Tiina Karu - Academia.edu (original) (raw)

Papers by Tiina Karu

Research paper thumbnail of Effects of Low-Power Light on Biological Systems V

Proceedings of SPIE - The International Society for Optical Engineering

Research paper thumbnail of Effects of Low-Power Light on Biological Systems IV

Proceedings of SPIE - The International Society for Optical Engineering

The biostimulative effects exerted by various low power lasers in the visible and near IR might b... more The biostimulative effects exerted by various low power lasers in the visible and near IR might be a consequence of reactive oxygen species (ROS) production. Although high concentration of ROS leads to cell death, low and controlled concentrations may play an important role ...

Research paper thumbnail of Effects of Low-Power Light on Biological Systems III

Proceedings of SPIE - The International Society for Optical Engineering

The biostimulative effects exerted by various low power lasers in the visible and near IR might b... more The biostimulative effects exerted by various low power lasers in the visible and near IR might be a consequence of reactive oxygen species (ROS) production. Although high concentration of ROS leads to cell death, low and controlled concentrations may play an important role ...

Research paper thumbnail of Influence of low-intensity red diode and laser radiation on the locomotor activity of sea urchin sperm

Doklady. Biochemistry and biophysics, 2014

Research paper thumbnail of Derepression of the Genome After Irradiation of Human Lymphocytes with He-Ne Laser

Research paper thumbnail of Chromophores (Photoacceptors) for Low-Level Laser Therapy

Handbook of Photomedicine, 2013

Research paper thumbnail of Chromophores (Photoacceptors) for Low-Level Laser Therapy

Handbook of Photomedicine, 2013

Research paper thumbnail of Low-Power Laser Effects

Research paper thumbnail of Low-Power Laser Therapy

Biomedical Photonics Handbook, 2003

Research paper thumbnail of Cellular Mechanisms of Low Power Laser Therapy: New Questions

Research paper thumbnail of <title>Can a mechanism based on changes in redox properties of cytochrome c oxidase be crucial in explaining low-power laser effects?</title>

ICONO '98: Laser Spectroscopy and Optical Diagnostics: Novel Trends and Applications in Laser Chemistry, Biophysics, and Biomedicine, 1999

Research paper thumbnail of Biological action of low-intensity visible light on HeLa cells as a function of the coherence, dose, wavelength, and irradiation regime

Soviet Journal of Quantum Electronics, 1982

An investigation was made of the action of λ = 633 nm low-intensity red light (He–Ne laser, incan... more An investigation was made of the action of λ = 633 nm low-intensity red light (He–Ne laser, incandescent lamp with light filters, dye laser pumped by a copper laser) on the rate of nucleic acid synthesis in HeLa cells 1.5 h after irradiation. It was found that DNA synthesis is stimulated almost equally by irradiation with an He–Ne laser and

Research paper thumbnail of Action of ultrashort ultraviolet laser pulses on HeLa tumor cells

Soviet Journal of Quantum Electronics

An investigation was made of the selective action of pulsed laser radiation (fourth harmonic of a... more An investigation was made of the selective action of pulsed laser radiation (fourth harmonic of a YAG:Nd3+ laser having a wavelength of 266 nm and a pulse duration of 35 psec) on nucleic acids in HeLa tumor cells which were at the logarithmic stage of growth. It was found that by varying the radiation parameters (number of pulses and their intensity), the rate of synthesis of nucleic acids could be varied, being either accelerated or slowed down. Irradiation by a dose of between 10−5 and 10−3 J/cm2 stimulates synthesis of DNA and RNA whilst the permeability of the cell membrane for synthesis precursors remains constant, whereas irradiation by doses between 10−3 and 0.1 J/cm2 inhibits synthesis of nucleic acids and the permeability of the cell membrane decreases.

Research paper thumbnail of <title>Primary mechanisms of action of low-intensity laser light on cells</title>

ALT'98 Selected Papers on Novel Laser Methods in Medicine and Biology, 1999

Research paper thumbnail of <title>Mechanisms of low-power laser light action on cellular level</title>

Effects of Low-Power Light on Biological Systems V, 2000

Research paper thumbnail of Mitochondrial Mechanisms of Photobiomodulation in Context of New Data About Multiple Roles of ATP

Photomedicine and Laser Surgery, 2010

Research paper thumbnail of High-tech helps to estimate cellular mechanisms of low power laser therapy

Lasers in Surgery and Medicine, 2004

Research paper thumbnail of Nonmonotonic behavior of the dose dependence of the radiation effect on cells in vitro exposed to pulsed laser radiation at λ = 820 nm

Lasers in Surgery and Medicine, 1997

In recent years, clinical low-intensity laser therapy practice has used pulsed radiation, mainly ... more In recent years, clinical low-intensity laser therapy practice has used pulsed radiation, mainly from semiconductor lasers. Experimental works devoted to the study of relationships between biological and clinical effects and parameters of pulsed radiation are practically absent. The radiation source was a laser diode emitting at 820 nm (292 and 700 Hz, duty factor 80%; doses from 7 J/m2 to 5 x 10(5) J/m2; intensities 4, 12, 51, 152, 633, and 1,900 W/m2; irradiation time from 1 to 30 s). Four biological models were used: nucleated cells of murine spleen (splenocytes) and bone marrow (karyocytes), murine blood, and HeLa cells cultivated in vitro. The intensity of luminol-amplified chemiluminescence (in case of murine models) and the adhesion of HeLa cell membranes were measured as a function of the irradiation dose. Within the wide exposure dose range used we obtained seven maxima in the dose vs. biological effect curves: at fluences near 20, 1 x 10(2), 3 x 10(2), 8 x 10(2), 3 x 10(3), 1 x 10(4), and 3 x 10(4) J/m2. The peaks coincided for all four models. The dose curves obtained with different cellular systems are of the same type and are characterized by seven peaks in the dose interval studied (7 J/m2 to 5 x 10(5) J/m2).

Research paper thumbnail of Laser biostimulation: A photobiological phenomenon

Journal of Photochemistry and Photobiology B: Biology, 1989

Research paper thumbnail of Should a PDT protocol certainly contain a “light only” experiment?

Journal of Photochemistry and Photobiology B: Biology, 1992

Research paper thumbnail of Effects of Low-Power Light on Biological Systems V

Proceedings of SPIE - The International Society for Optical Engineering

Research paper thumbnail of Effects of Low-Power Light on Biological Systems IV

Proceedings of SPIE - The International Society for Optical Engineering

The biostimulative effects exerted by various low power lasers in the visible and near IR might b... more The biostimulative effects exerted by various low power lasers in the visible and near IR might be a consequence of reactive oxygen species (ROS) production. Although high concentration of ROS leads to cell death, low and controlled concentrations may play an important role ...

Research paper thumbnail of Effects of Low-Power Light on Biological Systems III

Proceedings of SPIE - The International Society for Optical Engineering

The biostimulative effects exerted by various low power lasers in the visible and near IR might b... more The biostimulative effects exerted by various low power lasers in the visible and near IR might be a consequence of reactive oxygen species (ROS) production. Although high concentration of ROS leads to cell death, low and controlled concentrations may play an important role ...

Research paper thumbnail of Influence of low-intensity red diode and laser radiation on the locomotor activity of sea urchin sperm

Doklady. Biochemistry and biophysics, 2014

Research paper thumbnail of Derepression of the Genome After Irradiation of Human Lymphocytes with He-Ne Laser

Research paper thumbnail of Chromophores (Photoacceptors) for Low-Level Laser Therapy

Handbook of Photomedicine, 2013

Research paper thumbnail of Chromophores (Photoacceptors) for Low-Level Laser Therapy

Handbook of Photomedicine, 2013

Research paper thumbnail of Low-Power Laser Effects

Research paper thumbnail of Low-Power Laser Therapy

Biomedical Photonics Handbook, 2003

Research paper thumbnail of Cellular Mechanisms of Low Power Laser Therapy: New Questions

Research paper thumbnail of <title>Can a mechanism based on changes in redox properties of cytochrome c oxidase be crucial in explaining low-power laser effects?</title>

ICONO '98: Laser Spectroscopy and Optical Diagnostics: Novel Trends and Applications in Laser Chemistry, Biophysics, and Biomedicine, 1999

Research paper thumbnail of Biological action of low-intensity visible light on HeLa cells as a function of the coherence, dose, wavelength, and irradiation regime

Soviet Journal of Quantum Electronics, 1982

An investigation was made of the action of λ = 633 nm low-intensity red light (He–Ne laser, incan... more An investigation was made of the action of λ = 633 nm low-intensity red light (He–Ne laser, incandescent lamp with light filters, dye laser pumped by a copper laser) on the rate of nucleic acid synthesis in HeLa cells 1.5 h after irradiation. It was found that DNA synthesis is stimulated almost equally by irradiation with an He–Ne laser and

Research paper thumbnail of Action of ultrashort ultraviolet laser pulses on HeLa tumor cells

Soviet Journal of Quantum Electronics

An investigation was made of the selective action of pulsed laser radiation (fourth harmonic of a... more An investigation was made of the selective action of pulsed laser radiation (fourth harmonic of a YAG:Nd3+ laser having a wavelength of 266 nm and a pulse duration of 35 psec) on nucleic acids in HeLa tumor cells which were at the logarithmic stage of growth. It was found that by varying the radiation parameters (number of pulses and their intensity), the rate of synthesis of nucleic acids could be varied, being either accelerated or slowed down. Irradiation by a dose of between 10−5 and 10−3 J/cm2 stimulates synthesis of DNA and RNA whilst the permeability of the cell membrane for synthesis precursors remains constant, whereas irradiation by doses between 10−3 and 0.1 J/cm2 inhibits synthesis of nucleic acids and the permeability of the cell membrane decreases.

Research paper thumbnail of <title>Primary mechanisms of action of low-intensity laser light on cells</title>

ALT'98 Selected Papers on Novel Laser Methods in Medicine and Biology, 1999

Research paper thumbnail of <title>Mechanisms of low-power laser light action on cellular level</title>

Effects of Low-Power Light on Biological Systems V, 2000

Research paper thumbnail of Mitochondrial Mechanisms of Photobiomodulation in Context of New Data About Multiple Roles of ATP

Photomedicine and Laser Surgery, 2010

Research paper thumbnail of High-tech helps to estimate cellular mechanisms of low power laser therapy

Lasers in Surgery and Medicine, 2004

Research paper thumbnail of Nonmonotonic behavior of the dose dependence of the radiation effect on cells in vitro exposed to pulsed laser radiation at λ = 820 nm

Lasers in Surgery and Medicine, 1997

In recent years, clinical low-intensity laser therapy practice has used pulsed radiation, mainly ... more In recent years, clinical low-intensity laser therapy practice has used pulsed radiation, mainly from semiconductor lasers. Experimental works devoted to the study of relationships between biological and clinical effects and parameters of pulsed radiation are practically absent. The radiation source was a laser diode emitting at 820 nm (292 and 700 Hz, duty factor 80%; doses from 7 J/m2 to 5 x 10(5) J/m2; intensities 4, 12, 51, 152, 633, and 1,900 W/m2; irradiation time from 1 to 30 s). Four biological models were used: nucleated cells of murine spleen (splenocytes) and bone marrow (karyocytes), murine blood, and HeLa cells cultivated in vitro. The intensity of luminol-amplified chemiluminescence (in case of murine models) and the adhesion of HeLa cell membranes were measured as a function of the irradiation dose. Within the wide exposure dose range used we obtained seven maxima in the dose vs. biological effect curves: at fluences near 20, 1 x 10(2), 3 x 10(2), 8 x 10(2), 3 x 10(3), 1 x 10(4), and 3 x 10(4) J/m2. The peaks coincided for all four models. The dose curves obtained with different cellular systems are of the same type and are characterized by seven peaks in the dose interval studied (7 J/m2 to 5 x 10(5) J/m2).

Research paper thumbnail of Laser biostimulation: A photobiological phenomenon

Journal of Photochemistry and Photobiology B: Biology, 1989

Research paper thumbnail of Should a PDT protocol certainly contain a “light only” experiment?

Journal of Photochemistry and Photobiology B: Biology, 1992