medical group still experienced a primary end point during a median follow-up of 32.7 months. To determine baseline features that were associated with a high rate of a primary end point in the medical arm of the SAMMPRIS Trial. A post hoc analysis of patients in the medical arm only of the SAMMPRIS trial. Enrollment occurred between October 2008 and April 2013 and included 227 patients randomized to medical management alone. Baseline demographic features, vascular risk factors, qualifying event, brain imaging, and angiographic features were analyzed. Bivariate and multivariable proportional hazard regression modeling was performed to relate baseline features to the time until a primary end...

Research paper thumbnail of Abstract 78: Risk Factors Associated with Failure of Aggressive Medical Therapy in the SAMMPRIS Trial

Research paper thumbnail of CYP2C19 and CES1 polymorphisms and efficacy of clopidogrel and aspirin dual antiplatelet therapy in patients with symptomatic intracranial atherosclerotic disease

Journal of neurosurgery, Jan 20, 2015

OBJECT Symptomatic intracranial atherosclerotic disease (ICAD) has a high risk of recurrent strok... more OBJECT Symptomatic intracranial atherosclerotic disease (ICAD) has a high risk of recurrent stroke. Genetic polymorphisms in CYP2C19 and CES1 are associated with adverse outcomes in cardiovascular patients, but have not been studied in ICAD. The authors studied CYP2C19 and CES1 single-nucleotide polymorphisms (SNPs) in symptomatic ICAD patients. METHODS Genotype testing for CYP2C19*2, (*)3, (*)8, (*)17 and CES1 G143E was performed on 188 adult symptomatic ICAD patients from 3 medical centers who were medically managed with clopidogrel and aspirin. Testing was performed prospectively at 1 center, and retrospectively from a DNA sample biorepository at 2 centers. Multiple logistic regression and Cox regression analysis were performed to assess the association of these SNPs with the primary endpoint, which was a composite of transient ischemic attack (TIA), stroke, myocardial infarction, or death within 12 months. RESULTS The primary endpoint occurred in 14.9% of the 188 cases. In multi...

Research paper thumbnail of Hospital Characteristics and Mortality in Aneurysmal Subarachnoid Hemorrhage

Journal of Neuroscience Nursing

Research paper thumbnail of Emergency Department Length of Stay and Other Factors Contributing to Intracerebral Hemorrhage Patient Outcomes: An Executive Summary

Journal of Neuroscience Nursing

Research paper thumbnail of Factors Associated With Emergency Department Length of Stay and In-hospital Mortality in Intracerebral Hemorrhage Patients

Journal of Neuroscience Nursing

Research paper thumbnail of Factors Associated With Recurrent Ischemic Stroke in the Medical Group of the SAMMPRIS Trial

JAMA neurology, Jan 4, 2016

The Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial St... more The Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) Trial showed that aggressive medical therapy was more effective than stenting for preventing stroke in patients with symptomatic intracranial stenosis. However, 15% of patients in the medical group still experienced a primary end point during a median follow-up of 32.7 months. To determine baseline features that were associated with a high rate of a primary end point in the medical arm of the SAMMPRIS Trial. A post hoc analysis of patients in the medical arm only of the SAMMPRIS trial. Enrollment occurred between October 2008 and April 2013 and included 227 patients randomized to medical management alone. Baseline demographic features, vascular risk factors, qualifying event, brain imaging, and angiographic features were analyzed. Bivariate and multivariable proportional hazard regression modeling was performed to relate baseline features to the time until a primary end...

Research paper thumbnail of Abstract 78: Risk Factors Associated with Failure of Aggressive Medical Therapy in the SAMMPRIS Trial

Research paper thumbnail of CYP2C19 and CES1 polymorphisms and efficacy of clopidogrel and aspirin dual antiplatelet therapy in patients with symptomatic intracranial atherosclerotic disease

Journal of neurosurgery, Jan 20, 2015

OBJECT Symptomatic intracranial atherosclerotic disease (ICAD) has a high risk of recurrent strok... more OBJECT Symptomatic intracranial atherosclerotic disease (ICAD) has a high risk of recurrent stroke. Genetic polymorphisms in CYP2C19 and CES1 are associated with adverse outcomes in cardiovascular patients, but have not been studied in ICAD. The authors studied CYP2C19 and CES1 single-nucleotide polymorphisms (SNPs) in symptomatic ICAD patients. METHODS Genotype testing for CYP2C19*2, (*)3, (*)8, (*)17 and CES1 G143E was performed on 188 adult symptomatic ICAD patients from 3 medical centers who were medically managed with clopidogrel and aspirin. Testing was performed prospectively at 1 center, and retrospectively from a DNA sample biorepository at 2 centers. Multiple logistic regression and Cox regression analysis were performed to assess the association of these SNPs with the primary endpoint, which was a composite of transient ischemic attack (TIA), stroke, myocardial infarction, or death within 12 months. RESULTS The primary endpoint occurred in 14.9% of the 188 cases. In multi...

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