Tiny Nair - Academia.edu (original) (raw)

Papers by Tiny Nair

PubMed, Dec 1, 2018

1Cardiologist at MGM Hospital, Mumbai, Maharashtra; 2Chief of Cardiology, Holy Family Hospital, M... more 1Cardiologist at MGM Hospital, Mumbai, Maharashtra; 2Chief of Cardiology, Holy Family Hospital, Mumbai, Maharashtra; 3Interventional Cardiologist, Laxmi Hospital, Palakkad, Kerala; 4Interventional Cardiologist, PRS Hospital, Trivandrum, Kerala; 5Interventional Cardiologist, Medica Hospital, Patna, Bihar; 6Interventional Cardiologist, Apollo Hospital, Bhubaneshwar, Orissa; 7Interventional Cardiologist, Health world, Durgapur, West Bengal; 8Interventional Cardiologist, Fortis, Delhi; 9Interventional Cardiologist, Apollo Hospital, Hyderabad, Telangana; 10Interventional Cardiologist, Paritham Hospital, Kottyam, Kerala; 11Interventional Cardiologist, Krishna Medical Centre, Lucknow, Uttar Pradesh; 12Interventional Cardiologist, Sai Baba Hospital, Nasik, Maharashtra; 13Cardiologist at Old MLA Quarters, Bhopal, Madhya Pradesh

American heart journal, 2018

Thyroid Research and Practice, 2016

Hypertension journal, 2016

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Feb 1, 2022

Indian heart journal, Jul 1, 2020

Journal of Human Hypertension, May 14, 2019

Journal of Cardiac Failure, Dec 1, 2018

Heart Failure Journal of India

Journal of Association of Physicians of India, Feb 1, 2023

Wellcome Open Research

Background: Heart failure (HF) is a debilitating condition associated with enormous public health... more Background: Heart failure (HF) is a debilitating condition associated with enormous public health burden. Management of HF is complex as it requires care and coordination with different cadres of health care providers. In resource poor settings, physician driven initiatives to improve HF management is difficult due to multiple barriers. We propose to develop a team based collaborative care model (CCM), facilitated by a trained nurse, for management of HF with the support of mHealth and evaluate their acceptability and effectiveness in Indian setting. Methods: The proposed study will use mixed-methods research for assessment. A formative qualitative research will identify barriers and facilitators for implementing CCM for the management of HF and develop components of the intervention. Subsequently, a cluster randomised controlled trial (RCT) involving 22 centres (tertiary hospitals) with more than 1500 HF patients will be conducted to assess the effectiveness of the CCM in improving...

Journal of the Association of Physicians of India

Iron deficiency (ID) with or without anemia is frequently observed in patients with heart failure... more Iron deficiency (ID) with or without anemia is frequently observed in patients with heart failure (HF). Uncorrected ID is associated with higher hospitalization and mortality in patients with acute HF (AHF) and chronic HF (CHF). Hence, in addition to chronic renal insufficiency, anemia, and diabetes, ID appears as a novel comorbidity and a treatment target of CHF. Intravenous (IV) ferric carboxymaltose (FCM) reduces the hospitalization risk due to HF worsening and improves functional capacity and quality of life (QOL) in HF patients. The current consensus document provides criteria, an expert opinion on the diagnosis of ID in HF, patient profiles for IV FCM, and correct administration and monitoring of such patients

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy

Journal of Association of Physicians of India, Mar 1, 2022

AIM To address the existing gaps in knowledge about long-acting nitroglycerine (LA-NTG) and provi... more AIM To address the existing gaps in knowledge about long-acting nitroglycerine (LA-NTG) and provide recommendations to address these issues. METHODOLOGY Approved LA-NTG questionnaire that included 17 questions related to the role of LA-NTG in the management of angina and chronic coronary syndrome (CCS) was shared with 150 expert cardiologists from different regions from India. Results of these survey questionnaires were further discussed in 12 regional level meetings. The opinions and suggestions from all the meetings were compiled and analyzed. Further, recommendations were made with the help of attending national cardiology experts and a consensus statement was derived. RESULTS This is the first consensus on LA-NTG, summarizing the clinical evidence from India and suggesting recommendations based on these data. The experts recommended early use of LA-NTG as a first-line antianginal therapy in combination with beta-blocker since it improves exercise tolerance in patients with CCS. A strong consensus was observed for using LA-NTG in patients with co-morbid hypertension, diabetes, chronic kidney disease and post-percutaneous coronary intervention angina. As a part of cardiac rehabilitation, LA-NTG allows patients with angina to exercise to a greater functional capacity. CONCLUSIONS A national consensus was observed for several aspects of LA-NTG in the management of angina and CCS. The clinical experience of the experts confirmed an extremely satisfied patient perception about the efficacy of LA-NTG.

Current Medical Research and Opinion, 2021

Abstract Type 2 diabetes mellitus (T2DM) is a global epidemic. According to international guideli... more Abstract Type 2 diabetes mellitus (T2DM) is a global epidemic. According to international guidelines, the management protocol of T2DM includes lowering of blood glucose, along with preventing disease-related complications and maintaining optimal quality of life. Further, the guidelines recommend the use of a patient-centric approaches for the management of T2DM; however, Asian population is underrepresented in landmark cardiovascular outcome trials (CVOTs). There are several guidelines available today for the diagnosis and management of T2DM, and hence there is much confusion among practitioners about which guidelines to follow. A group of thirty international clinical experts comprising of endocrinologists, diabetologists and cardiologist from South Asia, Middle East and Africa met at New Delhi, India on February 8 and 9, 2020 and developed an international expert opinion statements via a structured modified Delphi method on the glucodynamic properties of OADs and the glucocratic treatment approach for the management of T2DM. In this modified Delphi consensus report, we document the glucodynamic properties of Modern SUs in terms of glucoconfidence, glucosafety, and gluconomics. According to glucodynamics theory, an ideal antidiabetic drug should be efficacious, safe, and affordable. Modern SUs as a class of OADs that have demonstrated optimal glucodynamics in terms of glucoconfidence, glucosafety, and gluconomics. Hence, modern SUs are most suitable second line drug after metformin for developing countries. Based on the current evidence, we recommend a glucocratic approach for the treatment of T2DM, where an individualized treatment plan with phenotype, lifestyle, environmental, social, and cultural factors should be considered for persons with T2DM in the South Asian, Middle Eastern and African regions.

$Research paper thumbnail of Consensus and development of document for management of stabilized acute decompensated heart failure with reduced ejection fraction in India$

Indian Heart Journal, 2020

Journal of Family Medicine and Primary Care, 2020

Type 2 diabetes mellitus (T2DM) is a progressive disease with multifactorial etiology. The first-... more Type 2 diabetes mellitus (T2DM) is a progressive disease with multifactorial etiology. The first-line therapy includes monotherapy (with metformin), which often fails to provide effective glycemic control, necessitating the addition of add-on therapy. In this regard, multiple single-dose agents formulated as a single-dose form called fixed-dose combinations (FDCs) have been evaluated for their safety, efficacy, and tolerability. The primary objective of this review is to develop practice-based expert group opinion on the current status and the causes of concern regarding the irrational use of FDCs, in Indian settings. After due discussions, the expert group analyzed the results from several clinical evidence in which various fixed combinations were used in T2DM management. The panel opined that FDCs (double or triple) improve patient adherence, reduce cost, and provide effective glycemic control and, thereby, play an important role in the management of T2DM. The expert group strongly recommended that the irrational metformin FDC's, banned by Indian government, should be stopped and could be achieved through active participation from the government, regulatory bodies, and health ministry, and through continuous education of primary care physicians and pharmacists. In T2DM management, FDCs play a crucial role in achieving glycemic targets effectively. However, understanding the difference between rational and irrational FDC combinations is necessary from the safety, efficacy, and tolerability perspective. In this regard, primary care physicians will have to use a multistep approach so that they can take informed decisions.